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Article ; Online: Unrelated hematopoietic stem cell donors as research subjects.

Appelbaum, F R

2011 Volume 46, Issue 1, Page(s) 14

MeSH term(s)	Hematopoietic Stem Cell Transplantation ; Humans ; Research Subjects ; Therapeutic Human Experimentation/ethics ; Tissue Donors ; Tissue and Organ Procurement/ethics ; United States
Language	English
Publishing date	2011-01
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2010.269
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Zs.A 2168: Show issues

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Article ; Online: Getting out of the bay faster: Assessing trauma team performance using trauma video review.

Maiga, Amelia W / Vella, Michael A / Appelbaum, Rachel D / Irlmeier, Rebecca / Ye, Fei / Holena, Daniel N / Dumas, Ryan P

The journal of trauma and acute care surgery

2023 Volume 96, Issue 1, Page(s) 76–84

Abstract: Background: Minutes matter for trauma patients in hemorrhagic shock. How trauma team function impacts time to the next phase of care has not been rigorously evaluated. We hypothesized better team performance scores to be associated with decreased time ... ...

Abstract	Background: Minutes matter for trauma patients in hemorrhagic shock. How trauma team function impacts time to the next phase of care has not been rigorously evaluated. We hypothesized better team performance scores to be associated with decreased time to the next phase of trauma care. Methods: This retrospective secondary analysis of a prospective multicenter observational study included hypotensive trauma patients at 19 centers. Using trauma video review, we analyzed team performance with the validated Non-Technical Skills for Trauma scale: leadership, cooperation and resource management, communication, assessment/decision making, and situational awareness. The primary outcome was minutes from patient arrival to next phase of care; deaths in the bay were excluded. Secondary outcomes included time to initiation and completion of first unit of blood and inpatient mortality. Associations between team dynamics and outcomes were assessed with a linear mixed-effects model adjusting for Injury Severity Score, mechanism, initial blood pressure and heart rate, number of team members, and trauma team lead training level and sex. Results: A total of 441 patients were included. The median Injury Severity Score was 22 (interquartile range, 10-34), and most (61%) sustained blunt trauma. The median time to next phase of care was 23.5 minutes (interquartile range, 17-35 minutes). Better leadership, communication, assessment/decision making, and situational awareness scores were associated with faster times to next phase of care (all p < 0.05). Each 1-point worsening in the Non-Technical Skills for Trauma scale score (scale, 5-15) was associated with 1.6 minutes more in the bay. The median resuscitation team size was 12 (interquartile range, 10-15), and larger teams were slower ( p < 0.05). Better situational awareness was associated with faster completion of first unit of blood by 4 to 5 minutes ( p < 0.05). Conclusion: Better team performance is associated with faster transitions to next phase of care in hypotensive trauma patients, and larger teams are slower. Trauma team training should focus on optimizing team performance to facilitate faster hemorrhage control. Level of evidence: Therapeutic/Care Management; Level III.
MeSH term(s)	Humans ; Retrospective Studies ; Prospective Studies ; Bays ; Clinical Competence ; Communication ; Resuscitation/education ; Patient Care Team
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004168
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Zs.A 127: Show issues

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Article ; Online: Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with MDS/AML or AML.

Orvain, Corentin / Ali, Naveed / Othus, Megan / Rodríguez-Arbolí, Eduardo / Milano, Filippo / Le, Calvin M / Sandmaier, Brenda M / Scott, Bart L / Appelbaum, Frederick R / Walter, Roland B

American journal of hematology

2024 Volume 99, Issue 5, Page(s) 862–870

Abstract: Multiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined ... ...

Abstract	Multiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined disease entity, myelodysplastic neoplasm (MDS)/AML is unknown. To assess the relationship between disease type, pre-HCT MRD, and post-HCT outcomes, we retrospectively analyzed 1265 adults with MDS/AML (n = 151) or AML (n = 1114) who received a first allograft in first or second morphologic remission at a single institution between April 2006 and March 2023. At 3 years, relapse rates (29% for MDS/AML vs. 29% for AML, p = .98), relapse-free survival (RFS; 50% vs. 55%, p = .22), overall survival (OS; 52% vs. 60%, p = .073), and non-relapse mortality (22% vs. 16%, p = .14) were not statistically significantly different. However, a significant interaction was found between pre-HCT MFC MRD and disease type (MDS/AML vs. AML) for relapse (p = .009), RFS (p = .011), and OS (p = .039). The interaction models indicated that the hazard ratios (HRs) for the association between pre-HCT MRD and post-HCT outcomes were lower in patients with MDS/AML (for relapse: HR = 1.75 [0.97-3.15] in MDS/AML vs. 4.13 [3.31-5.16] in AML; for RFS: HR = 1.58 [1.02-2.45] vs. 2.98 [2.48-3.58]; for OS: HR = 1.50 [0.96-2.35] vs. 2.52 [2.09-3.06]). On the other hand, residual cytogenetic abnormalities at the time of HCT were equally informative in MDS/AML as in AML patients. Our data indicate that MFC-based pre-HCT MRD testing, but not testing for residual cytogenetic abnormalities, is less informative for MDS/AML than AML patients when used for prognostication of post-HCT outcomes.
MeSH term(s)	Adult ; Humans ; Prognosis ; Flow Cytometry ; Retrospective Studies ; Recurrence ; Chromosome Aberrations ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual ; Chronic Disease
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27259
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Zs.A 1251: Show issues

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Article ; Online: Impact of socioeconomic disparities on outcomes in adults undergoing allogeneic hematopoietic cell transplantation for acute myeloid leukemia.

Olivieri, Daniel J / Othus, Megan / Orvain, Corentin / Rodríguez-Arbolí, Eduardo / Milano, Filippo / Sandmaier, Brenda M / Khan, Irum / Davis, Chris / Basom, Ryan S / Appelbaum, Frederick R / Walter, Roland B

Leukemia

2024 Volume 38, Issue 4, Page(s) 865–876

Abstract: Racial and socioeconomic disparities impact outcomes after chemotherapy and limit access to allogeneic hematopoietic cell transplantation (HCT) in acute myeloid leukemia (AML), yet studies have yielded mixed results on the influence of disparities on ... ...

Abstract	Racial and socioeconomic disparities impact outcomes after chemotherapy and limit access to allogeneic hematopoietic cell transplantation (HCT) in acute myeloid leukemia (AML), yet studies have yielded mixed results on the influence of disparities on post-HCT outcomes. Therefore, we studied 1024 adults with AML who underwent allogeneic HCT between 5/2006 and 10/2021 at a single large university-affiliated cancer center. Collected data included non-biologic and demographic characteristics (including race/ethnicity, marital status, distance traveled, and household size), transplant- and disease-related characteristics, and area-level and individual-level socioeconomic factors (i.e., area deprivation index and occupational status). After multivariable adjustment, no socioeconomic- or non-biologic factors were associated with non-relapse mortality (NRM), overall survival (OS), relapse-free survival (RFS), or relapse except being married (associated with improved NRM: hazard ratio [HR] = 0.7 [0.50-0.97]) and having no insurance (associated with worse OS: HR = 1.49 [1.05-2.12] and RFS: HR = 1.41 [1.00-1.98]). Despite a relatively racially homogenous cohort, Asian race was associated with improved NRM (HR = 0.47 [0.23-0.93]) and American Indian/Alaskan Native race was associated with higher relapse risk (HR = 2.45 [1.08-5.53]). In conclusion, in our retrospective analysis, socioeconomic-, demographic-, and non-biologic factors had limited impact on post-HCT outcomes in AML patients allografted in morphologic remission. Further research is needed to investigate disparities among HCT-eligible patients.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Socioeconomic Disparities in Health ; Hematopoietic Stem Cell Transplantation/methods ; Leukemia, Myeloid, Acute ; Recurrence ; Transplantation Conditioning/methods
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-024-02172-3
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Zs.A 2295: Show issues

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Article: Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish.

Lloyd, Evan / Xia, Fanning / Moore, Kinsley / Zertuche, Carolina / Rastogi, Aakriti / Kozol, Rob / Kenzior, Olga / Warren, Wesley / Appelbaum, Lior / Moran, Rachel L / Zhao, Chongbei / Duboue, Erik / Rohner, Nicolas / Keene, Alex C

bioRxiv : the preprint server for biology

2024

Abstract: Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of neuronal health. ...

Abstract	Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of neuronal health. While the effects of sleep on cellular function are not completely understood, growing evidence has identified an association between sleep loss and DNA damage, raising the possibility that sleep facilitates efficient DNA repair. The Mexican tetra fish,
Language	English
Publishing date	2024-04-21
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.18.590174
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Article ; Online: Contribution of measurable residual disease status to prediction accuracy of relapse and survival in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation.

Rodríguez-Arbolí, Eduardo / Othus, Megan / Orvain, Corentin / Zarling, Lucas C / Sandmaier, Brenda M / Milano, Filippo / Schoch, Gary / Davis, Chris / Deeg, H Joachim / Appelbaum, Frederick R / Storb, Rainer / Walter, Roland B

Haematologica

2023 Volume 108, Issue 1, Page(s) 273–277

MeSH term(s)	Adult ; Humans ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/therapy ; Chronic Disease ; Recurrence ; Neoplasm, Residual ; Retrospective Studies ; Transplantation Conditioning
Language	English
Publishing date	2023-01-01
Publishing country	Italy
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2022.281631
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Uh III Zs.76: Show issues

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Article: An Analysis of Motivating Factors in 1,725 Worldwide Cases of Mass Murder Between 1900-2019.

Brucato, Gary / Hesson, Hannah / Dishy, Gabriella / Lee, Kathryn / Pia, Tyler / Syed, Faizan / Villalobos, Alexandra / Rogers, R Tyler / Corbeil, Thomas / Stone, Michael H / Lieberman, Jeffrey A / Appelbaum, Paul S / Girgis, Ragy R

The journal of forensic psychiatry & psychology

2023 Volume 34, Issue 2, Page(s) 261–274

Abstract: Mass murder, particularly mass shootings, constitutes a major, growing public health concern. Specific motivations for these acts are not well understood, often overattributed to severe mental illness. Identifying diverse factors motivating mass murders ... ...

Abstract	Mass murder, particularly mass shootings, constitutes a major, growing public health concern. Specific motivations for these acts are not well understood, often overattributed to severe mental illness. Identifying diverse factors motivating mass murders may facilitate prevention. We examined 1,725 global mass murders from 1900-2019, publicly described in English in print or online. We empirically categorized each into one of ten categories reflecting reported primary motivating factors, which were analyzed across mass murderers generally, as well as between U.S- and non-U.S.-based mass-shooters. Psychosis or disorganization related to mental illness were infrequently motivational factors (166; 9.6%), and were significantly more associated with mass murder committed using methods other than firearms. The vast majority (998, 57.86%) of incidents were impulsive and emotionally-driven, following adverse life circumstances. Most mass murderers prompted by emotional upset were found to be driven by despair or extreme sadness over life events (161, 16.13% within the category); romantic rejection or loss, or severe jealousy (204, 20.44% within the category); some specific non-romantic grudge (212, 21.24% within the category); or explosive, overwhelming rage following a dispute (266, 26.65% within the category). Results suggest that policies seeking to prevent mass murder should focus on criminal history, as well as subacute emotional disturbances not associated with severe mental illness in individuals with poor coping skills who have recently experienced negative life events.
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2112051-1
ISSN	1478-9957 ; 1478-9949
ISSN (online)	1478-9957
ISSN	1478-9949
DOI	10.1080/14789949.2023.2208570
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Zs.A 2981: Show issues

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Article: Dose intensity and the toxicity and efficacy of allogeneic hematopoietic cell transplantation.

Appelbaum, F R

Leukemia

2005 Volume 19, Issue 2, Page(s) 171–175

MeSH term(s)	Combined Modality Therapy ; Graft vs Host Disease/epidemiology ; Humans ; Leukemia/drug therapy ; Leukemia/therapy ; Neoplasms/therapy ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/methods ; Transplantation, Homologous/adverse effects ; Transplantation, Homologous/physiology
Language	English
Publishing date	2005-02
Publishing country	England
Document type	Addresses ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/sj.leu.2403609
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Zs.A 2295: Show issues

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Article ; Online: Reducing the Single IRB Burden: Streamlining Electronic IRB Systems.

Murray, Alexandra / Pivovarova, Ekaterina / Klitzman, Robert / Stiles, Deborah F / Appelbaum, Paul / Lidz, Charles W

AJOB empirical bioethics

2020 Volume 12, Issue 1, Page(s) 33–40

Abstract: Electronic institutional review board systems (eIRBs) have become an integral component in ensuring compliance with Human Research Protection Program (HRPP) and IRB requirements. Despite this, few of these systems are configured to administer the single ... ...

Abstract	Electronic institutional review board systems (eIRBs) have become an integral component in ensuring compliance with Human Research Protection Program (HRPP) and IRB requirements. Despite this, few of these systems are configured to administer the single IRB (sIRB) process mandated by the National Institutes of Health (NIH) for multisite research. We interviewed 103 sIRB administrators, chairs, members, and staff members about their experiences with sIRB multisite research review. We observed three main obstacles to adapting existing eIRB systems to accommodate the sIRB process: (1) Existing systems are not designed for sIRBs and are not configured to administer sIRB responsibilities, (2) they are not interoperable, and (3) resources to improve existing systems are lacking. Our findings suggest that IRBs that act as an sIRB will need major changes to their electronic systems in order to accommodate sIRB processes. These difficulties threaten both the ability of IRBs to focus on ethical rather than bureaucratic problems and the efficiency of multisite trials.
MeSH term(s)	Biomedical Research/ethics ; Electronics ; Ethics Committees, Research ; Ethics, Research ; Humans ; Information Systems ; Multicenter Studies as Topic ; National Institutes of Health (U.S.) ; Social Control, Formal ; United States
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2763190-4
ISSN	2329-4523 ; 2329-4515
ISSN (online)	2329-4523
ISSN	2329-4515
DOI	10.1080/23294515.2020.1818877
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Zs.A 6890: Show issues

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Article ; Online: When IRBs Say No to Participating in Research about Single IRBs.

Klitzman, Robert / Appelbaum, Paul S / Murray, Alexandra / Pivovarova, Ekaterina / Stiles, Deborah F / Lidz, Charles W

Ethics & human research

2020 Volume 42, Issue 1, Page(s) 36–40

Abstract: In response to a policy of the National Institutes of Health and requirements in the revised Common Rule, a protocol for a multisite study must be reviewed by a single institutional review board (IRB), rather than by the IRB at each study site. The goal ... ...

Abstract	In response to a policy of the National Institutes of Health and requirements in the revised Common Rule, a protocol for a multisite study must be reviewed by a single institutional review board (IRB), rather than by the IRB at each study site. The goal of the single IRB approach is to increase the efficiency of IRB review of multisite research without jeopardizing protections for research subjects. Yet the extent to which these joint goals are being achieved is unclear. To better understand how single IRBs function, we recruited academic, government, and commercial single IRBs (N = 49) to participate in a study involving observation of protocol review meetings and/or interviews with their members, chairs, and administrators. Twenty (40.8%) agreed to participate, of which 50% agreed to both interviews and observation. While 81.8% (9/11) of academic and 50% (4/8) of government single IRBs participated in some way, only 23.3% (7/30) of commercial single IRBs did so. The four largest commercial single IRBs declined to participate. Because evaluation of single IRBs is important to inform development, implementation, monitoring, and refinement of federal policies, single IRBs should be encouraged to participate in research that examines how they function.
MeSH term(s)	Conflict of Interest ; Ethics Committees, Research/organization & administration ; Humans ; Interviews as Topic ; National Institutes of Health (U.S.)/organization & administration ; National Institutes of Health (U.S.)/standards ; Research/organization & administration ; Research/standards ; United States
Language	English
Publishing date	2020-01-22
Publishing country	United States
Document type	Journal Article
ISSN	2578-2363
ISSN (online)	2578-2363
DOI	10.1002/eahr.500041
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