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Book ; Thesis: Vorhofflimmern - eine diagnostische Herausforderung

Busch, Mathias C. / Felix, Stephan B. / Stangl, Karl / Wachter, Rolf

2020

Institution	Universität Greifswald
Author's details	vorgelegt von Mathias C. Bush ; 1. Gutachter: Prof. Dr. Stephan B. Felix, 2. Gutachter: Prof. Dr. Karl Stangl, 3. Gutachter: Prof. Dr. Rolf Wachter
Keywords	Vorhofflimmern ; Diagnostik
Subject	Medizinische Diagnostik ; Medizin ; Klinische Diagnostik ; Diagnostisches Verfahren ; Delirium cordis ; Herzvorhofflimmern ; Atrial fibrillation
Language	English ; German
Size	Getrennte Zählung, Illustrationen (teilweise farbig), Diagramme (farbig)
Publishing place	Greifswald
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Habilitationsschrift, Universitätsmedizin Greifswald, 2021
Note	Text teilweise deutsch, teilweise englisch ; Literaturverzeichnis: Blatt [18-22]
HBZ-ID	HT021060553
Database	Catalogue ZB MED Medicine, Health

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2021 E 1167	order for loan	Magazin

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Book: Pflanzenwurzeln

Sobotik, Monika / Eberwein, Roland Karl / Bodner, Gernot / Stangl, Rosemarie / Loiskandl, Willibald

Wurzeln begreifen - Zusammenhänge verstehen - in der Praxis anwenden

2020

Author's details	Monika Sobotik, Roland K. Eberwein, Gernot Bodner, Rosemarie Stangl, Willibald Loiskandl
Keywords	Grünland ; Wurzelsysteme ; Unkräuter ; Ackerbau ; Erosionsschutz ; Waldbau ; Bodenschutz ; Wurzelformen ; Pflanzenanatomie ; Wurzel ; Morphologie
Subject	Formenlehre ; Gestaltlehre ; Pflanzenwurzel ; Wurzelsystem ; Wurzeln ; Wurzelwerk ; Pflanzen ; Phytotomie
Subject code	580
Language	German
Size	314 Seiten, Illustrationen
Publisher	DLG-Verlag
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book
HBZ-ID	HT020573811
ISBN	978-3-7690-0855-5 ; 3-7690-0855-3
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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204/89	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Efficacy of CRT upgrade in pacemaker-induced cardiomyopathy in an outpatient clinic - Results of a prospective registry.

Christoph, Melzer / Marius, Schwerg / Karl, Stangl / Friedrich, Köhler

International journal of cardiology

2023 Volume 377, Page(s) 60–65

Abstract: Purpose: The aim of this prospective, monocentric registry study was to investigate whether upgrading to cardiac resynchronization therapy (CRT) in pacemaker-induced cardiomyopathy (PICM) can improve left ventricular function in typical outpatient ... ...

Abstract	Purpose: The aim of this prospective, monocentric registry study was to investigate whether upgrading to cardiac resynchronization therapy (CRT) in pacemaker-induced cardiomyopathy (PICM) can improve left ventricular function in typical outpatient clinical patients. Methods: We screened for PICM in a pacemaker outpatient clinic between 2017 and 2021. The follow-up period was 6 months. The primary endpoint was decreased left ventricular end systolic volume (LVESV), and the responder criterion was decreased LVESV >15%. Secondary endpoints were LVEF, NYHA class, device-associated complications and death. Results: 66 patients were newly diagnosed with PICM. 55 of them received a CRT upgrade. For the primary endpoint, LVESV decreased from 101.6 ± 48.2 ml to 75.9 ± 35.8 ml (p < 0.001). Secondary endpoints were: a) LVEF increased from 31.5 ± 5.4% to 46.1 ± 7.6% (p < 0.001) and b) NYHA class improved by an average of one class in both groups (p < 0.001). The overall complication rate was 1.8%. Conclusions: CRT upgrade in outpatient clinic patients with PICM improves left ventricular function and functional capacity and is associated with an acceptable complication rate.
MeSH term(s)	Humans ; Cardiac Resynchronization Therapy/adverse effects ; Heart Failure/diagnosis ; Pacemaker, Artificial/adverse effects ; Cardiomyopathies/etiology ; Cardiomyopathies/therapy ; Ventricular Function, Left ; Treatment Outcome ; Stroke Volume
Language	English
Publishing date	2023-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.01.077
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Zs.A 1673: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: mRNA vaccines for COVID-19 are safe and clinically effective in patients with cardiac amyloidosis.

Barzen, Gina / Rieber, Finn / Stangl, Karl / Hahn, Katrin / Spethmann, Sebastian

Vaccine

2023 Volume 42, Issue 4, Page(s) 723–726

Abstract: Introduction: Amyloidosis is a rare disease in which malformed proteins are deposited in tissues occurring mostly commonly in older age. These deposits can lead to severe organ dysfunction e.g. in the myocardium with great impact on prognosis. The Covid- ...

Abstract	Introduction: Amyloidosis is a rare disease in which malformed proteins are deposited in tissues occurring mostly commonly in older age. These deposits can lead to severe organ dysfunction e.g. in the myocardium with great impact on prognosis. The Covid-19 pandemic has caused excess mortality worldwide since 2020. Risk factors for a severe course include pre-existing cardiac diseases like heart failure and advanced age. Therefore, vaccination against Sars-CoV2 viruses is highly recommended for patients with cardiac amyloidosis. However, since there are no specific data on mRNA vaccines in patients with cardiac amyloidosis, some patients have concerns about cardiac adverse events following immunization (AEFI), such as myocarditis. Purpose: The purpose of the study is to assess the safety and efficacy of mRNA vaccines in patients with cardiac amyloidosis. Methods: Patients of the Amyloidosis Center Charité Berlin (ACCB) were assessed about the vaccination, its tolerability and clinical effectiveness. To date, we included 62 patients (54 men) with a median age of 82,5 years (range 37 to 92). 46 patients had wtATTR amyloidosis, ten patients had hATTR amyloidosis, and six patients had AL amyloidosis. The mean systolic left ventricular function was 51% (range 30 to 62) with a mean global strain of -11,5% (range -18,5 to -3,1). The mean NT-pro-BNP was 1145 ng/l (range 24 to 48297). Results: 59 patients were triple vaccinated and three patients so far are double vaccinated. Three of the patients were unvaccinated. 171 of the vaccine doses administered were mRNA vaccines and eight doses were a viral vector-vaccine. None of the patients reported severe side effects. Thirteen patients reported feeling of pressure and pain at the injection site after vaccination and four patients had fever of maximum two days, eight patients reported lower general condition of maximum five days. One patient reported malaise for 14 days after each vaccination, which resolved spontaneously. There was no clinical or laboratory evidence of suspected vaccine-induced myocarditis. Five patients reported of a COVID-19 breakthrough infection, all of which with a mild course of disease. None of the patients had symptoms of worsening heart failure in temporal relation to the vaccination. Most of the vaccinations (103) were performed at an official vaccination center, 59 were performed at a general practitioner. Conclusion: In patients with cardiac amyloidosis, mRNA vaccines for COVID-19 are safe with respect to severe cardiac adverse events and show effective protection against clinically relevant SARS-CoV2 infection.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Amyloidosis ; Breakthrough Infections ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Heart Failure ; mRNA Vaccines ; Myocarditis ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines ; mRNA Vaccines ; RNA, Viral
Language	English
Publishing date	2023-12-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.12.041
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article: G

Hohendanner, Felix / Prabhu, Ashok / Wilck, Nicola / Stangl, Verena / Pieske, Burkert / Stangl, Karl / Althoff, Till F

Biomedicines

2023 Volume 11, Issue 2

Abstract: Background: Atrial fibrillation (AF) is promoted by various stimuli like angiotensin II, endothelin-1, epinephrine/norepinephrine, vagal activation, or mechanical stress, all of which activate receptors coupled to G-proteins of the Gα: Methods and ... ...

Abstract	Background: Atrial fibrillation (AF) is promoted by various stimuli like angiotensin II, endothelin-1, epinephrine/norepinephrine, vagal activation, or mechanical stress, all of which activate receptors coupled to G-proteins of the Gα Methods and results: To define the role of G Conclusion: G
Language	English
Publishing date	2023-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11020526
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Article ; Online: Serum Starvation Accelerates Intracellular Metabolism in Endothelial Cells.

Lorenz, Mario / Fritsche-Guenther, Raphaela / Bartsch, Cornelia / Vietzke, Angelika / Eisenberger, Alina / Stangl, Karl / Stangl, Verena / Kirwan, Jennifer A

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are first sensed by endothelial cells, studies on their metabolic adaptations to diminished energy ... ...

Abstract	Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are first sensed by endothelial cells, studies on their metabolic adaptations to diminished energy supply are lacking. We analyzed the dynamic metabolic activity of human umbilical vein endothelial cells (HUVECs) in basal conditions and after serum starvation. Metabolites of glycolysis, the tricarboxylic acid (TCA) cycle, and the glycerol pathway showed lower levels after serum starvation, whereas amino acids had increased levels. A metabolic flux analysis with
MeSH term(s)	Humans ; Glutamine/metabolism ; Amino Acids/metabolism ; Glycolysis ; Glucose/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Starvation
Chemical Substances	Glutamine (0RH81L854J) ; Amino Acids ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021189
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Article ; Online: Serum starvation induces sexual dimorphisms in secreted proteins of human umbilical vein endothelial cells (HUVECs) from twin pairs.

Lorenz, Mario / Witt, Eric / Völker, Uwe / Stangl, Karl / Stangl, Verena / Hammer, Elke

Proteomics

2022 Volume 22, Issue 13-14, Page(s) e2100168

Abstract: There is growing evidence for sex and gender differences in the clinical manifestation and outcomes of human diseases. Human primary endothelial cells represent a useful cardiovascular model to study sexual dimorphisms at the cellular level. Here, we ... ...

Abstract	There is growing evidence for sex and gender differences in the clinical manifestation and outcomes of human diseases. Human primary endothelial cells represent a useful cardiovascular model to study sexual dimorphisms at the cellular level. Here, we analyzed sexual dimorphisms of the secretome after serum starvation using human umbilical vein endothelial cells (HUVECs) from twin pairs of the opposite sex to minimize the impact of varying genetic background. HUVECs were starved for 5 and 16 h, respectively, and proteins of the cell culture supernatants were analyzed by tandem mass spectrometry. Altogether, 960 extracellular proteins were identified of which 683 were amendable to stringent quantification. Significant alterations were observed for 455 proteins between long-term and short-term starvation and the majority were similar in both sexes. Only 5 proteins showed significant sex-specific regulation between long-versus short-term starvation. Furthermore, 19 unique proteins with significant sexual dimorphisms at the same time points of serum starvation were observed. A larger number of proteins, for example tissue factor inhibitor 2 (TFPI2), displayed higher levels in the supernatants of females compared to male cells after long term serum starvation that might point to higher adaptation capacity of female cells. The overall results demonstrate that male and female cells differ in their secretome.
MeSH term(s)	Cell Culture Techniques/methods ; Cells, Cultured ; Female ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Proteins/metabolism ; Sex Characteristics ; Sex Factors
Chemical Substances	Proteins
Language	English
Publishing date	2022-04-10
Publishing country	Germany
Document type	Journal Article ; Twin Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2032093-0
ISSN	1615-9861 ; 1615-9853
ISSN (online)	1615-9861
ISSN	1615-9853
DOI	10.1002/pmic.202100168
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Zs.A 5386: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 1868: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Feasibility of Goal-Directed Fluid Therapy in Patients with Transcatheter Aortic Valve Replacement - An Ambispective Analysis.

Trauzeddel, Ralf Felix / Nordine, Michael / Fucini, Giovanni B / Sander, Michael / Dreger, Henryk / Stangl, Karl / Treskatsch, Sascha / Habicher, Marit

Brazilian journal of cardiovascular surgery

2024 Volume 39, Issue 2, Page(s) e20220470

Abstract: Introduction: Goal-directed fluid therapy (GDFT) has been shown to reduce postoperative complications. The feasibility of GDFT in transcatheter aortic valve replacement (TAVR) patients under general anesthesia has not yet been demonstrated. We examined ... ...

Abstract	Introduction: Goal-directed fluid therapy (GDFT) has been shown to reduce postoperative complications. The feasibility of GDFT in transcatheter aortic valve replacement (TAVR) patients under general anesthesia has not yet been demonstrated. We examined whether GDFT could be applied in patients undergoing TAVR in general anesthesia and its impact on outcomes. Methods: Forty consecutive TAVR patients in the prospective intervention group with GDFT were compared to 40 retrospective TAVR patients without GDFT. Inclusion criteria were age ≥ 18 years, elective TAVR in general anesthesia, no participation in another interventional study. Exclusion criteria were lack of ability to consent study participation, pregnant or nursing patients, emergency procedures, preinterventional decubitus, tissue and/or extremity ischemia, peripheral arterial occlusive disease grade IV, atrial fibrillation or other severe heart rhythm disorder, necessity of usage of intra-aortic balloon pump. Stroke volume and stroke volume variation were determined with uncalibrated pulse contour analysis and optimized according to a predefined algorithm using 250 ml of hydroxyethyl starch. Results: Stroke volume could be increased by applying GDFT. The intervention group received more colloids and fewer crystalloids than control group. Total volume replacement did not differ. The incidence of overall complications as well as intensive care unit and hospital length of stay were comparable between both groups. GDFT was associated with a reduced incidence of delirium. Duration of anesthesia was shorter in the intervention group. Duration of the interventional procedure did not differ. Conclusion: GDFT in the intervention group was associated with a reduced incidence of postinterventional delirium.
MeSH term(s)	Humans ; Adolescent ; Transcatheter Aortic Valve Replacement/adverse effects ; Retrospective Studies ; Prospective Studies ; Feasibility Studies ; Goals ; Delirium/etiology ; Delirium/surgery ; Fluid Therapy/methods ; Aortic Valve Stenosis/surgery ; Aortic Valve/surgery ; Treatment Outcome ; Risk Factors ; Length of Stay
Language	English
Publishing date	2024-03-01
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2031026-2
ISSN	1678-9741 ; 1678-9741
ISSN (online)	1678-9741
ISSN	1678-9741
DOI	10.21470/1678-9741-2022-0470
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Frequenzadaptive Herzschrittmacher

Stangl, Karl

Physiologie, Technologie, klinische Ergebnisse

1990

Author's details	K. Stangl
Keywords	Pacemaker, Artificial ; Herzschrittmacher ; Herzfrequenz ; Anpassung
Subject	Adaptation ; Akkommodation ; Anpassungsfähigkeit ; Adaption ; Herzrhythmus ; Herzrate ; Herzschlagfolge ; Herzschlagfrequenz ; Pacemaker ; Künstlicher Herzschrittmacher
Language	German
Size	XV, 331 S. : graph. Darst.
Publisher	Steinkopff
Publishing place	Darmstadt
Document type	Book
HBZ-ID	HT003503110
ISBN	3-7985-0821-6 ; 978-3-7985-0821-7
Database	Catalogue ZB MED Medicine, Health

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1990 A 3894	order for loan	Magazin

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Article ; Online: Renal and hepatic function of patients with severe tricuspid regurgitation undergoing inferior caval valve implantation.

Hewing, Bernd / Mattig, Isabel / Knebel, Fabian / Stangl, Verena / Laule, Michael / Stangl, Karl / Dreger, Henryk

Scientific reports

2021 Volume 11, Issue 1, Page(s) 21800

Abstract: Due to progressive abdominal-venous congestion severe tricuspid regurgitation (TR) is a common cause of cardiorenal and cardiohepatic syndrome. We initiated the TRICAVAL study to compare interventional valve implantation into the inferior vena cava (CAVI) ...

Abstract	Due to progressive abdominal-venous congestion severe tricuspid regurgitation (TR) is a common cause of cardiorenal and cardiohepatic syndrome. We initiated the TRICAVAL study to compare interventional valve implantation into the inferior vena cava (CAVI) versus optimal medical therapy (OMT) in severe TR. In the present subanalysis, we aimed to evaluate the effects of CAVI on clinical signs of congestion, renal and hepatic function. TRICAVAL was an investigator-initiated, randomized trial. Twenty-eight patients with severe TR were randomized to OMT or CAVI using an Edwards Sapien XT valve. Probands who completed the 3-month follow-up (CAVI [n = 8], OMT [n = 10]) were evaluated by medical history, clinical examination, and laboratory testing at baseline, 3 and 12 months. After 3 months, the CAVI group exhibited a significant reduction of body weight (from 80.7 [69.0-87.7] kg to 75.5 [63.8-84.6] kg, p < 0.05) and abdominal circumference (from 101.5 ± 13.8 cm to 96.3 ± 15.4 cm, p ≤ 0.01) and a trend to lower doses of diuretics compared to OMT. Renal and hepatic function parameters did not change significantly. Within a short-term follow-up, CAVI led to an improvement of clinical signs of venous congestion and a non-significant reduction of diuretic doses compared to OMT.
MeSH term(s)	Acute Disease ; Aged ; Aged, 80 and over ; Blood Vessel Prosthesis Implantation ; Female ; Hemodynamics/physiology ; Humans ; Kidney/physiopathology ; Liver/physiopathology ; Male ; Tricuspid Valve Insufficiency/physiopathology ; Vena Cava, Inferior/surgery
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-01322-2
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