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Article ; Online: Learning leaves a memory trace in motor cortex.

Losey, Darby M / Hennig, Jay A / Oby, Emily R / Golub, Matthew D / Sadtler, Patrick T / Quick, Kristin M / Ryu, Stephen I / Tyler-Kabara, Elizabeth C / Batista, Aaron P / Yu, Byron M / Chase, Steven M

Current biology : CB

2024 Volume 34, Issue 7, Page(s) 1519–1531.e4

Abstract: How are we able to learn new behaviors without disrupting previously learned ones? To understand how the brain achieves this, we used a brain-computer interface (BCI) learning paradigm, which enables us to detect the presence of a memory of one behavior ... ...

Abstract	How are we able to learn new behaviors without disrupting previously learned ones? To understand how the brain achieves this, we used a brain-computer interface (BCI) learning paradigm, which enables us to detect the presence of a memory of one behavior while performing another. We found that learning to use a new BCI map altered the neural activity that monkeys produced when they returned to using a familiar BCI map in a way that was specific to the learning experience. That is, learning left a "memory trace" in the primary motor cortex. This memory trace coexisted with proficient performance under the familiar map, primarily by altering neural activity in dimensions that did not impact behavior. Forming memory traces might be how the brain is able to provide for the joint learning of multiple behaviors without interference.
MeSH term(s)	Motor Cortex ; Brain-Computer Interfaces ; Learning ; Brain ; Brain Mapping ; Electroencephalography
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2024.03.003
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Article ; Online: Swahili translation and cultural adaptation of the pediatric patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).

Schroeder, Kristin M / Rizzieri, Tyler / Lion, Ryan R / Mtenga, Norbert / Gisiri, Mwitasrobert / McFatrich, Molly / Reeve, Bryce B

Journal of patient-reported outcomes

2023 Volume 7, Issue 1, Page(s) 56

Abstract: Background: The pediatric patient-reported outcomes version of the common terminology criteria for adverse event measure was developed and validated for use in pediatric cancer clinical trials to better capture the symptom experiences through direct ... ...

Abstract	Background: The pediatric patient-reported outcomes version of the common terminology criteria for adverse event measure was developed and validated for use in pediatric cancer clinical trials to better capture the symptom experiences through direct self-report. The study aim was to develop and validate a Swahili language version of the patient-reported outcomes version of the common terminology criteria for adverse event measure. Methods: The pediatric version of 15 core symptom adverse events, and the corresponding questions, were selected from the patient-reported outcomes version of the common terminology criteria for adverse event library, then forward and back translated into Swahili by bilingual translators. The translated items were further refined using concurrent cognitive interviewing. Each round of interviews included five children, ages 8-17 years-old, receiving cancer therapy at Bugando Medical Centre, the cancer referral hospital for Northwest Tanzania, and continued until at least 80% of participants understood the question. Results: Three rounds of cognitive interviews were completed involving 13 patients and 5 caregivers. Among patients, 50% of questions (19/38) were fully comprehended after the first interview round. Two Adverse Events (anxiety and peripheral neuropathy) were the most difficult for participants to understand, associated with education level and experience. Goal comprehension was achieved after three rounds of interviews with no further revisions required. All parents in the first cognitive interview group comprehended the survey, with no additional revisions. Conclusion: A Swahili patient-reported outcomes version of the common terminology criteria for adverse event was effective in eliciting patient-reported Adverse Events related to cancer treatment, with good comprehension for children aged 8-17 years. This survey is important to incorporate patient self-reporting of symptomatic toxicities and is an effective tool to increase capacity for pediatric cancer clinical trials throughout East Africa, further reducing global disparities in cancer care.
MeSH term(s)	Humans ; Child ; Adolescent ; Language ; Translations ; Allied Health Personnel ; Patient Reported Outcome Measures ; Tanzania
Language	English
Publishing date	2023-06-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2509-8020
ISSN (online)	2509-8020
DOI	10.1186/s41687-023-00598-4
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Article ; Online: Sources of bias in applying close-kin mark-recapture to terrestrial game species with different life histories.

Sévêque, Anthony / Lonsinger, Robert C / Waits, Lisette P / Brzeski, Kristin E / Komoroske, Lisa M / Ott-Conn, Caitlin N / Mayhew, Sarah L / Norton, D Cody / Petroelje, Tyler R / Swenson, John D / Morin, Dana J

Ecology

2024 Volume 105, Issue 3, Page(s) e4244

Abstract: Close-kin mark-recapture (CKMR) is a method analogous to traditional mark-recapture but without requiring recapture of individuals. Instead, multilocus genotypes (genetic marks) are used to identify related individuals in one or more sampling occasions, ... ...

Abstract	Close-kin mark-recapture (CKMR) is a method analogous to traditional mark-recapture but without requiring recapture of individuals. Instead, multilocus genotypes (genetic marks) are used to identify related individuals in one or more sampling occasions, which enables the opportunistic use of samples from harvested wildlife. To apply the method accurately, it is important to build appropriate CKMR models that do not violate assumptions linked to the species' and population's biology and sampling methods. In this study, we evaluated the implications of fitting overly simplistic CKMR models to populations with complex reproductive success dynamics or selective sampling. We used forward-in-time, individual-based simulations to evaluate the accuracy and precision of CKMR abundance and survival estimates in species with different longevities, mating systems, and sampling strategies. Simulated populations approximated a range of life histories among game species of North America with lethal sampling to evaluate the potential of using harvested samples to estimate population size. Our simulations show that CKMR can yield nontrivial biases in both survival and abundance estimates, unless influential life history traits and selective sampling are explicitly accounted for in the modeling framework. The number of kin pairs observed in the sample, in combination with the type of kinship used in the model (parent-offspring pairs and/or half-sibling pairs), can affect the precision and/or accuracy of the estimates. CKMR is a promising method that will likely see an increasing number of applications in the field as costs of genetic analysis continue to decline. Our work highlights the importance of applying population-specific CKMR models that consider relevant demographic parameters, individual covariates, and the protocol through which individuals were sampled.
MeSH term(s)	Humans ; Population Density ; Bias ; Genotype ; North America
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010140-5
ISSN	1939-9170 ; 0012-9658
ISSN (online)	1939-9170
ISSN	0012-9658
DOI	10.1002/ecy.4244
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Article: Conserved 5-methyluridine tRNA modification modulates ribosome translocation.

Jones, Joshua D / Franco, Monika K / Tardu, Mehmet / Smith, Tyler J / Snyder, Laura R / Eyler, Daniel E / Polikanov, Yury / Kennedy, Robert T / Niederer, Rachel O / Koutmou, Kristin S

bioRxiv : the preprint server for biology

2023

Abstract: ... methyluridine at position 54 in tRNAs (m ...

Abstract	While the centrality of post-transcriptional modifications to RNA biology has long been acknowledged, the function of the vast majority of modified sites remains to be discovered. Illustrative of this, there is not yet a discrete biological role assigned for one the most highly conserved modifications, 5-methyluridine at position 54 in tRNAs (m
Language	English
Publishing date	2023-11-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.12.566704
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Article ; Online: Disparate Access to Fertility Preservation in Youth: A Call for Advocacy to Close the Gap.

Canavera, Kristin E / Bjornard, Kari L / Cost, Nicholas G / Grady, Allison / Irving, Helen / Kaye, Erica C / Ketterl, Tyler / Levine, Jennifer / Reinecke, Joyce / Rios, Julie / Roth, Michael / Sawyer, Kimberly / Thomas, Stefanie M / Unguru, Yoram / Johnson, Liza-Marie

The Journal of pediatrics

2023 Volume 261, Page(s) 113496

MeSH term(s)	Humans ; Adolescent ; Fertility Preservation ; Neoplasms
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2023.113496
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Article ; Online: Weight Bias Internalization and Psychosocial, Physical, and Behavioral Health: A Meta-Analysis of Cross-Sectional and Prospective Associations.

Romano, Kelly A / Heron, Kristin E / Sandoval, Cassidy M / MacIntyre, Rachel I / Howard, Lindsay M / Scott, Monica / Mason, Tyler B

Behavior therapy

2022 Volume 54, Issue 3, Page(s) 539–556

Abstract: ... that included between 14 and 18,766 participants (M sample size = 534.96, SD = 1,914.43; M age = 34.73, SD = 12 ...

Abstract	Coinciding with widespread efforts to address obesity, weight bias internalization (a process of self-devaluation wherein individuals apply weight-biased stereotypes to themselves) has gained increased attention as a robust correlate of poor health outcomes. The present meta-analysis aimed to provide the largest quantitative synthesis of associations between weight bias internalization and health-related correlates. Studies that provided zero-order correlations for cross-sectional or prospective associations between weight bias internalization and physical, psychosocial, and behavioral health correlates were included in the meta-analysis. Meta-regression determined whether these associations differed based on demographic (sex/gender, race, age), anthropometric (body mass index), and study-level (publication status, sample type, study quality) moderators. Data for 149 (sub)samples were identified that included between 14 and 18,766 participants (M sample size = 534.96, SD = 1,914.43; M age = 34.73, SD = 12.61, range = 9.95-65.70). Results indicated that greater weight bias internalization was concurrently associated with worse psychosocial (e.g., negative and positive mental health, social functioning), physical (e.g., BMI, weight maintenance, health-related quality of life [HRQoL]), and behavioral health (e.g., disordered eating behaviors, healthy eating, physical activity) across most constructs, with effects ranging from small to very large in magnitude. Preliminary evidence also suggested that greater weight bias internalization was subsequently associated with less weight loss and increased negative mental health. Notable variations in the nature and magnitude of these associations were identified based on the health-related correlate and moderator under consideration. These findings indicate that weight bias internalization is linked to multiple adverse health-related outcomes and provide insight into priorities for future research, theory building, and interventions in this area.
MeSH term(s)	Adult ; Humans ; Body Mass Index ; Body Weight ; Cross-Sectional Studies ; Obesity/psychology ; Quality of Life ; Weight Prejudice ; Child ; Adolescent ; Young Adult ; Middle Aged ; Aged
Language	English
Publishing date	2022-12-23
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	211996-1
ISSN	1878-1888 ; 0005-7894
ISSN (online)	1878-1888
ISSN	0005-7894
DOI	10.1016/j.beth.2022.12.003
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Article ; Online: A meta-analysis of associations between weight bias internalization and conceptually-related correlates: A step towards improving construct validity.

Romano, Kelly A / Heron, Kristin E / Sandoval, Cassidy M / Howard, Lindsay M / MacIntyre, Rachel I / Mason, Tyler B

Clinical psychology review

2022 Volume 92, Page(s) 102127

Abstract: Weight bias internalization (WBI), a process of weight-based self-devaluation, has been associated with adverse mental and physical health. However, there are limitations with the existing conceptualization and operationalization of WBI that raise ... ...

Abstract	Weight bias internalization (WBI), a process of weight-based self-devaluation, has been associated with adverse mental and physical health. However, there are limitations with the existing conceptualization and operationalization of WBI that raise questions about the implications of this evidence-base. To address these limitations, the present study investigated the construct validity of WBI by conducting a meta-analysis of associations between WBI (as currently operationalized) and conceptually-related correlates. Studies identified through October 2021 that provided zero-order correlations for associations between WBI and conceptually-related constructs were examined. Meta-regression determined whether these associations differed across WBI measures and demographic (age, sex/gender, race, BMI) and study-level (publication status, sample type, study quality) moderators. Data for 128 (sub)samples were identified (Msample size = 477.83, SD = 1679.90; Mage = 34.46, SD = 12.17; range = 10.21-56.60). Greater WBI exhibited large to very large associations with factors suggested to have considerable overlap with this construct (negative and positive body image, self-devaluation), general and weight-specific experiential avoidance, and individuals' anticipation of future weight stigma. Associations varied for other constructs that have been differentially included in conceptualizations of WBI (endorsing weight bias, weight stigma stereotype awareness, weight stigma experiences), and via measurement-related, demographic, and study-level factors. These findings provide important information that can advance WBI conceptualization and measure-refinement.
MeSH term(s)	Body Weight ; Humans ; Obesity ; Self Concept ; Social Stigma ; Weight Prejudice
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	604577-7
ISSN	1873-7811 ; 0272-7358
ISSN (online)	1873-7811
ISSN	0272-7358
DOI	10.1016/j.cpr.2022.102127
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Article ; Online: A humanized yeast model reveals dominant-negative properties of neuropathy-associated alanyl-tRNA synthetase mutations.

Meyer-Schuman, Rebecca / Marte, Sheila / Smith, Tyler J / Feely, Shawna M E / Kennerson, Marina / Nicholson, Garth / Shy, Mike E / Koutmou, Kristin S / Antonellis, Anthony

Human molecular genetics

2023 Volume 32, Issue 13, Page(s) 2177–2191

Abstract: Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate tRNA molecules to cognate amino acids. Heterozygosity for missense variants or small in-frame deletions in six ARS genes causes dominant axonal peripheral neuropathy. These pathogenic ... ...

Abstract	Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate tRNA molecules to cognate amino acids. Heterozygosity for missense variants or small in-frame deletions in six ARS genes causes dominant axonal peripheral neuropathy. These pathogenic variants reduce enzyme activity without significantly decreasing protein levels and reside in genes encoding homo-dimeric enzymes. These observations raise the possibility that neuropathy-associated ARS variants exert a dominant-negative effect, reducing overall ARS activity below a threshold required for peripheral nerve function. To test such variants for dominant-negative properties, we developed a humanized yeast assay to co-express pathogenic human alanyl-tRNA synthetase (AARS1) mutations with wild-type human AARS1. We show that multiple loss-of-function AARS1 mutations impair yeast growth through an interaction with wild-type AARS1, but that reducing this interaction rescues yeast growth. This suggests that neuropathy-associated AARS1 variants exert a dominant-negative effect, which supports a common, loss-of-function mechanism for ARS-mediated dominant peripheral neuropathy.
MeSH term(s)	Humans ; Alanine-tRNA Ligase/genetics ; Peripheral Nervous System Diseases/pathology ; Mutation ; Amino Acyl-tRNA Synthetases/genetics ; Peripheral Nerves/metabolism
Chemical Substances	Alanine-tRNA Ligase (EC 6.1.1.7) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-)
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddad054
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Article ; Online: Anticancer potential of nitric oxide (NO) in neuroblastoma treatment.

Gordon, Jenna L / Hinsen, Kristin J / Reynolds, Melissa M / Smith, Tyler A / Tucker, Haley O / Brown, Mark A

RSC advances

2021 Volume 11, Issue 16, Page(s) 9112–9120

Abstract: The most common extracranial solid tumor in childhood, paediatric neuroblastoma, is frequently diagnosed at advanced stages and identified as high risk. High risk neuroblastoma is aggressive and unpredictable, resulting in poor prognosis and only ∼40% ... ...

Abstract	The most common extracranial solid tumor in childhood, paediatric neuroblastoma, is frequently diagnosed at advanced stages and identified as high risk. High risk neuroblastoma is aggressive and unpredictable, resulting in poor prognosis and only ∼40% five-year survival rates. Herein, nitric oxide (NO) delivered
Language	English
Publishing date	2021-03-01
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra00275a
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Article ; Online: The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review.

Blaiss, Michael S / Bernstein, Jonathan A / Kessler, Adam / Pines, Jesse M / Camargo, Carlos A / Fulgham, Paula / Haumschild, Ryan / Rupp, Kristin / Tyler, Timothy / Moellman, Joseph

Advances in therapy

2021 Volume 39, Issue 1, Page(s) 178–192

Abstract: Since 1955, the only available ... ...

Abstract	Since 1955, the only available H
MeSH term(s)	Administration, Intravenous ; Adult ; Cetirizine/adverse effects ; Diphenhydramine/adverse effects ; Histamine H1 Antagonists/adverse effects ; Humans ; Urticaria/chemically induced ; Urticaria/drug therapy
Chemical Substances	Histamine H1 Antagonists ; Diphenhydramine (8GTS82S83M) ; Cetirizine (YO7261ME24)
Language	English
Publishing date	2021-12-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-021-01999-x
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