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  1. Article: The use of hyaluronic acid based dressings to treat burns: A review.

    Longinotti, Cristina

    Burns & trauma

    2014  Volume 2, Issue 4, Page(s) 162–168

    Abstract: Deep cutaneous lesions such as burns, traumas or ulcers are all conditions characterized by a massive loss of dermis, bringing several important consequences. For the treatment of these conditions, the evolution of material science has made available new ...

    Abstract Deep cutaneous lesions such as burns, traumas or ulcers are all conditions characterized by a massive loss of dermis, bringing several important consequences. For the treatment of these conditions, the evolution of material science has made available new dressings based on natural and synthetic polymers. Hyaluronic acid (HA) is involved in many steps of the wound healing process, such as inflammation, granulation and re-epithelialization. In order to overcome the poor physical properties of the native polymer, such as solubility and rapid degradation, insoluble molecules starting from the natural compound were produced via esterification. Thanks to their improved structural properties, the dressings based on these hyaluronic acid derivatives represent a valuable option for the treatment of deep burns. This narrative monograph describes the development and the outcome of the use of these products in burns. The currently available clinical experience suggests that these HA medical devices represent a safe therapeutic method useful for the treatment of acute wounds.
    Language English
    Publishing date 2014-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775996-9
    ISSN 2321-3876 ; 2321-3868
    ISSN (online) 2321-3876
    ISSN 2321-3868
    DOI 10.4103/2321-3868.142398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The use of hyaluronic acid based dressings to treat burns

    Cristina Longinotti

    Burns & Trauma, Vol 2, Iss 4, Pp 162-

    A review

    2014  Volume 168

    Abstract: Deep cutaneous lesions such as burns, traumas or ulcers are all conditions characterized by a massive loss of dermis, bringing several important consequences. For the treatment of these conditions, the evolution of material science has made available new ...

    Abstract Deep cutaneous lesions such as burns, traumas or ulcers are all conditions characterized by a massive loss of dermis, bringing several important consequences. For the treatment of these conditions, the evolution of material science has made available new dressings based on natural and synthetic polymers. Hyaluronic acid (HA) is involved in many steps of the wound healing process, such as inflammation, granulation and re-epithelialization. In order to overcome the poor physical properties of the native polymer, such as solubility and rapid degradation, insoluble molecules starting from the natural compound were produced via esterification. Thanks to their improved structural properties, the dressings based on these hyaluronic acid derivatives represent a valuable ­option for the treatment of deep burns. This narrative monograph describes the development and the outcome of the use of these products in burns. The currently available clinical experience suggests that these HA medical devices represent a safe therapeutic method useful for the treatment of acute wounds.
    Keywords Burns ; hyaluronic acid ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Oxford University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A novel pattern of uridine diphosphate glucuronosyltransferase polymorphisms associated with hyperbilirubinemia during nilotinib treatment.

    Fozza, Claudio / Pardini, Simonetta / Coiana, Alessandra / Rosatelli, Maria Cristina / Longinotti, Maurizio

    Blood cells, molecules & diseases

    2013  Volume 51, Issue 3, Page(s) 162

    MeSH term(s) Adult ; Genotype ; Glucuronosyltransferase/genetics ; Humans ; Hyperbilirubinemia/chemically induced ; Hyperbilirubinemia/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Male ; Polymorphism, Genetic ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use
    Chemical Substances Pyrimidines ; Glucuronosyltransferase (EC 2.4.1.17) ; nilotinib (F41401512X)
    Language English
    Publishing date 2013-06-13
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2013.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Preparation and characterization of a new gellan gum and sulphated hyaluronic acid hydrogel designed for epidural scar prevention.

    Cencetti, Claudia / Bellini, Davide / Longinotti, Cristina / Martinelli, Andrea / Matricardi, Pietro

    Journal of materials science. Materials in medicine

    2011  Volume 22, Issue 2, Page(s) 263–271

    Abstract: Postsurgical adhesions are a common problem in clinical practice, causing nerve compression, pain and discomfort. A new hydrogel based on gellan gum and sulphated hyaluronic acid was synthesized, with the aim to create an effective barrier for epidural ... ...

    Abstract Postsurgical adhesions are a common problem in clinical practice, causing nerve compression, pain and discomfort. A new hydrogel based on gellan gum and sulphated hyaluronic acid was synthesized, with the aim to create an effective barrier for epidural scar formation. Physico-chemical properties of the gel were analyzed, and preliminary biocompatibility data (i.e. cytotoxicity) have been collected in view of its potential clinical use. The characterization of the new material demonstrated that the hydrogel, due to its high-viscosity, could effectively act as a barrier with a long in situ residence time. In addition, the hydrogel can be easily extruded from a syringe and its structure exhibits excellent stabilizing properties. Furthermore, biological assays showed that this gel is suitable for further preclinical development.
    MeSH term(s) Absorption ; Adhesiveness ; Animals ; Biocompatible Materials/chemistry ; Biopolymers/chemistry ; Cicatrix/drug therapy ; Epidural Space/surgery ; Hyaluronic Acid/chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Hydrogels/chemistry ; Mice ; Polysaccharides, Bacterial/chemistry ; Rheology ; Spectroscopy, Fourier Transform Infrared/methods ; Sulfur/chemistry ; Syringes
    Chemical Substances Biocompatible Materials ; Biopolymers ; Hydrogels ; Polysaccharides, Bacterial ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; Sulfur (70FD1KFU70) ; gellan gum (7593U09I4D) ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2011-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1031752-1
    ISSN 1573-4838 ; 0957-4530
    ISSN (online) 1573-4838
    ISSN 0957-4530
    DOI 10.1007/s10856-010-4217-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3040: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: In vivo characterization of Hyalonect, a novel biodegradable surgical mesh.

    Rhodes, Nicholas P / Hunt, John A / Longinotti, Cristina / Pavesio, Alessandra

    The Journal of surgical research

    2010  Volume 168, Issue 1, Page(s) e31–8

    Abstract: Background: Musculoskeletal reconstructive surgery often requires removal of significant quantities of bone tissue, such as the periosteum, causing critical problems following surgery like friction between different tissues and adhesion of soft tissues ... ...

    Abstract Background: Musculoskeletal reconstructive surgery often requires removal of significant quantities of bone tissue, such as the periosteum, causing critical problems following surgery like friction between different tissues and adhesion of soft tissues to the underlying bone. We studied the long-term host response and closure of large bone defects for periosteal reconstruction using Hyalonect, a novel membrane comprising knitted fibers of esterified hyaluronan, (HYAFF11).
    Materials and methods: For biological characterization, 162 rats were used in a defect model in which a section of the dorsal muscular fascia was removed, and the membrane behavior observed over 540 d using conventional histology, with sham operated rats as controls. In addition, Hyalonect was used to cover defects made in the humeri of 7 dogs, filled with a variety of conventional bone filling compounds, and the regeneration process observed after 6 wks using histology.
    Results: Low levels of inflammation were observed in the dorsal muscle fascia defect model, with cellular colonization of the mesh by 30 d, vascularization by 120 days, matrix fiber organization by 270 d, and the appearance of connective tissue identical to the surrounding tissue between 365 and 540 d, without the formation of fibrotic tissue. In addition, Hyalonect was shown to allow the regeneration of bone within the humeral defects whilst preventing fibrotic tissue in-growth, and allowing regeneration of tissue which, by 6 wk, had begun to resemble natural periosteal tissue.
    Conclusion: Hyalonect is suitable for improving the outcome of the final phases of orthopedic and trauma reconstructive surgical procedures, especially in the reconstruction of periosteal tissue.
    MeSH term(s) Absorbable Implants ; Animals ; Bone Regeneration/physiology ; Fascia/pathology ; Fasciotomy ; Fibrosis/prevention & control ; Humerus/physiology ; Humerus/surgery ; Hyaluronic Acid/therapeutic use ; Male ; Models, Animal ; Rats ; Rats, Sprague-Dawley ; Surgical Mesh ; Treatment Outcome
    Chemical Substances Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2010-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2010.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing.

    Santoro, Rosaria / Olivares, Andy L / Brans, Gerben / Wirz, Dieter / Longinotti, Cristina / Lacroix, Damien / Martin, Ivan / Wendt, David

    Biomaterials

    2010  Volume 31, Issue 34, Page(s) 8946–8952

    Abstract: Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to ... ...

    Abstract Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to engineer human cartilage grafts in a size with clinical relevance for unicompartmental resurfacing of human knee joints (50 mm diameter × 3 mm thick). Computational fluid dynamics models were developed to optimize the flow profile when designing the perfusion chamber. Using the developed system, human chondrocytes could be seeded throughout large 50 mm diameter scaffolds with a uniform distribution. Following two weeks culture, tissues grown in the bioreactor were viable and homogeneously cartilaginous, with biomechanical properties approaching those of native cartilage. In contrast, tissues generated by conventional manual production procedures were highly inhomogeneous and contained large necrotic regions. The unprecedented engineering of human cartilage tissues in this large-scale opens the practical perspective of grafting functional biological substitutes for the clinical treatment for extensive cartilage defects, possibly in combination with surgical or pharmacological therapies to support durability of the implant. Ongoing efforts are aimed at integrating the up-scaled bioreactor based processes within a fully automated and closed manufacturing system for safe, standardized, and GMP compliant production of large-scale cartilage grafts.
    MeSH term(s) Arthroplasty/methods ; Biomechanical Phenomena ; Bioreactors ; Cartilage/transplantation ; Computer Simulation ; Glycosaminoglycans/metabolism ; Humans ; Joints/surgery ; Perfusion ; Rheology ; Tissue Engineering/instrumentation
    Chemical Substances Glycosaminoglycans
    Keywords covid19
    Language English
    Publishing date 2010-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2010.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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