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Article: Protective Effect of Casperome

Loeser, Konstantin / Seemann, Semjon / König, Stefanie / Lenhardt, Isabell / Abdel-Tawab, Mona / Koeberle, Andreas / Werz, Oliver / Lupp, Amelie

Frontiers in pharmacology

2018 Volume 9, Page(s) 387

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2018-04-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials.

Guhr, Anke / Kobold, Sabine / Seltmann, Stefanie / Seiler Wulczyn, Andrea E M / Kurtz, Andreas / Löser, Peter

Stem cell reports

2018 Volume 11, Issue 2, Page(s) 485–496

Abstract: The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The ... ...

Abstract	The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The number of papers describing experimental work involving hPSCs increased further with clear differences in the scientific impact of publications from different countries. Our results confirm the leading position of US-based hPSC research, although to a lesser degree than observed previously. Our data reveal that research into human induced pluripotent stem cells alone surpassed human embryonic stem cell (hESC) research by 2015 and rapidly grew after that. We also report on continuing and even slightly growing research activities in the hESC field as well as on a generally declining rate of the generation of new hESC lines. An increasing portion of new hESC lines represents disease-specific and clinical-grade cell lines. The previously noted usage of only a few early established hESC lines in the vast majority of scientific work is sustained. We also provide a comprehensive overview on clinical trials on the basis of hPSCs. We find that the vast majority of those trials are based on hESC-derived cell products that were generated from an only limited number of relatively old cell lines.
MeSH term(s)	Cell Line ; Clinical Trials as Topic ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Publications ; Stem Cell Research
Language	English
Publishing date	2018-07-19
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2018.06.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair.

Elsesy, Mohamed E / Oh-Hohenhorst, Su Jung / Löser, Anastassia / Oing, Christoph / Mutiara, Sally / Köcher, Sabrina / Meien, Stefanie / Zielinski, Alexandra / Burdak-Rothkamm, Susanne / Tilki, Derya / Huland, Hartwig / Schwarz, Rudolf / Petersen, Cordula / Bokemeyer, Carsten / Rothkamm, Kai / Mansour, Wael Y

Cancers

2020 Volume 12, Issue 9

Abstract: 1) ...

Abstract	(1)
Language	English
Publishing date	2020-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12092467
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Article ; Online: A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells.

Kobold, Sabine / Guhr, Anke / Mah, Nancy / Bultjer, Nils / Seltmann, Stefanie / Seiler Wulczyn, Andrea E M / Stacey, Glyn / Jie, Hao / Liu, Wang / Löser, Peter / Kurtz, Andreas

Stem cell reports

2020 Volume 15, Issue 2, Page(s) 546–555

Abstract: The last 5 years have witnessed a significant increase in the number of clinical studies based on human pluripotent stem cells (hPSCs). In parallel, concern is increasing about the proliferation of unregulated stem cell treatments worldwide. Regulated ... ...

Abstract	The last 5 years have witnessed a significant increase in the number of clinical studies based on human pluripotent stem cells (hPSCs). In parallel, concern is increasing about the proliferation of unregulated stem cell treatments worldwide. Regulated clinical testing is a de facto standard to establish the safety and efficacy of new cell therapies, yet reliable information on clinical studies involving hPSCs is scattered. Our analysis of a multitude of resources found 54 clinical studies involving several types of hPSCs, which are performed in ten countries. While the majority of those studies is based on human embryonic stem cells (hESCs), clinical studies involving human induced pluripotent stem cells increased more strongly in the past 2 years than the number of hESC-based studies. A publicly accessible database was created using the human pluripotent stem cell registry (https://hpscreg.eu) platform, providing a steadily updated comprehensive overview on hPSC-based clinical studies performed worldwide.
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2020.06.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b.

Loeser, Stefanie / Penninger, Josef M

Seminars in immunology

2007 Volume 19, Issue 3, Page(s) 206–214

Abstract: The family of the Casitas B-lineage Lymphoma (Cbl) proteins, c-Cbl, Cbl-b, and Cbl-3, function as E3 ubiquitin ligases and molecular adaptors. In particular, Cbl-b acts as a gatekeeper in T cell activation that controls activation thresholds and the ... ...

Abstract	The family of the Casitas B-lineage Lymphoma (Cbl) proteins, c-Cbl, Cbl-b, and Cbl-3, function as E3 ubiquitin ligases and molecular adaptors. In particular, Cbl-b acts as a gatekeeper in T cell activation that controls activation thresholds and the requirement for co-stimulation. Loss of Cbl-b expression renders animals susceptible to antigen-triggered autoimmunity suggesting that Cbl-b is a key autoimmunity gene. In addition, Cbl-b plays a critical role in T cell anergy and escape from regulatory T cells (Treg) suppression. Modulation of Cbl-b might provide us with a unique opportunity for future immune treatment of human disorders such as autoimmunity, immunodeficiency, or cancer.
MeSH term(s)	Adaptor Proteins, Signal Transducing/immunology ; Adaptor Proteins, Signal Transducing/metabolism ; Clonal Anergy/immunology ; Clonal Anergy/physiology ; Humans ; Proto-Oncogene Proteins c-cbl/immunology ; Proto-Oncogene Proteins c-cbl/metabolism ; Self Tolerance/immunology ; T-Lymphocytes/immunology ; Ubiquitin-Protein Ligases/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cblb protein, mouse ; Proto-Oncogene Proteins c-cbl (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2007-03-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2007.02.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity.

Loeser, Stefanie / Penninger, Josef M

Cell cycle (Georgetown, Tex.)

2007 Volume 6, Issue 20, Page(s) 2478–2485

Abstract: The implication of the immune system in tumor surveillance is proven and widely accepted. However, anti-cancer immunotherapy is still difficult due to insufficient activation, immune suppression and tolerance induction. The ubiquitin E3 ligase Cbl-b, is ... ...

Abstract	The implication of the immune system in tumor surveillance is proven and widely accepted. However, anti-cancer immunotherapy is still difficult due to insufficient activation, immune suppression and tolerance induction. The ubiquitin E3 ligase Cbl-b, is a member of the Cbl (casitas B-lineage lymphoma) protein family and was identified as a key dominant "tolerogenic" factor in T cells that directly regulates T-cell activation by controlling activation thresholds and the requirement for co-stimulation. Intriguingly, Cbl-b deficient mice spontaneously reject a variety of cancers including spontaneous solid tumors and hematopoietic malignancies. Mechanistically, modulation of Cbl-b in T cells controls activation of tumor-reactive cytotoxic T cells in vivo and might circumvent several limitations of T cell immunotherapy. Therefore manipulation of Cbl-b might provide us with a unique opportunity for future immune treatment of human disorders such as autoimmunity, chronic viral infections, or cancer.
MeSH term(s)	Animals ; Humans ; Immune Tolerance/immunology ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/immunology ; Protein Binding ; Proto-Oncogene Proteins c-cbl/deficiency ; Proto-Oncogene Proteins c-cbl/genetics ; Proto-Oncogene Proteins c-cbl/metabolism ; Signal Transduction/immunology ; T-Lymphocytes/enzymology ; T-Lymphocytes/immunology
Chemical Substances	Proto-Oncogene Proteins c-cbl (EC 2.3.2.27)
Language	English
Publishing date	2007-07-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.6.20.4797
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent Trends in Research with Human Pluripotent Stem Cells

Guhr, Anke / Kobold, Sabine / Seltmann, Stefanie / Seiler Wulczyn, Andrea E. M. / Kurtz, Andreas / Löser, Peter

Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials

2018

Abstract	The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The number of papers describing experimental work involving hPSCs increased further with clear differences in the scientific impact of publications from different countries. Our results confirm the leading position of US-based hPSC research, although to a lesser degree than observed previously. Our data reveal that research into human induced pluripotent stem cells alone surpassed human embryonic stem cell (hESC) research by 2015 and rapidly grew after that. We also report on continuing and even slightly growing research activities in the hESC field as well as on a generally declining rate of the generation of new hESC lines. An increasing portion of new hESC lines represents disease-specific and clinical-grade cell lines. The previously noted usage of only a few early established hESC lines in the vast majority of scientific work is sustained. We also provide a comprehensive overview on clinical trials on the basis of hPSCs. We find that the vast majority of those trials are based on hESC-derived cell products that were generated from an only limited number of relatively old cell lines. Peer Reviewed
Keywords	human pluripotent stem cells ; human embryonic stem cells ; human induced pluripotent stem cells ; research ; impact ; citation frequencies ; hESC lines ; clinical trials ; 610 Medizin und Gesundheit ; ddc:610
Subject code	306
Language	English
Publishing date	2018-07-19
Publisher	Robert Koch-Institut
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent Trends in Research with Human Pluripotent Stem Cells

Anke Guhr / Sabine Kobold / Stefanie Seltmann / Andrea E.M. Seiler Wulczyn / Andreas Kurtz / Peter Löser

Stem Cell Reports, Vol 11, Iss 2, Pp 485-

Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials

2018 Volume 496

Abstract: Summary: The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. ...

Abstract	Summary: The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The number of papers describing experimental work involving hPSCs increased further with clear differences in the scientific impact of publications from different countries. Our results confirm the leading position of US-based hPSC research, although to a lesser degree than observed previously. Our data reveal that research into human induced pluripotent stem cells alone surpassed human embryonic stem cell (hESC) research by 2015 and rapidly grew after that. We also report on continuing and even slightly growing research activities in the hESC field as well as on a generally declining rate of the generation of new hESC lines. An increasing portion of new hESC lines represents disease-specific and clinical-grade cell lines. The previously noted usage of only a few early established hESC lines in the vast majority of scientific work is sustained. We also provide a comprehensive overview on clinical trials on the basis of hPSCs. We find that the vast majority of those trials are based on hESC-derived cell products that were generated from an only limited number of relatively old cell lines. : Guhr et al. show that there are marked differences in the impact of recent hPSC research from different countries. The hESC line usage patterns remained mainly unchanged. The authors provide a comprehensive overview on clinical trials involving hPSC-derived cell products and find that these trials are mainly based on hESCs. Keywords: human pluripotent stem cells, human embryonic stem cells, human induced pluripotent stem cells, research, impact, citation frequencies, hESC lines, clinical trials
Keywords	Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	306
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.

Volkov, Anton / Hagner, Stefanie / Löser, Stephan / Alnahas, Safa / Raifer, Hartmann / Hellhund, Anne / Garn, Holger / Steinhoff, Ulrich

PloS one

2013 Volume 8, Issue 4, Page(s) e60565

Abstract: The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i ... ...

Abstract	The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i knockout (KO) and control mice were tested in different models of experimental allergic asthma. β5i-deficient mice showed reduced OVA/Alum- and subcutaneous/OVA-induced acute asthma with decreased eosinophilia in the bronchoalveolar lavage (BAL), low OVA-specific IgG1 and reduced local and systemic Th2 cytokines. While Th2 cells in the lungs were reduced, Tregs and Th1 cells were not affected. Attenuated asthma in β5i KO mice could not be attributed to defects in OVA uptake or maturation of dendritic cells in the lung. Surprisingly, β5i deficient mice developed HDM asthma which was comparable to control mice. Here, we present novel evidence for the requirement of the β5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma. The unexpected role of β5i in OVA asthma remains to be clarified.
MeSH term(s)	Adoptive Transfer ; Alum Compounds/adverse effects ; Animals ; Asthma/chemically induced ; Asthma/genetics ; Asthma/immunology ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Dendritic Cells/immunology ; Disease Models, Animal ; Female ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Knockout ; Ovalbumin/adverse effects ; Ovalbumin/immunology ; Phenotype ; Proteasome Endopeptidase Complex/deficiency ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/immunology ; T-Lymphocytes, Regulatory/immunology ; Th2 Cells/immunology ; Th2 Cells/metabolism
Chemical Substances	Alum Compounds ; ovalbumin-alum ; Ovalbumin (9006-59-1) ; LMP7 protein (EC 3.4.25.1) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2013-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0060565
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Article ; Online: β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.

Anton Volkov / Stefanie Hagner / Stephan Löser / Safa Alnahas / Hartmann Raifer / Anne Hellhund / Holger Garn / Ulrich Steinhoff

PLoS ONE, Vol 8, Iss 4, p e

2013 Volume 60565

Abstract	The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i knockout (KO) and control mice were tested in different models of experimental allergic asthma. β5i-deficient mice showed reduced OVA/Alum- and subcutaneous/OVA-induced acute asthma with decreased eosinophilia in the bronchoalveolar lavage (BAL), low OVA-specific IgG1 and reduced local and systemic Th2 cytokines. While Th2 cells in the lungs were reduced, Tregs and Th1 cells were not affected. Attenuated asthma in β5i KO mice could not be attributed to defects in OVA uptake or maturation of dendritic cells in the lung. Surprisingly, β5i deficient mice developed HDM asthma which was comparable to control mice. Here, we present novel evidence for the requirement of the β5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma. The unexpected role of β5i in OVA asthma remains to be clarified.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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