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Article ; Online: Isolated 17,20-Lyase Deficiency in a

Leung, Mei Tik / Cheung, Hoi Ning / Iu, Yan Ping / Choi, Cheung Hei / Tiu, Sau Cheung / Shek, Chi Chung

Journal of the Endocrine Society

2019 Volume 4, Issue 2, Page(s) bvz016

Abstract: Isolated 17,20-lyase deficiency may be caused by mutations in ... ...

Abstract	Isolated 17,20-lyase deficiency may be caused by mutations in the
Language	English
Publishing date	2019-11-18
Publishing country	United States
Document type	Case Reports
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvz016
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Article ; Online: Hyperthyroidism caused by a grave disease that is not Graves' disease.

Ng, Chiu-ming / Lai, Judy Po-shan / Shek, Chi-chung / Tiu, Sau-cheung

The American journal of medicine

2012 Volume 125, Issue 3, Page(s) e3–4

MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Choriocarcinoma, Non-gestational/diagnosis ; Choriocarcinoma, Non-gestational/drug therapy ; Chorionic Gonadotropin/blood ; Chorionic Gonadotropin/urine ; Diagnosis, Differential ; Female ; Graves Disease/diagnosis ; Humans ; Hyperthyroidism/diagnosis ; Lymphatic Metastasis ; Thyroid Function Tests
Chemical Substances	Chorionic Gonadotropin
Language	English
Publishing date	2012-03
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2011.09.022
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Ua VI Zs.289: Show issues

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Article ; Online: Is withdrawal of somatostatin analogue therapy in patients with acromegaly associated with an increased risk of acute biliary problems?

Ng, Chiu-Ming / Shek, Chi-Chung / Choi, Cheung-Hei / Tiu, Sau-Cheung

Clinical endocrinology

2007 Volume 68, Issue 1, Page(s) 153; author reply 153–4

MeSH term(s)	Acromegaly/complications ; Antineoplastic Agents, Hormonal/therapeutic use ; Female ; Gallstones/etiology ; Humans ; Male ; Octreotide/therapeutic use ; Receptors, Somatotropin/antagonists & inhibitors
Chemical Substances	Antineoplastic Agents, Hormonal ; Receptors, Somatotropin ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2007-09-04
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/j.1365-2265.2007.02993.x
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Zs.A 814: Show issues

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Article ; Online: Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database.

Luk, Andrea O Y / Hui, Eric M T / Sin, Ming-Chuen / Yeung, Chun-Yip / Chow, Wing-Sun / Ho, Andrew Y Y / Hung, Hin-Fai / Kan, Eva / Ng, Chiu-Ming / So, Wing-Yee / Yeung, Chi-Kin / Chan, Kin-Sang / Chan, Kin-Wah / Chan, Pang-Fai / Siu, Shing-Chung / Tiu, Sau-Cheung / Yeung, Vincent T F / Chan, Juliana C N / Chan, Frank W K /

Cheung, Clement / Cheung, Ngai-Tseung / Ho, Siu-Tung / Lam, Karen S L / Yu, Linda W L / Chao, David / Lau, Ip-Tim

Diabetes care

2017 Volume 40, Issue 7, Page(s) 928–935

Abstract: Objective: Nationwide studies on secular trends of diabetes complications are not available in Asia. We examined changes in risk factor control and incidence of complications from diabetes and death in a large longitudinal cohort of Chinese adults with ... ...

Abstract	Objective: Nationwide studies on secular trends of diabetes complications are not available in Asia. We examined changes in risk factor control and incidence of complications from diabetes and death in a large longitudinal cohort of Chinese adults with type 2 diabetes in Hong Kong. Research design and methods: Between 1 January 2000 and 31 December 2012, 338,908 Chinese adults with type 2 diabetes underwent metabolic and complication assessment in 16 diabetes centers operated by Hong Kong Hospital Authority that provided care to a large majority of diagnosed patients. Patients were followed for incident acute myocardial infarction (AMI), stroke, end-stage renal disease (ESRD), and death until 31 December 2012. Risk factor levels between enrollment periods were compared. Incidence of clinical events, stratified by diabetes duration, was examined over time. Results: Incidence of complications from diabetes and death declined over the observation period in patients at varying disease duration. Among the high-risk group with diabetes for at least 15 years, crude incidence of AMI decreased from 8.7 to 5.8, stroke from 13.5 to 10.1, ESRD from 25.8 to 22.5, and death from 29.0 to 26.6 per 1,000 person-year between the periods 2000 to 2002 and 2010 to 2012. Improvements in levels of metabolic risk factors were detected. Proportion of patients achieving HbA Conclusions: From this territory-wide Hong Kong Diabetes Database, we observed decreases in incidence of cardiovascular-renal complications and death and corresponding improvements in risk factor control over a 13-year period.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc16-2354
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article: Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency.

Mak, Ingrid Yin Fung / Au Yeung, Benjamin Yick Toa / Ng, Ying Wai / Choi, Cheung Hei / Iu, Heidi Yan Ping / Shek, Chi Chung / Tiu, Sau Cheung

Journal of the Endocrine Society

2017 Volume 1, Issue 2, Page(s) 96–108

Abstract: Context: Basal and poststimulation salivary cortisol and cortisone levels can be useful in the diagnosis of adrenal insufficiency. However, little is known about the optimal cutoffs and performance characteristics of these tests.: Objective: To ... ...

Abstract	Context: Basal and poststimulation salivary cortisol and cortisone levels can be useful in the diagnosis of adrenal insufficiency. However, little is known about the optimal cutoffs and performance characteristics of these tests. Objective: To derive the cutoff values and study the performance characteristics of salivary cortisol and salivary cortisone in the diagnosis of adrenal insufficiency. Design and setting: Prospective study in a regional hospital in Hong Kong from January 2014 to September 2015. Participants: Fifty-six Chinese healthy volunteers and 171 patients suspected of having adrenal insufficiency. Main outcome measures: All participants underwent low-dose short Synacthen test (LDSST) with intravenous injection of 1 μg of tetracosactide (Synacthen 1-24). Serum cortisol, salivary cortisol and cortisone levels were measured at baseline and 30 and 60 minutes afterward. Results: Using the reference cutoff (mean - 2 standard deviations of post-LDSST peak serum cortisol) derived from healthy volunteers as the gold standard, receiver operating characteristic analysis of patients' data revealed that both post-LDSST peak salivary cortisol and cortisone performed better than basal tests. The most optimal cutoff values for serum cortisol as measured by immunoassay and for salivary cortisol and salivary cortisone as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) were 376, 8.6, and 33.5 nmol/L, respectively, for post-LDSST peak values, and 170, 1.7, and 12.5 nmol/L, respectively, for basal values. Conclusions: We established method-specific reference cutoffs for serum cortisol, salivary cortisol, and salivary cortisone during LDSST. Both post-LDSST peak salivary cortisol and cortisone performed well as diagnostic tests for adrenal insufficiency. Their measurements by LC-MS/MS can alleviate problems associated with serum cortisol immunoassays.
Language	English
Publishing date	2017-01-13
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN	2472-1972
DOI	10.1210/js.2016-1056
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Article: Postprandial glucose response to Chinese foods in patients with type 2 diabetes.

Chan, Eliza M Y / Cheng, Winnie M W / Tiu, Sau-Cheung / Wong, Lily L L

Journal of the American Dietetic Association

2004 Volume 104, Issue 12, Page(s) 1854–1858

Abstract: The objective of this study is to examine the glycemic response to common Chinese foods in patients with type 2 diabetes. Twenty-four Chinese adults with type 2 diabetes participated. Subjects were allocated to eat a pair of test meals in random order. ... ...

Abstract	The objective of this study is to examine the glycemic response to common Chinese foods in patients with type 2 diabetes. Twenty-four Chinese adults with type 2 diabetes participated. Subjects were allocated to eat a pair of test meals in random order. Test meals included plain porridge with lean pork (meal 1A), plain porridge and Shrimp Shao Mai (Doll Brand, Winner Food Products Limited, Hong Kong) (meal 1B), boiled rice with boiled egg white (meal 2A), fried rice with whole egg (meal 2B), plain noodles in clear soup (meal 3A), and Pickled Vegetable and Pork-flavored Instant Bowl Noodles (Doll Brand, Winner Food Products Limited) (meal 3B). Nutritional content of the meals was calculated from the nutritional label on the food package and the food composition table. Plasma glucose was checked before the meal and in 30-minute intervals for up to 4 hours after the meal. Significant differences in the area under the curve of glucose up to 2 hours after the meal were detected between meal 1A and 2A ( P =.044), 1A and 3A ( P =.001), and 3A and 3B ( P =.017). The results suggest that fat alone does not alter the glycemic response to rice or porridge. Porridge produces a higher glycemic response than rice and noodles despite similar carbohydrate contents, and different noodles lead to differences in glycemic excursion, suggesting that the glycemic index of common Chinese foods is affected by cooking methods and food processing.
MeSH term(s)	Analysis of Variance ; Area Under Curve ; Blood Glucose/metabolism ; China/ethnology ; Cooking/methods ; Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/metabolism ; Diet ; Dietary Fats/administration & dosage ; Dietary Fats/metabolism ; Female ; Food Handling/methods ; Food Preferences/ethnology ; Glycemic Index ; Hong Kong ; Humans ; Insulin/metabolism ; Male ; Middle Aged ; Postprandial Period
Chemical Substances	Blood Glucose ; Dietary Fats ; Insulin
Language	English
Publishing date	2004-12
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	390806-9
ISSN	1878-3570 ; 0002-8223
ISSN (online)	1878-3570
ISSN	0002-8223
DOI	10.1016/j.jada.2004.09.020
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Book: Development of the human cerebral cortex

Tiu, Sau Cheung

a histochemical study

(Progress in histochemistry and cytochemistry, ; v. 38, no. 1)

2002

Author's details	Sau Cheung Tiu, David T. Yew, Wood Yee Chan
Series title	Progress in histochemistry and cytochemistry, ; v. 38, no. 1
Language	English
Size	149 p. :, ill. ;, 24 cm.
Publisher	Urban & Fischer
Publishing place	Jena, Germany
Document type	Book
Database	NAL-Catalogue (AGRICOLA)

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Article: The use of aldosterone-renin ratio as a diagnostic test for primary hyperaldosteronism and its test characteristics under different conditions of blood sampling.

Tiu, Sau-Cheung / Choi, Cheung-Hei / Shek, Chi-Chung / Ng, Ying-Wai / Chan, Fredriech K W / Ng, Chiu-Ming / Kong, Alice P S

The Journal of clinical endocrinology and metabolism

2005 Volume 90, Issue 1, Page(s) 72–78

Abstract: Recent reviews recommended the use of the aldosterone/renin ratio (ARR) to screen for primary hyperaldosteronism. However, widely different cutoff levels have been proposed, and test characteristics of ARR under different conditions of sampling are not ... ...

Abstract	Recent reviews recommended the use of the aldosterone/renin ratio (ARR) to screen for primary hyperaldosteronism. However, widely different cutoff levels have been proposed, and test characteristics of ARR under different conditions of sampling are not known. We conducted a retrospective review among 45 subjects with carefully validated diagnoses of primary hyperaldosteronism and 17 subjects with essential hypertension to study the utility of ARR. Sixty-two patients with 75 sets of plasma renin activity (PRA), aldosterone, and ARR values from a postural study and 48 sets of values from a saline suppression test were analyzed. Ninety-four percent of these subjects underwent investigations because of hypokalemic hypertension.ARR yielded larger areas under the curve in the receiver-operating-characteristics curve than PRA or aldosterone under all conditions of testing. Our results confirmed the superiority of ARR to either aldosterone or PRA alone as a diagnostic test for primary hyperaldosteronism.ARR cutoff levels were significantly affected by the condition of testing. Depending on posture and time of day, it varied from 13.1-35.0 ng/dl per ng/ml.h in our study population. When using ARR for screening primary hyperaldosteronism, posture and time of sampling should be standardized both within and between centers to minimize variability in cutoff levels.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aldosterone/blood ; Blood Specimen Collection/methods ; Female ; Humans ; Hyperaldosteronism/blood ; Hyperaldosteronism/diagnosis ; Male ; Middle Aged ; ROC Curve ; Renin/blood ; Retrospective Studies
Chemical Substances	Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2004-1149
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Article ; Online: Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

Cheung, Ching-Lung / Lau, Kam-Shing / Ho, Andrew Y Y / Lee, Ka-Kui / Tiu, Sau-Cheung / Lau, Emmy Y F / Leung, Jenny / Tsang, Man-Wo / Chan, Kin-Wah / Yeung, Chun-Yip / Woo, Yu-Cho / Cheung, Elaine Y N / Hung, Victor H F / Pang, Ho-Kwong / Hung, Chi-Sang / Sham, Pak-Chung / Kung, Annie W C

Nature genetics

2012 Volume 44, Issue 9, Page(s) 1026–1029

Abstract: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of thyrotoxicosis. We conducted a genome-wide association study (GWAS) and a replication study with a total of 123 southern Chinese with TPP (cases) and 1,170 healthy ... ...

Abstract	Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of thyrotoxicosis. We conducted a genome-wide association study (GWAS) and a replication study with a total of 123 southern Chinese with TPP (cases) and 1,170 healthy controls and identified a susceptibility locus on chromosome 17q24.3 near KCNJ2 (rs312691: odds ratio (OR) = 3.3; P(meta-analysis) = 1.8 × 10(-14)). All subjects with TPP also had Graves' disease, and subsequent TPP versus Graves' disease comparison confirmed that the association at 17q24.3 was specific to TPP. The area under the curve (AUC) of rs312691 genotype for risk prediction of TPP in subjects with Graves' disease was 0.73. Expression quantitative trait locus (eQTL) analysis identified SNPs in the region flanking rs312691 (±10 kb) that could potentially affect KCNJ2 expression (P = 0.0001). Our study has identified a susceptibility locus associated with TPP and provides insight into the causes of TPP.
MeSH term(s)	Adult ; Asian Continental Ancestry Group/genetics ; Chromosomes, Human, Pair 17/genetics ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Paralyses, Familial Periodic/ethnology ; Paralyses, Familial Periodic/etiology ; Paralyses, Familial Periodic/genetics ; Polymorphism, Single Nucleotide/physiology ; Potassium Channels, Inwardly Rectifying/genetics ; Quantitative Trait Loci/genetics ; Quantitative Trait Loci/physiology ; Thyrotoxicosis/complications ; Thyrotoxicosis/ethnology ; Thyrotoxicosis/genetics
Chemical Substances	KCNJ16 protein, human ; KCNJ2 protein, human ; Potassium Channels, Inwardly Rectifying
Language	English
Publishing date	2012-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/ng.2367
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Zs.A 3613: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Increased bone mineral density in patients with chronic hypoparathyroidism.

Chan, Fredriech K W / Tiu, Sau-Cheung / Choi, Kin-Lam / Choi, Cheung-Hei / Kong, Alice P S / Shek, Chi-Chung

The Journal of clinical endocrinology and metabolism

2003 Volume 88, Issue 7, Page(s) 3155–3159

Abstract: Bone mineral density (BMD) has been shown to be increased in postmenopausal females with postthyroidectomy hypoparathyroidism, but it is not known whether similar gains occur in patients with idiopathic hypoparathyroidism. In this study, we measured the ... ...

Abstract	Bone mineral density (BMD) has been shown to be increased in postmenopausal females with postthyroidectomy hypoparathyroidism, but it is not known whether similar gains occur in patients with idiopathic hypoparathyroidism. In this study, we measured the BMD of lumbar spine and proximal femur in 14 patients, 8 with idiopathic hypoparathyroidism and 6 with postthyroidectomy hypoparathyroidism, using dual-energy x-ray absorptiometry. Their age ranged from 23-57 yr old, with a mean of 42.5 yr. The results showed that patients with hypoparathyroidism had a higher BMD than the normal age- and sex-matched population. This was particularly evident at the lumbar spine (L2-L4), with positive Z-score of 1.93 +/- 1.03, whereas Z-score at the femoral neck was 1.14 +/- 0.62 SD. Subgroup analysis showed that those with postthyroidectomy hypoparathyroidism had a mean lumbar spine BMD of 1.434 g/cm(2) and femoral neck BMD of 1.026 g/cm(2), compared with a mean BMD of 1.364 g/cm(2) and 1.022 g/cm(2) at spine and hip, respectively, for those with idiopathic hypoparathyroidism. Statistical analysis did not reveal any significant difference in the BMD, T-score, and Z-score of the bone, at these two sites, between the two groups. In conclusion, the state of chronic hypoparathyroidism is associated with increased BMD, especially at the lumbar spine. Those with idiopathic hypoparathyroidism have a similar degree of increase in BMD as those with postthyroidectomy hypoparathyroidism.
MeSH term(s)	Absorptiometry, Photon ; Adult ; Bone Density ; Chronic Disease ; Cross-Sectional Studies ; Female ; Femur Neck/diagnostic imaging ; Femur Neck/pathology ; Humans ; Hypoparathyroidism/diagnostic imaging ; Hypoparathyroidism/etiology ; Hypoparathyroidism/pathology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/pathology ; Male ; Middle Aged ; Postoperative Complications ; Thyroidectomy
Language	English
Publishing date	2003-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2002-021388
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