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  1. Book: The SCID-D interview

    Steinberg, Marlene

    dissociation assessment in therapy, forensics, and research

    2023  

    Title variant Semi-structured clinical interview for dissociative symptoms and disorders
    Author's details Marlene Steinberg
    Keywords Dissociative Disorders / diagnosis ; Interview, Psychological / methods ; Psychiatric Status Rating Scale ; Structured Clinical Interview for DSM-IV Dissociative Disorders
    Subject code 616.8523075
    Language English
    Size 170 Seiten, Illustrationen, 28 cm
    Publisher American Psychiatric Association Publishing
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT021835427
    ISBN 978-1-61537-342-0 ; 1-61537-342-X
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Decoding the Cardiac Actions of Protein Kinase D Isoforms.

    Steinberg, Susan F

    Molecular pharmacology

    2021  Volume 100, Issue 6, Page(s) 558–567

    Abstract: Protein kinase D (PKD) consists of a family of three structurally related enzymes that play key ...

    Abstract Protein kinase D (PKD) consists of a family of three structurally related enzymes that play key roles in a wide range of biological functions that contribute to the evolution of cardiac hypertrophy and heart failure. PKD1 (the founding member of this enzyme family) has been implicated in the phosphorylation of substrates that regulate cardiac hypertrophy, contraction, and susceptibility to ischemia/reperfusion injury, and de novo
    MeSH term(s) Animals ; Heart Defects, Congenital/genetics ; Heart Defects, Congenital/metabolism ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mutation ; Myocytes, Cardiac/metabolism ; Protein Kinase C/genetics ; Protein Kinase C/metabolism
    Chemical Substances Isoenzymes ; protein kinase D (EC 2.7.10.-) ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/molpharm.121.000341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investigating Vitamin D Receptor Genetic Markers in a Cluster Headache Meta-Analysis.

    Jennysdotter Olofsgård, Felicia / Ran, Caroline / Qin, Yuyan / Fourier, Carmen / Sjöstrand, Christina / Waldenlind, Elisabet / Steinberg, Anna / Belin, Andrea Carmine

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: ... Vitamin D is essential for a variety of bodily functions and vitamin D levels are largely regulated ... between CH and three single-nucleotide polymorphisms in the vitamin D receptor gene, rs2228570, rs1544410 ... vitamin D involvement in CH, this study does not indicate any connection between CH and the three vitamin ...

    Abstract Patients diagnosed with the primary headache disorder known as cluster headache (CH) commonly report that their headache attacks occur in patterns of both circadian and seasonal rhythmicity. Vitamin D is essential for a variety of bodily functions and vitamin D levels are largely regulated by daylight exposure in connection with seasonal variation. For this Sweden-based study, the association between CH and three single-nucleotide polymorphisms in the vitamin D receptor gene, rs2228570, rs1544410, and rs731236, were investigated, as well as CH bouts and trigger factors in relation to seasonal and weather changes. Over 600 study participants with CH and 600 controls were genotyped for rs2228570, and genotyping results for rs1544410 and rs731236 were obtained from a previous genome-wide association study. The genotyping results were combined in a meta-analysis, with data from a Greek study. No significant association was found between rs2228570 and CH or the CH subtype in Sweden, nor did the meta-analysis show significant results for any of the three markers. The most common period of the year to experience CH bouts in Sweden was autumn, and conditions linked to weather or weather changes were also identified as potential triggers for CH bouts for a quarter of the responders who reported bout triggers. Though we cannot rule out vitamin D involvement in CH, this study does not indicate any connection between CH and the three vitamin D receptor gene markers.
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Receptors, Calcitriol/genetics ; Genetic Association Studies ; Genome-Wide Association Study ; Cluster Headache/genetics ; Genetic Markers ; Vitamin D/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances Receptors, Calcitriol ; Genetic Markers ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Indirect regulation of HMGB1 release by gasdermin D.

    Volchuk, Allen / Ye, Anna / Chi, Leon / Steinberg, Benjamin E / Goldenberg, Neil M

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 4561

    Abstract: ... treatment. We also explore whether HMGB1 is released via the pore-forming protein gasdermin D after ... and IL-1β secretion. During endotoxemia, gasdermin D knockout mice secrete HMGB1 normally ...

    Abstract The protein high-mobility group box 1 (HMGB1) is released into the extracellular space in response to many inflammatory stimuli, where it is a potent signaling molecule. Although research has focused on downstream HMGB1 signaling, the means by which HMGB1 exits the cell is controversial. Here we demonstrate that HMGB1 is not released from bone marrow-derived macrophages (BMDM) after lipopolysaccharide (LPS) treatment. We also explore whether HMGB1 is released via the pore-forming protein gasdermin D after inflammasome activation, as is the case for IL-1β. HMGB1 is only released under conditions that cause cell lysis (pyroptosis). When pyroptosis is prevented, HMGB1 is not released, despite inflammasome activation and IL-1β secretion. During endotoxemia, gasdermin D knockout mice secrete HMGB1 normally, yet secretion of IL-1β is completely blocked. Together, these data demonstrate that in vitro HMGB1 release after inflammasome activation occurs after cellular rupture, which is probably inflammasome-independent in vivo.
    MeSH term(s) Animals ; Disease Models, Animal ; Endotoxemia/metabolism ; Female ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipopolysaccharides/adverse effects ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphate-Binding Proteins/genetics ; Phosphate-Binding Proteins/metabolism ; Pyroptosis ; Signal Transduction
    Chemical Substances Gsdmd protein, mouse ; HMGB1 Protein ; HMGB1 protein, mouse ; IL1B protein, mouse ; Inflammasomes ; Interleukin-1beta ; Intracellular Signaling Peptides and Proteins ; Lipopolysaccharides ; Phosphate-Binding Proteins
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-18443-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Investigating Vitamin D Receptor Genetic Markers in a Cluster Headache Meta-Analysis

    Felicia Jennysdotter Olofsgård / Caroline Ran / Yuyan Qin / Carmen Fourier / Christina Sjöstrand / Elisabet Waldenlind / Anna Steinberg / Andrea Carmine Belin

    International Journal of Molecular Sciences, Vol 24, Iss 5950, p

    2023  Volume 5950

    Abstract: ... Vitamin D is essential for a variety of bodily functions and vitamin D levels are largely regulated ... between CH and three single-nucleotide polymorphisms in the vitamin D receptor gene, rs2228570, rs1544410 ... vitamin D involvement in CH, this study does not indicate any connection between CH and the three vitamin ...

    Abstract Patients diagnosed with the primary headache disorder known as cluster headache (CH) commonly report that their headache attacks occur in patterns of both circadian and seasonal rhythmicity. Vitamin D is essential for a variety of bodily functions and vitamin D levels are largely regulated by daylight exposure in connection with seasonal variation. For this Sweden-based study, the association between CH and three single-nucleotide polymorphisms in the vitamin D receptor gene, rs2228570, rs1544410, and rs731236, were investigated, as well as CH bouts and trigger factors in relation to seasonal and weather changes. Over 600 study participants with CH and 600 controls were genotyped for rs2228570, and genotyping results for rs1544410 and rs731236 were obtained from a previous genome-wide association study. The genotyping results were combined in a meta-analysis, with data from a Greek study. No significant association was found between rs2228570 and CH or the CH subtype in Sweden, nor did the meta-analysis show significant results for any of the three markers. The most common period of the year to experience CH bouts in Sweden was autumn, and conditions linked to weather or weather changes were also identified as potential triggers for CH bouts for a quarter of the responders who reported bout triggers. Though we cannot rule out vitamin D involvement in CH, this study does not indicate any connection between CH and the three vitamin D receptor gene markers.
    Keywords rs2228570 ; rs1544410 ; rs731236 ; pain ; seasonal rhythmicity ; Fok1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Relation of Lymphangiogenic Factor Vascular Endothelial Growth Factor-D to Elevated Pulmonary Artery Wedge Pressure.

    Houston, Brian A / Tedford, Ryan J / Baxley, Renee L / Sykes, Brandon / Powers, Eric R / Nielsen, Christopher D / Steinberg, Daniel H / Maran, Anbukarasi / Fernandes, Valerian L C / Todoran, Thomas / Jones, Jeffrey A / Zile, Michael R

    The American journal of cardiology

    2019  Volume 124, Issue 5, Page(s) 756–762

    Abstract: ... have indicated that vascular endothelial growth factors (VEGF-A, -C, and -D) are involved ... in lymphangiogenesis. This study examined the association between VEGF-A, -C, and -D levels, invasively measured ... measurement of VEGF-A, -C, and -D. Fifty-six patients were included for analysis. Subjects with elevated ...

    Abstract Lymphatic flow is augmented in states of chronic heart failure (cHF). However, the biological mechanism driving increased lymphatic flow capacity (lymphangiogenesis) in cHF is unknown. Recent studies have indicated that vascular endothelial growth factors (VEGF-A, -C, and -D) are involved in lymphangiogenesis. This study examined the association between VEGF-A, -C, and -D levels, invasively measured hemodynamics, and heart failure symptoms. Subjects who underwent clinically indicated right heart catheterization at Medical University of South Carolina between 12/2016 and 7/2018 were eligible for inclusion. These subjects underwent clinical assessment of cHF severity (including 6MWT and KCCQ), hemodynamic assessment with right heart catheterization, laboratory studies including B-type natriuretic peptide, and concomitant measurement of VEGF-A, -C, and -D. Fifty-six patients were included for analysis. Subjects with elevated pulmonary artery wedge pressure (PAWP) had significantly higher VEGF-D levels (263 ± 415 pg/ml vs 65 ± 101 pg/ml; p = 0.02). PAWP was not associated with VEGF-A or VEGF-C levels. When stratified by VEGF-D, subjects with elevated VEGF-D had clinical and hemodynamic characteristics associated with worse HF severity (lower ejection fraction, higher b-type natriuretic peptide, higher PAWP, lower cardiac output), but were not more symptomatic by Kansas City Cardiomyopathy Questionnaire scores and had similar 6-minute walk test distance compared with subjects with lower VEGF-D. Subjects with an elevated VEGF-D were more likely to have a diagnosis of heart failure for >3 years. In conclusion, VEGF-D is associated with elevated PAWP in cHF, and elevated VEGF-D may mitigate cHF symptoms.
    MeSH term(s) Adult ; Aged ; Biomarkers/metabolism ; Cardiac Catheterization/methods ; Chronic Disease ; Disease Progression ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Hemodynamics/physiology ; Hospitals, University ; Humans ; Hypertension, Pulmonary/physiopathology ; Lymphangiogenesis/physiology ; Male ; Middle Aged ; Prognosis ; Pulmonary Wedge Pressure/physiology ; Risk Assessment ; Sensitivity and Specificity ; Severity of Illness Index ; Stroke Volume/physiology ; Vascular Endothelial Growth Factor D/metabolism
    Chemical Substances Biomarkers ; Vascular Endothelial Growth Factor D
    Language English
    Publishing date 2019-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2019.05.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Indirect regulation of HMGB1 release by gasdermin D

    Allen Volchuk / Anna Ye / Leon Chi / Benjamin E. Steinberg / Neil M. Goldenberg

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis. ...

    Abstract HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
    Keywords Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Indirect regulation of HMGB1 release by gasdermin D

    Allen Volchuk / Anna Ye / Leon Chi / Benjamin E. Steinberg / Neil M. Goldenberg

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis. ...

    Abstract HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
    Keywords Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: [ANTI-N-METHYL-D-ASPARTATE (NMDA) ENCEPHALITIS: THE ISRAELI PEDIATRIC MULTI-CENTER EXPERIENCE].

    Politi, Keren / Marom, Dafna / Ashkenazi, Shay / Livni, Gilat / Goldberg, Hadassa / Shuper, Avinoam / Steinberg, Tami / Lahat, Eli / Haiman, Eli / Shtrausberg, Rachel

    Harefuah

    2017  Volume 156, Issue 8, Page(s) 478–481

    Abstract: Introduction: Anti-N-methyl-D-aspartate (NMDA) encephalitis is a disorder characterized by acute ...

    Abstract Introduction: Anti-N-methyl-D-aspartate (NMDA) encephalitis is a disorder characterized by acute neuro-psychiatric symptoms, appearing mostly after a recent febrile disease, with a gradual progressive course, associated with laboratory or radiologic evidence of active inflammation. Many of the patients will present with a continuous neuro-cognitive disorder which could lead to major morbidity and even mortality. It was recently reported that this disorder can present at childhood as a primary disease or as a secondary complication of herpes simplex infection. Early diagnosis and treatment have significantly improved the patients' prognosis and prevented chronic complications. We will present six pediatric patients at ages 1-14 years, followed from 2011-2014 in Schneider Children's Medical Center and Assaf Harofeh Medical Center due to acute encephalitis, with a clinical course under suspicion for anti-NMDA encephalitis. The article will review the clinical and diagnostic dilemmas and suggested guidelines. Pediatricians should be aware of this new emerging syndrome.
    MeSH term(s) Adolescent ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Autoantibodies ; Child ; Child, Preschool ; Early Diagnosis ; Female ; Humans ; Infant ; Male ; N-Methylaspartate ; Prognosis
    Chemical Substances Autoantibodies ; N-Methylaspartate (6384-92-5)
    Language Hebrew
    Publishing date 2017-08
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficient graphene saturable absorbers on D-shaped optical fiber for ultrashort pulse generation.

    Zapata, J D / Steinberg, D / Saito, L A M / de Oliveira, R E P / Cárdenas, A M / de Souza, E A Thoroh

    Scientific reports

    2016  Volume 6, Page(s) 20644

    Abstract: ... light field interaction of CVD monolayer graphene deposited on side-polished D-shaped optical fiber ...

    Abstract We demonstrated a method to construct high efficiency saturable absorbers based on the evanescent light field interaction of CVD monolayer graphene deposited on side-polished D-shaped optical fiber. A set of samples was fabricated with two different core-graphene distances (0 and 1 μm), covered with graphene ranging between 10 and 25 mm length. The mode-locking was achieved and the best pulse duration was 256 fs, the shortest pulse reported in the literature with CVD monolayer graphene in EDFL. As result, we find a criterion between the polarization relative extinction ratio in the samples and the pulse duration, which relates the better mode-locking performance with the higher polarization extinction ratio of the samples. This criterion also provides a better understanding of the graphene distributed saturable absorbers and their reproducible performance as optoelectronic devices for optical applications.
    Language English
    Publishing date 2016-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep20644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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