Article ; Online: Predicted structural differences of four fertility-related Y-chromosome proteins in Macaca mulatta, M. fascicularis, and their Indochinese hybrids.
2020 Volume 89, Issue 3, Page(s) 361–370
Abstract: ... of the rhesus macaque (Macaca mulatta) Y-chromosome deep into the range of the long-tailed macaque (M. fascicularis ... to experience intense levels of sperm competition. Several spermatogenesis genes are located on the Y-chromosome ... These observations have led to the prediction that the successful introgression of the rhesus Y-haplotype is due ...
| Abstract | Species in the genus Macaca typically live in multimale-multifemale social groups with male macaques exhibiting some of the largest testis: body weight ratios among primates. Males are believed to experience intense levels of sperm competition. Several spermatogenesis genes are located on the Y-chromosome and, interestingly, occasional hybridization between two species has led to the introgression of the rhesus macaque (Macaca mulatta) Y-chromosome deep into the range of the long-tailed macaque (M. fascicularis). These observations have led to the prediction that the successful introgression of the rhesus Y-haplotype is due to functional differences in spermatogenesis genes compared to those of the native long-tailed Y-haplotype. We examine here four Y-chromosomal loci-RBMY, XKRY, and two nearly identical copies of CDY-and their corresponding protein sequences. The genes were surveyed in representative animals from north of, south of, and within the rhesus x long-tailed introgression zone. Our results show a series of non-synonymous amino acid substitutions present between the two Y-haplotypes. Protein structure modeling via I-TASSER revealed different folding patterns between the two species' Y-proteins, and functional predictions via TreeSAAP further reveal physicochemical differences as a result of non-synonymous substitutions. These differences inform our understanding of the evolution of primate Y-proteins involved in spermatogenesis and, in turn, have biomedical implications for human male fertility. |
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| MeSH term(s) | Amino Acid Substitution/genetics ; Animals ; Computational Biology ; Genetic Introgression/genetics ; Haplotypes/genetics ; Macaca fascicularis/genetics ; Macaca mulatta/genetics ; Male ; Models, Molecular ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; Sequence Alignment ; Sequence Analysis, Protein ; Y Chromosome/genetics |
| Chemical Substances | Nuclear Proteins ; RNA-Binding Proteins |
| Language | English |
| Publishing date | 2020-11-15 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 806683-8 |
| ISSN | 1097-0134 ; 0887-3585 |
| ISSN (online) | 1097-0134 |
| ISSN | 0887-3585 |
| DOI | 10.1002/prot.26021 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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