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Article ; Online: Thalamo-cortical and cerebello-cortical functional connectivity in development.

Badke D'Andrea, Carolina / Marek, Scott / Van, Andrew N / Miller, Ryland L / Earl, Eric A / Stewart, Stephanie B / Dosenbach, Nico U F / Schlaggar, Bradley L / Laumann, Timothy O / Fair, Damien A / Gordon, Evan M / Greene, Deanna J

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 15, Page(s) 9250–9262

Abstract: The thalamus is a critical relay center for neural pathways involving sensory, motor, and cognitive functions, including cortico-striato-thalamo-cortical and cortico-ponto-cerebello-thalamo-cortical loops. Despite the importance of these circuits, their ... ...

Abstract	The thalamus is a critical relay center for neural pathways involving sensory, motor, and cognitive functions, including cortico-striato-thalamo-cortical and cortico-ponto-cerebello-thalamo-cortical loops. Despite the importance of these circuits, their development has been understudied. One way to investigate these pathways in human development in vivo is with functional connectivity MRI, yet few studies have examined thalamo-cortical and cerebello-cortical functional connectivity in development. Here, we used resting-state functional connectivity to measure functional connectivity in the thalamus and cerebellum with previously defined cortical functional networks in 2 separate data sets of children (7-12 years old) and adults (19-40 years old). In both data sets, we found stronger functional connectivity between the ventral thalamus and the somatomotor face cortical functional network in children compared with adults, extending previous cortico-striatal functional connectivity findings. In addition, there was more cortical network integration (i.e. strongest functional connectivity with multiple networks) in the thalamus in children than in adults. We found no developmental differences in cerebello-cortical functional connectivity. Together, these results suggest different maturation patterns in cortico-striato-thalamo-cortical and cortico-ponto-cerebellar-thalamo-cortical pathways.
MeSH term(s)	Adult ; Child ; Humans ; Young Adult ; Cerebellum/diagnostic imaging ; Magnetic Resonance Imaging ; Neural Pathways/diagnostic imaging ; Thalamus/diagnostic imaging ; Corpus Striatum
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad198
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Article ; Online: Preface to North American Crop Wild Relatives, Volume 1

Greene, Stephanie L. / Williams, Karen A. / Khoury, Colin K. / Kantar, Michael B. / Marek, Laura F.

2019

Keywords	genetic resources ; conservation ; crop wild relatives
Language	English
Publishing date	2019-01-25T19:29:13Z
Publisher	Springer
Publishing country	fr
Document type	Article ; Online
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Article ; Online: A review of Kenya's cancer policies to improve access to cancer testing and treatment in the country.

Makau-Barasa, Louise Kathini / Greene, Sandra / Othieno-Abinya, N A / Wheeler, Stephanie B / Skinner, Asheley / Bennett, Antonia V

Health research policy and systems

2020 Volume 18, Issue 1, Page(s) 2

Abstract: Background: Cancer is the third-leading cause of mortality in Kenya, resulting in unique challenges to the country's health system. An increase in the number of cancer cases in Kenya over the past decade resulted in legislative actions and policies to ... ...

Abstract	Background: Cancer is the third-leading cause of mortality in Kenya, resulting in unique challenges to the country's health system. An increase in the number of cancer cases in Kenya over the past decade resulted in legislative actions and policies to guide delivery of cancer services. Kenya's new national cancer control strategy and past policy efforts provide an opportunity to synergise information and enhance understanding to improve cancer diagnosis and treatment in the country. The objectives of this study are to (1) document policy-modifiable factors based on a review of policy documents and results of a key informant survey and (2) develop recommendations to improve policies affecting cancer testing and treatment services in Kenya. This study builds upon our previous study Improving Access to Cancer Testing and Treatment in Kenya (Makau Barasa et al. J Global Oncol 2(216), 2017). Methods: The study applied an in-depth systematic review of Kenya's cancer policies and guidelines, a qualitative analysis of results from a section of a semi-structured key informant survey focused on the opinions of clinicians delivering cancer services as well as cancer support groups and advocacy leaders, and a stakeholder analysis identifying key policy-makers and implementers. Details of the complete key informant survey were published in our previous study. Results: Kenya's cancer policies have guided progress made in providing the legal and implementation frameworks for the development and delivery of cancer services at the national and county levels. Some policy implementation gaps are noted. These include inadequate financing for cancer services, limited research and data to support policy formulation, and the concentration of cancer services in urban areas. The key informant survey identified policy-modifiable actions that can address some of the gaps and improve the delivery of and access to cancer testing and treatment services in the country. Some of these include addressing the financial barriers affecting cancer testing and treatment services; increasing stakeholder engagement in training health personnel to deliver cancer testing and treatment services; decentralising cancer services and improving cancer surveillance and research; and increasing education and awareness about cancer symptoms, screening procedures and treatment options. A set of priority policy actions were selected from the study findings and used to develop recommendations for Kenya's policy-makers and stakeholders. Conclusions: Revisions to Kenya's cancer policies are seeking to address gaps noted in past policies and to improve access to cancer testing and treatment in Kenya. However, based on study findings, additional actions can be taken to strengthen policy implementation. Considering the policy formulation and implementation process and costs, this study recommends focusing on three priority policy actions that can have significant impact on improving access to cancer testing and treatment services. These include addressing financing, insurance and human resources gaps; increasing stakeholder engagement; and decentralising health services for better surveillance and data to inform policies.
MeSH term(s)	Delivery of Health Care/economics ; Delivery of Health Care/organization & administration ; Delivery of Health Care/standards ; Early Detection of Cancer/standards ; Health Education/organization & administration ; Health Knowledge, Attitudes, Practice ; Health Policy ; Health Services Accessibility/economics ; Health Services Accessibility/statistics & numerical data ; Health Workforce/statistics & numerical data ; Humans ; Kenya ; Neoplasms/diagnosis ; Neoplasms/therapy ; Population Surveillance/methods ; Practice Guidelines as Topic ; Program Development ; Retrospective Studies
Language	English
Publishing date	2020-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-019-0506-2
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Article ; Online: Expanded Ethical Principles for Research Partnership and Transdisciplinary Natural Resource Management Science.

Wilmer, Hailey / Meadow, Alison M / Brymer, Amanda Bentley / Carroll, Stephanie Russo / Ferguson, Daniel B / Garba, Ibrahim / Greene, Christina / Owen, Gigi / Peck, Dannele E

Environmental management

2021 Volume 68, Issue 4, Page(s) 453–467

Abstract: Natural resource researchers have long recognized the value of working closely with the managers and communities who depend on, steward, and impact ecosystems. These partnerships take various forms, including co-production and transdisciplinary research ... ...

Abstract	Natural resource researchers have long recognized the value of working closely with the managers and communities who depend on, steward, and impact ecosystems. These partnerships take various forms, including co-production and transdisciplinary research approaches, which integrate multiple knowledges in the design and implementation of research objectives, questions, methods, and desired outputs or outcomes. These collaborations raise important methodological and ethical challenges, because partnering with non-scientists can have real-world risks for people and ecosystems. The social sciences and biomedical research studies offer a suite of conceptual tools that enhance the quality, ethical outcomes, and effectiveness of research partnerships. For example, the ethical guidelines and regulations for human subjects research, following the Belmont Principles, help prevent harm and promote respectful treatment of research participants. However, science-management partnerships require an expanded set of ethical concepts to better capture the challenges of working with individuals, communities, organizations, and their associated ecosystems, as partners, rather than research subjects. We draw from our experiences in collaborative teams, and build upon the existing work of natural resources, environmental health, conservation and ecology, social science, and humanities scholars, to develop an expanded framework for ethical research partnership. This includes four principles: (1) appropriate representation, (2) self-determination, (3) reciprocity, and (4) deference, and two cross-cutting themes: (1) applications to humans and non-human actors, and (2) acquiring appropriate research skills. This framework is meant to stimulate important conversations about expanding ethics training and skills for researchers in all career-stages to improve partnerships and transdisciplinary natural resources research.
MeSH term(s)	Communication ; Ecology ; Ecosystem ; Humans ; Natural Resources ; Research Personnel
Language	English
Publishing date	2021-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-021-01508-4
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Article ; Online: In-Hospital Virtual Peer-to-Peer Consultation to Increase Guideline-Directed Medical Therapy for Heart Failure: A Pilot Randomized Trial.

Rao, Vishal N / Shah, Anand / McDermott, Jaime / Barnes, Stephanie G / Murray, Evan M / Kelsey, Michelle D / Greene, Stephen J / Fudim, Marat / DeVore, Adam D / Patel, Chetan B / Blazing, Michael A / O'Brien, Cara / Mentz, Robert J

Circulation. Heart failure

2022 Volume 16, Issue 2, Page(s) e010158

Abstract: Background: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing GDMT in the hospital is associated with greater long-term use in HFrEF. This study ... ...

Abstract	Background: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing GDMT in the hospital is associated with greater long-term use in HFrEF. This study aimed to describe the efficacy of a multidisciplinary virtual HF intervention on GDMT optimization among patients with HFrEF admitted for any cause. Methods: In this pilot randomized, controlled study, consecutive patients with HFrEF admitted to noncardiology medicine services for any cause were identified at a large academic tertiary care hospital between May to September 2021. Major exclusions were end-stage renal disease, hemodynamic instability, concurrent COVID-19 infection, and current enrollment in hospice care. Patients were randomized to a clinician-level virtual peer-to-peer consult intervention providing GDMT recommendations and information on medication costs versus usual care. Primary end points included (1) proportion of patients with new GDMT initiation or use and (2) changes to HF optimal medical therapy scores which included target dosing (range, 0-9). Results: Of 242 patients identified, 91 (38%) were eligible and randomized to intervention (N=52) or usual care (N=39). Baseline characteristics were similar between intervention and usual care (mean age 63 versus 67 years, 23% versus 26% female, 46% versus 49% Black, mean ejection fraction 33% versus 31%). GDMT use on admission was also similar. There were greater proportions of patients with GDMT initiation or continuation with the intervention compared with usual care. After adjusting for optimal medical therapy score on admission, changes to optimal medical therapy score at discharge were higher for the intervention group compared with usual care (+0.44 versus -0.31, absolute difference +0.75, adjusted estimate 0.86±0.42; Conclusions: Among eligible patients with HFrEF hospitalized for any cause on noncardiology services, a multidisciplinary pilot virtual HF consultation increased new GDMT initiation and dose optimization at discharge.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Heart Failure/therapy ; Quality of Life ; Pilot Projects ; Stroke Volume ; COVID-19 ; Hospitals ; Referral and Consultation
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.122.010158
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Article ; Online: A review of Kenya’s cancer policies to improve access to cancer testing and treatment in the country

Louise Kathini Makau-Barasa / Sandra Greene / N. A. Othieno-Abinya / Stephanie B. Wheeler / Asheley Skinner / Antonia V. Bennett

Health Research Policy and Systems, Vol 18, Iss 1, Pp 1-

2020 Volume 10

Abstract: Abstract Background Cancer is the third-leading cause of mortality in Kenya, resulting in unique challenges to the country’s health system. An increase in the number of cancer cases in Kenya over the past decade resulted in legislative actions and ... ...

Abstract	Abstract Background Cancer is the third-leading cause of mortality in Kenya, resulting in unique challenges to the country’s health system. An increase in the number of cancer cases in Kenya over the past decade resulted in legislative actions and policies to guide delivery of cancer services. Kenya’s new national cancer control strategy and past policy efforts provide an opportunity to synergise information and enhance understanding to improve cancer diagnosis and treatment in the country. The objectives of this study are to (1) document policy-modifiable factors based on a review of policy documents and results of a key informant survey and (2) develop recommendations to improve policies affecting cancer testing and treatment services in Kenya. This study builds upon our previous study Improving Access to Cancer Testing and Treatment in Kenya (Makau Barasa et al. J Global Oncol 2(216), 2017). Methods The study applied an in-depth systematic review of Kenya’s cancer policies and guidelines, a qualitative analysis of results from a section of a semi-structured key informant survey focused on the opinions of clinicians delivering cancer services as well as cancer support groups and advocacy leaders, and a stakeholder analysis identifying key policy-makers and implementers. Details of the complete key informant survey were published in our previous study. Results Kenya’s cancer policies have guided progress made in providing the legal and implementation frameworks for the development and delivery of cancer services at the national and county levels. Some policy implementation gaps are noted. These include inadequate financing for cancer services, limited research and data to support policy formulation, and the concentration of cancer services in urban areas. The key informant survey identified policy-modifiable actions that can address some of the gaps and improve the delivery of and access to cancer testing and treatment services in the country. Some of these include addressing the financial barriers affecting ...
Keywords	Cancer policy ; Health systems ; Health services access ; Cancer ; Testing ; Treatment ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neuroophthalmological manifestations of congenital aqueductal stenosis.

Patel, Aneek / Abou-Al-Shaar, Hussam / Chiang, Michael C / Algattas, Hanna N / McDowell, Michael M / Stone, Jeremy G / Mitchell, Ellen B / Emery, Stephen P / Greene, Stephanie

Journal of neurosurgery. Pediatrics

2021 Volume 28, Issue 3, Page(s) 320–325

Abstract: Objective: Congenital aqueductal stenosis (CAS) is a common etiology of hydrocephalus that occurs in a subset of infants and may be linked to an increased incidence of ophthalmological abnormalities and delayed developmental milestones. Although ... ...

Abstract	Objective: Congenital aqueductal stenosis (CAS) is a common etiology of hydrocephalus that occurs in a subset of infants and may be linked to an increased incidence of ophthalmological abnormalities and delayed developmental milestones. Although hydrocephalus is common and widely studied, sparse literature exists on patients with isolated (no identifiable genetic link) CAS along with analysis of ophthalmological manifestations. In this study, the authors sought to describe the ophthalmological abnormalities and delayed developmental milestones of patients with isolated CAS. Methods: Data of patients with CAS were prospectively entered and monitored in a surgical database maintained by the Department of Neurological Surgery at Children's Hospital of Pittsburgh from January 2005 to October 2016. Patients with a family history of congenital hydrocephalus, positive testing for genetic forms of aqueductal stenosis, other congenital abnormalities suggesting an underlying genetic syndrome, and stenosis/obstruction due to secondary causes were excluded from this study. Prenatal and perinatal history, CSF diversion history, and a variety of outcomes, including ophthalmological deficits and developmental milestones, were collected and analyzed. Results: A total of 41 patients with isolated CAS were identified, with a mean follow-up duration of 6 years. Among that cohort, 26 patients (63.4%) developed neuroophthalmological complications, which were further stratified. Fourteen patients (34.1%) developed strabismus and 11 (26.8%) developed astigmatism, and 1 patient (2.4%) with papilledema was recorded. Among patients with ophthalmological abnormalities, 76.9% had delayed developmental milestones (p = 0.045). Conclusions: Patients with CAS were found to have increased risk of ophthalmological abnormalities requiring correction, along with an increased risk of delayed developmental milestones. Importantly, there was a significant correlation between the development of ophthalmological abnormalities and delayed developmental milestones that was independent of CSF diversion history. Larger patient cohort studies are required to explore whether earlier development of hydrocephalus, as is the case in CAS, causes elevated rates of neurological and ophthalmological complications, and if earlier CSF diversion correlates with improved outcomes.
Language	English
Publishing date	2021-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2021.2.PEDS20824
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Article: Expanded Ethical Principles for Research Partnership and Transdisciplinary Natural Resource Management Science

Wilmer, Hailey / Meadow, Alison M. / Brymer, Amanda Bentley / Carroll, Stephanie Russo / Ferguson, Daniel B. / Garba, Ibrahim / Greene, Christina / Owen, Gigi / Peck, Dannele E.

Environmental management. 2021 Oct., v. 68, no. 4

2021

Abstract	Natural resource researchers have long recognized the value of working closely with the managers and communities who depend on, steward, and impact ecosystems. These partnerships take various forms, including co-production and transdisciplinary research approaches, which integrate multiple knowledges in the design and implementation of research objectives, questions, methods, and desired outputs or outcomes. These collaborations raise important methodological and ethical challenges, because partnering with non-scientists can have real-world risks for people and ecosystems. The social sciences and biomedical research studies offer a suite of conceptual tools that enhance the quality, ethical outcomes, and effectiveness of research partnerships. For example, the ethical guidelines and regulations for human subjects research, following the Belmont Principles, help prevent harm and promote respectful treatment of research participants. However, science–management partnerships require an expanded set of ethical concepts to better capture the challenges of working with individuals, communities, organizations, and their associated ecosystems, as partners, rather than research subjects. We draw from our experiences in collaborative teams, and build upon the existing work of natural resources, environmental health, conservation and ecology, social science, and humanities scholars, to develop an expanded framework for ethical research partnership. This includes four principles: (1) appropriate representation, (2) self-determination, (3) reciprocity, and (4) deference, and two cross-cutting themes: (1) applications to humans and non-human actors, and (2) acquiring appropriate research skills. This framework is meant to stimulate important conversations about expanding ethics training and skills for researchers in all career-stages to improve partnerships and transdisciplinary natural resources research.
Keywords	biomedical research ; environmental health ; environmental management ; ethics ; humans ; natural resource management ; social sciences
Language	English
Dates of publication	2021-10
Size	p. 453-467.
Publishing place	Springer US
Document type	Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-021-01508-4
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Article ; Online: Migratory Bee Hive Transportation Contributes Insignificantly to Transgenic Pollen Movement Between Spatially Isolated Alfalfa Seed Fields.

Boyle, Natalie K / Kesoju, Sandya R / Greene, Stephanie L / Martin, Ruth C / Walsh, Douglas B

Journal of economic entomology

2017 Volume 110, Issue 1, Page(s) 6–12

Abstract: Contracted commercial beekeeping operations provide an essential pollination service to many agricultural systems worldwide. Increased use of genetically engineered crops in agriculture has raised concerns over pollinator-mediated gene flow between ... ...

Abstract	Contracted commercial beekeeping operations provide an essential pollination service to many agricultural systems worldwide. Increased use of genetically engineered crops in agriculture has raised concerns over pollinator-mediated gene flow between transgenic and conventional agricultural varieties. This study evaluated whether contracted migratory beekeeping practices influence transgenic pollen flow among spatially isolated alfalfa fields. Twelve honey bee (Apis mellifera L.) colonies were permitted to forage on transgenic alfalfa blossoms for 1 wk in Touchet, WA. The hives were then transported 112 km to caged conventional alfalfa plots following one and two nights of isolation (8 and 32 h, respectively) from the transgenic source. Alfalfa seed harvested from the conventional plots was assessed for the presence of the transgene using a new seedling germination assay. We found that 8 h of isolation from a transgenic alfalfa source virtually eliminated the incidence of cross-pollination between the two varieties.
Language	English
Publishing date	2017--01
Publishing country	England
Document type	Journal Article
ZDB-ID	3031-4
ISSN	1938-291X ; 0022-0493
ISSN (online)	1938-291X
ISSN	0022-0493
DOI	10.1093/jee/tow243
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Article ; Online: A high black-hole-to-host mass ratio in a lensed AGN in the early Universe.

Furtak, Lukas J / Labbé, Ivo / Zitrin, Adi / Greene, Jenny E / Dayal, Pratika / Chemerynska, Iryna / Kokorev, Vasily / Miller, Tim B / Goulding, Andy D / de Graaff, Anna / Bezanson, Rachel / Brammer, Gabriel B / Cutler, Sam E / Leja, Joel / Pan, Richard / Price, Sedona H / Wang, Bingjie / Weaver, John R / Whitaker, Katherine E /

Atek, Hakim / Bogdán, Ákos / Charlot, Stéphane / Curtis-Lake, Emma / van Dokkum, Pieter / Endsley, Ryan / Feldmann, Robert / Fudamoto, Yoshinobu / Fujimoto, Seiji / Glazebrook, Karl / Juneau, Stéphanie / Marchesini, Danilo / Maseda, Micheal V / Nelson, Erica / Oesch, Pascal A / Plat, Adèle / Setton, David J / Stark, Daniel P / Williams, Christina C

Nature

2024 Volume 628, Issue 8006, Page(s) 57–61

Abstract: Early JWST observations have uncovered a population of red sources that might represent a previously overlooked phase of supermassive black hole ... ...

Abstract	Early JWST observations have uncovered a population of red sources that might represent a previously overlooked phase of supermassive black hole growth
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07184-8
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