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  1. Book ; Conference proceedings: The next steps forward in reducing the impact of preterm birth

    Lamont, Ronald F.

    proceedings of the 2nd International Preterm Labour Congress, 2 - 4 September 2004, Montreux, Switzerland

    (BJOG ; 112, Suppl. 1)

    2005  

    Event/congress International Preterm Labour Congress (2, 2004, Montreux)
    Author's details guest ed.: R. F. Lamont
    Series title BJOG ; 112, Suppl. 1
    Collection
    Language English
    Size 121 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014310080
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  2. Article ; Online: Spontaneous preterm labour that leads to preterm birth: An update and personal reflection.

    Lamont, Ronald F

    Placenta

    2019  Volume 79, Page(s) 21–29

    Abstract: Objective: The objective was to provide an update of progress made over time (including personal reflection) of our attempts to reduce the mortality and morbidity associated with spontaneous preterm labour that leads to preterm birth.: Methods: An ... ...

    Abstract Objective: The objective was to provide an update of progress made over time (including personal reflection) of our attempts to reduce the mortality and morbidity associated with spontaneous preterm labour that leads to preterm birth.
    Methods: An experienced and evidence based approach was taken to provide an overview of progress made over a generation (∼40 years) in our understanding of spontaneous preterm labour.
    Results: It is evident that we have made significant progress in our understanding of the aetiology, the measurement of the burden, the basic science, systems biology and mechanical pathways of the preterm parturition syndrome. We have better ways of predicting, preventing and managing spontaneous preterm labour than existed a generation ago.
    Conclusions: The profile of spontaneous preterm labour that leads to preterm birth, thanks to organisations such as the March of Dimes, WHO and PREBIC is much more evident than before. However, while we have come a long way, we must not be complacent, and clinicians and basic scientists must continue to work in harmony, while recruiting and encouraging young investigators to join the effort to improve survival and handicap in what is one of the Great Obstetric Syndromes.
    MeSH term(s) Animals ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Predictive Value of Tests ; Pregnancy ; Premature Birth/diagnosis ; Premature Birth/etiology ; Premature Birth/prevention & control
    Language English
    Publishing date 2019-03-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2019.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The safety of phthalate-containing medications used during pregnancy.

    Ali, Amaan / Jørgensen, Jan Stener / Lamont, Ronald F

    Expert opinion on drug safety

    2023  Volume 22, Issue 4, Page(s) 293–302

    Abstract: Introduction: Phthalates freely cross the placenta and have the potential to influence pregnancy outcomes, with evidence of an increased incidence of preterm birth, low birth weight, pregnancy loss, and gestational diabetes. There is no regulation of ... ...

    Abstract Introduction: Phthalates freely cross the placenta and have the potential to influence pregnancy outcomes, with evidence of an increased incidence of preterm birth, low birth weight, pregnancy loss, and gestational diabetes. There is no regulation of phthalate concentrations in medications, which is often found in enteric coatings. Ingestion of phthalate containing medication during pregnancy may result in materno-fetal harm.
    Areas covered: Phthalate subtypes, sources of phthalate exposure, mechanisms of phthalate toxicity, associations between phthalate exposure and incidence of preterm birth, low birth weight, fetal growth, gestational diabetes, and placental development.
    Expert opinion: There is robust evidence to link exposure to phthalates in medical products including preterm birth, gestational diabetes, pregnancy-induced hypertension, and miscarriage. Nevertheless, future studies need to address standardization to avoid the heterogeneity of current studies. In future, the use of naturally occurring biopolymers may be safer, and the role of vitamin D as an immune modulator also has promise.
    MeSH term(s) Pregnancy ; Humans ; Infant, Newborn ; Female ; Placenta ; Premature Birth/chemically induced ; Premature Birth/epidemiology ; Diabetes, Gestational ; Maternal Exposure ; Pregnancy Outcome ; Abortion, Spontaneous
    Chemical Substances phthalic acid (6O7F7IX66E)
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2023.2205637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The contribution of bacteriophages to the aetiology and treatment of the bacterial vaginosis syndrome.

    Ali, Amaan / Jørgensen, Jan Stener / Lamont, Ronald F

    Faculty reviews

    2022  Volume 11, Page(s) 8

    Abstract: Bacteriophages are obligate intracellular viruses that parasitize bacteria, making use of the host biosynthetic machinery. Bacterial vaginosis (BV) causes serious adverse sequelae, such as sexually transmitted infections, seroconversion to HIV positivity, ...

    Abstract Bacteriophages are obligate intracellular viruses that parasitize bacteria, making use of the host biosynthetic machinery. Bacterial vaginosis (BV) causes serious adverse sequelae, such as sexually transmitted infections, seroconversion to HIV positivity, and preterm birth. The aetiology of BV is multifactorial, and the vaginal microbiota, the response to antibiotics, and the phenotypic outcomes differ between cases. The choice of antibiotics to treat BV depends on the clinician's personal experience, which contributes to the poor outcome of BV treatment and high recurrence rate. In this review, we classify BV into two subtypes based on whether or not the BV case is sexually associated (potentially phage-related). An appropriate antibiotic can be selected on the basis of this BV-typing to optimise the short- and long-term effects of treatment. Not all
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/11-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Antibiotics for the prevention of infection related preterm birth.

    Lamont, Ronald F

    BMJ (Clinical research ed.)

    2016  Volume 355, Page(s) i5805

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Humans ; Infant, Newborn ; Obstetric Labor, Premature/drug therapy ; Pregnancy Complications, Infectious/drug therapy ; Premature Birth/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2016--02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.i5805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safety and Efficacy of Tocolytics for the Treatment of Spontaneous Preterm Labour.

    Lamont, Ronald F / Jørgensen, Jan S

    Current pharmaceutical design

    2019  Volume 25, Issue 5, Page(s) 577–592

    Abstract: Background: Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Attempts to reduce the burden may be proactive using biochemical or biophysical prediction and preventative measures. If these efforts fail, then the approach ... ...

    Abstract Background: Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Attempts to reduce the burden may be proactive using biochemical or biophysical prediction and preventative measures. If these efforts fail, then the approach may have to be reactive using tocolytics to inhibit spontaneous preterm labour.
    Objective: We have reviewed the evidence concerning the safety and efficacy of various classes of tocolytic agents.
    Results: The evidence to support the use of magnesium sulfate or nitric oxide donors as a tocolytic is poor. Compared to placebo or no treatment, there is evidence to support the efficacy of calcium channel blockers (mainly nifedipine), prostaglandin synthetase inhibitors (mainly indomethacin and sulindac), oxytocin receptor antagonists (mainly atosiban) and β2-agonists (mainly ritodrine, terbutaline, salbutamol and fenoterol). Maternal safety concerns have reduced the use of β2-agonists. Fetal safety and gestational age restrictions have largely condemned prostaglandin synthetase inhibitors to second-line therapy. First-line therapy in Europe and other parts of the world outside the USA and Australia is limited to calcium channel blockers and oxytocin receptor antagonists. With respect to efficacy, atosiban and nifedipine are similar, but the robustness of the evidence favours atosiban. With respect to safety, atosiban is clearly the safest tocolytic as there are fetomaternal concerns with nifedipine, particularly in high daily doses.
    Conclusion: The perfect tocolytic that is uniformly effective and safe does not exist. Cost, licensing and informed consent are considerations involved in the choice. Efforts continue to develop and introduce other or better agents, including novel compounds such as progesterone, PGF2α antagonists and statins.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Obstetric Labor, Premature/drug therapy ; Pregnancy ; Premature Birth ; Tocolytic Agents/adverse effects ; Tocolytic Agents/therapeutic use
    Chemical Substances Tocolytic Agents
    Language English
    Publishing date 2019-01-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612825666190329124214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Advances in the Prevention of Infection-Related Preterm Birth.

    Lamont, Ronald F

    Frontiers in immunology

    2015  Volume 6, Page(s) 566

    Abstract: Infection-related preterm birth (PTB) is more common at early gestational ages and is associated with major neonatal mortality and morbidity. Abnormal genital tract microflora in early pregnancy predicts late miscarriage and early PTB. Accordingly, it is ...

    Abstract Infection-related preterm birth (PTB) is more common at early gestational ages and is associated with major neonatal mortality and morbidity. Abnormal genital tract microflora in early pregnancy predicts late miscarriage and early PTB. Accordingly, it is logical to consider antibiotics as an intervention. Unfortunately, the conclusions of systematic reviews and meta-analyses (SR&MAs) carried out in an attempt to explain the confusion over the heterogeneity of individual studies are flawed by the fact that undue reliance was placed on studies which: (a) had a suboptimal choice of antibiotic (mainly metronidazole) or used antibiotics not recommended for the treatment of bacterial vaginosis (BV) or BV-related organisms; (b) used antibiotics too late in pregnancy to influence outcome (23-27 weeks); and (c) included women whose risk of PTB was not due to abnormal genital tract colonization and hence unlikely to respond to antibiotics. These risks included: (a) previous PTB of indeterminate etiology; (b) low weight/body mass index; or (c) detection of fetal fibronectin, ureaplasmas, Group B streptococcus or Trichomonas vaginalis). While individual studies have found benefit of antibiotic intervention for the prevention of PTB, in meta-analyses these effects have been negated by large methodologically flawed studies with negative results. As a result, many clinicians think that any antibiotic given at any time in pregnancy to any woman at risk of PTB will cause more harm than good. Recently, a more focused SR&MA has demonstrated that antibiotics active against BV-related organisms, used in women whose risk of PTB is due to abnormal microflora, and used early in pregnancy before irreversible inflammatory damage has occurred, can reduce the rate of PTB. This review presents those data, the background and attempts to explain the confusion using new information from culture-independent molecular-based techniques. It also gives guidance on the structure of putative future antibiotic intervention studies.
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2015.00566
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  8. Article ; Online: Re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset group B streptococcal disease: a systematic review and meta-analysis.

    Lamont, Ronald F / Jørgensen, Jan Stener / Vinter, Christina A

    BJOG : an international journal of obstetrics and gynaecology

    2020  Volume 127, Issue 9, Page(s) 1167–1168

    MeSH term(s) Antibiotic Prophylaxis ; Delivery, Obstetric ; Female ; Humans ; Parturition ; Pregnancy ; Streptococcus agalactiae
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.16298
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  9. Article ; Online: Oxytocin-receptor antagonists in the aetiology of autism spectrum disorder.

    Lamont, Ronald F / Jørgensen, Jan Stener

    Early human development

    2017  Volume 112, Page(s) 60–61

    MeSH term(s) Autism Spectrum Disorder ; Autistic Disorder ; Humans ; Oxytocin ; Receptors, Oxytocin ; Social Behavior
    Chemical Substances Receptors, Oxytocin ; Oxytocin (50-56-6)
    Language English
    Publishing date 2017
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2017.04.012
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  10. Article ; Online: Research to achieve a reduction in the global rate of preterm birth needs attention: Preface to the special issue by the preterm Birth International Collaborative (PREBIC).

    Menon, Ramkumar / Williams, Scott M / Lamont, Ronald F

    Placenta

    2019  Volume 79, Page(s) 1–2

    MeSH term(s) Humans ; International Cooperation ; Premature Birth/prevention & control
    Language English
    Publishing date 2019-01-09
    Publishing country Netherlands
    Document type Introductory Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2019.01.008
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