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  1. Book ; Thesis: Hippocampusvolumetrie bei Kindern

    Weil, Sabine

    1999  

    Author's details vorgelegt von Sabine Weil
    Language German
    Size 76 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1999
    HBZ-ID HT011126235
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Long-term results of Waldenström macroglobulinaemia treatment by bendamustine and rituximab: A study on behalf of the French Innovative Leukemia Organization (FILO).

    Laribi, Kamel / Poulain, Stéphanie / Willems, Lise / Merabet, Fatiha / Herbaux, Charles / Roos-Weil, Damien / Laribi de Materre, Inès / Roussel, Xavier / Nudel, Morgane / Tricot, Sabine / Dupuis, Jehan / Le Calloch, Ronan / Bareau, Benoit / Leblond, Véronique

    British journal of haematology

    2024  

    Abstract: The bendamustine-rituximab (BR) schedule is an efficient first-line therapy in Waldenström macroglobulinaemia (WM). A previous analysis of 69 patients who received this treatment confirmed a high response rate and good progression-free (PFS) and overall ... ...

    Abstract The bendamustine-rituximab (BR) schedule is an efficient first-line therapy in Waldenström macroglobulinaemia (WM). A previous analysis of 69 patients who received this treatment confirmed a high response rate and good progression-free (PFS) and overall survival (OS). With a median follow-up of 76.1 months (95% confidence interval [CI] 69.9-80.6), 5-year outcome is still excellent at 66.63% (95% CI 56.09-79.17) for PFS and 80.01% (95% CI 70.82-90.41) for OS. The rate of secondary cancers is 17.66% (IQR 7.99-27.64) at 66 months. Relapsed patients who received ibrutinib as second-line clearly benefited from this schedule. This confirms current recommendations suggesting BR long-term efficacy as first-line option in WM.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19409
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  3. Article ; Online: Association of European Paediatric and Congenital Cardiology practical recommendations for surveillance and prevention of cardiac disease in childhood cancer survivors: the importance of physical activity and lifestyle changes From the Association of European Paediatric and Congenital Cardiology Working Group Sports Cardiology, Physical Activity and Prevention, Working Group Adult Congenital Heart Disease, Working Group Imaging and Working Group Heart Failure.

    Kesting, Sabine / Giordano, Ugo / Weil, Jochen / McMahon, Colin J / Albert, Dimpna C / Berger, Claire / Budts, Werner / Fritsch, Peter / Hidvégi, Erzsébet V / Oberhoffer-Fritz, Renate / Milano, Giuseppe M / Wacker-Gußmann, Annette / Herceg-Čavrak, Vesna

    Cardiology in the young

    2024  Volume 34, Issue 2, Page(s) 250–261

    Abstract: Background: Childhood cancer survivors are at increased risk of developing cardiovascular diseases, presenting as the main causes of morbidity and mortality within this group. Besides the usual primary and secondary prevention in combination with ... ...

    Abstract Background: Childhood cancer survivors are at increased risk of developing cardiovascular diseases, presenting as the main causes of morbidity and mortality within this group. Besides the usual primary and secondary prevention in combination with screening during follow-up, the modifiable lifestyle factors of physical activity, nutrition, and body weight have not yet gained enough attention regarding potential cardiovascular risk reduction.
    Objective: These practical recommendations aim to provide summarised information and practical implications to paediatricians and health professionals treating childhood cancer survivors to reduce the risk of cardiovascular late effects.
    Methods: The content derives from either published guidelines or expert opinions from Association of European Paediatric and Congenital Cardiology working groups and is in accordance with current state-of-the-art.
    Results: All usual methods of prevention and screening regarding the risk, monitoring, and treatment of occurring cardiovascular diseases are summarised. Additionally, modifiable lifestyle factors are explained, and clear practical implications are named.
    Conclusion: Modifiable lifestyle factors should definitely be considered as a cost-effective and complementary approach to already implemented follow-up care programs in cardio-oncology, which can be actively addressed by the survivors themselves. However, treating physicians are strongly encouraged to support survivors to develop and maintain a healthy lifestyle, including physical activity as one of the major influencing factors. This article summarises relevant background information and provides specific practical recommendations on how to advise survivors to increase their level of physical activity.
    MeSH term(s) Child ; Humans ; Adult ; Heart Defects, Congenital/complications ; Cardiovascular Diseases/prevention & control ; Cancer Survivors ; Neoplasms/complications ; Cardiology ; Heart Failure ; Exercise ; Life Style
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951123004213
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  4. Article ; Online: FMRI-based prediction of naltrexone response in alcohol use disorder: a replication study.

    Bach, Patrick / Weil, Georg / Pompili, Enrico / Hoffmann, Sabine / Hermann, Derik / Vollstädt-Klein, Sabine / Kiefer, Falk / Mann, Karl / Sommer, Wolfgang H

    European archives of psychiatry and clinical neuroscience

    2021  Volume 271, Issue 5, Page(s) 915–927

    Abstract: Pharmacological treatment in alcohol use disorder suffers from modest effect sizes. Efforts have been undertaken to identify patient characteristics that help to select individuals that benefit from pharmacological treatment. Previous studies indicated ... ...

    Abstract Pharmacological treatment in alcohol use disorder suffers from modest effect sizes. Efforts have been undertaken to identify patient characteristics that help to select individuals that benefit from pharmacological treatment. Previous studies indicated that neural alcohol cue-reactivity (CR) might provide a marker that identifies patients, which benefit from naltrexone treatment.We investigated the reproducibility of the association between ventral striatum (VS) activation and naltrexone (NTX) treatment response by analyzing data from a recent longitudinal clinical trial in N = 44 abstinent treatment-seeking alcohol-dependent patients. A follow-up was conducted over 3 months. We computed the percentage of significant voxels in VS and tested main effects and interactions with NTX treatment on relapse risk using Cox Regression models.We found a significant interaction effect between pre-treatment cue reactivity in the VS and NTX treatment on time to first heavy relapse (Hazard Ratio = 7.406, 95% CI 1.17-46.56, p = 0.033), such that the patient group with high VS activation (defined by a mean split) showed a significant medication effect (Hazard Ratio = 0.140, 95% CI 0.02-0.75, p = 0.022) with a number needed to treat of 3.4 [95% CI 2.413.5], while there was no significant effect in the group with low VS activation (Hazard Ratio = 0.726, p = 0.454).Thus, using an independent sample we replicated the previously described positive association between VS activation and NTX efficacy. Although our results should be considered cautiously in light of the small sample size, our results support the potential of neural alcohol CR as a tool for precision medicine approaches in alcohol dependence.
    MeSH term(s) Alcoholism/diagnostic imaging ; Alcoholism/drug therapy ; Humans ; Magnetic Resonance Imaging ; Naltrexone/therapeutic use ; Recurrence ; Reproducibility of Results ; Treatment Outcome
    Chemical Substances Naltrexone (5S6W795CQM)
    Language English
    Publishing date 2021-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-021-01259-7
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  5. Book ; Thesis: Perioperativer Einsatz des Fluorchinolons Marbofloxacin in Kombination mit den nichtsteroidalen Antiphlogistika Carprofen und Cimicoxib beim Hund

    Weil, Clarissa / Kästner, Sabine

    2015  

    Author's details vorgelegt von Clarissa Weil
    Language German
    Size 129 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tierärztl. Hochsch., Klinik für Kleintiere, Diss.--Hannover, 2015
    Database Special collection on veterinary medicine and general parasitology

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  6. Book ; Online ; Thesis: Perioperativer Einsatz des Fluorchinolons Marbofloxacin in Kombination mit den nichtsteroidalen Antiphlogistika Carprofen und Cimicoxib beim Hund

    Kästner, Sabine / Weil, Clarissa

    2015  

    Abstract: Fluorchinolon, NSAID, Elektroenzephalogramm. - Ziel der Studie war es einerseits die möglicherweise auftretenden Einflüsse der Kombination des Fluorchinolons Marbofloxacin mit den beiden nichtsteroidalen Antiphlogistika Carprofen (CAR) oder Cimicoxib ( ... ...

    Author's details vorgelegt von Clarissa Weil
    Abstract Fluorchinolon, NSAID, Elektroenzephalogramm. - Ziel der Studie war es einerseits die möglicherweise auftretenden Einflüsse der Kombination des Fluorchinolons Marbofloxacin mit den beiden nichtsteroidalen Antiphlogistika Carprofen (CAR) oder Cimicoxib (CIM) bei Hunden ohne Erkrankung des zentralnervösen Systems auf das Elektroenzephalogramm (EEG) zu untersuchen. Das zweite Ziel der Studie war der Vergleich der postoperativen Analgesie zwischen präoperativ intravenös verabreichtem Carprofen und präoperativ oral appliziertem Cimicoxib. Es wurde eine prospektive, geblindete, teilrandomisierte (matched pairs) Studie durchgeführt. Dazu wurden zwei Gruppen gebildet mit 10 (CIM) bzw. 11 (CAR) Privathunden verschiedener Rassen, die zu verschiedenen Weichteil- und chirurgischen Eingriffen vorstellig wurden. Hunden der Gruppe CIM wurde 2 mg/kg KGW Cimicoxib oral, Hunde der Gruppe CAR 4 mg/kg KGW Carprofen intravenös appliziert. Während der Ableitung eines EEGs wurden 2 mg/kg KGW Marbofloxacin intravenös injiziert. Die Analgesie wurde postoperativ mit Hilfe des short-form Glasgow Composite Measure Pain Scales (CMPS-SF) und der Erfassung von mittlerem arteriellen Blutdruck (MAP), Herzfrequenz (HF) und Atemfrequenz (AF) beurteilt. Zusätzlich erhielten die Besitzer bei Entlassung einen Fragebogen zur Beurteilung ....
    Language German
    Size Online-Ressource (129 S. = 2.441 kb, text), graph. Darst.
    Publisher Tierärztl. Hochsch
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Hannover, Tierärztl. Hochsch., Klinik für Kleintiere, Diss., 2015
    Database Special collection on veterinary medicine and general parasitology

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  7. Book ; Online ; Thesis: Perioperativer Einsatz des Fluorchinolons Marbofloxacin in Kombination mit den nichtsteroidalen Antiphlogistika Carprofen und Cimicoxib beim Hund

    Kästner, Sabine / Weil, Clarissa

    2015  

    Abstract: Fluorchinolon, NSAID, Elektroenzephalogramm. - Ziel der Studie war es einerseits die möglicherweise auftretenden Einflüsse der Kombination des Fluorchinolons Marbofloxacin mit den beiden nichtsteroidalen Antiphlogistika Carprofen (CAR) oder Cimicoxib ( ... ...

    Author's details vorgelegt von Clarissa Weil
    Abstract Fluorchinolon, NSAID, Elektroenzephalogramm. - Ziel der Studie war es einerseits die möglicherweise auftretenden Einflüsse der Kombination des Fluorchinolons Marbofloxacin mit den beiden nichtsteroidalen Antiphlogistika Carprofen (CAR) oder Cimicoxib (CIM) bei Hunden ohne Erkrankung des zentralnervösen Systems auf das Elektroenzephalogramm (EEG) zu untersuchen. Das zweite Ziel der Studie war der Vergleich der postoperativen Analgesie zwischen präoperativ intravenös verabreichtem Carprofen und präoperativ oral appliziertem Cimicoxib. Es wurde eine prospektive, geblindete, teilrandomisierte (matched pairs) Studie durchgeführt. Dazu wurden zwei Gruppen gebildet mit 10 (CIM) bzw. 11 (CAR) Privathunden verschiedener Rassen, die zu verschiedenen Weichteil- und chirurgischen Eingriffen vorstellig wurden. Hunden der Gruppe CIM wurde 2 mg/kg KGW Cimicoxib oral, Hunde der Gruppe CAR 4 mg/kg KGW Carprofen intravenös appliziert. Während der Ableitung eines EEGs wurden 2 mg/kg KGW Marbofloxacin intravenös injiziert. Die Analgesie wurde postoperativ mit Hilfe des short-form Glasgow Composite Measure Pain Scales (CMPS-SF) und der Erfassung von mittlerem arteriellen Blutdruck (MAP), Herzfrequenz (HF) und Atemfrequenz (AF) beurteilt. Zusätzlich erhielten die Besitzer bei Entlassung einen Fragebogen zur Beurteilung ....
    Language German
    Size Online-Ressource (129 S. = 2.441 kb, text), graph. Darst.
    Publisher Tierärztl. Hochsch
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Tierärztl. Hochsch., Klinik für Kleintiere, Diss.--Hannover, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Pattern and predictors of sites of relapse in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project.

    Vo, Kieuhoa T / DuBois, Steven G / Neuhaus, John / Braunstein, Steve E / Weil, Brent R / Naranjo, Arlene / Irtan, Sabine / Balaguer, Julia / Matthay, Katherine K

    Pediatric blood & cancer

    2022  Volume 69, Issue 9, Page(s) e29616

    Abstract: Purpose: We sought to analyze biologic, clinical, and prognostic differences according to pattern of failure at the time of first relapse in neuroblastoma.: Patients and methods: Children <21 years diagnosed with neuroblastoma between 1989 and 2017 ... ...

    Abstract Purpose: We sought to analyze biologic, clinical, and prognostic differences according to pattern of failure at the time of first relapse in neuroblastoma.
    Patients and methods: Children <21 years diagnosed with neuroblastoma between 1989 and 2017 with known site of first relapse (isolated local vs. distant only vs. combined local and distant sites) were identified from the International Neuroblastoma Risk Group (INRG) database. Data were compared between sites of relapse according to clinical features, biologic features, initial treatment, time to first relapse, and overall survival (OS) from time of first relapse.
    Results: Pattern of first relapse among 1833 children was 19% isolated local; 65% distant only; and 16% combined sites. All evaluated clinical and biologic variables with exception of tumor diagnosis differed statistically by relapse pattern, with patients with isolated local failure having more favorable prognostic features. Patients with stage 3 disease were more likely to have isolated local failure compared to all other stages (49% vs. 16%; p < .001). OS significantly differed by relapse pattern (5-year OS ± SE): isolated local: 64% ± 3%; distant only: 23% ± 2%; and combined: 26% ± 4% (p < .001). After controlling for age, stage, and MYCN status, patients with isolated local failure (adjusted hazard ratio [HR] = 0.46; 95% confidence interval [CI]: 0.33-0.62; p < .001) and distant-only failure (adjusted HR = 0.57; 95% CI: 0.45-0.71; p < .001) remained at decreased risk for death as compared to patients with combined failure.
    Conclusion: Patients with distant-only and combined failures have a higher proportion of unfavorable clinical and biological features, and a lower survival than those with isolated local relapse.
    MeSH term(s) Biological Products ; Child ; Humans ; Infant ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Neuroblastoma/pathology ; Prognosis
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29616
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    Zs.A 1131: Show issues Location:
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  9. Article ; Online: Increased network centrality of the anterior insula in early abstinence from alcohol.

    Bordier, Cecile / Weil, Georg / Bach, Patrick / Scuppa, Giulia / Nicolini, Carlo / Forcellini, Giulia / Pérez-Ramirez, Ursula / Moratal, David / Canals, Santiago / Hoffmann, Sabine / Hermann, Derik / Vollstädt-Klein, Sabine / Kiefer, Falk / Kirsch, Peter / Sommer, Wolfgang H / Bifone, Angelo

    Addiction biology

    2021  Volume 27, Issue 1, Page(s) e13096

    Abstract: Abnormal resting-state functional connectivity, as measured by functional magnetic resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings are so far inconsistent. Here, we exploited recent developments in graph- ... ...

    Abstract Abnormal resting-state functional connectivity, as measured by functional magnetic resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings are so far inconsistent. Here, we exploited recent developments in graph-theoretical analyses, enabling improved resolution and fine-grained representation of brain networks, to investigate functional connectivity in 35 recently detoxified alcohol dependent patients versus 34 healthy controls. Specifically, we focused on the modular organization, that is, the presence of tightly connected substructures within a network, and on the identification of brain regions responsible for network integration using an unbiased approach based on a large-scale network composed of more than 600 a priori defined nodes. We found significant reductions in global connectivity and region-specific disruption in the network topology in patients compared with controls. Specifically, the basal brain and the insular-supramarginal cortices, which form tightly coupled modules in healthy subjects, were fragmented in patients. Further, patients showed a strong increase in the centrality of the anterior insula, which exhibited stronger connectivity to distal cortical regions and weaker connectivity to the posterior insula. Anterior insula centrality, a measure of the integrative role of a region, was significantly associated with increased risk of relapse. Exploratory analysis suggests partial recovery of modular structure and insular connectivity in patients after 2 weeks. These findings support the hypothesis that, at least during the early stages of abstinence, the anterior insula may drive exaggerated integration of interoceptive states in AUD patients with possible consequences for decision making and emotional states and that functional connectivity is dynamically changing during treatment.
    MeSH term(s) Adult ; Alcohol Abstinence ; Alcoholism/pathology ; Brain/drug effects ; Humans ; Image Processing, Computer-Assisted ; Insular Cortex/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.13096
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  10. Article ; Online: Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma.

    Jung, Erik / Osswald, Matthias / Ratliff, Miriam / Dogan, Helin / Xie, Ruifan / Weil, Sophie / Hoffmann, Dirk C / Kurz, Felix T / Kessler, Tobias / Heiland, Sabine / von Deimling, Andreas / Sahm, Felix / Wick, Wolfgang / Winkler, Frank

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 1014

    Abstract: Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term ... ...

    Abstract Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term tracking of tumor cell fate and dynamics in the live mouse brain, differential therapeutic responses in both niches are determined. Both the PVN, a preferential location of long-term quiescent glioma cells, and network integration facilitate resistance against cytotoxic effects of radiotherapy and chemotherapy-independently of each other, but with additive effects. Perivascular glioblastoma cells are particularly able to actively repair damage to tumor regions. Population of the PVN and resistance in it depend on proficient NOTCH1 expression. In turn, NOTCH1 downregulation induces resistant multicellular networks by TM extension. Our findings identify NOTCH1 as a central switch between the PVN and network niche in glioma, and demonstrate robust cross-compensation when only one niche is targeted.
    MeSH term(s) Animals ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Plasticity/physiology ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glioma/metabolism ; Glioma/pathology ; Humans ; Mice ; Neoplastic Stem Cells ; Pericytes/metabolism ; Receptor, Notch1/genetics ; Tumor Microenvironment/physiology
    Chemical Substances Notch1 protein, mouse ; Receptor, Notch1
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-21117-3
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