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Article ; Online: Aptamer-functionalized magnetic supports for sample preparation

Natalia Piqueras-García / María Vergara-Barberán / María Jesús Lerma-García / José Manuel Herrero-Martínez

Advances in Sample Preparation, Vol 7, Iss , Pp 100083- (2023)

2023

Abstract: In the last few years, aptamer-functionalized materials have been used as promising affinity sorbents for sample preparation purposes. These selective materials have attracted much attention due to their excellent molecular recognition properties, high ... ...

Abstract	In the last few years, aptamer-functionalized materials have been used as promising affinity sorbents for sample preparation purposes. These selective materials have attracted much attention due to their excellent molecular recognition properties, high stability, and the possibility of incorporation onto the surface of different supporting materials, such as nanoparticles, polymers, etc. On the other hand, current trends in extraction techniques encompass the use of miniaturized devices integrated with advanced affinity-based sorbents. Within these sample preparation devices, magnetic nanoparticles have become excellent candidates for the preparation of new functional nanomaterials for the solid-phase extraction processes. In addition to this approach, magnetic elements can be integrated in extraction devices (e.g., stir bars, stir cakes, etc.) to provide efficient extraction/stirring integrated techniques able to simplify the extraction and improve the performance. This review gives an overview of the literature published regarding aptamer-based sorbents using as host supports magnetic nanoparticles and integrated stirred units. For this purpose, the most relevant developments and applications achieved in the last seven years (from 2017 to 2023) in sample preparation by the integration of these affinity-based materials in extraction techniques such as magnetic solid-phase extraction and stir bar sorptive extraction will be reviewed.
Keywords	Aptamer ; Magnetic nanoparticles ; Sample preparation ; Magnetic solid-phase extraction ; Stir bar sorptive extraction ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Galactose-functionalized methacrylate polymers as affinity sorbents for extraction of food allergen lectins.

Vergara-Barberán, María / Lerma-García, María Jesús / Simó-Alfonso, Ernesto Francisco / Herrero-Martínez, José Manuel

Analytica chimica acta

2023 Volume 1255, Page(s) 341142

Abstract: In this study, glycidyl methacrylate (GMA)-based materials functionalized with different galactose derivatives were prepared to be used as affinity sorbents for solid-phase extraction (SPE) of several food allergen lectins (such as phytohemagglutinin ( ... ...

Abstract	In this study, glycidyl methacrylate (GMA)-based materials functionalized with different galactose derivatives were prepared to be used as affinity sorbents for solid-phase extraction (SPE) of several food allergen lectins (such as phytohemagglutinin (PHA)). First, GMA-based polymers were synthesized and then galactose derivatives were immobilized onto the GMA surface using two different synthetic routes. In the first approach, the bare polymer was modified with ethylenediamine and glutaraldehyde, and subsequently two galactose derivatives were immobilized. In the second strategy, the starting polymer was modified with cystamine and gold nanoparticles (AuNPs), on which a thiolated galactose derivative was subsequently anchored. The resulting materials were characterized by scanning electron microscopy and used as SPE sorbents for the isolation of PHA (as probe protein) from food matrices. Different SPE parameters (sample pH, eluent solution composition, binding capacity, sample volume, selectivity and reusability) were evaluated. The material that provided the best PHA recovery (98%) was the one obtained in the second approach, being this material successfully applied to the selective extraction of PHA and other similar lectins from different foods (red and lima dried beans, fresh soybeans and biscuits containing soybean protein traces as indicated in their label). After SDS-PAGE of eluates, all samples only exhibited the characteristic PHA band around 30 kDa, suggesting the high potential of the developed material for application in food allergy field.
MeSH term(s)	Humans ; Polymers/chemistry ; Gold/chemistry ; Galactose ; Lectins ; Metal Nanoparticles/chemistry ; Methacrylates/chemistry ; Solid Phase Extraction/methods ; Food Hypersensitivity/prevention & control ; Allergens
Chemical Substances	Polymers ; Gold (7440-57-5) ; Galactose (X2RN3Q8DNE) ; Lectins ; glycidyl methacrylate (R8WN29J8VF) ; Methacrylates ; Allergens
Language	English
Publishing date	2023-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341142
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Article: The untold stories of the speech gene, the

Herrero, Maria Jesus / Gitton, Yorick

Genes & cancer

2018 Volume 9, Issue 1-2, Page(s) 11–38

Abstract: ... ...

Abstract	FOXP2
Language	English
Publishing date	2018-04-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2538519-7
ISSN	1947-6027 ; 1947-6019
ISSN (online)	1947-6027
ISSN	1947-6019
DOI	10.18632/genesandcancer.169
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Article ; Online: Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.

Bidooki, Seyed Hesamoddin / Sánchez-Marco, Javier / Martínez-Beamonte, Roberto / Herrero-Continente, Tania / Navarro, María A / Rodríguez-Yoldi, María J / Osada, Jesús

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Non-alcoholic fatty liver disease or steatosis is an accumulation of fat in the liver. Increased amounts of non-esterified fatty acids, calcium deficiency, or insulin resistance may disturb endoplasmic reticulum (ER) homeostasis, which leads to the ... ...

Abstract	Non-alcoholic fatty liver disease or steatosis is an accumulation of fat in the liver. Increased amounts of non-esterified fatty acids, calcium deficiency, or insulin resistance may disturb endoplasmic reticulum (ER) homeostasis, which leads to the abnormal accumulation of misfolded proteins, activating the unfolded protein response. The ER is the primary location site for chaperones like thioredoxin domain-containing 5 (TXNDC5). Glutathione participates in cellular oxidative stress, and its interaction with TXNDC5 in the ER may decrease the disulfide bonds of this protein. In addition, glutathione is utilized by glutathione peroxidases to inactivate oxidized lipids. To characterize proteins interacting with TXNDC5, immunoprecipitation and liquid chromatography-mass spectrometry were used. Lipid peroxidation, reduced glutathione, inducible phospholipase A
MeSH term(s)	Cell Line ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Glutathione/metabolism ; Lipid Metabolism ; Lipid Peroxidation ; Liver/metabolism ; Phospholipases A2, Calcium-Independent/metabolism ; Protein Disulfide-Isomerases/genetics ; Protein Disulfide-Isomerases/metabolism ; Thioredoxins/metabolism ; Animals ; Mice
Chemical Substances	Glutathione (GAN16C9B8O) ; Phospholipases A2, Calcium-Independent (EC 3.1.1.4) ; Protein Disulfide-Isomerases (EC 5.3.4.1) ; Thioredoxins (52500-60-4) ; Prdx6 protein, mouse (EC 1.11.1.15) ; Hspa9 protein, mouse
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417131
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Article ; Online: Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation.

Olazagoitia-Garmendia, Ane / Rojas-Márquez, Henar / Romero, Maria Del Mar / Ruiz, Pamela / Agirre-Lizaso, Aloña / Chen, Yantao / Perugorria, Maria Jesus / Herrero, Laura / Serra, Dolors / Luo, Cheng / Bujanda, Luis / He, Chuan / Castellanos-Rubio, Ainara

Gut

2023

Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Letter
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2023-330459
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Article ; Online: COVID-19-associated pulmonary aspergillosis (CAPA) in hematological patients: Could antifungal prophylaxis be necessary? A nationwide study.

Tamayo-Velasco, Álvaro / López-Herrero, Rocío / Gómez-García, Lara María / Sánchez-de Prada, Laura / Aguilar-Monserrate, Gerardo / Martín-Fernández, Marta / Bardají-Carrillo, Miguel / Álvaro-Meca, Alejandro / Tamayo, Eduardo / Resino, Salvador / Miramontes-González, José Pablo / Peñarrubia-Ponce, María Jesús

Journal of infection and public health

2024 Volume 17, Issue 6, Page(s) 939–946

Abstract: Background: COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a relatively common complication. Multiple studies described this relationship in critical patients, however its incidence and outcome in other risk groups such as ... ...

Abstract	Background: COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a relatively common complication. Multiple studies described this relationship in critical patients, however its incidence and outcome in other risk groups such as immunosuppressed patients remains unknown. In this sense, we aimed to evaluate the rates and outcomes of CAPA in hematological patients and according to the different hematological malignances, comparing to invasive pulmonary aspergillosis (IPA) in non-COVID-19 ones. Methods: Nationwide, population-based and retrospective observational cohort study including all adult patients with hematological malignancies admitted in Spain since March 1, 2020 to December 31, 2021. The main outcome variable was the diagnosis of IPA during hospitalization in hematological patients with or without COVID-19 at admission. The rate of CAPA compared to IPA in non-COVID-19 patients in each hematological malignancy was also performed, as well as survival curve analysis. Findings: COVID-19 was diagnosed in 3.85 % (4367 out of 113,525) of the hematological adult inpatients. COVID-19 group developed more fungal infections (5.1 % vs. 3 %; p < 0.001). Candida spp. showed higher rate in non-COVID-19 (74.2 % vs. 66.8 %; p = 0.015), meanwhile Aspergillus spp. confirmed its predominance in COVID-19 hematological patients (35.4 % vs. 19.1 %; p < 0.001). IPA was diagnosed in 703 patients and 11.2 % (79 cases) were CAPA. The multivariate logistic regression analysis found that the diagnosis of COVID-19 disease at hospital admission increased more than two-fold IPA development [OR: 2.5, 95CI (1.9-3.1), p < 0.001]. B-cell malignancies - specifically B-cell non-Hodgkin lymphoma, multiple myeloma, chronic lymphocytic leukemia and acute lymphoblastic leukemia - showed between four- and six-fold higher CAPA development and 90-day mortality rates ranging between 50 % and 72 %. However, myeloid malignancies did not show higher CAPA rates compared to IPA in non-COVID-19 patients. Conclusion: COVID-19 constitutes an independent risk factor for developing aspergillosis in B-cell hematological malignancies and the use of antifungal prophylaxis during hospitalizations may be warranted.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2024.04.005
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Article ; Online: Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line

Seyed Hesamoddin Bidooki / Javier Sánchez-Marco / Roberto Martínez-Beamonte / Tania Herrero-Continente / María A. Navarro / María J. Rodríguez-Yoldi / Jesús Osada

International Journal of Molecular Sciences, Vol 24, Iss 24, p

2023 Volume 17131

Abstract	Non-alcoholic fatty liver disease or steatosis is an accumulation of fat in the liver. Increased amounts of non-esterified fatty acids, calcium deficiency, or insulin resistance may disturb endoplasmic reticulum (ER) homeostasis, which leads to the abnormal accumulation of misfolded proteins, activating the unfolded protein response. The ER is the primary location site for chaperones like thioredoxin domain-containing 5 (TXNDC5). Glutathione participates in cellular oxidative stress, and its interaction with TXNDC5 in the ER may decrease the disulfide bonds of this protein. In addition, glutathione is utilized by glutathione peroxidases to inactivate oxidized lipids. To characterize proteins interacting with TXNDC5, immunoprecipitation and liquid chromatography–mass spectrometry were used. Lipid peroxidation, reduced glutathione, inducible phospholipase A 2 (iPLA 2 ) and hepatic transcriptome were assessed in the AML12 and TXNDC5-deficient AML12 cell lines. The results showed that HSPA9 and PRDX6 interact with TXNDC5 in AML12 cells. In addition, TXNDC5 deficiency reduced the protein levels of PRDX6 and HSPA9 in AML12. Moreover, lipid peroxidation, glutathione and iPLA 2 activities were significantly decreased in TXNDC5-deficient cells, and to find the cause of the PRDX6 protein reduction, proteasome suppression revealed no considerable effect on it. Finally, hepatic transcripts connected to PRDX6 and HSPA9 indicated an increase in the Dnaja3 , Mfn2 and Prdx5 and a decrease in Npm1 , Oplah , Gstp3 , Gstm6 , Gstt1 , Serpina1a , Serpina1b , Serpina3m , Hsp90aa1 and Rps14 mRNA levels in AML12 KO cells. In conclusion, the lipid peroxidation system and glutathione mechanism in AML12 cells may be disrupted by the absence of TXNDC5, a novel protein–protein interacting partner of PRDX6 and HSPA9.
Keywords	protein interaction ; TXNDC5 ; endoplasmic reticulum ; PRDX6 ; HSPA9 ; glutathione ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Retinal vascular abnormalities in a case of phakomatosis pigmentovascularis.

Sánchez-Vicente, José Luis / López-Herrero, Fernando / Suárez-Pérez, Jesús / Franco-Ruedas, Carolina / De Las Morenas-Iglesias, Juan / Rodríguez-Fernández, Carla María / González-Jauregui-López, Bosco / Sotomayor-Toribio, Magdalena / Talego-Sancha, Arturo / Espiñeira-Periñán, María Ángeles

Clinical & experimental optometry

2023 , Page(s) 1–3

Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	639275-1
ISSN	1444-0938 ; 0816-4622
ISSN (online)	1444-0938
ISSN	0816-4622
DOI	10.1080/08164622.2023.2220882
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Article: Post-operative sepsis-induced acute respiratory distress syndrome: risk factors for a life-threatening complication.

Bardají-Carrillo, Miguel / Martín-Fernández, Marta / López-Herrero, Rocío / Priede-Vimbela, Juan Manuel / Heredia-Rodríguez, María / Gómez-Sánchez, Esther / Gómez-Pesquera, Estefanía / Lorenzo-López, Mario / Jorge-Monjas, Pablo / Poves-Álvarez, Rodrigo / Villar, Jesús / Tamayo, Eduardo

Frontiers in medicine

2024 Volume 11, Page(s) 1338542

Abstract: Introduction: Prevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are ... ...

Abstract	Introduction: Prevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality. Methods: We performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU. Patients were stratified in two groups depending on whether they met criteria for ARDS. Primary outcome was 60-day mortality of post-operative sepsis-induced ARDS. Secondary outcome measures were potential risk factors for post-operative sepsis-induced ARDS, and for 60-day mortality. Results: Higher SOFA score (OR 1.1, 95% CI 1.0-1.3, Conclusion: Post-operative sepsis-induced ARDS is associated with higher 60-day mortality compared to non-ARDS post-operative septic patients. Post-operative septic patients with higher severity of illness have a greater risk of ARDS and worse outcomes. Further investigation is needed in post-operative sepsis-induced ARDS to prevent ARDS.
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1338542
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Article ; Online: Proliferative ischaemic retinopathy in a case of primary antiphospholipid syndrome.

Sánchez-Vicente, José Luis / López-Herrero, Fernando / Suárez-Pérez, Jesús / De Las Morenas-Iglesias, Juan / Franco-Ruedas, Carolina / Gonzalez-Jauregui-López, Bosco / Sotomayor-Toribio, Magdalena / Rodríguez-Fernández, Carla María / Contieri-Lambiase, Fabio / Moruno-Rodríguez, Antonio

Clinical & experimental optometry

2023 Volume 107, Issue 3, Page(s) 360–365

MeSH term(s)	Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Fluorescein Angiography ; Retinal Vein Occlusion ; Female ; Middle Aged
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639275-1
ISSN	1444-0938 ; 0816-4622
ISSN (online)	1444-0938
ISSN	0816-4622
DOI	10.1080/08164622.2023.2183817
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