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Article: Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione, the B,C,D ring core of the shermilamine alkaloids.

Townsend, Norman O / Jackson, Yvette A

2003 Volume 1, Issue 20, Page(s) 3557–3563

Abstract: Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione (4), from N-(4-bromo-2,5 ...

Abstract	Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione (4), from N-(4-bromo-2,5-dimethoxyphenyl)acetamide (23) is described. Oxidative cyclisation of 2,2'-disulfanediylbis[N-(2,5-dimethoxyphenyl)acetamide] (19) to 5,8-dimethoxy-2H-1,4-benzothiazin-3(4H)-one (7b) is also reported.
Language	English
Publishing date	2003-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/b307124c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Besprechung von:] Allen, G. C.: British industry and economic policy. London 1979

Townsend, Harry / Allen, G. C

The economic journal : the journal of the Royal Economic Society Vol. 89 , p. 699-700

1979 Volume 89, Page(s) 699–700

Author's details	Harry Townsend
Publisher	Blackwell
Publishing place	Oxford [u.a.]
Document type	Article
ZDB-ID	3025-9
Database	ECONomics Information System

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Article ; Online: Innovations and trends in antibody repertoire analysis.

Townsend, Douglas R / Towers, Dalton M / Lavinder, Jason J / Ippolito, Gregory C

Current opinion in biotechnology

2024 Volume 86, Page(s) 103082

Abstract: ... antibody-based therapeutics (e.g. bispecific antibodies and chimeric antigen receptor T cells ...

Abstract	Monoclonal antibodies have revolutionized the treatment of human diseases, which has made them the fastest-growing class of therapeutics, with global sales expected to reach $346.6 billion USD by 2028. Advances in antibody engineering and development have led to the creation of increasingly sophisticated antibody-based therapeutics (e.g. bispecific antibodies and chimeric antigen receptor T cells). However, approaches for antibody discovery have remained comparatively grounded in conventional yet reliable in vitro assays. Breakthrough developments in high-throughput single B-cell sequencing and immunoglobulin proteomic serology, however, have enabled the identification of high-affinity antibodies directly from endogenous B cells or circulating immunoglobulin produced in vivo. Moreover, advances in artificial intelligence offer vast potential for antibody discovery and design with large-scale repertoire datasets positioned as the optimal source of training data for such applications. We highlight advances and recent trends in how these technologies are being applied to antibody repertoire analysis.
MeSH term(s)	Humans ; Proteomics ; Artificial Intelligence ; Antibodies, Monoclonal ; Antibodies, Bispecific
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Bispecific
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1052045-4
ISSN	1879-0429 ; 0958-1669
ISSN (online)	1879-0429
ISSN	0958-1669
DOI	10.1016/j.copbio.2024.103082
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Zs.A 3071: Show issues

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Article ; Online: Neurorehabilitation across the Continuum: From the Neurocritical care unit to home.

Ankar, Alexander / Hermes, Emily / Wheless, Catherine / Nguyen, Gabrielle / Townsend, Taryn / Risen, Sarah

Seminars in pediatric neurology

2024 Volume 49, Page(s) 101121

Abstract: Children admitted to neurocritical care units often experience new neurodevelopmental disabilities due to both their acquired neurologic injuries and deconditioning from prolonged hospitalizations. Rehabilitation for critically ill children is ... ...

Abstract	Children admitted to neurocritical care units often experience new neurodevelopmental disabilities due to both their acquired neurologic injuries and deconditioning from prolonged hospitalizations. Rehabilitation for critically ill children is multifactorial and begins in the intensive care unit itself. The goals of rehabilitation include prevention of complications associated with immobilization and evolving tone, comprehensive evaluation and treatment of functional deficits, and implementation of adaptive strategies with the goal of maximizing recovery. As a child progresses along the medical continuum from the neurocritical care unit to acute care to post-hospitalization settings, their rehabilitative needs and interventions should also evolve. A child in the neurocritical care unit is likely to have sustained an acquired brain injury. Whether resulting from traumatic or non-traumatic causes, all etiologies of pediatric acquired brain injury can result in significant challenges for the child and their family. Post-intensive care syndrome-pediatrics is a clinical construct that that systematically organizes the range of physical, cognitive, psychological, and social symptoms that emerge in both a child and their family members following a critical illness. Ideally, outpatient care for this population evaluates and supports all areas of post-intensive care syndrome-pediatrics through an interdisciplinary clinical care model. Proactive and comprehensive rehabilitation across the continuum provides the opportunity to support the child and their family in all areas affected, thereby minimizing distress, maximizing function, and optimizing outcomes.
MeSH term(s)	Humans ; Neurological Rehabilitation/methods ; Child ; Critical Care ; Continuity of Patient Care ; Brain Injuries/rehabilitation ; Critical Illness/rehabilitation
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1290000-x
ISSN	1558-0776 ; 1071-9091
ISSN (online)	1558-0776
ISSN	1071-9091
DOI	10.1016/j.spen.2024.101121
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Zs.A 4772: Show issues

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Article ; Online: Mentoring to engage diverse undergraduate nursing students in honors research.

Opsahl, Angela G / Townsend, Carolyn

Nursing forum

2020 Volume 56, Issue 1, Page(s) 19–23

Abstract: Background: A diverse workforce is necessary to reflect our communities and impact the health disparities of our increasingly diverse populations. Students from ethnic minority and socioeconomically disadvantaged backgrounds face many challenges and ... ...

Abstract	Background: A diverse workforce is necessary to reflect our communities and impact the health disparities of our increasingly diverse populations. Students from ethnic minority and socioeconomically disadvantaged backgrounds face many challenges and barriers to their academic success. Faculty must try new ways of supporting the engagement of this student population to positively affect quality outcomes for the entire community. Methods: High-performing students were recruited from undergraduate research courses to participate in a study to determine how honors research mentoring programs affect the engagement of undergraduate nursing students from ethnic minority and socioeconomically disadvantaged backgrounds. Findings: Study participants who were mentored for 3 years had a retention rate of 98%, compared to a rate of 73% in the year before the start of the mentoring initiative with faculty. NCLEX (National Council Licensure Examination)-RN pass rates were 95% for those in the mentoring program, compared to 84% for those not mentored. Of the students completing the program and passing the NCLEX-RN, 100% are employed in the local community. Conclusions: A competent and diverse nursing workforce is a priority for eliminating health disparities in rural and underserved communities. Supporting ethnic minority and socioeconomically disadvantaged students is valuable to bridging this gap and positively influencing our communities.
MeSH term(s)	Cultural Diversity ; Education, Nursing, Baccalaureate/methods ; Education, Nursing, Baccalaureate/trends ; Educational Measurement/methods ; Educational Measurement/standards ; Educational Status ; Humans ; Mentoring/methods ; Mentoring/statistics & numerical data ; Minority Groups/education ; Minority Groups/psychology ; Minority Groups/statistics & numerical data ; Students, Nursing/psychology ; Students, Nursing/statistics & numerical data
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	412336-0
ISSN	1744-6198 ; 0029-6473
ISSN (online)	1744-6198
ISSN	0029-6473
DOI	10.1111/nuf.12503
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Zs.B 623: Show issues

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Article ; Online: The benefits of difference-education interventions in lower-resourced institutions.

Stephens, Nicole M / Townsend, Sarah S M / Carey, Rebecca M / Hamedani, MarYam G / Brannon, Tiffany N / Murphy, Mary C

Journal of experimental psychology. General

2023 Volume 153, Issue 2, Page(s) 399–417

Abstract: Difference-education is an intervention that addresses psychological barriers that can undermine the academic performance of first-generation college students (i.e., those who have parents without 4-year degrees). Difference-education interventions ... ...

Abstract	Difference-education is an intervention that addresses psychological barriers that can undermine the academic performance of first-generation college students (i.e., those who have parents without 4-year degrees). Difference-education interventions improve first-generation students' performance by empowering them to navigate higher education environments more effectively. They also improve students'
MeSH term(s)	Humans ; Students/psychology ; Schools ; Educational Status ; Universities
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	189732-9
ISSN	1939-2222 ; 0096-3445
ISSN (online)	1939-2222
ISSN	0096-3445
DOI	10.1037/xge0001499
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Zs.A 2255: Show issues

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Article ; Online: Systems Thinking and Solid Waste Management in Puerto Rico

Amanda Brinton / Timothy G. Townsend / David C. Diehl / Katherine Deliz Quiñones / Mark M. Lichtenstein

Sustainability, Vol 15, Iss 4648, p

Feedback Loops over Time

2023 Volume 4648

Abstract: This article uses a systems-thinking framework to analyze Puerto Rico’s solid waste system. Our findings were based on 36 semi-structured interviews from stakeholders that work within the solid waste system. Interviewees represented businesses, advocacy ... ...

Abstract	This article uses a systems-thinking framework to analyze Puerto Rico’s solid waste system. Our findings were based on 36 semi-structured interviews from stakeholders that work within the solid waste system. Interviewees represented businesses, advocacy organizations, a university, and government agencies, including municipal, central, and federal government. This research is unique because it focuses on a case study using a historical lens to explore the policies and stakeholder dynamics that shape a system’s behavior, where the behavior is in reference to the flows of discarded materials either entering the circular economy or the island’s waste disposal facilities. Through our research, we found that Puerto Rico’s overall solid waste system is stalled within a balancing feedback loop where policies and dynamics have taken place that have created resistance to efforts to improve the current situation. In our discussion, we reflect on the policies and stakeholder dynamics that have caused this balancing feedback loop and make recommendations to better support a reinforcing feedback loop that will lead to changes to achieve Puerto Rico’s solid waste disposal and recycling plans and goals required to foster a circular economy. This study can inform future policy making and institutional coordination efforts within Puerto Rico and abroad.
Keywords	systems thinking ; history ; solid waste management ; Puerto Rico ; feedback loops ; stakeholder dynamics ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Life cycle GHG emissions of MSW landfilling versus Incineration: Expected outcomes based on US landfill gas collection regulations.

Anshassi, Malak / Smallwood, Thomas / Townsend, Timothy G

Waste management (New York, N.Y.)

2022 Volume 142, Page(s) 44–54

Abstract: ... rates, and low concentrations of nonmethane organic compounds (C ...

Abstract	From a GHG perspective, most LCA studies find incineration (MSWI) to be preferred over landfilling because of high energy recovery offsets. In some studies, however, landfilling results in less greenhouse gases (GHG) emissions than MSWI. We investigated using LCA, the landfill gas (LFG) collection efficiencies and waste composition that led to landfills resulting in less GHG emissions. Then, we explored what theoretical minimum lifetime gas collection efficiencies can be expected when following US LFG regulations. Only landfills with high LFG collection efficiencies (at least 81%) and recovery of methane for energy resulted in less GHG emissions compared to the management of the same waste stream in MSWI; required efficiency increased to 93% without LFG energy recovery. Expected theoretical lifetime LFG collection efficiencies were modeled in the range of 30-80%, with the lower rates associated with landfills having smaller input masses, high decay rates, and low concentrations of nonmethane organic compounds (C
MeSH term(s)	Animals ; Greenhouse Effect ; Greenhouse Gases ; Incineration/methods ; Life Cycle Stages ; Methane/analysis ; Refuse Disposal/methods ; Waste Disposal Facilities
Chemical Substances	Greenhouse Gases ; Methane (OP0UW79H66)
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2022.01.040
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Article ; Online: Automated Decellularization of Musculoskeletal Tissues with High Extracellular Matrix Retention.

Hamilton, Alex G / Townsend, Jakob M / Detamore, Michael S

Tissue engineering. Part C, Methods

2022 Volume 28, Issue 4, Page(s) 137–147

Abstract: Manual tissue decellularization is an onerous process that requires the application of many sequential treatments by an operator and can be prone to user error and result variability. While automated decellularization devices have been previously ... ...

Abstract	Manual tissue decellularization is an onerous process that requires the application of many sequential treatments by an operator and can be prone to user error and result variability. While automated decellularization devices have been previously reported, with advances being made in recent years toward open-source platforms, previous automated decellularization devices have been reliant on hardware or software components that are closed-source and proprietary. The aim of the current work was to develop and validate a full open-source automated decellularization system to be available for others to adopt. The open-source decellularization apparatus is a low-cost (<$2000) device that may easily be adapted to an array of decellularization protocols, with an example parts' list provided herein. The automated decellularization device was used to decellularize hyaline cartilage, knee meniscus, and tendon tissues. Cartilage, meniscus, and tendon tissue demonstrated 97%, 99%, and 96% reduction in DNA content after decellularization, respectively, and with effective decellularization confirmed visually via histology. High retentions of glycosaminoglycans (GAGs), collagen, and other proteins were observed in meniscus and tendon following decellularization. Results with manual decellularization with meniscus tissue were consistent with the automated decellularization process. Decellularized cartilage (DCC) demonstrated a 34% decrease in GAG content, while the protein and collagen content did not significantly change. The current study demonstrated that native-like decellularized tissues were produced reproducibly using the reported open-source automated decellularization platform, providing an adoptable platform for production of decellularized tissues by others. Impact statement Decellularized extracellular matrix (ECM)-based materials are appealing for tissue engineering, but production of these materials is historically time-intensive, tedious, and prone to user error. Adoption of an automated system may be a barrier for many research groups due to cost and complexity. In this article, a low-cost open-source platform for automated decellularization is presented. This method is validated by decellularizing porcine musculoskeletal tissues and demonstrating the native-like compositional properties of these decellularized tissues. The ability to produce decellularized tissue in an automated manner is useful for further research of ECM-based materials and potential clinical applications.
MeSH term(s)	Animals ; Cartilage ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Glycosaminoglycans/metabolism ; Swine ; Tissue Engineering/methods ; Tissue Scaffolds
Chemical Substances	Glycosaminoglycans ; Collagen (9007-34-5)
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2420585-0
ISSN	1937-3392 ; 1937-3384
ISSN (online)	1937-3392
ISSN	1937-3384
DOI	10.1089/ten.TEC.2022.0005
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Zs.A 5500/C: Show issues

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Article ; Online: Characterizing Rhodopsin-Arrestin Interactions with the Fragment Molecular Orbital (FMO) Method.

Heifetz, Alexander / Townsend-Nicholson, Andrea

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2114, Page(s) 177–186

Abstract: Arrestin binding to G protein-coupled receptors (GPCRs) plays a vital role in receptor signaling ... residues of arrestin. Two major regions of interaction were identified: at the C-terminal tail of rhodopsin ...

Abstract	Arrestin binding to G protein-coupled receptors (GPCRs) plays a vital role in receptor signaling. Recently, the crystal structure of rhodopsin bound to activated visual arrestin was resolved using XFEL (X-ray free electron laser). However, even with the crystal structure in hand, our ability to understand GPCR-arrestin binding is limited by the availability of accurate tools to explore receptor-arrestin interactions. We applied fragment molecular orbital (FMO) method to explore the interactions formed between the residues of rhodopsin and arrestin. FMO enables ab initio approaches to be applied to systems that conventional quantum mechanical (QM) methods would be too compute-expensive. The FMO calculations detected 35 significant interactions involved in rhodopsin-arrestin binding formed by 25 residues of rhodopsin and 28 residues of arrestin. Two major regions of interaction were identified: at the C-terminal tail of rhodopsin (D330-S343) and where the "finger loop" (G69-T79) of arrestin directly inserts into rhodopsin active core. Out of these 35 interactions, 23 were mainly electrostatic and 12 hydrophobic in nature.
MeSH term(s)	Arrestin/chemistry ; Crystallography, X-Ray/methods ; Protein Binding/physiology ; Quantum Theory ; Receptors, G-Protein-Coupled/chemistry ; Rhodopsin/chemistry
Chemical Substances	Arrestin ; Receptors, G-Protein-Coupled ; Rhodopsin (9009-81-8)
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-0282-9_12
Database	MEDical Literature Analysis and Retrieval System OnLINE

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