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  1. Article ; Online: Erratum: SHENGBO ZHOU (), LI HE (), SIYU MA (), SHUJUN XU (), QIANG ZHAI (), PING GUAN (), HUI WANG ()amp; JINGSONG SHI () (2022)Taxonomic status of Rana nigromaculata mongolia and the validity of Pelophylax tenggerensis (Anura, Ranidae) Zootaxa 5165 (4): 486500.

    Zhou, Shengbo / He, L I / Ma, Siyu / Xu, Shujun / Zhai, Qiang / Guan, Ping / Wang, Hui / Shi, Jingsong

    Zootaxa

    2022  Volume 5174, Issue 5, Page(s) 600

    Language English
    Publishing date 2022-08-12
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5174.5.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of living alone and living alone time with hypertension among Chinese men aged 80 years and older

    Xiang Wang / Miao Dai / Jingsong Xu

    Frontiers in Public Health, Vol

    a cohort study

    2024  Volume 11

    Abstract: ObjectiveThere is little evidence of the influence of living alone on hypertension risk among men 80 years or older. Additionally, the influence of living alone duration on hypertension risk lacks thorough investigation. Hence, this cohort study examines ...

    Abstract ObjectiveThere is little evidence of the influence of living alone on hypertension risk among men 80 years or older. Additionally, the influence of living alone duration on hypertension risk lacks thorough investigation. Hence, this cohort study examines living alone and its duration’s link to hypertension risk in this specific group.MethodsWe included 2009 older men aged ≥80 years without hypertension from the Chinese Longitudinal Healthy Longevity Survey in the 2008 wave. Follow-up was conducted in the 2011 wave. Multivariable Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) to assess hypertension risk related to living alone and living alone time.ResultsWe included 2,009 older men, with a mean age of 90.7 years (standard deviation: 6.8). Over a median follow-up of 2.9 (1.3–3.0) years, 573 participants (28.5%) developed hypertension. Living alone was significantly associated with a higher hypertension risk than living with family (HR: 1.42; 95% CI 1.11–1.80). When compared to living with family, the hypertension risk was increased in the first quartile of living alone time (0–6.1 years) (HR: 1.76; 95% CI 1.16–2.66), the second quartile (6.1–10.6 years) (HR: 1.56; 95% CI 1.07–2.29), and the third quartile (10.6–19.3 years) (HR: 1.66; 95% CI 1.08–2.55). Surprisingly, no significant association was found in the fourth quartile (≥19.3 years) with hypertension risk. Stratified and Interaction analyses indicated no significant interaction effects between subgroups. Sensitivity analyses yielded consistent results.ConclusionLiving alone was independently associated with an increased risk of hypertension in older men. The highest risk was found in those with the least time alone. These findings imply that social isolation and lack of companionship could be pivotal in hypertension development. Furthermore, the study highlights the need to consider living alone duration when assessing its impact on health outcomes.
    Keywords living alone ; living alone time ; hypertension ; oldest-old men ; cohort study ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Association of living alone and living alone time with hypertension among Chinese men aged 80 years and older: a cohort study.

    Wang, Xiang / Dai, Miao / Xu, Jingsong

    Frontiers in public health

    2024  Volume 11, Page(s) 1274955

    Abstract: Objective: There is little evidence of the influence of living alone on hypertension risk among men 80 years or older. Additionally, the influence of living alone duration on hypertension risk lacks thorough investigation. Hence, this cohort study ... ...

    Abstract Objective: There is little evidence of the influence of living alone on hypertension risk among men 80 years or older. Additionally, the influence of living alone duration on hypertension risk lacks thorough investigation. Hence, this cohort study examines living alone and its duration's link to hypertension risk in this specific group.
    Methods: We included 2009 older men aged ≥80 years without hypertension from the Chinese Longitudinal Healthy Longevity Survey in the 2008 wave. Follow-up was conducted in the 2011 wave. Multivariable Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) to assess hypertension risk related to living alone and living alone time.
    Results: We included 2,009 older men, with a mean age of 90.7 years (standard deviation: 6.8). Over a median follow-up of 2.9 (1.3-3.0) years, 573 participants (28.5%) developed hypertension. Living alone was significantly associated with a higher hypertension risk than living with family (HR: 1.42; 95% CI 1.11-1.80). When compared to living with family, the hypertension risk was increased in the first quartile of living alone time (0-6.1 years) (HR: 1.76; 95% CI 1.16-2.66), the second quartile (6.1-10.6 years) (HR: 1.56; 95% CI 1.07-2.29), and the third quartile (10.6-19.3 years) (HR: 1.66; 95% CI 1.08-2.55). Surprisingly, no significant association was found in the fourth quartile (≥19.3 years) with hypertension risk. Stratified and Interaction analyses indicated no significant interaction effects between subgroups. Sensitivity analyses yielded consistent results.
    Conclusion: Living alone was independently associated with an increased risk of hypertension in older men. The highest risk was found in those with the least time alone. These findings imply that social isolation and lack of companionship could be pivotal in hypertension development. Furthermore, the study highlights the need to consider living alone duration when assessing its impact on health outcomes.
    MeSH term(s) Aged, 80 and over ; Humans ; Male ; Asian People ; China/epidemiology ; Cohort Studies ; Home Environment ; Hypertension/epidemiology ; Social Determinants of Health
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1274955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Modified Neo-Bioscore System for Staging Breast Cancer Treated with Neoadjuvant Therapy Based on Prognostic Significance of HER2-Low Expression.

    Zhao, Yingying / Chen, Xinru / Wang, Yaohui / Zhang, Xueqing / Lu, Jingsong / Yin, Wenjin

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Construction of a Prediction Model for Voriconazole-Induced Hepatotoxicity Based on Mixed-Effects Random Forest.

    Tong, Danyang / Wang, Yu / Ma, Jing / Wang, Jiaqi / Li, Jingsong

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 319–323

    Abstract: Voriconazole is a second-generation triazole antifungal agent with strong antifungal activity against a variety of clinically significant pathogens. Controlling blood concentrations within guideline limits through blood concentration monitoring can ... ...

    Abstract Voriconazole is a second-generation triazole antifungal agent with strong antifungal activity against a variety of clinically significant pathogens. Controlling blood concentrations within guideline limits through blood concentration monitoring can reduce the probability of hepatotoxicity in patients with voriconazole. However, statistical analysis based on real-world data found that there were still several patients who had blood concentration monitoring developed voriconazole induced hepatotoxicity. Therefore, it has important clinical significance to predict whether hepatotoxicity will occur in patients who meet the guidelines for voriconazole plasma concentration requirements. In this study, based on real-world data, the mixed-effects random forest was used to analyze the electronic medical record data of patients who met the guidelines for voriconazole blood concentration requirements during hospitalization, and a predictive model was constructed to predict whether patients would develop hepatotoxicity within 30 days after using voriconazole.
    MeSH term(s) Humans ; Voriconazole/adverse effects ; Random Forest ; Electronic Health Records ; Hospitalization ; Chemical and Drug Induced Liver Injury/etiology
    Chemical Substances Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Block copolymer-templated surface-enhanced Raman scattering-active nanofibers for hydrogen sulfide detection.

    Zhao, Xingjuan / Wang, Jingsong / Jia, Yuechen

    Talanta

    2023  Volume 270, Page(s) 125608

    Abstract: Metabolic disorders involving endogenous ... ...

    Abstract Metabolic disorders involving endogenous H
    MeSH term(s) Humans ; Nanofibers ; Metal Nanoparticles ; Hydrogen Sulfide ; Spectrum Analysis, Raman/methods ; Reproducibility of Results ; Gold ; Silver ; Polymers
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Gold (7440-57-5) ; Silver (3M4G523W1G) ; Polymers
    Language English
    Publishing date 2023-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury.

    Luan, Zhiwei / Liu, Jingsong / Li, Mi / Wang, Yangyang / Wang, Yansong

    Journal of orthopaedic surgery and research

    2024  Volume 19, Issue 1, Page(s) 184

    Abstract: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system and leads to incomplete or complete loss of the body's autonomous motor and sensory functions, seriously endangering human health. Recently, exosomes have been proposed ...

    Abstract Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system and leads to incomplete or complete loss of the body's autonomous motor and sensory functions, seriously endangering human health. Recently, exosomes have been proposed as important substances in cell-to-cell interactions. Mesenchymal stem cell (MSC)-derived exosomes exert good therapeutic effects and play a crucial role in neurological damage repair. However, the detailed mechanisms underlying their effects remain unknown. Herein, we found that compared to SCI rats, those subjected to umbilical cord MSC (UC-MSC)-derived exosomes injection showed an improved motor ability. Nevertheless, the transcriptome of BV2 microglia in different treatment groups indicated that the action pathway of exosomes might be the NF-κB/MAPK pathway. Additionally, exosomes from UC-MSCs could inhibit P38, JNK, ERK, and P65 phosphorylation in BV2 microglia and SCI rat tissues. Moreover, exosomes could inhibit apoptosis and inflammatory reaction and reactive oxygen species (ROS) production of BV2 microglia in vitro and in vivo. In conclusion, UC-MSCs-derived exosomes might protect SCI in rats by inhibiting inflammatory response via the NF-κB/MAPK signaling pathway, representing novel treatment targets or approaches for SCI.
    MeSH term(s) Rats ; Humans ; Animals ; NF-kappa B/metabolism ; Exosomes/metabolism ; Mesenchymal Stem Cells/metabolism ; Signal Transduction ; Spinal Cord Injuries/therapy ; Spinal Cord Injuries/metabolism ; Umbilical Cord/metabolism
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-024-04651-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Hemodialysis Mortality Prediction Model Based on Active Contrastive Learning.

    Wang, Feng / Chi, Shengqiang / Li, Xueyao / Zhang, Hang / Li, Jingsong

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 720–724

    Abstract: Hemodialysis (HD) is the main treatment for end-stage renal disease with high mortality and heavy economic burdens. Predicting the mortality risk in patients undergoing maintenance HD and identifying high-risk patients are critical to enable early ... ...

    Abstract Hemodialysis (HD) is the main treatment for end-stage renal disease with high mortality and heavy economic burdens. Predicting the mortality risk in patients undergoing maintenance HD and identifying high-risk patients are critical to enable early intervention and improve quality of life. In this study, we proposed a two-stage protocol based on electronic health record (EHR) data to predict mortality risk of maintenance HD patients. First, we developed a multilayer perceptron (MLP) model to predict mortality risk. Second, an Active Contrastive Learning (ACL) method was proposed to select sample pairs and optimize the representation space to improve the prediction performance of the MLP model. Our ACL method outperforms other methods and has an average F1-score of 0.820 and an average area under the receiver operating characteristic curve of 0.853. This work is generalizable to analyses of cross-sectional EHR data, while this two-stage approach can be applied to other diseases as well.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Quality of Life ; Renal Dialysis ; Problem-Based Learning ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Graph Neural Network Based Multi-Label Hierarchical Classification for Disease Predictions in General Practice.

    Chi, Shengqiang / Wang, Yuqing / Zhang, Ying / Zhu, Weiwei / Li, Jingsong

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 725–729

    Abstract: General practitioners are supposed to be better diagnostics to detect patients with serious diseases earlier, and conduct early interventions and appropriate referrals of patients. However, in the current general practice, primary general practitioners ... ...

    Abstract General practitioners are supposed to be better diagnostics to detect patients with serious diseases earlier, and conduct early interventions and appropriate referrals of patients. However, in the current general practice, primary general practitioners lack sufficient clinical experiences, and the correct rate of general disease diagnosis is low. To assist general practitioners in diagnosis, this paper proposes a multi-label hierarchical classification method based on graph neural network, which integrates medical knowledge and electronic health record (EHR) data to build a disease prediction model. The experimental results based on data consist of 231,783 visits from EHR show that the proposed model outperforms all baseline models in the general disease prediction task with a top-3 recall of 0.865. The interpretable results of the model can effectively help clinicians understand the basis of the model's decision-making.
    MeSH term(s) Humans ; General Practice ; Family Practice ; General Practitioners ; Knowledge ; Neural Networks, Computer
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Post-Marketing Drug Evaluation Framework Based on Real-World Electronic Health Records Data.

    Wang, Yu / Ma, Shuang / Ru, Hua / Ni, Hongyi / Li, Jingsong

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 134–138

    Abstract: Real-world data (RWD) could be a new way to evaluate the safety and efficacy of post-marketing drugs, while there is no common method for how to use RWD for drug evaluation. In this paper, we present a framework for real-world drug evaluation based on ... ...

    Abstract Real-world data (RWD) could be a new way to evaluate the safety and efficacy of post-marketing drugs, while there is no common method for how to use RWD for drug evaluation. In this paper, we present a framework for real-world drug evaluation based on electronic medical record (EHR) data. We designed a data model customized for post-marketing drug evaluation and a unified post-marketing drug evaluation pipeline. The proposed framework can be applied to drug evaluations with different study paradigms for different purposes by flexible use of the proposed data model and pipeline. A prototype system has been developed according to the framework. Real-world EHRs in a tertiary hospital in China between 2010 and 2020 were converted to the proposed data model, and as a test case, we conducted a research on the risk of allergic reactions to cefodizime and ceftriaxone using the prototype system.
    MeSH term(s) Drug Evaluation ; Electronic Health Records ; Ceftriaxone ; China ; Marketing
    Chemical Substances Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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