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  1. Article ; Online: Easy to miss large left atrial myxoma.

    Kelleher, Art Burgess / Ní Dhonnchu, Tara / Vaughan, Carl / O'Connor, Terence M

    BMJ case reports

    2023  Volume 16, Issue 8

    MeSH term(s) Humans ; Atrial Fibrillation
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255616
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  2. Article ; Online: Situated learning in community environments (SLICE): Systems design of an immersive and integrated curriculum for community-based learning.

    Taoube, Linda / Khanna, Priya / Schneider, Carl / Burgess, Annette / Bleasel, Jane / Haq, Inam / Roberts, Chris

    Medical teacher

    2022  Volume 45, Issue 1, Page(s) 80–88

    Abstract: Purpose: We sought to design a micro-curriculum to structure supervised clinical placements for junior medical students within a variety of community-based settings of differing clinical disciplines. Given the gaps in the literature, this paper reflects ...

    Abstract Purpose: We sought to design a micro-curriculum to structure supervised clinical placements for junior medical students within a variety of community-based settings of differing clinical disciplines. Given the gaps in the literature, this paper reflects on the opportunities and challenges of our design, implementation, and evaluation strategies in constructing an integrated task-based micro-curriculum for interprofessional community-based learning in year 2 of a four-year graduate entry program.
    Methods: The design was informed by a systems thinking framework and guided by contemporary curricular theories on self-directed and interprofessional learning. Extensive consultations with stakeholders were undertaken. Alignment with relevant national level documents and curricular frameworks was ensured.
    Results: The systems thinking approach provided first, an experience of applying thinking tools for a deeper understanding of how various parts of this micro-curriculum and subsystems should be integrated. Second, applying the toolkit uncovered tension points on which leverage could optimise future enhancements. Eighteen types of health professions were recruited including 105 general practitioners and 253 healthcare practitioners from a range of disciplines.
    Conclusion: Systems thinking allows for the identification of various interacting elements within the curriculum to be considered as part of an integrated whole. Insights from this model could inform the design of similar innovative curricula.
    MeSH term(s) Humans ; Curriculum ; Learning ; Models, Educational ; Health Occupations ; Students, Medical
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2022.2102468
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    Zs.B 2176: Show issues Location:
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  3. Article ; Online: Assessing Immediate Bed Availability and Barriers to Discharge in a United States Children's Hospital.

    Burgess, M Catherine / DeLorenzo, Debbie / Eriksson, Carl

    Disaster medicine and public health preparedness

    2020  Volume 15, Issue 5, Page(s) 563–567

    Abstract: Objectives: The aim of this study was to quantify immediate bed availability (IBA) in a United States children's hospital and treatment needs of hospitalized patients whose needs could be met outside a traditional hospital setting.: Methods: Using a ... ...

    Abstract Objectives: The aim of this study was to quantify immediate bed availability (IBA) in a United States children's hospital and treatment needs of hospitalized patients whose needs could be met outside a traditional hospital setting.
    Methods: Using a novel tool to capture census, scheduled discharges, and resource needs for hospitalized patients, we surveyed our hospital's 5 non-neonatal inpatient pediatric units on 4 d over 1 y.
    Results: Median ward occupancy was 81% (range, 58-79), median intensive care unit occupancy was 80% (range, 7-19), and median IBA was 42% (range, 34-59). A median of 14 patients per day (13% of total capacity) had treatment needs that could be met by providing limited support in a nontraditional setting; the most common reason for requiring ongoing hospitalization in this group of patients was a safe discharge plan.
    Conclusions: Our median IBA of 42% exceeds federal recommendations, but varies widely between days surveyed. Even on days when IBA percentage is high, our total number of available beds is unlikely to meet pediatric population needs in a large-scale public health emergency.
    MeSH term(s) Child ; Hospitals, Pediatric ; Humans ; Intensive Care Units ; Patient Discharge ; United States
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2020.62
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  4. Article: Right in two: capabilities of ion mobility spectrometry for untargeted metabolomics.

    Moses, Tessa / Burgess, Karl

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1230282

    Abstract: This mini review focuses on the opportunities provided by current and emerging separation techniques for mass spectrometry metabolomics. The purpose of separation technologies in metabolomics is primarily to reduce complexity of the heterogeneous systems ...

    Abstract This mini review focuses on the opportunities provided by current and emerging separation techniques for mass spectrometry metabolomics. The purpose of separation technologies in metabolomics is primarily to reduce complexity of the heterogeneous systems studied, and to provide concentration enrichment by increasing sensitivity towards the quantification of low abundance metabolites. For this reason, a wide variety of separation systems, from column chemistries to solvent compositions and multidimensional separations, have been applied in the field. Multidimensional separations are a common method in both proteomics applications and gas chromatography mass spectrometry, allowing orthogonal separations to further reduce analytical complexity and expand peak capacity. These applications contribute to exponential increases in run times concomitant with first dimension fractionation followed by second dimension separations. Multidimensional liquid chromatography to increase peak capacity in metabolomics, when compared to the potential of running additional samples or replicates and increasing statistical confidence, mean that uptake of these methods has been minimal. In contrast, in the last 15 years there have been significant advances in the resolution and sensitivity of ion mobility spectrometry, to the point where high-resolution separation of analytes based on their collision cross section approaches chromatographic separation, with minimal loss in sensitivity. Additionally, ion mobility separations can be performed on a chromatographic timescale with little reduction in instrument duty cycle. In this review, we compare ion mobility separation to liquid chromatographic separation, highlight the history of the use of ion mobility separations in metabolomics, outline the current state-of-the-art in the field, and discuss the future outlook of the technology. "Where there is one, you're bound to divide it. Right in two", James Maynard Keenan.
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1230282
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  5. Article ; Online: Assessment of post-concussion emotional symptom load using PCSS and PROMIS instruments in pediatric patients.

    Johnson, Gina M / Wild, Jacob T / Burgess, Jamie K / McCracken, Kristi / Malekian, Sina / Turner, Jacqueline A / King, Kiana / Kwon, Soyang / Carl, Rebecca L / LaBella, Cynthia R

    The Physician and sportsmedicine

    2023  , Page(s) 1–9

    Abstract: Objectives: The purpose of this study is to evaluate the utility of the Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and depressive symptom domains in conjunction with the Post-Concussion Symptom Scale (PCSS)for identifying ... ...

    Abstract Objectives: The purpose of this study is to evaluate the utility of the Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and depressive symptom domains in conjunction with the Post-Concussion Symptom Scale (PCSS)for identifying pediatric patients with emotional symptoms following a concussion, and to identify predictors of higher emotional symptom loads.
    Methods: We recruited English-speaking patients aged 8-17 years presenting to a tertiary-care concussion clinic from 2014 to 2018 (
    Results: Overall, 425 (92.8%) reported ≥1 emotional symptom on either PROMIS or PCSS. Predictors of higher emotional symptom loads were abnormal VOMS, female sex, history of anxiety or depression, and longer time since injury.
    Conclusion: Our results suggest that adding PROMIS anxiety and depressive symptom surveys to pediatric concussion evaluations may identify more children with emotional symptoms, allowing clinicians to better direct post-concussion treatment and incorporate psychological support for patients if necessary. Future studies should examine whether earlier identification of emotional symptoms with these tools facilitates recovery and improves short- and/or long-term psychological outcomes in pediatric concussion.
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 753046-8
    ISSN 2326-3660 ; 0091-3847
    ISSN (online) 2326-3660
    ISSN 0091-3847
    DOI 10.1080/00913847.2023.2239159
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    Zs.B 1926: Show issues Location:
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  6. Article ; Online: Impact of the COVID-19 pandemic on transgender and gender diverse health care.

    Burgess, Claire M / Batchelder, Abagail W / Sloan, Colleen A / Ieong, Michael / Streed, Carl G

    The lancet. Diabetes & endocrinology

    2021  Volume 9, Issue 11, Page(s) 729–731

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Delivery of Health Care/methods ; Delivery of Health Care/trends ; Humans ; Pandemics ; Transgender Persons/psychology ; Transsexualism/psychology ; Transsexualism/therapy
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(21)00266-7
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  7. Article: Optimisation of surfactin yield in

    Albornoz, Ricardo Valencia / Oyarzún, Diego / Burgess, Karl

    Computational and structural biotechnology journal

    2024  Volume 23, Page(s) 1226–1233

    Abstract: Integration of machine learning and high throughput measurements are essential to drive the next generation of the design-build-test-learn (DBTL) cycle in synthetic biology. Here, we report the use of active learning in combination with metabolomics for ... ...

    Abstract Integration of machine learning and high throughput measurements are essential to drive the next generation of the design-build-test-learn (DBTL) cycle in synthetic biology. Here, we report the use of active learning in combination with metabolomics for optimising production of surfactin, a complex lipopeptide resulting from a non-ribosomal assembly pathway. We designed a media optimisation algorithm that iteratively learns the yield landscape and steers the media composition toward maximal production. The algorithm led to a 160 % yield increase after three DBTL runs as compared to an M9 baseline. Metabolomics data helped to elucidate the underpinning biochemistry for yield improvement and revealed Pareto-like trade-offs in production of other lipopeptides from related pathways. We found positive associations between organic acids and surfactin, suggesting a key role of central carbon metabolism, as well as system-wide anisotropies in how metabolism reacts to shifts in carbon and nitrogen levels. Our framework offers a novel data-driven approach to improve yield of biological products with complex synthesis pathways that are not amenable to traditional yield optimisation strategies.
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2024.02.012
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  8. Article: "I Can't Get No Satisfaction": Measuring Student Satisfaction in the Age of a Consumerist Higher Education.

    Senior, Carl / Moores, Elisabeth / Burgess, Adrian P

    Frontiers in psychology

    2017  Volume 8, Page(s) 980

    Language English
    Publishing date 2017-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2017.00980
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  9. Article ; Online: A 10-year case study on the changing determinants of university student satisfaction in the UK.

    Burgess, Adrian / Senior, Carl / Moores, Elisabeth

    PloS one

    2018  Volume 13, Issue 2, Page(s) e0192976

    Abstract: Higher Education (HE), once the prerogative of a tiny elite, is now accessible to larger numbers of people around the world than ever before yet despite the fact that an understanding of student satisfaction has never been more important for today's ... ...

    Abstract Higher Education (HE), once the prerogative of a tiny elite, is now accessible to larger numbers of people around the world than ever before yet despite the fact that an understanding of student satisfaction has never been more important for today's universities, the concept remains poorly understood. Here we use published data from the UK's National Student Survey (NSS), representing data from 2.3 million full-time students collected from 2007 to 2016, as a case study of the benefits and limitations of measuring student satisfaction that might have applicability for other countries, particularly those that, like the UK, have experienced significant growth in student numbers. The analyses showed that the factor structure of the NSS remained generally stable and that the ability of the NSS to discriminate between different subjects at different universities actually improved over the ten-year sample period. The best predictors of overall satisfaction were 'Teaching Quality' and 'Organisation & Management', with 'Assessment & Feedback' having relatively weak predictive ability, despite the sector's tangible efforts to improve on this metric. The tripling of student fees in 2012 for English students (but not the rest of the UK) was used as a 'natural experiment' to investigate the sensitivity of student satisfaction ratings to the real economic costs of HE. The tuition fee increase had no identifiable negative effect, with student satisfaction steadily improving throughout the decade. Although the NSS was never designed to measure perceived value-for-money, its insensitivity to major changes in the economic costs of HE to the individual suggest that the conventional concept of student satisfaction is incomplete. As such we propose that the concept of student satisfaction: (i) needs to be widened to take into account the broader economic benefits to the individual student by including measures of perceived value-for-money and (ii) should measure students' level of satisfaction in the years post-graduation, by which time they may have a greater appreciation of the value of their degree in the workplace.
    MeSH term(s) Educational Measurement ; Factor Analysis, Statistical ; Humans ; Personal Satisfaction ; Students/psychology ; United Kingdom ; Universities/economics ; Universities/trends
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0192976
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  10. Article ; Online: Ability of 3- to 5-year-old children to use simplified self-report measures of pain intensity.

    Jaaniste, Tiina / Burgess, Ashleigh / Mohanachandran, Mathushinee / von Baeyer, Carl L / Champion, G David

    Journal of child health care : for professionals working with children in the hospital and community

    2020  Volume 25, Issue 3, Page(s) 442–456

    Abstract: Little is known about self-report pain intensity scales best suited for young children. We tested the ability of preschool children to use two simplified scales (concrete ordinal and faces). Three- to 5-year-olds ( ...

    Abstract Little is known about self-report pain intensity scales best suited for young children. We tested the ability of preschool children to use two simplified scales (concrete ordinal and faces). Three- to 5-year-olds (
    MeSH term(s) Child, Preschool ; Humans ; Pain ; Pain Measurement ; Self Report
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299167-0
    ISSN 1741-2889 ; 1367-4935
    ISSN (online) 1741-2889
    ISSN 1367-4935
    DOI 10.1177/1367493520951302
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