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  1. Article ; Online: Searching for a better mousetrap for ablation of Barrett's esophagus.

    Dumot, John A

    Endoscopy

    2022  Volume 54, Issue 6, Page(s) 553–554

    MeSH term(s) Barrett Esophagus/surgery ; Catheter Ablation ; Esophageal Neoplasms/surgery ; Humans
    Language English
    Publishing date 2022-02-01
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1722-2885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Searching for a better mousetrap for ablation of Barrett’s esophagus

    Dumot, John A.

    Endoscopy

    2022  Volume 54, Issue 06, Page(s) 553–554

    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1722-2885
    Database Thieme publisher's database

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  3. Article ; Online: Injury of the aberrant bile duct: beware of what you don't see.

    Dumot, John A

    Gastrointestinal endoscopy

    2020  Volume 91, Issue 3, Page(s) 593–594

    MeSH term(s) Cholecystectomy ; Endoscopy ; Hepatic Duct, Common ; Liver
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2019.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Two Cases of Gastric and Esophageal Amyloidosis.

    Shatnawei, Abdullah / Dasari, Vijaya / Dumot, John / Kirby, Donald F

    Gastroenterology & hepatology

    2024  Volume 5, Issue 8, Page(s) 571–574

    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The little engine that could.

    Dumot, John A

    Gastrointestinal endoscopy

    2018  Volume 87, Issue 2, Page(s) 582–583

    Language English
    Publishing date 2018
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2017.10.009
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  6. Article: The use of cryotherapy for treatment of barrett esophagus.

    Dumot, John

    Gastroenterology & hepatology

    2014  Volume 9, Issue 12, Page(s) 811–813

    Language English
    Publishing date 2014-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Effect of Delayed Endoscopy Protocol on Timing and Safety of Endoscopy for Foreign Body Ingestion and Esophageal Food Impaction.

    Karb, Daniel / DeLozier, Sara / Raad, Dany / Dumot, John / Mok, Shaffer

    Journal of clinical gastroenterology

    2023  Volume 57, Issue 9, Page(s) 890–894

    Abstract: Background and aims: Endoscopic procedures for foreign body ingestion (FBI) and esophageal food impactions (EFI) performed during on-call hours are associated with increased stress, risk, and cost. We implemented a Foreign Body Algorithm (FBA) designed ... ...

    Abstract Background and aims: Endoscopic procedures for foreign body ingestion (FBI) and esophageal food impactions (EFI) performed during on-call hours are associated with increased stress, risk, and cost. We implemented a Foreign Body Algorithm (FBA) designed to delay all but the most urgent endoscopy for EFI and FBI until regular working hours.
    Methods: Using endoscopy records from multiple academic and community hospitals within a large integrated health system in the United states, we identified esophagogastroduodenoscopy (EGD) performed for food impactions and foreign body ingestions occurring between May 2011 and February 2021.
    Results: We identified 479 EGDs performed for FBI and EFI. The introduction of the FBA was associated with a shorter length of stay (LOS) for overall cases (0.35 vs. 0.8 d P <0.001), day cases (0.16 vs. 1.0 d P <0.001), and night cases (0.40 vs. 0.6 d P =0.03). The introduction of the FBA did not change the rate of overall adverse events (AE) or night AE. AE from the entire cohort was rare (3%; 16 total). Of the AE, most were sedation related. The introduction of the FBA did not affect the overall rate of night cases or AE, but the rate of after-hours endoscopy for intentional ingestions decreased from 17.2% to 3.1% ( P =0.01).
    Conclusion: This is one of the largest studies of esophageal impactions and foreign bodies in adults in the United States, and the first to examine the effects of a protocol designed to avoid after-hours endoscopy. These results suggest that postponing after-hours EGD until the daytime is not associated with adverse safety outcomes or increased LOS.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Endoscopy, Gastrointestinal/adverse effects ; Endoscopy, Gastrointestinal/methods ; Esophageal Diseases ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Eating ; Endoscopy
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Maximizing the Effectiveness of Colonoscopy in the Prevention of Colorectal Cancer.

    Sullivan, John F / Dumot, John A

    Surgical oncology clinics of North America

    2017  Volume 27, Issue 2, Page(s) 367–376

    Abstract: Colonoscopy is a proven screening test for colorectal cancer; maximizing its effectiveness is the best way to decrease interval colorectal cancer. The adenoma detection rate can be improved by monitoring physician detection rates. Assistive devices and ... ...

    Abstract Colonoscopy is a proven screening test for colorectal cancer; maximizing its effectiveness is the best way to decrease interval colorectal cancer. The adenoma detection rate can be improved by monitoring physician detection rates. Assistive devices and innovative endoscopic equipment may also decrease adenoma miss rates. Complete polypectomy of adenomatous lesions and recommending the proper date for the next examination are important considerations. Advanced polypectomy techniques including endoscopic mucosal resection and endoscopic mucosal dissection have a clear role in the nonsurgical management of large laterally spreading adenomatous polyps that previously would have required surgical resection.
    MeSH term(s) Colonoscopy/methods ; Colonoscopy/standards ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/prevention & control ; Humans ; Prognosis
    Language English
    Publishing date 2017-12-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2017.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: MULTICENTER, PROSPECTIVE TRIAL OF NON-ENDOSCOPIC BIOMARKER-DRIVEN DETECTION OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA.

    Moinova, Helen R / Verma, Suman / Dumot, John / Faulx, Ashley / Iyer, Prasad G / Canto, Marcia Irene / Wang, Jean S / Shaheen, Nicholas J / Thota, Prashanthi N / Aklog, Lishan / Willis, Joseph E / Markowitz, Sanford D / Chak, Amitabh

    The American journal of gastroenterology

    2024  

    Abstract: Background: Preliminary data suggest that an encapsulated balloon (EsoCheckTM), coupled with a two methylated DNA biomarker panel (EsoGuardTM), detects Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with high accuracy. The initial assay ... ...

    Abstract Background: Preliminary data suggest that an encapsulated balloon (EsoCheckTM), coupled with a two methylated DNA biomarker panel (EsoGuardTM), detects Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with high accuracy. The initial assay required sample freezing upon collection.
    Aim: Assess a next-generation EsoCheck sampling device and EsoGuard assay in a much-enlarged multicenter study clinically enhanced by utilizing a CLIA-compliant assay and samples maintained at room temperature.
    Methods: Cases with nondysplastic BE (NDBE), dysplastic BE (indefinite=IND, low grade dysplasia = LGD, high grade dysplasia = HGD), EAC, junctional adenocarcinoma (JAC), plus endoscopy controls without esophageal intestinal metaplasia, were prospectively enrolled. Medical assistants at six institutions delivered the encapsulated balloon per orally, with inflation in the stomach. The inflated balloon sampled the distal 5 cm of the esophagus, then was deflated and retracted into the capsule, preventing sample contamination. EsoGuard bisulfite sequencing assayed levels of methylated Vimentin (mVIM) and methylated Cyclin A1 (mCCNA1).
    Results: A total of 243 evaluable patients - 88 cases (median age 68, 78% men, 92% white) and 155 controls (median age 57, 41% men, 88% white) - underwent adequate EsoCheck sampling. Mean procedural time was approximately 3 minutes. Cases included 31 NDBE, 16 IND/LGD, 23 HGD, and 18 EAC/JAC. Thirty-seven (53%) non-dysplastic and dysplastic BE cases were short segment BE (SSBE; < 3 cm). Overall sensitivity was 85% (95% CI= 0.78-0.93), and specificity was 85% (95% CI=0.79-0.90). Sensitivity for NDBE was 84%. EsoCheck/EsoGuard detected 100% of cancers (n=18).
    Conclusion: EsoCheck/EsoGuard demonstrated high sensitivity and specificity in detecting BE and BE-related neoplasia.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: LIQUID NITROGEN SPRAY CRYOTHERAPY FOR ERADICATION OF DYSPLASTIC BARRETT'S ESOPHAGUS: RESULTS FROM A MULTICENTER PROSPECTIVE REGISTRY.

    Eluri, Swathi / Cotton, Cary C / Kaul, Vivek / McKinley, Matthew / Pleskow, Douglas / Nishioka, Norman / Hoffman, Brenda / Nieto, Jose / Tsai, Franklin / Coyle, Walter / Kothari, Shivangi / Joshi, Virendra / Dumot, John / Greenwald, Bruce / Habr, Fadlallah G / Shaheen, Nicholas J

    Gastrointestinal endoscopy

    2024  

    Abstract: Background and aims: Liquid nitrogen spray cryotherapy (SCT) is an alternative to radiofrequency ablation (RFA) for eradication of dysplastic Barrett's esophagus (BE). We aimed to assess the safety, efficacy, and durability of SCT in a multicenter U.S. ... ...

    Abstract Background and aims: Liquid nitrogen spray cryotherapy (SCT) is an alternative to radiofrequency ablation (RFA) for eradication of dysplastic Barrett's esophagus (BE). We aimed to assess the safety, efficacy, and durability of SCT in a multicenter U.S. registry.
    Methods: This is a multicenter prospective registry of adults with BE treated with truFreeze Spray Cryotherapy (4 community and 11 academic sites, 2013-2022). Complete eradication of intestinal metaplasia (CEIM) and dysplasia (CED) were assessed in BE with dysplasia or intramucosal adenocarcinoma (IMC). Kaplan-Meier analysis of CEIM and CED was performed. Hazard ratios for CEIM stratified by baseline risk factors were calculated.
    Results: Among 138 subjects, with LGD (24%), HGD (49%) and IMC (27%), 34% received prior RFA therapy. Subjects received a median of 2 SCT sessions. Adverse events were uncommon, with 5.5% reporting strictures and 0.7% a perforation. Rates of CEIM and CED, respectively, were 66% and 84% after two years, and 67% and 92% after three years. In RFA-naive patients, CEIM was 77% and CED was 96% at 3 years. Increasing BE length (adjusted hazard ratio [95% CI]:0.90 [0.83-0.96] per cm) and prior treatment with RFA (0.39 [0.22-0.69]) were associated with a lower rate of CEIM. Recurrence occurred in 8.8% (n=6) at a mean follow-up of 2.5 years after CEIM.
    Conclusion: In this largest reported prospective cohort, liquid nitrogen SCT was safe and effective for treatment of dysplastic and neoplastic BE. Response was lower in those with prior failed RFA; in that cohort approximately 50% attained CEIM at 3 years.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2024.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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