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  1. Article ; Online: The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?

    Jamerson, Brenda D / Haryadi, T Ho

    Medical hypotheses

    2020  Volume 144, Page(s) 109880

    Abstract: Fever has been reported as a common symptom occurring in COVID-19 illness. Over the counter antipyretics such as ibuprofen and acetaminophen are often taken by individuals to reduce the discomfort of fever. Recently, the safety of ibuprofen in COVID-19 ... ...

    Abstract Fever has been reported as a common symptom occurring in COVID-19 illness. Over the counter antipyretics such as ibuprofen and acetaminophen are often taken by individuals to reduce the discomfort of fever. Recently, the safety of ibuprofen in COVID-19 patients has been questioned due to anecdotal reports of worsening symptoms in previously healthy young adults. Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen. As fever may have benefit in shortening the duration of viral illness, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness.
    MeSH term(s) Acetaminophen/therapeutic use ; Antipyretics/adverse effects ; Antipyretics/therapeutic use ; COVID-19/drug therapy ; Fever/drug therapy ; Fever/physiopathology ; Humans ; Ibuprofen/adverse effects ; Ibuprofen/therapeutic use ; Models, Theoretical ; Patient Safety ; Treatment Outcome
    Chemical Substances Antipyretics ; Acetaminophen (362O9ITL9D) ; Ibuprofen (WK2XYI10QM)
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109880
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  2. Article ; Online: The use of ibuprofen to treat fever in COVID-19

    Jamerson, Brenda D. / Haryadi, T. Ho

    Medical Hypotheses

    A possible indirect association with worse outcome?

    2020  Volume 144, Page(s) 109880

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109880
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  3. Article ; Online: Glucose-6-Phosphate Dehydrogenase Deficiency: An Actionable Risk Factor for Patients with COVID-19?

    Jamerson, Brenda D / Haryadi, T Ho / Bohannon, Arline

    Archives of medical research

    2020  Volume 51, Issue 7, Page(s) 743–744

    Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or ... ...

    Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or infections can trigger acute hemolytic anemia. Given the potential for coronavirus to trigger oxidative stress, unrecognized G6PD deficiency in the presence of the COVID-19 viral infection may cause hemolytic crisis and worse outcome in affected individuals. Further, since certain drugs that may be used to treat COVID-19 infection may cause hemolytic crisis in individuals with G6PD deficiency, it may be warranted to recommend adding G6PD deficiency to the list of screening elements in a COVID-19 workup for those patients where there is a high suspicion for this genetic mutation.
    MeSH term(s) COVID-19 ; Glucosephosphate Dehydrogenase Deficiency ; Humans ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.06.006
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  4. Article: The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?

    Jamerson, Brenda D / Haryadi, T Ho

    Med Hypotheses

    Abstract: Fever has been reported as a common symptom occurring in COVID-19 illness. Over the counter antipyretics such as ibuprofen and acetaminophen are often taken by individuals to reduce the discomfort of fever. Recently, the safety of ibuprofen in COVID-19 ... ...

    Abstract Fever has been reported as a common symptom occurring in COVID-19 illness. Over the counter antipyretics such as ibuprofen and acetaminophen are often taken by individuals to reduce the discomfort of fever. Recently, the safety of ibuprofen in COVID-19 patients has been questioned due to anecdotal reports of worsening symptoms in previously healthy young adults. Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen. As fever may have benefit in shortening the duration of viral illness, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #361316
    Database COVID19

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  5. Article ; Online: Glucose-6-Phosphate Dehydrogenase Deficiency

    Jamerson, Brenda D. / Haryadi, T. Ho / Bohannon, Arline

    Archives of Medical Research

    An Actionable Risk Factor for Patients with COVID-19?

    2020  Volume 51, Issue 7, Page(s) 743–744

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1156844-6
    ISSN 0188-4409 ; 0188-0128
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.06.006
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  6. Article: Glucose-6-Phosphate Dehydrogenase Deficiency: An Actionable Risk Factor for Patients with COVID-19?

    Jamerson, Brenda D / Haryadi, T Ho / Bohannon, Arline

    Arch Med Res

    Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or ... ...

    Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked mutation that is more prevalent in African, Asian, Latin American and Mediterranean populations. Although most individuals are asymptomatic, exposure to certain food, drugs, or infections can trigger acute hemolytic anemia. Given the potential for coronavirus to trigger oxidative stress, unrecognized G6PD deficiency in the presence of the COVID-19 viral infection may cause hemolytic crisis and worse outcome in affected individuals. Further, since certain drugs that may be used to treat COVID-19 infection may cause hemolytic crisis in individuals with G6PD deficiency, it may be warranted to recommend adding G6PD deficiency to the list of screening elements in a COVID-19 workup for those patients where there is a high suspicion for this genetic mutation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #549131
    Database COVID19

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  7. Article ; Online: A New Method of Identifying Characteristics of Needing Help to Take Medications in an Older Representative Community-Dwelling Population: The Older Adults Medication Assist Scale.

    Jamerson, Brenda D / Fillenbaum, Gerda G / Sloane, Richard / Morey, Miriam C

    Journal of the American Geriatrics Society

    2016  Volume 64, Issue 6, Page(s) 1195–1202

    Abstract: Objectives: To determine the sociodemographic characteristics, health conditions, and cognitive and functional status associated with baseline prevalence and new need for help taking medication 3 years later and to construct a brief scale indicative of ... ...

    Abstract Objectives: To determine the sociodemographic characteristics, health conditions, and cognitive and functional status associated with baseline prevalence and new need for help taking medication 3 years later and to construct a brief scale indicative of need for help taking medications.
    Design: Retrospective cross-sectional and 3-year longitudinal study.
    Setting: Five-county area in north-central Piedmont, North Carolina.
    Participants: Representative community-dwelling sample of black and white individuals aged 65 and older (N = 4,136).
    Measurements: Information was obtained in person in participants' homes using structured questionnaires. Health conditions included sensory impairment and self-report of physician-diagnosed conditions. Cognitive status was assessed using the 10-item Short Portable Mental Status Questionnaire. Functional status was assessed using the three-item Rosow-Breslau scale, the five-item Katz activity of daily living scale, and a modified six-item Older Americans Resources and Services instrumental activities of daily living scale.
    Results: Characteristics associated with need for help taking medications were aged 80 and older, being male, living with others, having four or more chronic conditions, and impaired cognitive or functional status (c-statistic 0.94, 77.1% sensitivity, 87.9% specificity). Predictors of new need for help with medications 3 years later included aged 75 and older at baseline, being male, and impaired cognitive and functional status (c-statistic 0.75).
    Conclusion: This brief scale can help identify persons needing help with medications and could be useful in assisting clinicians with medication management.
    MeSH term(s) Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Chronic Disease/drug therapy ; Cognition ; Cross-Sectional Studies ; Female ; Geriatric Assessment ; Health Services Needs and Demand ; Humans ; Independent Living ; Longitudinal Studies ; Male ; Medication Adherence/statistics & numerical data ; North Carolina ; Retrospective Studies ; Socioeconomic Factors ; Surveys and Questionnaires
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.14166
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  8. Article: Antidepressant-related adverse effects impacting treatment compliance: Results of a patient survey.

    Ashton, Adam Keller / Jamerson, Brenda D / L Weinstein, Wendy / Wagoner, Christine

    Current therapeutic research, clinical and experimental

    2014  Volume 66, Issue 2, Page(s) 96–106

    Abstract: Background: Despite the high prevalence of depression in the United States, 10 few studies have identified which adverse effects (AEs) patients are willing or unwilling to tolerate when receiving antidepressants.: Objective: The aim of this study was ...

    Abstract Background: Despite the high prevalence of depression in the United States, 10 few studies have identified which adverse effects (AEs) patients are willing or unwilling to tolerate when receiving antidepressants.
    Objective: The aim of this study was to identify reasons for discontinuation10 and noncompliance with antidepressant medications, the impact of AEs on compliance and quality of life (assessed using impact of AEs on activities of daily living), and patients' suggestions for improving their medication, using a patient survey.
    Methods: Patients aged 18 to 65 years with mild to severe depression were 10 randomly selected by their physicians to be sent an invitation to complete the 42-question survey. Three hundred physicians nationwide assessed the severity of depression and symptoms of anxiety in each respondent, using their judgment. Patients were asked specific questions to assess reasons for discontinuation/noncompliance. Patients were also asked to rate AEs based on how difficult they were to "live with," and what 2 aspects of their antidepressant medication they would change if they could.
    Results: In a separate, concurrent study, physicians classified 175 (50%) abdResults:0 mildly to moderately depressed and 84 (24%) as severely depressed. Ninety-one respondents (26%) were classified as having symptoms of anxiety. Two hundred seven patients (60%) indicated they had discontinued treatment with an antidepressant agent at some point in their lives, the most common reason for which was lack of efficacy (92 patients [44%]). Of the 344 patients currently being treated with an antidepressant, 75 (22%) reported noncompliance. The most common reasons for noncompliance were "have trouble remembering to take it" (19/44 patients [43%]), "gained a lot of weight" (11/41 [27%]), "unable to have an orgasm" (8/40 [20%]), and "lost interest in sex" (8/41 [20%]). The 4 AEs patients expressed as "extremely difficult to live with" were "weight gain" (104 patients [31%]), "unable to have erection" (83 [25%]), "difficulty reaching orgasm" (80 [24%]), and "tired during the day/no energy" (69 patients [21%]). The 3 most frequently cited improvements patients (n = 327) would make to their medications were better efficacy (176 patients [54%]) and eliminating AEs related to sexual desire and weight gain (112 [34%] and 105 [32%] patients, respectively).
    Conclusions: The findings of this survey of patients with mild to severe10 depression suggest that compliance, and hence efficacy, can be promoted by (1) understanding what patients expect and desire from the antidepressants they are prescribed and (2) prescribing antidepressants associated with low rates of weight gain, sexual dysfunction, or tiredness.
    Language English
    Publishing date 2014-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2005.04.006
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  9. Article ; Online: Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression.

    Jamerson, Brenda D / Payne, Martha E / Garrett, Melanie E / Ashley-Koch, Allison E / Speer, Marcy C / Steffens, David C

    International journal of geriatric psychiatry

    2012  Volume 28, Issue 9, Page(s) 925–932

    Abstract: Objective: The primary aims of this study were to (i) determine whether folate metabolism genetic polymorphisms predict age of onset and occurrence of late life depression; and (ii) determine whether folate metabolism genetic polymorphisms predict ... ...

    Abstract Objective: The primary aims of this study were to (i) determine whether folate metabolism genetic polymorphisms predict age of onset and occurrence of late life depression; and (ii) determine whether folate metabolism genetic polymorphisms predict response to antidepressant medications in late-life depression.
    Methods: This study used the Conte Center for the Neuroscience of Depression and the Neurocognitive Outcomes of Depression in the Elderly Study database, which includes individuals aged ≥60. The folate nutrition assessment was determined by the Block Food Frequency Questionnaire. Genotype was evaluated for 15 single nucleotide polymorphisms from 10 folate metabolism genes. Logistic regression models were used to examine genetic polymorphisms and folate estimates with association with depression age of onset and remission status.
    Results: There were 304 Caucasians in the database, 106 of these were not depressed and 198 had a diagnosis of depression. There were no significant differences between remitters and non-remitters in age, sex or estimated folate intakes. There were no folate estimates or folate metabolism gene single nucleotide polymorphisms that significantly predicted age of onset of depression or occurrence of depression. Methionine synthase reductase (MTRR) A66G (rs1801394) was significantly associated with remission status (p = 0.0077) such that those with the AA genotype were 3.2 times as likely as those with the GG genotype to be in remission (p = 0.0020). Methylenetetrahydrofolate reductase A1298C (rs1801131) achieved a borderline significance for association with remission status (p = 0.0313).
    Conclusion: The major finding from this study is that the MTRR A66G genotype predicts response to selective serotonin reuptake inhibitor antidepressants in late life depression.
    MeSH term(s) Age of Onset ; Aged ; Antidepressive Agents/therapeutic use ; Cystathionine beta-Synthase/genetics ; Depressive Disorder/drug therapy ; Depressive Disorder/genetics ; Diet ; Female ; Ferredoxin-NADP Reductase/genetics ; Folic Acid/administration & dosage ; Folic Acid/genetics ; Folic Acid/metabolism ; Genetic Predisposition to Disease ; Genotype ; Glycine Hydroxymethyltransferase/genetics ; Humans ; Logistic Models ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Predictive Value of Tests ; Serotonin Uptake Inhibitors/therapeutic use
    Chemical Substances Antidepressive Agents ; Serotonin Uptake Inhibitors ; Folic Acid (935E97BOY8) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20) ; Glycine Hydroxymethyltransferase (EC 2.1.2.1) ; SHMT protein, human (EC 2.1.2.1) ; Cystathionine beta-Synthase (EC 4.2.1.22)
    Language English
    Publishing date 2012-12-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.3899
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  10. Article ; Online: Natural food folate and late-life depression.

    Payne, Martha E / Jamerson, Brenda D / Potocky, Christopher F / Ashley-Koch, Allison E / Speer, Marcy C / Steffens, David C

    Journal of nutrition for the elderly

    2010  Volume 28, Issue 4, Page(s) 348–358

    Abstract: Low folate status has been linked to depression, but findings have been inconsistent. The authors sought to examine the association between folate intake and late-life depression. This cross-sectional study included individuals age 60 and older (n = 111 ... ...

    Abstract Low folate status has been linked to depression, but findings have been inconsistent. The authors sought to examine the association between folate intake and late-life depression. This cross-sectional study included individuals age 60 and older (n = 111 depression, n = 136 comparison). Depression participants received psychiatric care. Folate and kilocalorie intakes were assessed with a Block 1998 food frequency questionnaire. Naturally occurring food folate was inversely associated with depression after controlling for age, sex, race, education, and total energy (P = 0.0047). All other folate variables including total dietary folate and folic acid were non-significant for depression. These findings may indicate that the naturally occurring form of folate is uniquely protective for depression and perhaps brain health. Alternatively, natural folate may be a surrogate for other nutrients or overall dietary quality.
    MeSH term(s) Aged ; Aging/physiology ; Case-Control Studies ; Cross-Sectional Studies ; Depression/blood ; Depression/epidemiology ; Female ; Folic Acid/administration & dosage ; Folic Acid/blood ; Humans ; Male ; Middle Aged ; Nutritional Status ; Vitamin B Complex/administration & dosage
    Chemical Substances Vitamin B Complex (12001-76-2) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2010-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604638-1
    ISSN 1540-8566 ; 0163-9366
    ISSN (online) 1540-8566
    ISSN 0163-9366
    DOI 10.1080/01639360903417181
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