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Article ; Online: The role of high dose vitamin d and glutathione supplementation in COVID-19 treatment: A case series.

Burhan, Erlina / Wijaya, Indra

Journal of infection in developing countries

2023 Volume 17, Issue 2, Page(s) 188–193

Abstract: COVID-19 has been affecting millions of people worldwide and becoming a global public health burden. Therefore, exploring treatment options is essential to help flatten the curve and reduce hospitalization time. This is a case series of ten COVID-19 ... ...

Abstract	COVID-19 has been affecting millions of people worldwide and becoming a global public health burden. Therefore, exploring treatment options is essential to help flatten the curve and reduce hospitalization time. This is a case series of ten COVID-19 patients in Jakarta and Tangerang, Indonesia, who received a high dose of vitamin D and glutathione supplementation daily. Within 5-7 days of treatment, all patients were confirmed COVID-19 negative. To date, this is the first report from Indonesia describing the potential benefit of supplementing vitamin D and glutathione concurrently in improving clinical conditions and expediting the recovery time of COVID-19 patients.
MeSH term(s)	Humans ; Vitamin D ; COVID-19 ; SARS-CoV-2 ; Dietary Supplements ; Vitamins ; Glutathione
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-02-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.17109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sustainability Green Raw Material Inventory with Continuous Replenishment Method

Wijaya Dendhy Indra / Maulana Ahmad / Yulianto Hubertus Davy

E3S Web of Conferences, Vol 388, p

A Case Study Housing Construction Company

2023 Volume 01034

Abstract: The company is engaged in housing construction. Every year their production increase using green materials, from 2018 to 2021. This growth emerges problems such as overstock and dead stock. So the company has to determine the best Inventory Control ... ...

Abstract	The company is engaged in housing construction. Every year their production increase using green materials, from 2018 to 2021. This growth emerges problems such as overstock and dead stock. So the company has to determine the best Inventory Control Method to help the company get so much lost in stock and dead stock. In another way, the company can calculate the total cost for all the inventory activities. In the first calculation, we find the best solution forecast method for the next year in moving averages. The best forecast fit in best criteria, such as Mean Absolute Deviation, Mean Absolute Percentage Error, CFE, and Mean Square Error. Calculating the Inventory Control Method employing continuous replenishment, it is interpreted that the customer is still waiting for the product that has not been fulfilled. This Continuous Replenishment Method can calculate Safety Stock, Reorder Point, and Stock Out to minimize the total cost.
Keywords	Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Innovative management for Occupational Safety and Health

Priatin Wannur / Wijaya Dendhy Indra / Yulianto Hubertus Davy

E3S Web of Conferences, Vol 426, p

A tower engineering project

2023 Volume 02064

Abstract: Risk is very attached to every activity. Potential risks also occur in antenna installation projects at telecommunications company vendors, which create hazardous work. The aim of the research is to identify the causes of accidents at the Base ... ...

Abstract	Risk is very attached to every activity. Potential risks also occur in antenna installation projects at telecommunications company vendors, which create hazardous work. The aim of the research is to identify the causes of accidents at the Base Transceiver Station (BTS) tower and make recommendations for ways to reduce the accident rate for tower workers by using Failure Mode Effect and Analysis (FMEA) and Fault Tree Analysis (FTA) method. The results based on the FMEA method used indicate that: the highest work accident rate is obtained from being hit by heavy material (RPN = 128), with a percentage of 31%. Whereas in the FTA method, the most fundamental factor in the occurrence of material overlap work accidents is technical factors where the antenna installation is not perfect, the tools used are not based on standards, supported by the results of data verification by the internal control team which found 6% of engineers do not have proper helmets. Improvements were made by eliminating the existing failure modes, namely by equipping PPE for workers who do not yet have PPE and training certificates to work at tower heights.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients.

Wijaya, Indra / Prameswara, M Lucky Nurdiansyah / Prasetya, Dimmy / Hamijoyo, Laniyati / Alisjahbana, Bachti / Rahmadi, Andri Reza

Acta medica Indonesiana

2024 Volume 56, Issue 1, Page(s) 20–25

Abstract: Background: Osteoporosis is a major problem in transfusion-dependent thalassemia patients (TDT) patients. Osteoprotegerin (OPG) is one of several bone markers that are closely associated with osteoporosis in TDT patients. OPG is a glycoprotein that ... ...

Abstract	Background: Osteoporosis is a major problem in transfusion-dependent thalassemia patients (TDT) patients. Osteoprotegerin (OPG) is one of several bone markers that are closely associated with osteoporosis in TDT patients. OPG is a glycoprotein that functions as a feedback receptor for the Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), which is an alpha tumor necrosis factor receptor. One of the causes of decreased bone mass density is iron toxicity, which can be identified by showing elevated transferrin saturation. Bone mass dual X-ray absorptiometry (DEXA) is a gold standard for the diagnosis of osteoporosis, these procedures are not commonly available in Indonesia. This study was conducted to analyze the correlation between serum levels of OPG and transferrin saturation in TDT patients. Methods: A correlational study with a cross-sectional approach analyzed data from TDT patients at Hemato-Oncology Medic Outpatient Clinic, Hasan Sadikin General Hospital, Bandung, Indonesia. Primary data were obtained through blood sampling and anthropometry measurement while secondary data were obtained from the patient's medical records. OPG and transferrin saturation levels were assessed using the ELISA method. Research data were analyzed using the rank Spearman correlation test. Results: Data were collected from 51 research subjects (30 women dan 21 men). The median OPG level was 380 (170-1230) pg/mL and the median transferrin saturation level was 89.4 (66.7 - 96.2)%. Analysis of correlation showed a significant correlation between and transferrin saturation level with a coefficient value of r -0.539 and p-value <0.001. Conclusion: There was a significant inverse correlation between OPG with transferrin saturation in TDT patients.
MeSH term(s)	Male ; Humans ; Female ; Osteoprotegerin ; Bone Density ; Osteoporosis/etiology ; Osteoporosis/pathology ; Thalassemia/therapy ; Thalassemia/complications ; Transferrins ; RANK Ligand
Chemical Substances	Osteoprotegerin ; Transferrins ; RANK Ligand
Language	English
Publishing date	2024-04-02
Publishing country	Indonesia
Document type	Journal Article
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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Article: Chronic Hypoparathyroidism Due to Partial Thyroidectomy with Intracranial Calcification.

Wijaya, Indra

Acta medica Indonesiana

2016 Volume 48, Issue 1, Page(s) 68–69

Abstract: A 57 year old female came with the complaint of recurrent headache, often fatigue, and sometimes feel numbs and rigid in her extremities, no other symptom was noted. Her body weight is stable and she was in menopausal state. She had a history of partial ... ...

Abstract	A 57 year old female came with the complaint of recurrent headache, often fatigue, and sometimes feel numbs and rigid in her extremities, no other symptom was noted. Her body weight is stable and she was in menopausal state. She had a history of partial thyroidectomy 20 years ago and continues thiamazole 2.5 mg with seldom regular consult to physician. From the physical examination, the patient had a scar from thyroid surgery and other organs were in the normal condition. From laboratory examination, there was slight normocytic normochromic anemia (Hb: 10.7 gr/dL), normal fT4: 1.21 ng/dL (0.7-1.48 ng/dL), slightly low Calcium: 8.3 mg/dL (8.5-10.2 mg/dL), others were within normal limit but there was no Phosphorus level data. She was currently on medication: thiamazole 2.5 mg once daily, CaCO3 500 mg once daily, and alfacalcidol 1 mcg once daily, to prevent the rigid and numbness that she felt before. For further investigation, we performed a PTH test with result of hypoparathyroidism with parathyroid hormone 7 pg/mL (15-65 pg/mL) and brain CT-scan with result there was a symmetrical bilateral calcification in radiate corona, frontal lobes, temporal lobes, basal ganglia, thalamic, and dentate nuclei of cerebelli. There was no data about the histopathology examination of the thyroid tumor because the patient did not keep the data. The mechanism of intracranial calcification in hypoparathyroidism, more often seen in pseudohypoparathyroidism than in idiopathic hypoparathyroidism, has not been completely elucidated. It may be related more to the duration of hypocalcaemia and hyperphosphataemia than parathyroid hormone itself. Hyperphosphataemia promotes ectopic calcification in brain tissue in hypoparathyroidism. Intracranial calcification is one of the features of chronic hypocalcemia, and the calcifications typically involve basal ganglia, thalami, and the cerebellum.
MeSH term(s)	Brain/diagnostic imaging ; Calcinosis/diagnostic imaging ; Calcium/blood ; Female ; Humans ; Hypocalcemia/blood ; Hypoparathyroidism/complications ; Hypoparathyroidism/diagnosis ; Methimazole/therapeutic use ; Middle Aged ; Thyroidectomy/adverse effects ; Tomography, X-Ray Computed
Chemical Substances	Methimazole (554Z48XN5E) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-01
Publishing country	Indonesia
Document type	Case Reports ; Journal Article
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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Article ; Online: Chronic Hypoparathyroidism Due to Partial Thyroidectomy with Intracranial Calcification

Indra Wijaya

Acta Medica Indonesiana, Vol 48, Iss

2016 Volume 1

Abstract	A 57 year old female came with the complaint of recurrent headache, often fatigue, and sometimes feel numbs and rigid in her extremities, no other symptom was noted. Her body weight is stable and she was in menopausal state (Figure 1a and 1b). She had a history of partial thyroidectomy 20 years ago and continues thiamazole 2.5 mg with seldom regular consult to physician. From the physical examination, the patient had a scar from thyroid surgery and other organs were in the normal condition. From laboratory examination, there was slight normocytic normochromic anemia (Hb: 10.7 gr/dL), normal fT4: 1.21 ng/dL (0.7-1.48 ng/dL), slightly low Calcium: 8.3 mg/dL (8.5-10.2 mg/dL), others were within normal limit but there was no Phosphorus level data.
Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis: an Evidence-based Case Report.

Wijaya, Indra

Acta medica Indonesiana

2015 Volume 47, Issue 4, Page(s) 352–357

Abstract: Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis.: Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta- ... ...

Abstract	Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obtained. Through critical appraisal, it was concluded that the articles meet the criteria for validity and relevance. Results: the article found that there is a positive effect of ursodeoxycholic acid on the activity of serum transaminases and cholestasis indexes. However, there is insufficient evidence to support or to refute effects of ursodeoxycholic acid on disease's course as well as the viral load. Conclusion: better method of clinical trials are needed to obtain a valid and applicable result for daily practice.
MeSH term(s)	Antibodies, Viral/immunology ; Cholagogues and Choleretics/therapeutic use ; Hepatitis Viruses/immunology ; Hepatitis, Viral, Human/drug therapy ; Hepatitis, Viral, Human/virology ; Humans ; Male ; Ursodeoxycholic Acid/therapeutic use ; Young Adult
Chemical Substances	Antibodies, Viral ; Cholagogues and Choleretics ; Ursodeoxycholic Acid (724L30Y2QR)
Language	English
Publishing date	2015-10
Publishing country	Indonesia
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Ursodeoxycholic Acid in Acute Viral Hepatitis

Indra Wijaya

Acta Medica Indonesiana, Vol 47, Iss

an Evidence-based Case Report

2015 Volume 4

Abstract: Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta- ... ...

Abstract	Aim: to review the role of ursodeoxycholic acid in acute viral hepatitis. Methods: following literature searching according to the clinical question on Pubmed and Cochrane Library. After filtered with our inclusion and exclusion criteria, one meta-analysis and two randomized clinical trials are obtained. Through critical appraisal, it was concluded that the articles meet the criteria for validity and relevance. Results: the article found that there is a positive effect of ursodeoxycholic acid on the activity of serum transaminases and cholestasis indexes. However, there is insufficient evidence to support or to refute effects of ursodeoxycholic acid on disease’s course as well as the viral load. Conclusion: better method of clinical trials are needed to obtain a valid and applicable result for daily practice. Key words: ursodeoxycholic acid, acute viral hepatitis
Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Gender Disparities in Psychological Disturbances and Quality of Life Among Adolescent and Adult Patients with Thalassemia: A Review.

Fianza, Pandji Irani / Rahmawati, Anita / Wijaya, Indra / Oehadian, Amaylia / Prasetya, Dimmy / Vidyaniati, Putri / Harti, Gusti Fungani / Fadjari, Trinugroho Heri / Panigoro, Ramdan

Journal of multidisciplinary healthcare

2024 Volume 17, Page(s) 1663–1669

Abstract: Thalassemia is a chronic disease caused by impaired globin chain synthesis, leading to ineffective erythropoiesis, hemolysis, and chronic anemia. The treatment of patients with thalassemia, including blood transfusion combined with chelation therapy has ... ...

Abstract	Thalassemia is a chronic disease caused by impaired globin chain synthesis, leading to ineffective erythropoiesis, hemolysis, and chronic anemia. The treatment of patients with thalassemia, including blood transfusion combined with chelation therapy has progressed and improved their survival and prognosis. However, thalassemia-related psychological problems and impaired health-related quality of life (QoL) challenges still exist. Gender is one of the factors that has been suggested, to contribute to the disparities in psychological outcomes. This review article examined the evidence for gender differences in psychological disturbances and QoL in adolescent and adult patients with thalassemia. A non-systematic search of the literature was conducted in PubMed and Google Scholar for English full-text available from 2013 to 2023. We identified 23 studies with a sample size ≥ 100 that examined gender disparities in anxiety, depression, and QoL in adolescent and adult patients with thalassemia (mean prevalence of female = 53.1%; mean age = 28 years). Our review shows that there are gender disparities in psychological distress and QoL in adolescent and adult patients with thalassemia. Statistically significant gender differences were demonstrated in 62% of the psychological and QoL outcomes from 16 studies. Female patients had a higher prevalence of anxiety, depression, and poorer QoL in some studies. However, further studies with sufficient power and design are necessary to confirm the existence of gender disparities in psychological disturbances and QoL outcomes.
Language	English
Publishing date	2024-04-17
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S444592
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Article ; Online: The role of chidamide in the treatment of B-cell non-Hodgkin lymphoma: An updated systematic review.

Ridwansyah, Hastono / Wijaya, Indra / Bashari, Muhammad Hasan / Sundawa Kartamihardja, Achmad Hussein / Hernowo, Bethy Suryawathy

Biomolecules & biomedicine

2023 Volume 23, Issue 5, Page(s) 727–739

Abstract: B-cell non-Hodgkin lymphoma (B-NHL) is a lymphoid malignancy derived from B-cells that remains difficult to treat. Moreover, relapses and refractory cases are common. Abnormalities in epigenetic mechanisms, such as imbalanced histone acetylation ... ...

Abstract	B-cell non-Hodgkin lymphoma (B-NHL) is a lymphoid malignancy derived from B-cells that remains difficult to treat. Moreover, relapses and refractory cases are common. Abnormalities in epigenetic mechanisms, such as imbalanced histone acetylation affecting certain genes, contribute to relapses and refractory cases. Chidamide (tucidinostat) is a novel histone deacetylase inhibitor that can reverse this epigenetic imbalance and has been approved for the treatment of T-cell malignancies. However, the use of chidamide for B-NHL remains limited, and the lack of relevant literature exacerbates this limitation. We conducted this review to summarize the anticancer activity of chidamide against B-NHL and its clinical applications to overcome drug resistance. This systematic review was conducted according to the PRISMA 2020 guidelines, using some keyword combinations from MEDLINE and EBSCO. The inclusion and exclusion criteria were also defined. Of the 131 records retrieved from databases, 16 were included in the review. Nine articles revealed that chidamide limited tumor progression by modifying the tumor microenvironment, stopping the cell cycle, inducing apoptosis and autophagy, and enhancing complement-dependent and antibody-dependent cell-mediated cytotoxicities.According to seven other studies, administering chidamide in combination with another existing therapeutic regimen may benefit not only patients with relapsed/refractory B-NHL, but also those with newly diagnosed B-NHL. Chidamide plays many important roles in limiting B-NHL progression through epigenetic modifications. Thus, combining chidamide with other anticancer drugs may be more beneficial for patients with newly diagnosed and relapsed/refractory B-NHL.
MeSH term(s)	Humans ; Neoplasm Recurrence, Local/chemically induced ; Lymphoma, B-Cell/chemically induced ; Antineoplastic Agents/pharmacology ; Aminopyridines/adverse effects ; Tumor Microenvironment
Chemical Substances	N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide (87CIC980Y0) ; Antineoplastic Agents ; Aminopyridines
Language	English
Publishing date	2023-09-04
Publishing country	Bosnia and Herzegovina
Document type	Systematic Review ; Journal Article ; Review
ISSN	2831-090X
ISSN (online)	2831-090X
DOI	10.17305/bb.2023.8791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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