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  1. Article: Editorial: Viral vector-based gene therapy in neurological disease: The future is now.

    Smith, Jared B / Cancedda, Laura / Jozwiak, Sergiusz / Mercer, Andrew C

    Frontiers in neurology

    2023  Volume 14, Page(s) 1153681

    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1153681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perceptions of weather-based pain forecasts and their effect on daily activities.

    Elcik, Christopher J / Fuhrmann, Christopher M / Sheridan, Scott C / Sherman-Morris, Kathleen / Mercer, Andrew E

    International journal of biometeorology

    2023  Volume 68, Issue 1, Page(s) 109–123

    Abstract: As studies begin to have more success uncovering the relationships between atmospheric conditions and pain, weather-based pain forecasting becomes more of a reality. In this study, a survey was used to determine if people living with migraines and/or ... ...

    Abstract As studies begin to have more success uncovering the relationships between atmospheric conditions and pain, weather-based pain forecasting becomes more of a reality. In this study, a survey was used to determine if people living with migraines and/or other pain-related conditions are receptive to weather-based pain forecasts. Moreover, we wished to identify whether these forecasts actually impact the decision-making of those who use them. Survey respondents were generally eager to use these novel forecasts. Furthermore, when provided with different scenarios involving weather-based pain forecasts, the respondents' actions were altered. When a hypothetical forecast indicated that the weather was conducive to migraines or other types of pain, many indicated that they would likely take preventative measures (e.g., medication). Additionally, respondents were less likely to continue with a planned activity, regardless of length, as forecast severity increased. The results from this survey highlight the importance of developing and improving weather-based pain forecasting.
    MeSH term(s) Humans ; Decision Making ; Weather ; Climate ; Forecasting ; Migraine Disorders
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280324-0
    ISSN 1432-1254 ; 0020-7128
    ISSN (online) 1432-1254
    ISSN 0020-7128
    DOI 10.1007/s00484-023-02575-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Geographical variability in the relationship between synoptic weather type and emergency department visits for pain across North Carolina.

    Elcik, Christopher / Fuhrmann, Christopher M / Sheridan, Scott C / Mercer, Andrew E / Sherman-Morris, Kathleen

    International journal of biometeorology

    2021  Volume 66, Issue 3, Page(s) 559–572

    Abstract: Bodily pain plagues populations across the globe. Past studies have discovered some links between synoptic weather types and different kinds of pain. These relationships are essential as they can aide in treatment and potentially prevention of pain. In ... ...

    Abstract Bodily pain plagues populations across the globe. Past studies have discovered some links between synoptic weather types and different kinds of pain. These relationships are essential as they can aide in treatment and potentially prevention of pain. In this study, the role of geographical characteristics on the relationships between synoptic weather type and pain were looked at. North Carolina was separated into three geographic sections: Appalachian Mountains, Piedmont Plateau, and Coastal Plain. Over a 7-year period, synoptic weather types and emergency department (ED) visits for various kinds of pain (migraine, fibromyalgia, rheumatoid arthritis, osteoarthritis, and general back pain) were collected. Bootstrapped confidence intervals of the mean number of population-adjusted ED visit rates (per 100,000 persons), for the different synoptic weather types, were compared across the different geographic regions. In the plateau region, Moist Tropical and Moist Moderate weather types were often linked to the highest rates of ED visits, while Polar weather types were frequently associated with the fewest visits. The mountainous portion of the state displayed similar patterns between synoptic weather types and the different forms of pain, with migraine and fibromyalgia being the exceptions. Few statistically significant relationships were noted for the coastal region.
    MeSH term(s) Emergency Service, Hospital ; Geography ; Humans ; North Carolina/epidemiology ; Pain ; Weather
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280324-0
    ISSN 1432-1254 ; 0020-7128
    ISSN (online) 1432-1254
    ISSN 0020-7128
    DOI 10.1007/s00484-021-02217-7
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  4. Article ; Online: Design of synthetic promoters for controlled expression of therapeutic genes in retinal pigment epithelial cells.

    Johari, Yusuf B / Mercer, Andrew C / Liu, Ye / Brown, Adam J / James, David C

    Biotechnology and bioengineering

    2021  Volume 118, Issue 5, Page(s) 2001–2015

    Abstract: Age-related macular degeneration (AMD) associated with dysfunction of retinal pigment epithelial (RPE) cells is the most common cause of untreatable blindness. To advance gene therapy as a viable treatment for AMD there is a need for technologies that ... ...

    Abstract Age-related macular degeneration (AMD) associated with dysfunction of retinal pigment epithelial (RPE) cells is the most common cause of untreatable blindness. To advance gene therapy as a viable treatment for AMD there is a need for technologies that enable controlled, RPE-specific expression of therapeutic genes. Here we describe design, construction and testing of compact synthetic promoters with a pre-defined transcriptional activity and RPE cell specificity. Initial comparative informatic analyses of RPE and photoreceptor (PR) cell transcriptomic data identified conserved and overrepresented transcription factor regulatory elements (TFREs, 8-19 bp) specifically associated with transcriptionally active RPE genes. Both RPE-specific TFREs and those derived from the generically active cytomegalovirus-immediate early (CMV-IE) promoter were then screened in vitro to identify sequence elements able to control recombinant gene transcription in model induced pluripotent stem (iPS)-derived and primary human RPE cells. Two libraries of heterotypic synthetic promoters varying in predicted RPE specificity and transcriptional activity were designed de novo using combinations of up to 20 discrete TFREs in series (323-602 bp) and their transcriptional activity in model RPE cells was compared to that of the endogenous BEST1 promoter (661 bp, plus an engineered derivative) and the highly active generic CMV-IE promoter (650 bp). Synthetic promoters with a highpredicted specificity, comprised predominantly of endogenous TFREs exhibited a range of activities up to 8-fold that of the RPE-specific BEST1 gene promoter. Moreover, albeit at a lower predicted specificity, synthetic promoter transcriptional activity in model RPE cells was enhanced beyond that of the CMV-IE promoter when viral elements were utilized in combination with endogenous RPE-specific TFREs, with a reduction in promoter size of 15%. Taken together, while our data reveal an inverse relationship between synthetic promoter activity and cell-type specificity, cell context-specific control of recombinant gene transcriptional activity may be achievable.
    MeSH term(s) Cells, Cultured ; Epithelial Cells/cytology ; Genes, Synthetic/genetics ; Genetic Therapy/methods ; Humans ; Organ Specificity/genetics ; Promoter Regions, Genetic/genetics ; Retinal Pigment Epithelium/cytology ; Synthetic Biology/methods ; Transcriptome/genetics
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.27713
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  5. Article: Geographical variability in the relationship between synoptic weather type and emergency department visits for pain across North Carolina

    Elcik, Christopher / Fuhrmann, Christopher M. / Sheridan, Scott C. / Mercer, Andrew E. / Sherman-Morris, Kathleen

    International journal of biometeorology. 2022 Mar., v. 66, no. 3

    2022  

    Abstract: Bodily pain plagues populations across the globe. Past studies have discovered some links between synoptic weather types and different kinds of pain. These relationships are essential as they can aide in treatment and potentially prevention of pain. In ... ...

    Abstract Bodily pain plagues populations across the globe. Past studies have discovered some links between synoptic weather types and different kinds of pain. These relationships are essential as they can aide in treatment and potentially prevention of pain. In this study, the role of geographical characteristics on the relationships between synoptic weather type and pain were looked at. North Carolina was separated into three geographic sections: Appalachian Mountains, Piedmont Plateau, and Coastal Plain. Over a 7-year period, synoptic weather types and emergency department (ED) visits for various kinds of pain (migraine, fibromyalgia, rheumatoid arthritis, osteoarthritis, and general back pain) were collected. Bootstrapped confidence intervals of the mean number of population-adjusted ED visit rates (per 100,000 persons), for the different synoptic weather types, were compared across the different geographic regions. In the plateau region, Moist Tropical and Moist Moderate weather types were often linked to the highest rates of ED visits, while Polar weather types were frequently associated with the fewest visits. The mountainous portion of the state displayed similar patterns between synoptic weather types and the different forms of pain, with migraine and fibromyalgia being the exceptions. Few statistically significant relationships were noted for the coastal region.
    Keywords bioclimatology ; coastal plains ; coasts ; geographical variation ; migraine ; mountains ; osteoarthritis ; pain ; piedmont ; rheumatoid arthritis ; weather ; North Carolina
    Language English
    Dates of publication 2022-03
    Size p. 559-572.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 127361-9
    ISSN 0067-8902 ; 0020-7128
    ISSN 0067-8902 ; 0020-7128
    DOI 10.1007/s00484-021-02217-7
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Variable effects of exposure to ionic silver in wound-associated bacterial pathogens.

    Binsuwaidan, Reem / Almuzaini, Osama / Mercer, Steven / Doherty, Christopher / Mokhtar, Jawahir / McBain, Andrew J / Ledder, Ruth / Humphreys, Gavin J

    Letters in applied microbiology

    2024  Volume 77, Issue 4

    Abstract: Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobials over prolonged periods of time. In this study, a panel of chronic wound ...

    Abstract Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobials over prolonged periods of time. In this study, a panel of chronic wound bacteria, Pseudomonas aeruginosa (two strains), Staphylococcus aureus, and Escherichia coli, were exposed to silver nitrate on agar. Phenotypic characterization was achieved using broth microdilution sensitivity testing, a crystal violet biofilm assay, and a wax moth pathogenesis model. Repeated exposure to ionic silver did not result in planktonic phenotypic silver resistance in any of the test panels, although S. aureus demonstrated reversible increases in minimum bactericidal concentration. An ulcer-derived P. aeruginosa exhibited marked reductions in biofilm eradication concentration as well as significantly increased biofilm formation and wax moth killing when compared to the same progenitor. These changes were reversible, trending towards baseline measurements following 10 passages on silver-free media. Changes in virulence and biofilm formation in the other test bacteria were generally limited. In summary, phenotypic adaptation following exposure to ionic silver was manifested other than through changes in planktonic susceptibility. Significant changes in pseudomonas biofilm formation and sensitivity could have implications for wound care regimes and therefore warrant further investigation.
    MeSH term(s) Humans ; Staphylococcus aureus ; Anti-Infective Agents/pharmacology ; Bacteria ; Bandages ; Staphylococcal Infections ; Biofilms ; Pseudomonas aeruginosa ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 632584-1
    ISSN 1472-765X ; 0266-8254
    ISSN (online) 1472-765X
    ISSN 0266-8254
    DOI 10.1093/lambio/ovae030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: British Thoracic Society Guideline for pleural disease.

    Roberts, Mark E / Rahman, Najib M / Maskell, Nick A / Bibby, Anna C / Blyth, Kevin G / Corcoran, John P / Edey, Anthony / Evison, Matthew / de Fonseka, Duneesha / Hallifax, Rob / Harden, Susan / Lawrie, Iain / Lim, Eric / McCracken, David J / Mercer, Rachel / Mishra, Eleanor K / Nicholson, Andrew G / Noorzad, Farinaz / Opstad, Kirstie /
    Parsonage, Maria / Stanton, Andrew E / Walker, Steven

    Thorax

    2023  Volume 78, Issue Suppl 3, Page(s) s1–s42

    MeSH term(s) Humans ; Pleural Diseases/diagnosis ; Pleural Diseases/therapy
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Practice Guideline
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219784
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  8. Article ; Online: British Thoracic Society Guideline for pleural disease.

    Roberts, Mark E / Rahman, Najib M / Maskell, Nick A / Bibby, Anna C / Blyth, Kevin G / Corcoran, John P / Edey, Anthony / Evison, Matthew / de Fonseka, Duneesha / Hallifax, Rob / Harden, Susan / Lawrie, Iain / Lim, Eric / McCracken, David / Mercer, Rachel / Mishra, Eleanor K / Nicholson, Andrew G / Noorzad, Farinaz / Opstad, Kirstie S /
    Parsonage, Maria / Stanton, Andrew E / Walker, Steven

    Thorax

    2023  Volume 78, Issue 11, Page(s) 1143–1156

    MeSH term(s) Humans ; Pleural Diseases/diagnosis ; Pleural Diseases/therapy ; Pleural Effusion/therapy
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220304
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  9. Article ; Online: Relationship between synoptic weather type and emergency department visits for different types of pain across the Triangle region of North Carolina.

    Elcik, Christopher / Fuhrmann, Christopher M / Sheridan, Scott C / Mercer, Andrew E / Sherman-Morris, Kathleen

    International journal of biometeorology

    2020  Volume 64, Issue 11, Page(s) 1815–1823

    Abstract: Many people around the world are impacted by some form of bodily pain. Outside factors, such as weather, are thought to help trigger pain, especially in those who have pain-related conditions. When it comes to human health and comfort, understanding the ... ...

    Abstract Many people around the world are impacted by some form of bodily pain. Outside factors, such as weather, are thought to help trigger pain, especially in those who have pain-related conditions. When it comes to human health and comfort, understanding the potential external factors that aide in triggering pain is essential. Identifying such factors makes prevention and treatment of pain more feasible. This study focused on how those who suffer from various pain-related conditions (fibromyalgia, rheumatoid arthritis, osteoarthritis, and general back pain) are impacted by different synoptic weather types (i.e., air masses). Synoptic weather types and emergency department (ED) visits for pain in select central North Carolina counties were collected over a seven-year period to determine a potential relationship. Bootstrapped confidence intervals revealed that moist tropical weather types resulted in the highest number of ED visits for each of the conditions examined, while moist polar weather types often resulted in the fewest. The barometric pressure changes associated with transitional weather types, which are often associated with fronts, did not have any significant relationships with pain.
    MeSH term(s) Atmospheric Pressure ; Emergency Service, Hospital ; Humans ; North Carolina/epidemiology ; Pain ; Weather
    Language English
    Publishing date 2020-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280324-0
    ISSN 1432-1254 ; 0020-7128
    ISSN (online) 1432-1254
    ISSN 0020-7128
    DOI 10.1007/s00484-020-01966-1
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  10. Article: Orf Virus IL-10 and VEGF-E Act Synergistically to Enhance Healing of Cutaneous Wounds in Mice.

    Wise, Lyn M / Stuart, Gabriella S / Jones, Nicola C / Fleming, Stephen B / Mercer, Andrew A

    Journal of clinical medicine

    2020  Volume 9, Issue 4

    Abstract: Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which ...

    Abstract Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study examined the effects of the VEGF-E and ovIL-10 combination on healing processes in a murine wound model. Treatments with viral proteins, individually and in combination, were compared to a mammalian VEGF-A and IL-10 combination. Wound biopsies were harvested to measure re-epithelialisation and scarring (histology), inflammation, fibrosis and angiogenesis (immunofluorescence), and gene expression (quantitative polymerase chain reaction). VEGF-E and ovIL-10 showed additive effects on wound closure and re-epithelialisation, and suppressed M1 macrophage and myofibroblast infiltration, while allowing M2 macrophage recruitment. The viral combination also increased endothelial cell density and pericyte coverage, and improved collagen deposition while reducing the scar area. The mammalian combination showed equivalent effects on wound closure, re-epithelialisation and fibrosis, but did not promote blood vessel stabilisation or collagen remodeling. The combination treatments also differentially altered the expression of transforming growth factor beta isoforms,
    Language English
    Publishing date 2020-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9041085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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