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Article ; Online: Dental Bite-Sized Bits: A Module for Teaching Common Oral Health Conditions to Multidisciplinary Students.

Mills, Denise A / Chu, Anita S / Burns, Andrea / Hoover, Eve B / Wild, Jennifer / Post, Gretchen / Sears, Robyn / Herrick, Amber / Black, Deborah / Roberts, Eugenia P / Roberts, Bradley S

Medical science educator

2023 Volume 33, Issue 2, Page(s) 451–458

Abstract: The Surgeon General's report in the year 2000 highlighted the association between chronic diseases and oral health infections. Current healthcare education programs, regrettably, report only 1 to 3 h of oral health instruction within curricula. In the ... ...

Abstract	The Surgeon General's report in the year 2000 highlighted the association between chronic diseases and oral health infections. Current healthcare education programs, regrettably, report only 1 to 3 h of oral health instruction within curricula. In the years 2020-2022, as part of their respective oral health curricula, 278 first-year physician assistant and 12 pre-clinical second-year pharmacy students were invited to participate in a voluntary survey examining the effectiveness of animated succinct, online video-based oral health units. Among all student responses for the post-use survey, respondents "strongly agreed" or "agreed" that learning objectives of the unit(s) were achieved after reviewing the videos. Of the participants, 97% "strongly agreed" or "agreed" that the videos helped them understand information of which they had no prior knowledge. Similarly, 98% "strongly agreed" or "agreed" the information was appropriate for their level of knowledge. Most students, 93%, "strongly agreed" or "agreed" the exercise was a valuable learning experience. Regarding the importance of future interprofessional collaboration pertaining to a mutual patient's oral health, 95% of participants "strongly agreed" or "agreed" that they would be likely to collaborate. This study demonstrates the importance of oral health as a critical area of focus in healthcare education. The study also confirms the hypothesis that Dental Bite-Sized Bits units deliver engaging, valuable oral health education for preclinical healthcare learners, incorporating interprofessional perspectives from the disciplines of dental, pharmacy, and physician assistant.
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ISSN	2156-8650
ISSN (online)	2156-8650
DOI	10.1007/s40670-023-01760-9
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Article ; Online: Collaboration in interprofessional teams: A needs assessment of factors that impact new resident physicians.

B Allen, Brittany / H Schiller, Jocelyn / J Roberts, Suni / G Allen, Steven / K Morgan, Helen / Malone, Anita

Journal of interprofessional care

2022 Volume 37, Issue 3, Page(s) 392–399

Abstract: Many resident physicians struggle with effective interprofessional collaboration (IPC), but characterization of their challenges is not well known. This study examines gaps in IPC skills for graduating medical students entering residency. A needs ... ...

Abstract	Many resident physicians struggle with effective interprofessional collaboration (IPC), but characterization of their challenges is not well known. This study examines gaps in IPC skills for graduating medical students entering residency. A needs assessment was completed to evaluate factors that impact resident physicians' ability to effectively collaborate with other healthcare professionals. This study included online surveys of 123 recent medical school graduates, 21 semi-structured interviews of residency program directors, and 3 focus groups of healthcare professionals who interacted with residents. Survey results were analyzed for means and narratives from surveys, interviews, and focus groups were analyzed for themes. We found that graduates felt they did not have a strong understanding of other providers' roles and did not feel well prepared to handle conflict with other providers or navigate interprofessional team dynamics. Themes emerging from narrative data generally aligned with the Interprofessional Education Collaborative core competencies including understanding team roles, communicating effectively, and working effectively in a team, but these interviews also elucidated an additional theme, overcoming system barriers. Data from this work can inform curricula in preparation for the transition to residency. The authors also offer an educational framework for learning effective IPC as a new team member.
MeSH term(s)	Humans ; Needs Assessment ; Interprofessional Relations ; Health Personnel ; Focus Groups ; Physicians
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1099758-1
ISSN	1469-9567 ; 0884-3988 ; 1356-1820
ISSN (online)	1469-9567
ISSN	0884-3988 ; 1356-1820
DOI	10.1080/13561820.2022.2094902
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Article ; Online: The Discovery and Early Days of TGF-β: A Historical Perspective.

Moses, Harold L / Roberts, Anita B / Derynck, Rik

Cold Spring Harbor perspectives in biology

2016 Volume 8, Issue 7

Abstract: Transforming growth factors (TGFs) were discovered as activities that were secreted by cancer cells, and later by normal cells, and had the ability to phenotypically and reversibly transform immortalized fibroblasts. TGF-β distinguished itself from TGF-α ...

Abstract	Transforming growth factors (TGFs) were discovered as activities that were secreted by cancer cells, and later by normal cells, and had the ability to phenotypically and reversibly transform immortalized fibroblasts. TGF-β distinguished itself from TGF-α because it did not bind to the same epidermal growth factor (EGF) receptor as TGF-α and, therefore, acted through different cell-surface receptors and signaling mediators. This review summarizes the discovery of TGF-β, the early developments in its molecular and biological characterization with its many biological activities in different cell and tissue contexts and its roles in disease, the realization that there is a family of secreted TGF-β-related proteins with many differentiation functions in development and activities in normal cell and tissue physiology, and the subsequent identification and characterization of the receptors and effectors that mediate TGF-β family signaling responses.
MeSH term(s)	Animals ; Cloning, Molecular ; DNA, Complementary/genetics ; Humans ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/physiology
Chemical Substances	DNA, Complementary ; Transforming Growth Factor beta
Language	English
Publishing date	2016-07-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a021865
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Article ; Online: Making Sense of Late Tissue Nodules Associated With Hyaluronic Acid Injections.

Goodman, Greg J / McDonald, Cara B / Lim, Adrian / Porter, Catherine E / Deva, Anand K / Magnusson, Mark / Patel, Anita / Hart, Sarah / Callan, Peter / Rudd, Alice / Roberts, Stefania / Wallace, Katy / Bekhor, Philip / Clague, Michael / Williams, Linda / Corduff, Niamh / Wines, Nina / Al-Niaimi, Firas / Fabi, Sabrina G /

Studniberg, Howard M / Smith, Saxon / Tsirbas, Angelo / Arendse, Sean / Ciconte, Antoinette / Poon, Terence

Aesthetic surgery journal

2023 Volume 43, Issue 6, Page(s) NP438–NP448

MeSH term(s)	Humans ; Hyaluronic Acid/adverse effects ; Injections ; Cosmetic Techniques/adverse effects ; Inflammation/etiology ; Dermal Fillers/adverse effects
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Dermal Fillers
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad028
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Article ; Online: From doctors to ancillary staff: Regional and metropolitan cancer workforce perceptions and distress resulting from COVID-19 pandemic adaptations.

Roberts, Natasha A / Ahern, Elizabeth / Pelecanos, Anita / Gasper, Harry / Chan, Bryan / Lwin, Zarnie

Seminars in oncology

2023 Volume 49, Issue 6, Page(s) 490–496

Abstract: Introduction: The declaration of the COVID-19 pandemic has resulted in necessary and rapid changes to health service delivery. In the Australian context, it has been broadly identified that these impacts have been felt by health care workers (HCW) ... ...

Abstract	Introduction: The declaration of the COVID-19 pandemic has resulted in necessary and rapid changes to health service delivery. In the Australian context, it has been broadly identified that these impacts have been felt by health care workers (HCW) providing care. We aimed to capture oncology HCW perceptions of support, stress, personal ability to meet needs and institutional preparedness across longitudinal periods of COVID-19 response in the early stages of the pandemic. Methods and materials: An electronic survey was developed to measure the weekly impacts and distress experienced by HCW during the early phases of the pandemic. Hospital email communications relating to pandemic directives were noted. HCW included nursing, medical, ancillary staff and allied health team members at 2 study sites, 1 metropolitan and 1 regional center in Queensland, Australia. Descriptive statistics were applied to quantitative data, and a framework analysis for qualitative data. Key themes were synthesized using mixed methods approaches. Results: A total of 176 HCW consented to participate. Four key themes were identified. Key theme 1 was strategies for protection, and included the subthemes of self-isolation, using personal protective equipment (PPE), protecting patients and families and each other. Key theme 2 was navigating rules and keeping up, and included the subthemes of compliance, exceptions, conflict and complex decision fatigue. Key theme 3 was tempered optimism, with subthemes including this is grief, pride in one's place and strategies for coping. Key theme 4 was framing the new normal, with subthemes including using technology, second wave and uncertainty. Conclusion: Staff groups reported the emotional impacts of rapid change across clinical areas and centers. Distress corresponded to rapid change amid uncertainty, rather than reported infection rates. These findings give insight into the experiences of patient facing oncology HCW during periods of uncertainty, potentially informing policy in the future.
MeSH term(s)	Humans ; COVID-19 ; Pandemics/prevention & control ; SARS-CoV-2 ; Australia ; Workforce ; Neoplasms
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	189220-4
ISSN	1532-8708 ; 0093-7754
ISSN (online)	1532-8708
ISSN	0093-7754
DOI	10.1053/j.seminoncol.2023.01.008
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Article: DRAGON-Data: a platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts.

BJPsych open

2023 Volume 9, Issue 2, Page(s) e32

Abstract: Background: Current psychiatric diagnoses, although heritable, have not been clearly mapped onto distinct underlying pathogenic processes. The same symptoms often occur in multiple disorders, and a substantial proportion of both genetic and ... ...

Abstract	Background: Current psychiatric diagnoses, although heritable, have not been clearly mapped onto distinct underlying pathogenic processes. The same symptoms often occur in multiple disorders, and a substantial proportion of both genetic and environmental risk factors are shared across disorders. However, the relationship between shared symptoms and shared genetic liability is still poorly understood. Aims: Well-characterised, cross-disorder samples are needed to investigate this matter, but few currently exist. Our aim is to develop procedures to purposely curate and aggregate genotypic and phenotypic data in psychiatric research. Method: As part of the Cardiff MRC Mental Health Data Pathfinder initiative, we have curated and harmonised phenotypic and genetic information from 15 studies to create a new data repository, DRAGON-Data. To date, DRAGON-Data includes over 45 000 individuals: adults and children with neurodevelopmental or psychiatric diagnoses, affected probands within collected families and individuals who carry a known neurodevelopmental risk copy number variant. Results: We have processed the available phenotype information to derive core variables that can be reliably analysed across groups. In addition, all data-sets with genotype information have undergone rigorous quality control, imputation, copy number variant calling and polygenic score generation. Conclusions: DRAGON-Data combines genetic and non-genetic information, and is available as a resource for research across traditional psychiatric diagnostic categories. Algorithms and pipelines used for data harmonisation are currently publicly available for the scientific community, and an appropriate data-sharing protocol will be developed as part of ongoing projects (DATAMIND) in partnership with Health Data Research UK.
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2829557-2
ISSN	2056-4724
ISSN	2056-4724
DOI	10.1192/bjo.2022.636
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Article ; Online: The PARTNER trial of neoadjuvant olaparib in triple-negative breast cancer.

Abraham, Jean E / Pinilla, Karen / Dayimu, Alimu / Grybowicz, Louise / Demiris, Nikolaos / Harvey, Caron / Drewett, Lynsey M / Lucey, Rebecca / Fulton, Alexander / Roberts, Anne N / Worley, Joanna R / Chhabra, Anita / Qian, Wendi / Vallier, Anne-Laure / Hardy, Richard M / Chan, Steve / Hickish, Tamas / Tripathi, Devashish / Venkitaraman, Ramachandran /

Persic, Mojca / Aslam, Shahzeena / Glassman, Daniel / Raj, Sanjay / Borley, Annabel / Braybrooke, Jeremy P / Sutherland, Stephanie / Staples, Emma / Scott, Lucy C / Davies, Mark / Palmer, Cheryl A / Moody, Margaret / Churn, Mark J / Newby, Jacqueline C / Mukesh, Mukesh B / Chakrabarti, Amitabha / Roylance, Rebecca R / Schouten, Philip C / Levitt, Nicola C / McAdam, Karen / Armstrong, Anne C / Copson, Ellen R / McMurtry, Emma / Tischkowitz, Marc / Provenzano, Elena / Earl, Helena M

Nature

2024

Abstract: PARTNER is a prospective, phase II-III, randomised controlled clinical trial, which recruited patients with Triple Negative Breast Cancer (TNBC) ...

Abstract	PARTNER is a prospective, phase II-III, randomised controlled clinical trial, which recruited patients with Triple Negative Breast Cancer (TNBC)
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07384-2
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Article ; Online: A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial.

Ngu, Natalie Ly / Saxby, Edward / Worland, Thomas / Anderson, Patricia / Stothers, Lisa / Figredo, Anita / Hunter, Jo / Elford, Alexander / Ha, Phil / Hartley, Imogen / Roberts, Andrew / Seah, Dean / Tambakis, George / Liew, Danny / Rogers, Benjamin / Sievert, William / Bell, Sally / Le, Suong

Trials

2022 Volume 23, Issue 1, Page(s) 744

Abstract: ... from randomisation. Three exploratory subgroup analyses will be conducted by (a) source of referral, (b) unplanned ...

Abstract	Background: Acute-on-chronic liver failure (ACLF) represents a rising global healthcare burden, characterised by increasing prevalence among patients with decompensated cirrhosis who have a 28-day transplantation-free mortality of 33.9%. Due to disease complexity and a high prevalence of socio-economic disadvantage, there are deficits in quality of care and adherence to guideline-based treatment in this cohort. Compared to other chronic conditions such as heart failure, those with liver disease have reduced access to integrated ambulatory care services. The LivR Well programme is a multidisciplinary intervention aimed at improving 28-day mortality and reducing 30-day readmission through a home-based, liver optimisation programme implemented in the first 28 days after an admission with either ACLF or hepatic decompensation. Outcomes from our feasibility study suggest that the intervention is safe and acceptable to patients and carers. Methods: We will recruit adult patients with chronic liver disease from the emergency departments, in-patient admissions, and an ambulatory liver clinic of a multi-site quaternary health service in Melbourne, Australia. A total of 120 patients meeting EF-Clif criteria will be recruited to the ACLF arm, and 320 patients to the hepatic decompensation arm. Participants in each cohort will be randomised to the intervention arm, a 28-day multidisciplinary programme or to standard ambulatory care in a 1:1 ratio. The intervention arm includes access to nursing, pharmacy, physiotherapy, dietetics, social work, and neuropsychiatry clinicians. For the ACLF cohort, the primary outcome is 28-day mortality. For the hepatic decompensation cohort, the primary outcome is 30-day re-admission. Secondary outcomes assess changes in liver disease severity and quality of life. An interim analysis will be performed at 50% recruitment to consider early cessation of the trial if the intervention is superior to the control, as suggested in our feasibility study. A cost-effectiveness analysis will be performed. Patients will be followed up for 12 weeks from randomisation. Three exploratory subgroup analyses will be conducted by (a) source of referral, (b) unplanned hospitalisation, and (c) concurrent COVID-19. The trial has been registered with the Australian New Zealand Clinical Trials Registry. Discussion: This study implements a multidisciplinary intervention for ACLF patients with proven benefits in other chronic diseases with the addition of novel digital health tools to enable remote patient monitoring during the COVID-19 pandemic. Our feasibility study demonstrates safety and acceptability and suggests clinical improvement in a small sample size. An RCT is required to generate robust outcomes in this frail, high healthcare resource utilisation cohort with high readmission and mortality risk. Interventions such as LivR Well are urgently required but also need to be evaluated to ensure feasibility, replicability, and scalability across different healthcare systems. The implications of this trial include the generalisability of the programme for implementation across regional and urban centres. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12621001703897 . Registered on 13 December 2021. WHO Trial Registration Data Set. See Appendix 1.
MeSH term(s)	Acute-On-Chronic Liver Failure/diagnosis ; Acute-On-Chronic Liver Failure/therapy ; Adult ; Australia ; COVID-19 ; Hospitalization ; Humans ; Pandemics ; Quality of Life ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06679-x
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Article: Medicine: Smoke signals for lung disease.

Roberts, Anita B

Nature

2003 Volume 422, Issue 6928, Page(s) 130–131

MeSH term(s)	Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Disease Progression ; Disease Susceptibility ; Humans ; Integrin beta Chains/genetics ; Integrin beta Chains/metabolism ; Integrins/genetics ; Integrins/metabolism ; Macrophages, Alveolar/enzymology ; Matrix Metalloproteinase 12 ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Mice ; Pulmonary Emphysema/enzymology ; Pulmonary Emphysema/genetics ; Pulmonary Emphysema/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Chemical Substances	Antigens, Neoplasm ; Integrin beta Chains ; Integrins ; Transforming Growth Factor beta ; integrin alphavbeta6 ; integrin beta6 ; Metalloendopeptidases (EC 3.4.24.-) ; MMP12 protein, human (EC 3.4.24.65) ; Matrix Metalloproteinase 12 (EC 3.4.24.65)
Language	English
Publishing date	2003-03-13
Publishing country	England
Document type	Comment ; News
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/422130a
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Article: The ever-increasing complexity of TGF-beta signaling.

Roberts, Anita B

Cytokine & growth factor reviews

2001 Volume 13, Issue 1, Page(s) 3–5

MeSH term(s)	Animals ; DNA-Binding Proteins/metabolism ; Humans ; Phosphorylation ; Signal Transduction ; Smad Proteins ; Trans-Activators/metabolism ; Transforming Growth Factor beta/metabolism
Chemical Substances	DNA-Binding Proteins ; Smad Proteins ; Trans-Activators ; Transforming Growth Factor beta
Language	English
Publishing date	2001-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1330534-7
ISSN	1359-6101
ISSN	1359-6101
DOI	10.1016/s1359-6101(01)00027-2
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