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Article ; Online: Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression: A study of phytotherapeutic-based modulation.

Wang, Jiao / Behl, Tapan / Rana, Tarapati / Sehgal, Aayush / Wal, Pranay / Saxena, Bhagawati / Yadav, Shivam / Mohan, Syam / Anwer, Md Khalid / Chigurupati, Sridevi / Zaheer, Imran / Shen, Bairong / Singla, Rajeev K

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 127, Page(s) 155466

Abstract: Background: The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense ... ...

Abstract	Background: The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense enzyme, is highlighted due to its association with depression, characterized by heightened neuroinflammation and impaired oxidative stress responses. Methodology: We observed the pathophysiology of HO-1 and phytochemicals as its modulator. We explored Science Direct, Scopus, and PubMed for a comprehensive literature review. Bibliometric and temporal trend analysis were done using VOSviewer. Results: Several phytochemicals can potentially alleviate neuroinflammation and oxidative stress-induced depressive symptoms. These effects result from inhibiting the MAPK and NK-κB pathways - both implicated in the overproduction of pro-inflammatory factors - and from the upregulation of HO-1 expression mediated by Nrf2. Bibliometric and temporal trend analysis further validates these associations. Conclusion: In summary, our findings suggest that antidepressant agents can mitigate neuroinflammation and depressive disorder pathogenesis via the upregulation of HO-1 expression. These agents suppress pro-inflammatory mediators and depressive-like symptoms, demonstrating that HO-1 plays a significant role in the neuroinflammatory process and the development of depression.
MeSH term(s)	Humans ; Heme Oxygenase-1/metabolism ; Neuroinflammatory Diseases ; Depression/drug therapy ; Heme Oxygenase (Decyclizing)/metabolism ; Antioxidants/pharmacology ; Oxidative Stress ; NF-E2-Related Factor 2/metabolism
Chemical Substances	Heme Oxygenase-1 (EC 1.14.14.18) ; Heme Oxygenase (Decyclizing) (EC 1.14.14.18) ; Antioxidants ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155466
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Article: Knowledge, attitude, and perceptions about cancer genetic testing in clinical practice in Karachi, Pakistan.

Shafqat, Shameel / Naseem, Masooma / Rana, Masooma / Naseem, Zehra / Ahmed, Warda / Musharraf, Muhammad Daniyal / Zaheer, Arisha / Shaikh, Ahmed Safiullah / Musharraf, Muhammad Bazil / Niaz, Mahnoor / Khan, Saifullah / Irfan, Rabiya / Imran, Areeba / Mehmood, Zahid

Journal of community genetics

2023 Volume 14, Issue 3, Page(s) 337–344

Abstract: Healthcare professionals (HCP) play an important role in the practical application of genetic screening tests but often feel inadequately prepared for cancer genetic testing (CGT) in clinical care. As the complexity of gene-related malignancies increases, ...

Abstract	Healthcare professionals (HCP) play an important role in the practical application of genetic screening tests but often feel inadequately prepared for cancer genetic testing (CGT) in clinical care. As the complexity of gene-related malignancies increases, it demands HCPs' preparedness to cater to patients' needs. Therefore, the aim of our study is to assess the knowledge, attitude, and practices of HCPs in Pakistan regarding the application of cancer genetics. Our cross-sectional survey was conducted from April 2022 to June 2022 amongst HCPs at a private and a governmental institution in Karachi, Pakistan. Non-probability random convenience sampling was used to select the population; however. non-clinical HCPs, as well as Interns, were excluded from our study. A total of 210 HCPs, 56.7% (119) bearing an experience of over 5 years of clinical experience, were included in this study. Most respondents from both hospitals deemed their knowledge inadequate, with only 2% (2) and 1.8% (2) being extremely knowledgeable, respectively. 68.6% (144) HCPs displayed a positive attitude towards CGT, with 55.2% (116) participants perceiving CGT in a positive light. As compared to the private sector, significantly more HCPs in the public sector dedicated ≥ 5 h/week for CME (P = 0.006), and were better prepared to counsel patients (P = 0.021) and interpret results concerning CGT (P = 0.020). Additionally, screening tests for specific cancer types were popularly considered a worthwhile avenue of investment to improve the current state of CGT in our healthcare system [47.6% (N = 100)]. Demonstrating a lack of knowledge among Pakistani doctors, our results call upon the need for additional training concerning CGT in both the public and private sectors alike. Understanding specific gaps in knowledge may further help enhance post-graduate training programs and eventually lead to effective incorporation of CGT into our healthcare setting.
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543127-4
ISSN	1868-6001 ; 1868-310X
ISSN (online)	1868-6001
ISSN	1868-310X
DOI	10.1007/s12687-023-00650-2
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Article: Hierarchical NiMn-LDH Hollow Spheres as a Promising Pseudocapacitive Electrode for Supercapacitor Application.

Kumar, Jai / Neiber, Rana R / Abbas, Zaheer / Soomro, Razium Ali / BaQais, Amal / Amin, Mohammed A / El-Bahy, Zeinhom M

Micromachines

2023 Volume 14, Issue 2

Abstract: Layered double hydroxides (LDH) are regarded as attractive pseudocapacitive materials due to their impressive capacitive qualities that may be adjustable to their morphological features. However, the layered structure of LDH renders them susceptible to ... ...

Abstract	Layered double hydroxides (LDH) are regarded as attractive pseudocapacitive materials due to their impressive capacitive qualities that may be adjustable to their morphological features. However, the layered structure of LDH renders them susceptible to structural aggregation, which inhibits effective electrolyte transport and limits their practical applicability after limited exposure to active areas. Herein, we propose a simple template-free strategy to synthesize hierarchical hollow sphere NiMn-LDH material with high surface area and exposed active as anode material for supercapacitor application. The template-free approach enables the natural nucleation of Ni-Mn ions resulting in thin sheets that self-assemble into a hollow sphere, offering expended interlayer spaces and abundant redox-active active sites. The optimal NiMn-LDH-12 achieved a specific capacitance of 1010.4 F g
Language	English
Publishing date	2023-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14020487
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Article: Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.

Gnoni, Martin / Zaheer, Kamran / Vasser, Melinda M / Singh, Monider / Ajmeri, Aman / Harter, Stephanie R / Mughees Rana, Abdul / Aguilar, Rodrigo

IDCases

2018 Volume 13, Page(s) e00446

Abstract: Varicella Zoster when described has the typical presentation of a dermatomal distribution of a rash and can further lead to CNS complications. This can be treated accordingly with the proper protocol, but if the presentation is atypical and the protocol ... ...

Abstract	Varicella Zoster when described has the typical presentation of a dermatomal distribution of a rash and can further lead to CNS complications. This can be treated accordingly with the proper protocol, but if the presentation is atypical and the protocol is challenged or changed per specific patient outcomes, new developments can occur. Here we present a case of a 29-year-old Caucasian female that presented to the emergency department with headache, photophobia, and chills for 5 days. She was previously healthy and immunocompetent; CSF PCR analysis revealed a VZV infection causing acute aseptic meningitis with no shingles rash eruption on physical examination. The patient was not willing to stay hospitalized for the duration of the treatment. This gave us an opportunity to treat her with an oral, rather than IV, antiviral. The patient was successfully treated with oral valacyclovir 2 g Q6H after only receiving two days of IV acyclovir. To the best of our knowledge, this is the first reported case of a patient with VZV-associated meningitis successfully treated with oral valacyclovir.
Language	English
Publishing date	2018-08-25
Publishing country	Netherlands
Document type	Journal Article ; Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2018.e00446
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Article ; Online: Correction to: Elucidating the distinct interactive impact of cadmium and nickel on growth, photosynthesis, metal-homeostasis, and yield responses of mung bean (Vigna radiata L.) varieties.

Aqeel, Muhammad / Khalid, Noreen / Tufail, Aasma / Ahmad, Rana Zaheer / Akhter, Muhammad Salim / Luqman, Muhammad / Javed, Muhammad Tariq / Irshad, Muhammad Kashif / Alamri, Saad / Hashem, Mohamed / Noman, Ali

Environmental science and pollution research international

2021 Volume 28, Issue 21, Page(s) 27391

Language	English
Publishing date	2021-02-23
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-13093-4
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Article: Synthesis and characterization of Cu-Zn/TiO

Rana, Adeem Ghaffar / Ahmad, Waqar / Al-Matar, Ali / Shawabkeh, Reyad / Aslam, Zaheer

Environmental technology

2017 Volume 38, Issue 9, Page(s) 1085–1092

Abstract: Different Cu-Zn/ ... ...

Abstract	Different Cu-Zn/TiO
MeSH term(s)	Carbon Dioxide/chemistry ; Catalysis ; Copper/chemistry ; Hydrogenation ; Methane/chemistry ; Microscopy, Electron, Scanning ; Photolysis ; Titanium/chemistry ; Zinc/chemistry
Chemical Substances	Carbon Dioxide (142M471B3J) ; titanium dioxide (15FIX9V2JP) ; Copper (789U1901C5) ; Titanium (D1JT611TNE) ; Zinc (J41CSQ7QDS) ; Methane (OP0UW79H66)
Language	English
Publishing date	2017-05
Publishing country	England
Document type	Journal Article
ISSN	0959-3330
ISSN	0959-3330
DOI	10.1080/09593330.2016.1217940
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Article: Geospatial Assessment of Soil Erosion Intensity and Sediment Yield Using the Revised Universal Soil Loss Equation (RUSLE) Model

Maqsoom, Ahsen / Aslam, Bilal / Hassan, Usman / Kazmi, Zaheer Abbas / Sodangi, Mahmoud / Tufail, Rana Faisal / Farooq, Danish

ISPRS international journal of geo-information. 2020 May 27, v. 9, no. 6

2020

Abstract: Land degradation caused by soil erosion is considered among the most severe problems of the 21stcentury. It poses serious threats to soil fertility, food availability, human health, and the world ecosystem. The purpose of the study is to make a ... ...

Abstract	Land degradation caused by soil erosion is considered among the most severe problems of the 21stcentury. It poses serious threats to soil fertility, food availability, human health, and the world ecosystem. The purpose of the study is to make a quantitative mapping of soil loss in the Chitral district, Pakistan. For the estimation of soil loss in the study area, the Revised Universal Soil Loss Equation (RUSLE) model was used in combination with Remote Sensing (RS) and Geographic Information System (GIS). Topographical features of the study area show that the area is more vulnerable to soil loss, having the highest average annual soil loss of 78 ton/ha/year. Maps generated in the study show that the area has the highest sediment yield of 258 tons/ha/year and higher average annual soil loss of 450 tons/ha/year. The very high severity class represents 8%, 16% under high, 21% under moderate, 12% under low, and 13% under very low soil loss in the Chitral district. The above study is helpful to researchers and planners for better planning to control the loss of soil in the high severity zones. Plantation of trees and structures should be built like check dams, which effectively control the soil erosion process.
Keywords	Revised Universal Soil Loss Equation ; ecosystems ; food availability ; geographic information systems ; geospatial data processing ; human health ; land degradation ; sediment yield ; soil ; soil erosion ; soil fertility ; spatial data ; Pakistan
Language	English
Dates of publication	2020-0527
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2655790-3
ISSN	2220-9964
ISSN	2220-9964
DOI	10.3390/ijgi9060356
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Elucidating the distinct interactive impact of cadmium and nickel on growth, photosynthesis, metal-homeostasis, and yield responses of mung bean (Vigna radiata L.) varieties.

Environmental science and pollution research international

2021 Volume 28, Issue 21, Page(s) 27376–27390

Abstract: Contamination of soils with heavy metals (HMs) caused serious problems because plants tend to absorb HMs from the soil. In view of HM hazards to plants as well as agro-ecosystems, we executed this study to assess metal toxicity to mung bean (Vigna ... ...

Abstract	Contamination of soils with heavy metals (HMs) caused serious problems because plants tend to absorb HMs from the soil. In view of HM hazards to plants as well as agro-ecosystems, we executed this study to assess metal toxicity to mung bean (Vigna radiata) plants cultivated in soil with six treatment levels of cadmium (Cd) and nickel (Ni) and to find metal tolerant variety, i.e., M-93 (V
MeSH term(s)	Cadmium ; Ecosystem ; Homeostasis ; Nickel ; Photosynthesis ; Vigna
Chemical Substances	Cadmium (00BH33GNGH) ; Nickel (7OV03QG267)
Language	English
Publishing date	2021-01-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-12579-5
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Article ; Online: Two Promising Anti-Cancer Compounds, 2-Hydroxycinnaldehyde and 2- Benzoyloxycinnamaldehyde: Where do we stand?

Iqbal, Haroon / Menaa, Farid / Khan, Naveed Ullah / Razzaq, Anam / Khan, Zaheer Ullah / Ullah, Kifayat / Kamal, Robia / Sohail, Muhammad / Thiripuranathar, Gobika / Uzair, Bushra / Rana, Nosheen Fatima / Khan, Barkat Ali / Menaa, Bouzid

Combinatorial chemistry & high throughput screening

2021 Volume 25, Issue 5, Page(s) 808–818

Abstract: Natural bioactive compounds with anti-carcinogenic activity are gaining tremendous interest in the field of oncology. Cinnamon, an aromatic condiment commonly used in tropical regions, appeared incredibly promising as an adjuvant for cancer therapy. ... ...

Abstract	Natural bioactive compounds with anti-carcinogenic activity are gaining tremendous interest in the field of oncology. Cinnamon, an aromatic condiment commonly used in tropical regions, appeared incredibly promising as an adjuvant for cancer therapy. Indeed, its whole or active parts (e.g., bark, leaf) exhibited significant anti-carcinogenic activity, which is mainly due to two cinnamaldehyde derivatives, namely 2-hydroxycinnaldehyde (HCA) and 2- benzoyloxycinnamaldehyde (BCA). In addition to their anti-cancer activity, HCA and BCA exert immunomodulatory, anti-platelets, and anti-inflammatory activities. The highly reactive α,ßunsaturated carbonyl pharmacophore, called Michael acceptor, contributes to their therapeutic effects. The molecular mechanisms underlying their anti-tumoral and anti-metastatic effects are miscellaneous, strongly suggesting that these compounds are multi-targeting compounds. Nevertheless, unravelling the exact molecular mechanisms of HCA and BCA remains a challenging matter which is necessary for optimal controlled-drug targeting delivery, safety, and efficiency. Eventually, their poor pharmacological properties (e.g., systemic bioavailability and solubility) represent a limitation and depend both on their administration route (e.g., per os, intravenously) and the nature of the formulation (e.g., free, smart nano-). This concise review focused on the potential of HCA and BCA as adjuvants in cancer. We describe their medicinal effects as well as provide an update about their molecular mechanisms reported either in-vitro, ex-vivo, or in animal models.
MeSH term(s)	Adjuvants, Immunologic ; Animals ; Anti-Inflammatory Agents/pharmacology ; Neoplasms/drug therapy
Chemical Substances	Adjuvants, Immunologic ; Anti-Inflammatory Agents
Language	English
Publishing date	2021-02-16
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207324666210216094428
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Article ; Online: Pure primary squamous cell carcinoma of breast

Mohammed Akram / Samreen Zaheer / Shahid A Siddiqui / Rana K Sherwani

Clinical Cancer Investigation Journal, Vol 4, Iss 2, Pp 271-

A rare entity

2015 Volume 273

Abstract: Squamous cell carcinoma (SCC) of the breast is very rare malignancy, and only few cases have been reported in the literature. Also, it is aggressive in nature, and the standard treatment is still debated. We share our experience of a case of primary SCC ... ...

Abstract	Squamous cell carcinoma (SCC) of the breast is very rare malignancy, and only few cases have been reported in the literature. Also, it is aggressive in nature, and the standard treatment is still debated. We share our experience of a case of primary SCC of breast which was initially misdiagnosed as adenocarcinoma on fine needle aspiration cytology but later confirmed to be pure primary squamous cell carcinoma of breast on histopathological examination.
Keywords	Breast ; primary ; squamous cell carcinoma ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Medknow Publications Pvt Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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