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  1. Article ; Online: Renal Function Improvement With Glucagon-Like Peptide-1 Receptor Agonist in a Patient With Type 2 Diabetes.

    Yanai, Hidekatsu

    Journal of medical cases

    2024  Volume 15, Issue 2-3, Page(s) 37–42

    Abstract: Diabetic kidney disease (DKD) includes hypertensive nephrosclerosis, aging, obesity, and atherosclerosis-related renal diseases, in addition to classical diabetic nephropathy. Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have been approved for ... ...

    Abstract Diabetic kidney disease (DKD) includes hypertensive nephrosclerosis, aging, obesity, and atherosclerosis-related renal diseases, in addition to classical diabetic nephropathy. Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have been approved for diabetic and non-diabetic patients at risk of chronic kidney disease progression. As the main mechanism for SGLT2i-mediated improvement of renal function, the normalization of tubulo-glomerular feedback (TGF) has been proposed. Enhanced TGF and resulting glomerular hypertension are observed in diabetic patients, and SGLT2is normalize TGF, reducing the intraglomerular pressure, which may reduce albuminuria and improve renal function. A type 2 diabetic patient with DKD complicated with hypertensive nephrosclerosis, whose renal function was deteriorated by SGLT2i and improved by glucagon-like peptide-1 receptor agonists (GLP-1RAs), was presented. In patients with hypertensive nephrosclerosis such as this case, the normalization of TGF by SGLT2i may further reduce afferent arteriolar blood flow which may worsen glomerular ischemia, resulting in deterioration of renal function. GLP-1RAs have no effect on TGF and have multiple effects to improve vascular endothelial function, which may be associated with an improvement in renal function in this patient.
    Language English
    Publishing date 2024-04-08
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc4189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Parity and Maternal Cardiovascular Disease.

    Yanai, Hidekatsu

    Journal of atherosclerosis and thrombosis

    2022  Volume 30, Issue 2, Page(s) 107–109

    MeSH term(s) Pregnancy ; Female ; Humans ; Parity ; Cardiovascular Diseases ; Risk Factors
    Language English
    Publishing date 2022-05-21
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Acute Effects of Preventing Heart Failure by Sodium-Glucose Cotransporter 2 Inhibitors.

    Yanai, Hidekatsu

    Cardiology research

    2021  Volume 12, Issue 5, Page(s) 324–326

    Language English
    Publishing date 2021-08-31
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Adiposity is the Crucial Enhancer of COVID-19.

    Yanai, Hidekatsu

    Cardiology research

    2020  Volume 11, Issue 5, Page(s) 353–354

    Keywords covid19
    Language English
    Publishing date 2020-08-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Significance of High Prevalence of Diabetes and Hypertension in Severe COVID-19 Patients.

    Yanai, Hidekatsu

    Journal of clinical medicine research

    2020  Volume 12, Issue 6, Page(s) 389–392

    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr4218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Significant Correlations of SARS-CoV-2 Infection With Prevalence of Overweight/Obesity and Mean Body Mass Index in the SARS-CoV-2 Endemic Countries.

    Yanai, Hidekatsu

    Cardiology research

    2020  Volume 11, Issue 6, Page(s) 412–414

    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Metabolic Syndrome and COVID-19.

    Yanai, Hidekatsu

    Cardiology research

    2020  Volume 11, Issue 6, Page(s) 360–365

    Abstract: Recent studies showed that comorbidities such as diabetes, hypertension and obesity contribute to severe and worse outcomes of coronavirus disease 2019 (COVID-19), suggesting that metabolic syndrome and its components are associated with severity of ... ...

    Abstract Recent studies showed that comorbidities such as diabetes, hypertension and obesity contribute to severe and worse outcomes of coronavirus disease 2019 (COVID-19), suggesting that metabolic syndrome and its components are associated with severity of COVID-19. Here, I systematically reviewed a possible association of metabolic syndrome with the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity of COVID-19 by literature search. A population-based study and UK Biobank studies showed that patients with metabolic syndrome is highly susceptible to SARS-CoV-2 infection. Recent meta-analyses showed that metabolic syndrome is significantly associated with the development of severe COVID-19. Angiotensin-converting enzyme (ACE) 2 is the cellular entry receptor of SARS-CoV-2. Enhanced ACE2 expression, pre-existing endothelial dysfunction and procoagulant state induced by adipocytokines dysregulation in metabolic syndrome may play a crucial role for the development of severe COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2598593-0
    ISSN 1923-2837 ; 1923-2829
    ISSN (online) 1923-2837
    ISSN 1923-2829
    DOI 10.14740/cr1181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Periodic health checkups reduce the risk of hospitalization in patients with type 2 diabetes.

    Hamasaki, Hidetaka / Yanai, Hidekatsu

    Frontiers in clinical diabetes and healthcare

    2023  Volume 4, Page(s) 1087303

    Abstract: Introduction: Periodic health checkups (PHCs) represent a unique system in Japan that is useful for the early detection of lifestyle-related diseases and cardiovascular diseases (CVDs). This study aims to investigate the association of PHCs with the ... ...

    Abstract Introduction: Periodic health checkups (PHCs) represent a unique system in Japan that is useful for the early detection of lifestyle-related diseases and cardiovascular diseases (CVDs). This study aims to investigate the association of PHCs with the hospitalization risk of patients with type 2 diabetes mellitus (T2DM).
    Methods: A retrospective cohort study was conducted from April 2013 to December 2015 and included participant information such as CVD history, lifestyle, and whether PHC was conducted in addition to regular medical examinations. Difference in clinical data between patients with and without PHC was examined. Furthermore, Cox regression analysis was performed to investigate the independent association of PHCs with hospitalization.
    Results: Herein, 1,256 patients were selected and followed up for 2.35 ± 0.73 years. In the PHC group, body mass index, waist circumference, proportion of patients with a history of CVD, and number of hospitalizations were lower than those in the non-PHC group. Furthermore, the PHC group exhibited a significant association with lower hospitalization risk (hazard ratio = 0.825; 95% confidence interval, 0.684 to 0.997; p = 0.046) in the Cox model.
    Conclusion: This study revealed that PHCs minimized the risk of hospitalization in patients with T2DM. Furthermore, we discussed the effectiveness of PHCs in enhancing health outcomes and reducing health care costs in such patients.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6616
    ISSN (online) 2673-6616
    DOI 10.3389/fcdhc.2023.1087303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Handgrip strength is inversely associated with augmentation index in patients with type 2 diabetes.

    Hamasaki, Hidetaka / Yanai, Hidekatsu

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1125

    Abstract: Handgrip strength (HGS) is a measure of overall skeletal muscle strength and is used to identify risks for cardiovascular disease and mortality. Furthermore, HGS is an indicator of arterial stiffness that leads to atherosclerotic cardiovascular disease. ... ...

    Abstract Handgrip strength (HGS) is a measure of overall skeletal muscle strength and is used to identify risks for cardiovascular disease and mortality. Furthermore, HGS is an indicator of arterial stiffness that leads to atherosclerotic cardiovascular disease. This study aimed to examine the relationship between HGS and augmentation index (AIx) in patients with type 2 diabetes. A cross-sectional study was conducted to examine patients with type 2 diabetes whose HGS and AIx were measured in our hospital. AIx was measured noninvasively using an applanation tonometer, and multiple regression analyses were conducted to assess the independent relationship between HGS and AIx. This study included 404 patients. After adjusting for age, gender, body mass index, duration of diabetes, smoking and exercise habit, biochemical parameters, and physiological parameters related to arterial stiffness, HGS was found to be independently and inversely associated with AIx (β = - 0.270, p = 0.006). HGS was independently and inversely associated with AIx in patients with type 2 diabetes. Patients with diminished HGS should be subjected to intensive exercise therapy for reducing the risk of arterial stiffness and cardiovascular disease.Trial registration: UMIN000023010.
    MeSH term(s) Humans ; Hand Strength/physiology ; Diabetes Mellitus, Type 2 ; Cardiovascular Diseases ; Cross-Sectional Studies ; Muscle Strength/physiology
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28392-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of the use of psychotropic drugs with hospitalization, cardiovascular events, and mortality in patients with type 2 diabetes: a propensity score-matched cohort study.

    Hamasaki, Hidetaka / Yanai, Hidekatsu

    Frontiers in clinical diabetes and healthcare

    2023  Volume 4, Page(s) 1181998

    Abstract: Background: Use of psychotropic drugs (PD) may be associated with impairment of physical function. However, few studies have assessed the impact of PD on health outcomes in patients with type 2 diabetes. This study aimed to examine the associations ... ...

    Abstract Background: Use of psychotropic drugs (PD) may be associated with impairment of physical function. However, few studies have assessed the impact of PD on health outcomes in patients with type 2 diabetes. This study aimed to examine the associations between psychotropic drug use and handgrip strength (HGS) and between the use of PD and hospitalization in patients with type 2 diabetes.
    Methods: From April 2013 to December 2015, we conducted a retrospective cohort study in patients with type 2 diabetes at the National Center for Global Health and Medicine Kohnodai Hospital. Patients aged 20 years and over who can measure HGS were included. All participants received nutritional guidance regarding diet therapy for type 2 diabetes at baseline. Nonpsychotropic drug users were matched one-to-one with the PD users using propensity score matching method with respect to their baseline covariates. The differences in HGS and the number of patients who had hospitalizations during the study period were examined. By Cox proportional hazard regression analysis, the association between the use of PD and repeated hospitalizations was estimated.
    Results: A total of 1,282 patients were enrolled and followed up for 2.36 ± 0.73 years. In the propensity score matching cohort, HGS was significantly lower (p = 0.006) in PD users than non-PD users. PD users had more hospitalizations than non-PD users. Cox proportional hazard regression analysis confirmed the association of repeated hospitalizations with the use of PD (hazard ratio = 2.138; 95% confidence interval, 1.144-3.995, p = 0.017)). In addition, HGS was significantly and inversely correlated with the number of hospitalizations (r = -0.143, p = 0.013).
    Conclusions: The use of PD could increase the risk of repeated hospitalizations. Skeletal muscle may play a role in reducing the risk of hospitalization in patients who are treated with PD.
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6616
    ISSN (online) 2673-6616
    DOI 10.3389/fcdhc.2023.1181998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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