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Article: Are Biasing Factors Idiosyncratic to Measures? A Comparison of Interpersonal Conflict, Organizational Constraints, and Workload.

Spector, Paul E / Gray, Cheryl E / Rosen, Christopher C

2022 , Page(s) 1–20

Abstract: Widespread concern has been raised about the possibility of potential biasing factors influencing the measurement of organizational variables and distorting inferences and conclusions reached about them. Recent research calls for a measure-centric ... ...

Abstract	Widespread concern has been raised about the possibility of potential biasing factors influencing the measurement of organizational variables and distorting inferences and conclusions reached about them. Recent research calls for a measure-centric approach in which every measure is independently evaluated to assess what factor(s) may uniquely bias it. This paper examines three popular stressor measures from this perspective. Across three studies, we examine factors that may bias three popular measures of job stressors: The Interpersonal Conflict at Work Scale (ICAWS), the Organizational Constraints Scale (OCS), and the Quantitative Workload Inventory (QWI). The first study used a two-wave design to survey 276 MTurk workers to assess the three stressor scales, four strains, and five measures of potential bias sources: hostile attribution bias, negative affectivity, mood, neutral objects satisfaction, and social desirability. The second study used an experimental design with 439 MTurk workers who were randomly assigned to a positive, negative, or no mood induction condition to assess effects on means of the three stressor measures and their correlations with strains. The third study surveyed 161 employee-supervisor dyads to explore the convergence of results involving the three stressor measures across sources. Based on several forms of evidence we conclude that potential biasing factors affect the three stressor measures differently, supporting the merits of a measure centric approach, even among measures in the same domain.
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016738-6
ISSN	1573-353X ; 0889-3268
ISSN (online)	1573-353X
ISSN	0889-3268
DOI	10.1007/s10869-022-09838-8
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Article: Severe COVID-19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals.

Gray, Paul E / Bartlett, Adam W / Tangye, Stuart G

Clinical & translational immunology

2022 Volume 11, Issue 4, Page(s) e1365

Abstract: Since the emergence of the COVID-19 pandemic in early 2020, a key challenge has been to define risk factors, other than age and pre-existing comorbidities, that predispose some people to severe disease, while many other SARS-CoV-2-infected individuals ... ...

Abstract	Since the emergence of the COVID-19 pandemic in early 2020, a key challenge has been to define risk factors, other than age and pre-existing comorbidities, that predispose some people to severe disease, while many other SARS-CoV-2-infected individuals experience mild, if any, consequences. One explanation for intra-individual differences in susceptibility to severe COVID-19 may be that a growing percentage of otherwise healthy people have a pre-existing asymptomatic primary immunodeficiency (PID) that is unmasked by SARS-CoV-2 infection. Germline genetic defects have been identified in individuals with life-threatening COVID-19 that compromise local type I interferon (IFN)-mediated innate immune responses to SARS-CoV-2. Remarkably, these variants - which impact responses initiated through TLR3 and TLR7, as well as the response to type I IFN cytokines - may account for between 3% and 5% of severe COVID-19 in people under 70 years of age. Similarly, autoantibodies against type I IFN cytokines (IFN-α, IFN-ω) have been detected in patients' serum prior to infection with SARS-CoV-2 and were found to cause
Language	English
Publishing date	2022-04-17
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2694482-0
ISSN	2050-0068
ISSN	2050-0068
DOI	10.1002/cti2.1365
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Article ; Online: The use of Traditional Chinese Medicines to treat SARS-CoV-2 may cause more harm than good.

Gray, Paul E / Belessis, Yvonne

Pharmacological research

2020 Volume 156, Page(s) 104776

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Medicine, Chinese Traditional ; Pandemics ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2 ; COVID-19 Drug Treatment
Keywords	covid19
Language	English
Publishing date	2020-04-03
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2020.104776
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Zs.A 721: Show issues

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Article ; Online: Use of sensory modulation approaches to improve compression garment adherence in adults after burn: An e-Delphi study.

Crofton, Erin / Meredith, Pamela / Gray, Paul / Strong, Jennifer

Burns : journal of the International Society for Burn Injuries

2022 Volume 49, Issue 2, Page(s) 353–364

Abstract: Background: Sensory over-responsiveness, identified through self-report and quantitative sensory testing, has been associated with compression garment non-adherence in a burn-injured cohort. This study sought expert consensus on the usefulness of, and ... ...

Abstract	Background: Sensory over-responsiveness, identified through self-report and quantitative sensory testing, has been associated with compression garment non-adherence in a burn-injured cohort. This study sought expert consensus on the usefulness of, and recommendations for, sensory modulation strategies to improve compression garment adherence in sensory over-responsive adults after burn. Method: Experts in the field of sensory modulation were invited to participate in a mixed-methods, three-round electronic Delphi study. Results: Experts (N = 18) agreed that sensory modulation therapy may be a useful clinical tool to improve compression garment adherence. Twenty-two items reached consensus as essential to assessment, treatment, or therapist training. Conclusion: With adequate therapist training and individualized assessment and treatment, sensory modulation strategies may be a useful clinical approach to improving compression garment adherence in those who are sensory over-responsive after burn. Further research is needed to gather perceptions from burns therapists, and to implement and evaluate the effectiveness in clinical practice.
MeSH term(s)	Humans ; Adult ; Compression Bandages ; Delphi Technique ; Burns/therapy ; Clothing ; Self Report
Language	English
Publishing date	2022-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2022.04.001
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Zs.A 1250: Show issues

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Article ; Online: Pyrin variant E148Q potentiates inflammasome activation and the effect of pathogenic mutations in cis.

Reygaerts, Thomas / Laohamonthonkul, Pawat / Hrovat-Schaale, Katja / Moghaddas, Fiona / Baker, Paul J / Gray, Paul E / Masters, Seth L

Rheumatology (Oxford, England)

2023 Volume 63, Issue 3, Page(s) 882–890

Abstract: Objective: The p.E148Q variant in pyrin is present in different populations at a frequency of up to 29%, and has been associated with diseases, including vasculitis and FMF. The pathogenicity of p.E148Q in FMF is unclear, even when observed in cis or in ...

Abstract	Objective: The p.E148Q variant in pyrin is present in different populations at a frequency of up to 29%, and has been associated with diseases, including vasculitis and FMF. The pathogenicity of p.E148Q in FMF is unclear, even when observed in cis or in trans to a single, typically recessive, pathogenic mutation. We performed functional validation to determine whether p.E148Q increases the ability of pyrin to form an active inflammasome complex in cell lines. Methods: We interrogated the Australian Autoinflammatory Disease RegistrY (AADRY) to find candidate inheritance patterns for the p.E148Q variant in pyrin. Different pyrin variant combinations were tested in HEK293T cells stably expressing the adaptor protein apoptosis-associated speck-like (ASC), which were analysed by flow cytometry to visualize inflammasome formation, with and without stimulation by Clostridioides difficile toxin B (TcdB). Inflammasome-dependent cytokine secretion was also quantified by ELISA of supernatants from THP-1 cells transduced with lentiviral expression vectors. Results: In AADRY, we observed the p.E148Q allele in individuals with autoinflammatory diseases alone or in conjunction with other pyrin variants. Two FMF families harboured the allele p.E148Q-M694I in cis with dominant heritability. In vitro, p.E148Q pyrin could spontaneously potentiate inflammasome formation, with increased IL-1β and IL-18 secretion. p.E148Q in cis to classical FMF mutations provided significant potentiation of inflammasome formation. Conclusion: The p.E148Q variant in pyrin potentiates inflammasome activation in vitro. In cis, this effect is additive to known pathogenic FMF mutations. In some families, this increased effect could explain why FMF segregates as an apparently dominant disease.
MeSH term(s)	Humans ; Australia ; Bacterial Toxins/pharmacology ; HEK293 Cells ; Inflammasomes/genetics ; Mutation ; Pyrin/genetics
Chemical Substances	Bacterial Toxins ; Inflammasomes ; Pyrin ; toxB protein, Clostridium difficile
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead376
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: Infliximab Reverses Symptoms and May Protect from Developing Chronic Restrictive Ophthalmopathy in Children with Familial Orbital Myositis: A Case Report.

Huynh, Aimee / Siggs, Owen M / Wainstein, Brynn K / Gray, Paul E

Ocular immunology and inflammation

2022 Volume 31, Issue 5, Page(s) 1097–1100

Abstract: Background: Orbital myositis is a rare sporadic eye disease associated with extraocular eye muscle inflammation. To date, there have been two reports of familial orbital myositis (FOM), which demonstrate partially penetrant autosomal dominant ... ...

Abstract	Background: Orbital myositis is a rare sporadic eye disease associated with extraocular eye muscle inflammation. To date, there have been two reports of familial orbital myositis (FOM), which demonstrate partially penetrant autosomal dominant inheritance. Cases: We report six new Australian cases of FOM, four of whom extend one of the reported pedigrees, as well as a separate mother and daughter manifesting orbital myositis, which constitutes a third report of familial occurrence. We can confirm that the disease has onset in childhood, appearing to go into remission in adult life, and that the inflammation is corticosteroid-responsive. However, one patient went on to develop permanent diplopia in upgaze. We also report two children suffering chronic pain and diplopia who demonstrated complete resolution of symptoms with the anti-TNF-α monoclonal infliximab. Conclusion: Uncontrolled FOM in childhood may result in permanent extraocular eye muscle damage, while TNF-α blockade provides an excellent steroid-sparing effect.
MeSH term(s)	Adult ; Humans ; Child ; Orbital Myositis/diagnosis ; Orbital Myositis/drug therapy ; Orbital Myositis/etiology ; Infliximab/therapeutic use ; Diplopia/complications ; Tumor Necrosis Factor Inhibitors ; Australia ; Orbital Diseases/diagnosis ; Inflammation/complications
Chemical Substances	Infliximab (B72HH48FLU) ; Tumor Necrosis Factor Inhibitors
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2022.2074464
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Zs.A 4004: Show issues

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Article: The use of Traditional Chinese Medicines to treat SARS-CoV-2 may cause more harm than good

Gray, Paul E / Belessis, Yvonne

Pharmacol Res

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #31511
Database	COVID19

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Article ; Online: The use of Traditional Chinese Medicines to treat SARS-CoV-2 may cause more harm than good

Gray, Paul E. / Belessis, Yvonne

Pharmacological Research

2020 Volume 156, Page(s) 104776

Keywords	Pharmacology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1043-6618
DOI	10.1016/j.phrs.2020.104776
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Helping may be Harming: unintended negative consequences of providing social support.

Gray, Cheryl E / Spector, Paul E / Lacey, Kayla N / Young, Briana G / Jacobsen, Scott T / Taylor, Morgan R

Work and stress

2023 Volume 34, Issue 4, Page(s) 359–385

Abstract: ... higher organisational frustration, and more physical symptoms (e.g. headache, nausea, and fatigue ...

Abstract	While social support is generally considered a helpful resource for employees, it can also serve as a job stressor. Unhelpful workplace social support (UWSS) is any action taken by a supervisor and/or colleague that the recipient believes was intended to benefit him or her but is perceived as unhelpful or harmful. Two studies, one qualitative and one quantitative, identified types of UWSS and demonstrated that unhelpful support can operate as a job stressor in relating to strains. In Study 1, critical incidents were collected from 116 employees, and a content analysis revealed 11 distinct categories of UWSS. In Study 2, the taxonomy of UWSS was further refined using quantitative methods. Results of two samples (176 diverse employees and 496 registered nurses) demonstrate that UWSS is associated with higher job-related negative affect, lower competence-based self-esteem, lower coworker satisfaction, higher work-related burnout, higher organisational frustration, and more physical symptoms (e.g. headache, nausea, and fatigue) among recipients. Together, the studies demonstrate that unhelpful workplace social support is a meaningful job stressor worthy of further investigation.
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	645530-x
ISSN	1464-5335 ; 0267-8373
ISSN (online)	1464-5335
ISSN	0267-8373
DOI	10.1080/02678373.2019.1695294
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Zs.A 2672: Show issues

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Article ; Online: Solutions Trial: Solution Focused Brief Therapy (SFBT) in 10-17-year-olds presenting at police custody: a randomised controlled trial.

Moody, Gwenllian / Coulman, Elinor / Crocker-White, Emma / Gray, Kylie / Hastings, Richard P / Longman, Andrea / Lugg-Widger, Fiona / Playle, Rebecca / Segrott, Jeremy / Thompson, Paul / Badger, Julia / Langdon, Peter E / Flynn, Samantha

Trials

2024 Volume 25, Issue 1, Page(s) 159

Abstract: Background: Within England, children and young people (CYP) who come into police custody are referred to Liaison and Diversion (L&D) teams. L&D teams have responsibility for liaising with healthcare and other support services while working to divert CYP ...

Abstract	Background: Within England, children and young people (CYP) who come into police custody are referred to Liaison and Diversion (L&D) teams. L&D teams have responsibility for liaising with healthcare and other support services while working to divert CYP away from the criminal justice system but have traditionally not provided targeted psychological interventions to CYP. Considering evidence that Solution Focused Brief Therapy (SFBT) leads to a reduction in internalising and externalising behaviour problems in CYP, the aim of this randomised controlled trial (RCT) was to determine whether there is a difference between services as usual (SAU) plus SFBT offered by trained therapists working within a L&D team, and SAU alone, in reducing offending behaviours in 10-17-year-olds presenting at police custody. Methods: Design: two-arm individually RCT with internal pilot and process evaluation. Participants: N = approximately 448 CYP aged 10-17 years presenting at one of three police custody suites in the area served by Lancashire and South Cumbria NHS Foundation Trust (LSCFT) who are referred to the L&D team. Participants will be recruited and allocated to intervention:control on a 1:1 basis. Interviews will be performed with 30-40 CYP in the intervention arm, 15 CYP in the control arm, up to 20 parents/guardians across both arms, up to 15 practitioners, and up to 10 site staff responsible for screening CYP for the trial. Intervention and control: Those allocated to the intervention will be offered SAU plus SFBT, and control participants will receive SAU only. Primary outcome: CYP frequency of offending behaviours assessed through the Self-Report Delinquency Measure (SRDM) at 12 months post-randomisation. Secondary outcomes: criminal offence data (national police database); emotional and behavioural difficulties (self-report and parent/guardian reported); gang affiliation (self-report). Process evaluation: evaluation of acceptability and experiences of the CYP, parents/guardians, site staff and practitioners; fidelity of SFBT delivery. Discussion: This two-arm individually RCT will evaluate the effectiveness of SFBT in reducing offending behaviours in CYP presenting at police custody suites within the area served by LSCFT. Our process evaluation will assess the fidelity of delivery of SFBT, the factors affecting implementation, the acceptability of SFBT in CYP aged 10-17 years and recruitment and reach. We will also examine systems and structures for future delivery, therefore assessing overall scalability. Trial registration: ClinicalTrials.gov ISRCTN14195235 . Registered on June 16, 2023.
MeSH term(s)	Child ; Humans ; Adolescent ; Police ; Psychotherapy, Brief ; England ; Self Report ; Cost-Benefit Analysis
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-024-07904-5
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