LIVIVO - Search results -

Search results

Result 1 - 10 of total 118

Search options

Article ; Online: Ataxia espinocerebelar (doença de Machado-Joseph)

Dayane Alves Brandão Cyrne / William Malagutti / Anderson Sena Barnabé / João Victor Fornari / Francisco Sandro Menezes Rodrigues / Renato Ribeiro Nogueira Ferraz

ConScientiae Saúde, Vol 10, Iss 2, Pp 346-

três relatos de caso

2011 Volume 355

Abstract: ... also known as Machado-Joseph Disease (MJD). Objective: To describe the feelings and expectations ...

Abstract	Introduction: Spinocerebellar ataxias (SCA) are genetic neuro-degenerative diseases that are characterized by a progressive loss of cerebellar neurons. In Brazil, the most common form of SCA is the SCA3, also known as Machado-Joseph Disease (MJD). Objective: To describe the feelings and expectations of the MJD patients about their own illness. Method: We conducted interview with targeted three patients with MJD from the same family. Results and conclusion: The respondents know that the disease is hereditary, have ataxia, dysmetria, motor coordination difficulties and depression. The severity of the disease is perceived through the deaths experienced between family members. The MJD brings major changes in activities of daily living, leading to need help from others. The participants' feelings toward the disease are expressed ambiguously, appearing rebellion and conformity.
Keywords	Diseases of the musculoskeletal system ; RC925-935 ; Sports medicine ; RC1200-1245
Subject code	610
Language	Portuguese
Publishing date	2011-01-01T00:00:00Z
Publisher	Universidade Nove de Julho
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Movimentos sociais, de Joseph Huber

Aico Sipriano Nogueira / Joaquim Aguiar Duarte

Plural, Vol

1995 Volume 2

Abstract: Os novos movimentos sociais (NMS) - ambientalismo, feminismo, pacifismo, etc. - não são realmente novos, mas vêm se mantendo de forma recorrente nos últimos duzentos anos. Tais movimentos têm um papel importante no processo da contínua modernização, ... ...

Abstract	Os novos movimentos sociais (NMS) - ambientalismo, feminismo, pacifismo, etc. - não são realmente novos, mas vêm se mantendo de forma recorrente nos últimos duzentos anos. Tais movimentos têm um papel importante no processo da contínua modernização, ainda que tenham a intenção de serem antimodernistas. Agem no sentido de impulsionar uma readaptação periódica do sistema industrial ao seu contexto natural e cultural
Keywords	Sociology (General) ; HM401-1281 ; Social sciences (General) ; H1-99
Language	Spanish
Publishing date	1995-12-01T00:00:00Z
Publisher	Universidade de São Paulo (USP)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Adjuvant proton beam therapy in patients with grade 2 meningiomas.

Wilson, Taylor Anne / Kang, Joseph I / Huang, Lei / Vacaru, Alexandra / Martins, Kevin Nogueira / Boling, Warren W

Surgical neurology international

2024 Volume 15, Page(s) 62

Abstract: Background: The World Health Organization (WHO) grade 2 meningiomas behave aggressively with a high proclivity toward recurrence despite maximal surgical resection. Our institution, a pioneer of proton therapy, uses exclusively proton beam radiation, ... ...

Abstract	Background: The World Health Organization (WHO) grade 2 meningiomas behave aggressively with a high proclivity toward recurrence despite maximal surgical resection. Our institution, a pioneer of proton therapy, uses exclusively proton beam radiation, and thus, we present a retrospective cohort analysis of patients with WHO grade 2 meningiomas treated with adjuvant proton beam therapy (PBT) at our institution between 2007 and 2019. The effects of adjuvant PBT were evaluated. Methods: Data collected include diagnosis, gender, histological subtype, WHO grade, the extent of surgical resection, adjuvant PBT radiation, details of the PBT radiation, recurrence, any additional PBT radiation, systemic medical therapy, and disease-specific survival. Results: Among the WHO grade 2 meningiomas ( Conclusion: Our results suggest that adjuvant PBT is well tolerated with minimal radiation toxicity. Alternative to photon radiation, PBT may be considered at least as safe and effective for adjuvant treatment of WHO grade 2 meningiomas when it is available.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_485_2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A robust role for motor cortex.

Lopes, Gonçalo / Nogueira, Joana / Dimitriadis, George / Menendez, Jorge Aurelio / Paton, Joseph J / Kampff, Adam R

Frontiers in neuroscience

2023 Volume 17, Page(s) 971980

Abstract: The role of motor cortex in non-primate mammals remains unclear. More than a century of stimulation, anatomical and electrophysiological studies has implicated neural activity in this region with all kinds of movement. However, following the removal of ... ...

Abstract	The role of motor cortex in non-primate mammals remains unclear. More than a century of stimulation, anatomical and electrophysiological studies has implicated neural activity in this region with all kinds of movement. However, following the removal of motor cortex, rats retain most of their adaptive behaviors, including previously learned skilled movements. Here we revisit these two conflicting views of motor cortex and present a new behavior assay, challenging animals to respond to unexpected situations while navigating a dynamic obstacle course. Surprisingly, rats with motor cortical lesions show clear impairments facing an unexpected collapse of the obstacles, while showing no impairment with repeated trials in many motor and cognitive metrics of performance. We propose a new role for motor cortex: extending the robustness of sub-cortical movement systems, specifically to unexpected situations demanding rapid motor responses adapted to environmental context. The implications of this idea for current and future research are discussed.
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.971980
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Metabolic Profiling and Comparative Proteomic Insight in Respect of Amidases during Iprodione Biodegradation.

Donoso-Piñol, Pamela / Briceño, Gabriela / Evaristo, Joseph A M / Nogueira, Fábio C S / Leiva, Barbara / Lamilla, Claudio / Schalchli, Heidi / Diez, María Cristina

Microorganisms

2023 Volume 11, Issue 10

Abstract: The fungicide iprodione (IPR) (3-(3,5-dichlorophenyl) N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide) is a highly toxic compound. Although IPR has been restricted, it is still being applied in many places around the world, constituting an environmental ...

Abstract	The fungicide iprodione (IPR) (3-(3,5-dichlorophenyl) N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide) is a highly toxic compound. Although IPR has been restricted, it is still being applied in many places around the world, constituting an environmental risk. The biodegradation of IPR is an attractive option for reducing its residues. In this study, we isolated thirteen IPR-tolerant bacteria from a biopurification system designed to treat pesticides. A study of biodegradation using different strains was comparatively evaluated, and the best degradation rate of IPR was presented by
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11102367
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains.

Lourenco Nogueira, Christiane / Boegel, Scott Joseph / Shukla, Manish / Ngo, William / Jones, Lyndon / Aucoin, Marc G

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Background: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) surrogates for ... ...

Abstract	Background: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) surrogates for SARS-CoV-2 was investigated. Methods: Biotrue and Boston Simplus (Bausch&Lomb), OPTI-FREE Puremoist and Clear Care (Alcon), and cleadew and cleadew GP (Ophtecs) were tested. Their ability to inactivate HCoV was evaluated using contact times of 4 and 6 h as well as 1% and 10% of virus inoculum. Results: Non-oxidative systems (Biotrue, Boston Simplus, and OPTI-FREE) did not exhibit a significant log10 reduction compared to controls for the two viral strains for either incubation time (all p > 0.05) when 10% tests were performed. For the 1% test, while Boston Simplus and OPTI-FREE exhibited a significant log10 reduction of both HCoV-229E (after 6 h) and HCoV-OC43 (after either 4 or 6 h incubation), those products showed less than 1 log10 reduction of the two infectious viruses. Oxidative systems based on hydrogen peroxide or povidone-iodine showed a significant log10 reduction compared with the controls for both HCoV-229E and HCoV-OC43 in all tested conditions (all p < 0.01). Clear Care led to virus inactivation to below the limit of quantification for tests performed with 1% of inoculum after 6 h incubation, while cleadew and cleadew GP led to inactivation of the two viruses to below the limit of quantification in all tested conditions. Conclusion: Oxidative CL disinfection systems showed significant virucidal activity against HCoV-229E and HCoV-OC43, while non-oxidative systems showed minimal ability to inactivate the HCoV species examined.
Language	English
Publishing date	2022-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11040472
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The impact of a rub and rinse regimen on removal of human coronaviruses from contemporary contact lens materials.

Nogueira, Christiane Lourenco / Boegel, Scott Joseph / Shukla, Manish / Ngo, William / Jones, Lyndon / Aucoin, Marc G

Contact lens & anterior eye : the journal of the British Contact Lens Association

2022 Volume 45, Issue 6, Page(s) 101719

Abstract: Purpose: To assess the influence of contemporary contact lens (CL) materials on human coronavirus attachment and the influence of a rub and rinse step to remove these viruses.: Methods: The binding rates of HCoV-229E and HCoV-OC43 to eight soft CL ... ...

Abstract	Purpose: To assess the influence of contemporary contact lens (CL) materials on human coronavirus attachment and the influence of a rub and rinse step to remove these viruses. Methods: The binding rates of HCoV-229E and HCoV-OC43 to eight soft CL materials and four rigid gas permeable materials were analyzed. The impact of a rub and rinse step to remove these viruses from all materials was examined. The efficacy of Biotrue (Bausch & Lomb), OPTI-FREE Puremoist (Alcon), Clear Care (Alcon) and cleadew (Ophtecs) to remove virus contamination from two representative soft lens materials (etafilcon A and lotrafilcon B) was also determined. Results: Approximately 10 Conclusion: Human coronavirus contamination can be easily removed from CL surfaces. Although CL care products containing hydrogen peroxide and povidone-iodine efficiently removed virus contamination from CL surfaces without the need for a rub and rinse step, a full regimen including rub and rinse steps is crucial when using CL care products based on non-oxidative systems.
MeSH term(s)	Humans ; Contact Lens Solutions/pharmacology ; Contact Lenses, Hydrophilic ; Methacrylates ; Coronavirus
Chemical Substances	Contact Lens Solutions ; etafilcon ; Methacrylates
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2004847-6
ISSN	1476-5411 ; 1367-0484
ISSN (online)	1476-5411
ISSN	1367-0484
DOI	10.1016/j.clae.2022.101719
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Proteomic analysis of boar seminal plasma: Putative markers for fertility based on capacity of semen preservation at 17°C.

Lucca, Matheus S / Bustamante-Filho, Ivan C / Ulguim, Rafael R / Gianluppi, Rafael D F / Evaristo, Joseph A M / Nogueira, Fábio C S / Timmers, Luís F S M / Mellagi, Ana P G / Wentz, Ivo / Bortolozzo, Fernando P

Molecular reproduction and development

2024 Volume 91, Issue 1, Page(s) e23735

Abstract: Boar seminal plasma (SP) proteins were associated with differences on sperm resistance to cooling at 17°C. However, information about seminal plasma proteins in boars classified by capacity of semen preservation and in vivo fertility remains lacking. ... ...

Abstract	Boar seminal plasma (SP) proteins were associated with differences on sperm resistance to cooling at 17°C. However, information about seminal plasma proteins in boars classified by capacity of semen preservation and in vivo fertility remains lacking. Thus, the objective was to evaluate the SP proteome in boars classified by capacity of semen preservation and putative biomarkers for fertility. The ejaculates from high-preservation (HP) showed higher progressive motility during all 5 days than the low-preservation (LP) boars. There was no difference for farrowing rate between ejaculates from LP (89.7%) and HP boars (88.4%). The LP boars presented lower total piglets born (14.0 ± 0.2) than HP (14.8 ± 0.2; p < 0.01). A total of 257 proteins were identified, where 184 were present in both classes of boar, and 41 and 32 were identified only in LP and HP boars, respectively. Nine proteins were differently expressed: five were more abundant in HP (SPMI, ZPBP1, FN1, HPX, and C3) and four in LP boars (B2M, COL1A1, NKX3-2, and MPZL1). The HP boars had an increased abundance of SP proteins related to sperm resistance and fecundation process which explains the better TPB. LP boars had a higher abundance of SP proteins associated with impaired spermatogenesis.
MeSH term(s)	Swine ; Animals ; Male ; Semen/metabolism ; Semen Preservation/veterinary ; Proteomics ; Insemination, Artificial ; Spermatozoa ; Fertility ; Semen Analysis ; Seminal Plasma Proteins/metabolism ; Sperm Motility
Chemical Substances	Seminal Plasma Proteins
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.23735
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2759: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro.

Menezes, Aline / Julião, Glaucia / Mariath, Fernanda / Ferreira, Ana Luiza / Oliveira-Nunes, Maria Cecilia / Gallucci, Lara / Evaristo, Joseph Albert Medeiros / Nogueira, Fábio César Sousa / Pereira, Denise de Abreu / Carneiro, Katia

Molecular & cellular proteomics : MCP

2024 Volume 23, Issue 3, Page(s) 100722

Abstract: Glioblastoma (GBM) is the most aggressive brain tumor and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. Epitranscriptomics has shed light on new druggable Epigenetic therapies specifically designed to ...

Abstract	Glioblastoma (GBM) is the most aggressive brain tumor and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. Epitranscriptomics has shed light on new druggable Epigenetic therapies specifically designed to modulate GBM biology and behavior such as Histone Deacetylase inhibitors (iHDAC). Although the effects of iHDAC on GBM have been largely explored, there is a lack of information on the underlaying mechanisms HDAC-dependent that modulate the repertoire of GBM secreted molecules focusing on the set of Extracellular Matrix (ECM) associated proteins, the Matrisome, that may impact the surrounding tumor microenvironment. To acquire a better comprehension of the impacts of HDAC activity on the GBM Matrisome, we studied the alterations on the Matrisome-associated ECM regulators, Core Matrisome ECM glycoproteins, ECM-affiliated proteins and Proteoglycans upon HDAC inhibition in vitro as well as their relationship with glioma pathophysiological/clinical features and angiogenesis. For this, U87MG GBM cells were treated for with iHDAC or vehicle (control) and the whole secretome was processed by Mass Spectrometry NANOLC-MS/MS. In silico analyses revealed that proteins associated to the Angiogenic Matrisome (AngioMatrix), including Decorin, ADAM10, ADAM12 and ADAM15 were differentially regulated in iHDAC versus control secretome. Interestingly, genes coding for the Matrisome proteins differentially regulated were found mutated in patients and were correlated to glioma pathophysiological/clinical features. In vitro functional assays, using HBMEC endothelial cells exposed to the secretome of control or iHDAC treated GBM cells, coupled to 2D and 3D GBM cell culture system, showed impaired migratory capacity of endothelial cells and disrupted tubulogenesis in a Fibronectin and VEGF independent fashion. Collectively, our study provides understanding of epigenetic mechanisms HDAC-dependent to key Matrisomal proteins that may contribute to identify new druggable Epigenetic therapies or gliomagenesis biomarkers with relevant implications to improve therapeutic protocols for this malignancy.
MeSH term(s)	Humans ; Glioblastoma/genetics ; Glioblastoma/pathology ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Endothelial Cells/metabolism ; Tandem Mass Spectrometry ; Extracellular Matrix/metabolism ; Glioma/metabolism ; Epigenesis, Genetic ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Brain Neoplasms/drug therapy ; Tumor Microenvironment ; Membrane Proteins/metabolism ; ADAM Proteins/metabolism
Chemical Substances	Histone Deacetylases (EC 3.5.1.98) ; Extracellular Matrix Proteins ; ADAM15 protein, human (EC 3.4.24.-) ; Membrane Proteins ; ADAM Proteins (EC 3.4.24.-)
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2024.100722
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assessment of the Root Canal Similarity in Contralateral Mandibular Incisors.

Johnsen, Gaute Floer / Haugen, Håvard / Nogueira, Liebert Parreiras / Sevgi, Usame / Jimenez, Ashley Mae / DeLuca, Joseph T / Mancuso, Ryan / Piasecki, Lucila

International dental journal

2022 Volume 73, Issue 1, Page(s) 71–78

Abstract: Introduction: The purpose of this study was to determine the degree of similarity between contralateral mandibular incisors utilising 3-dimensional (3D) models obtained from micro-computed tomographic (micro-CT) scans of extracted human teeth. The null ... ...

Abstract	Introduction: The purpose of this study was to determine the degree of similarity between contralateral mandibular incisors utilising 3-dimensional (3D) models obtained from micro-computed tomographic (micro-CT) scans of extracted human teeth. The null hypothesis was that contralateral mandibular incisors do not exhibit matching symmetry. Methods: Sixty pairs (n = 120) of extracted mandibular incisors were obtained from 30 patients and scanned with micro-CT with a voxel size of 15.0 μm. 3D virtual models of the pulpal cavities were rendered. Geometric morphometric deviation analysis was performed after mirroring, automatic alignment, and co-registration of the models of contralateral teeth root mean square (RMS) errors were calculated. The quantitative analysis of the 3D models included 6 different geometric parameters. Data sets were examined with a 2-sample Kolmogorov-Smirnov test. Post hoc retrospective power analysis was performed to find statistical power (α = 0.05). Results: Contralateral pairs had a narrower distribution in deviation than random pairs. Also, contralateral pairs showed a statistically higher similarity coefficient (5 out of 6 geometric parameters) compared to random pairs (P < .001); no difference was found when comparing central to lateral pairs or between Vertucci type I configurations compared to non-type I. RMS errors had significantly lower Contralateral premolars (CPs) values than random pairs (P < .001). Conclusions: A high degree of similarity was demonstrated for pairing contralateral mandibular incisors using 3D models. The similarity between contralateral central and lateral incisors suggests that when screened and matched, these 4 teeth might be used in endodontic research where similar root canal anatomy is crucial.
MeSH term(s)	Humans ; Dental Pulp Cavity/anatomy & histology ; Incisor/diagnostic imaging ; Retrospective Studies ; Bicuspid/anatomy & histology ; Mandible/diagnostic imaging ; Cone-Beam Computed Tomography
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	218262-2
ISSN	1875-595X ; 0020-6539
ISSN (online)	1875-595X
ISSN	0020-6539
DOI	10.1016/j.identj.2022.04.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 205: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito