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Article: Effect of lignocellulosic corn stalk on mechanical, physical, and thermal properties of injection moulded low density polyethylene composites: An approach towards a circular economy.

Khan, Anam / Mishra, Alka / Patidar, Ravi / Pappu, Asokan

2024 Volume 10, Issue 4, Page(s) e25287

Abstract: Escalating concern over global warming, which is mostly associated with deforestation, has led to the development of new classes of materials that can replace wood and better utilise natural resources. Presently, waste is a significant factor in ... ...

Abstract	Escalating concern over global warming, which is mostly associated with deforestation, has led to the development of new classes of materials that can replace wood and better utilise natural resources. Presently, waste is a significant factor in recycling. In this regard, one of the leading contributors to waste is agricultural waste, which includes dried branches, leaves of trees, plants, and other organic materials. In the current study, waste from corn agriculture was utilised as a potential reinforcement for the fabrication of corn stalk-low density polyethylene (CS-LDPE) composites via an injection moulding technique at 170 °C. The different parameters were assessed to develop composites using CS, including physico-chemical, macromolecular, mineralogical, elemental, and morphological analysis. The amount of corn stalk (CS) was varied from 10 to 50 wt% with respect to the polymer. The mechanical, physical and thermal performance of the composites was examined. The density and water absorption of the composites were found to remain within the ranges of 1.00-1.11 g/cm
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25287
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Article ; Online: A piecewise spline approach for modeling of ECG signals.

Mishra, Alka / Bhusnur, Surekha

Biomedical physics & engineering express

2023 Volume 9, Issue 6

Abstract: This paper presents a new spline-based modeling method of electrocardiogram (ECG) signal that can reproduce normal as well as abnormal ECG beats. Large volume ECG data is required for automatic machine learning diagnostic systems, medical education, ... ...

Abstract	This paper presents a new spline-based modeling method of electrocardiogram (ECG) signal that can reproduce normal as well as abnormal ECG beats. Large volume ECG data is required for automatic machine learning diagnostic systems, medical education, research and testing purposes but due to privacy issues, access to this medical data is very difficult. Given this, modeling an ECG signal is a very challenging task in the field of biomedical signal processing. Spline-based modeling is the latest and one of the most efficient methods with very low computational complexity in the domain of ECG signal generation. In this paper, healthy ECG and arrhythmia conditions have been considered for the synthetic generation, (namely Atrial fibrillation and Congestive heart failure ECG beats) because these are the leading causes of death globally. To validate the performance of the presented modeling method, it is tested on 100 signals, also the percentage root mean square difference (PRD) and the root mean square error (RMSE) have been determined. These calculated values are analyzed and the results are found to be very promising and show that the presented method is one of the best methods in the field of synthetic ECG signal generation. A comparison amongst relevant existing techniques and the proposed method is also presented. The performance merit values PRD and RMSE, for the proposed method obtained are 38.99 and 0.10092, respectively, which are lower than the values obtained in other compared methods. To ensure fidelity of the proposed modeling technique with respect to IEC60601 standard, few Conformance Testing Services (CTS)database signals have also been modelled with a very close resemblance with the standard signals.
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/acf37d
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Article ; Online: Exploring the Science of Marma - An Ancient Healing Technique

Alka Mishra / Vandana Shrivastava

Dev Sanskriti: Interdisciplinary International Journal, Vol

Marma Therapy

2023 Volume 22

Abstract: Marma Science, an extraordinary gem in the vast treasure of Ayurvedic knowledge, represents the science of specific vital places in the body (Marmas), that are the ‘seats of life’ (Prana - the vital life force). As any injury to these parts may lead to ... ...

Abstract	Marma Science, an extraordinary gem in the vast treasure of Ayurvedic knowledge, represents the science of specific vital places in the body (Marmas), that are the ‘seats of life’ (Prana - the vital life force). As any injury to these parts may lead to severe pain, disability, loss of function, loss of sensation, or death, therefore, they hold an important place in the science of surgery. The ancient scriptures have strictly prohibited causing any injury to the Marmas. However, recent researches have used Marma stimulation for theraputic benefits, with encouraging outcomes. Looking at these mutually conflicting, important applications of Marma Science, the present study was undertaken for its in-depth analysis. Previously, we have explored different aspects of Marma Science in ancient and classical Indian scriptures. In addition, our other study have provided detailed description of the number of Marmas, their location, structures involved, classification, effect of trauma, etc., as per classical texts, as well as correlation with modern science. Previously, we also published its use in Yoga and other ancient Indian traditions, both as a therapeutic technique, as well as for self-defense and inflicting injury on the opponents. The present article explored its application as a therapeutic procedure (Marma Therapy). Different methods of Marma stimulation have been compiled. Therapeutic classification and applications of Marmas have been listed, and several research studies on Marma Therapy have been presented. Several mechanisms for the mode of action of Marma Therapy have been discussed. It is concluded that Marma Science holds significant promise as an effective therapeutic procedure.
Keywords	Ayurveda ; Marma Science ; Marma Therapy ; Marma Mechanism ; Yoga ; Kalaripayat ; Other systems of medicine ; RZ201-999
Subject code	501
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Dr. Chinmay Pandya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Significance of histopathological features in the diagnosis of Budd-Chiari syndrome on liver biopsies.

Prasad, Pallavi / Singh, Anurag / Singh, Alka / Mishra, Prabhaker / Krishnani, Narendra

Indian journal of pathology & microbiology

2024 Volume 67, Issue 1, Page(s) 96–101

Abstract: Background: Budd-Chiari syndrome (BCS) requires a constellation of clinical, imaging, and histological findings for diagnosis. Liver biopsy serves as a tool for confirming the diagnosis, even though the histological characteristics are not pathognomonic. ...

Abstract	Background: Budd-Chiari syndrome (BCS) requires a constellation of clinical, imaging, and histological findings for diagnosis. Liver biopsy serves as a tool for confirming the diagnosis, even though the histological characteristics are not pathognomonic. Aims: To determine which constellation of morphologic findings could aid in establishing a diagnosis of BCS in clinically suspected cases. Materials and methods: A 5-year retrospective observational study was conducted. The clinical, laboratory, and histological findings of liver biopsies in patients with a clinical diagnosis of BCS were studied. Cases were segregated into two groups on the basis of the number of histological features present. A scoring system was then devised to assess the efficacy of the histological findings in diagnosing BCS. Statistical analysis used: The continuous variables were compared using the Mann-Whitney U-test, and categorical variables were compared using the Fisher-exact test. Results: The common histopathological findings were the presence of red blood cells in the space of disse (100%), peri-portal fibrosis (97.1%), sinusoidal dilation (97.1%), portal inflammation (67.6%), centrilobular necrosis (61.8%) and pericellular/sinusoidal fibrosis (61.8%). Comparison between the two groups showed that centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis were significant parameters. No correlation was found between the clinical and laboratory parameters and the two groups. Conclusions: The liver biopsy features in BCS are often nonspecific, and no single feature in isolation is characteristic. A constellation of features (centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis), when present together, indicate the possibility of BCS.
MeSH term(s)	Humans ; Budd-Chiari Syndrome/diagnosis ; Budd-Chiari Syndrome/pathology ; Liver/pathology ; Fibrosis ; Necrosis/pathology ; Inflammation/pathology ; Biopsy
Language	English
Publishing date	2024-02-12
Publishing country	India
Document type	Observational Study ; Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_325_22
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Article ; Online: Exploring the Science of Marma - An Ancient Healing Technique

Alka Mishra / Vandana Shrivastava

Dev Sanskriti: Interdisciplinary International Journal, Vol

Marma in Yoga and Other Ancient Indian Traditions

2022 Volume 19

Abstract: Marma Science is an extremely important branch of Ayurveda. Marma points are important vital places in the body, that are the ‘seats of life’ (Prana - the vital life force). As any injury to these parts may lead to severe pain, disability, loss of ... ...

Abstract	Marma Science is an extremely important branch of Ayurveda. Marma points are important vital places in the body, that are the ‘seats of life’ (Prana - the vital life force). As any injury to these parts may lead to severe pain, disability, loss of function, loss of sensation, or death, therefore, they hold an important place in the science of surgery, wherein they are considered ‘Shalya Vishayardha’ (half of the entire science of surgery). The ancient scriptures have strictly directed against causing any injury to these vital spots. However, recent research have attempted the stimulation of Marma points for therapeutic benefits, with encouraging outcomes. In view of these mutually conflicting, importance applications of Marma Science, the present study was undertaken for its in-depth study. Part-1 of this study presented information about different aspects of Marma Science in various ancient / classical Indian scriptures. Part-2 gave a detailed description of the number of marmas, their location, structures involved, classification, the effect of trauma, etc., as per classical texts, as well as correlation with modern science. The present article, which is part-3 of this study, explores the use of Marma Science in Yoga and other ancient Indian traditions. It is observed that various Yogic practices had been devised with the primary aim of stimulating specific Marma points, with important healing applications. Several ancient Indian traditions used Marma Science both as a martial art for self-defense and inflicting injury on the opponents, and as a therapeutic technique for healing purposes.
Keywords	Ayurveda ; Marma Science ; Ashtanga Yoga ; Chakras ; Kalaripayat ; Varma-kalai ; Other systems of medicine ; RZ201-999
Subject code	501
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Dr. Chinmay Pandya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Comprehensive Literature Review of Borderline Personality Disorder: Unraveling Complexity From Diagnosis to Treatment.

Mishra, Sanskar / Rawekar, Alka / Sapkale, Bhagyesh

Cureus

2023 Volume 15, Issue 11, Page(s) e49293

Abstract: Borderline personality disorder (BPD) is a severe mental illness marked by unpredictable feelings, behaviors, and relationships. Symptoms like emotional instability, impulsivity, and poor social connections are the basis for diagnostic criteria. A ... ...

Abstract	Borderline personality disorder (BPD) is a severe mental illness marked by unpredictable feelings, behaviors, and relationships. Symptoms like emotional instability, impulsivity, and poor social connections are the basis for diagnostic criteria. A noteworthy discovery highlights the clinical overlap between BPD and several psychotic disorders by arguing that BPD and psychotic symptoms raise the risk of psychopathology. According to neuroimaging evidence, structural and functional brain changes, notably in regions controlling affective regulation and impulse control, are seen in BPD patients. Adolf Stern, a psychoanalyst, used the word "borderline" in 1938 to describe patients who exhibited increased symptoms during therapy and displayed masochistic tendencies. Modern BPD research has highlighted the complexity of symptoms like boredom, a former diagnostic criterion associated with feelings of emptiness. Though there are still unanswered problems regarding its precise, practical components, the treatment technique known as Schema therapy (ST) has shown promise in treating BPD. It's interesting to note that BPD displays complex relationships with other illnesses; for instance, some neurochemical pathways coincide with those in bulimia nervosa, pointing to a deeper level of interconnection. Concerning diagnosis, BPD's defining symptoms include, among others, the fear of abandonment, identity disruption, and recurrent suicidal conduct. The range of treatment options includes pharmacological interventions and psychotherapies like dialectical behavior therapy (DBT). Even though antidepressants like selective serotonin reuptake inhibitors (SSRIs) are routinely prescribed, research on their efficacy is ongoing, underlining the significance of thorough treatment planning. In conclusion, BPD continues to be a complex condition that calls for early detection, especially considering that it usually manifests in adolescence. While many patients report symptom relief, lingering problems still exist, emphasizing the value of comprehensive and personalized treatment strategies.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49293
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Article ; Online: Polymeric Gel Scaffolds and Biomimetic Environments for Wound Healing.

Alka / Verma, Abhishek / Mishra, Nidhi / Singh, Neelu / Singh, Priya / Nisha, Raquibun / Pal, Ravi Raj / Saraf, Shubhini A

Current pharmaceutical design

2024 Volume 29, Issue 40, Page(s) 3221–3239

Abstract: Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed. Effective wound care becomes a bigger ... ...

Abstract	Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed. Effective wound care becomes a bigger problem when various traditional wound healing methods and products may not only fail to promote good healing. Still, it may also hinder the healing process, causing wounds to stay open longer. Progress in tissue regeneration has led to developing three-dimensional scaffolds (3D) or constructs that can be leveraged to facilitate cell growth and regeneration while preventing infection and accelerating wound healing. Tissue regeneration uses natural and fabricated biomaterials that encourage the growth of tissues or organs. Even though the clinical need is urgent, the demand for polymer-based therapeutic techniques for skin tissue abnormalities has grown quickly. Hydrogel scaffolds have become one of the most imperative 3D cross-linked scaffolds for tissue regeneration because they can hold water perfectly and are porous, biocompatible, biodegradable, and biomimetic. For damaged organs or tissues to heal well, the porosity topography of the natural extracellular matrix (ECM) should be imitated. This review details the scaffolds that heal wounds and helps skin tissue to develop. After a brief overview of the bioactive and drug-loaded polymeric hydrogels, the discussion moves on to how the scaffolds are made and what they are made of. It highlights the present uses of
MeSH term(s)	Humans ; Tissue Scaffolds ; Biomimetics ; Wound Healing ; Polymers/pharmacology ; Hydrogels/pharmacology
Chemical Substances	Polymers ; Hydrogels
Language	English
Publishing date	2024-04-19
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666230816100631
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Article ; Online: Exploring the Science of Marma - An Ancient Healing Technique

Alka Mishra / Vandana Shrivastava

Dev Sanskriti: Interdisciplinary International Journal, Vol

Its mention in Ancient Indian Scriptures

2021 Volume 17

Abstract: The complex science of Marma holds an extremely important place in Ayurveda. The Marmas are specific anatomical locations in body through which vital life/bio energies of the human body flows. To be more specific, a Marma point is defined as an ... ...

Abstract	The complex science of Marma holds an extremely important place in Ayurveda. The Marmas are specific anatomical locations in body through which vital life/bio energies of the human body flows. To be more specific, a Marma point is defined as an anatomical site where muscles, veins, ligaments, bones and joints meet together. These are very important places, serving as the ‘seats of life’ (Prana - the vital life force). Any injury to these parts may lead to severe pain, disability, loss of function, loss of sensation and death. Therefore, it has been stated in the scriptures that these vital points should not be injured, and should be kept intact even while performing surgeries. Recent research indicate that if any Marma point is inflamed or painful, then stimulating its nearby Marma points can help in alleviating this pain. Several studies and texts have reported the therapeutic benefits of Marma Therapy in treating various physical and mental disorders. Looking at the importance of Marma Science with regards to surgeries, as well as their recent use and future possibilities as an effective therapeutic procedure, the present study was undertaken for an in-depth study of the Science of Marma. The present article, which is Part-1 of this study, gives an account of various ancient / classical Indian scriptures, including the Vedas, Upanishads, Puranas, Epics, Samhitas, etc., that mention different aspects of the Science of Marma. Both the spiritual aspects and complete anatomical description of Marmas are available in these scriptures. It is observed that the knowledge of Marmas was being extensively used for various purposes like warfare, self-defense, surgery, etc., ever since the Vedic age.
Keywords	Ayurveda ; Marma Science ; Marma Therapy ; Ancient Scriptures ; Veda ; Upanishad ; Other systems of medicine ; RZ201-999
Subject code	501
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Dr. Chinmay Pandya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the Science of Marma - An Ancient Healing Technique

Alka Mishra / Vandana Shrivastava

Dev Sanskriti: Interdisciplinary International Journal, Vol

Definition and Properties of Marma

2021 Volume 18

Abstract: In the vast sea of the knowledge of Ayurveda, Marma is one of the extremely important topics. Marma points have been unanimously accepted as the ‘seats of life’ (Prana - the vital life force). If these locations are injured, then it may lead to severe ... ...

Abstract	In the vast sea of the knowledge of Ayurveda, Marma is one of the extremely important topics. Marma points have been unanimously accepted as the ‘seats of life’ (Prana - the vital life force). If these locations are injured, then it may lead to severe pain, disability, loss of function, loss of sensation, or death. Therefore, the ancient scriptures have strictly directed that these vital locations should not be injured, and due care should be taken in this regard even while doing surgeries. However, recent researches indicate that if there is inflammation or pain at any Marma point, then stimulating its nearby Marma points can help in alleviating this pain. This Marma Therapy has been used in treating various physical and mental disorders, with encouraging results. In view of the importance of Marma Science mentioned in scriptures and with regards to surgeries, as well as the encouraging outcomes of Marma Therapy in recent times, the present study was undertaken for an in-depth study of the Science of Marma. Part-1 of this study gave an account of various ancient / classical Indian scriptures that mention different aspects of the Science of Marma. The present article, which is Part-2 of this study, gives a detailed description of the number of marmas, their location, structures involved, correlation with Panchamahabhutas, classification, as well as a detailed explanation of marmaghata or viddha lakshanas (effect of trauma), as given in classical texts written during Samhita kala. The anatomical correlation with modern science is also presented.
Keywords	Ayurveda ; Marma Science ; Marma Therapy ; Marma Classification ; Marmaghata ; Other systems of medicine ; RZ201-999
Subject code	501
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Dr. Chinmay Pandya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of Predictors for Late or No Registration of Pregnancy by Selecting an Appropriate Logistic Model after Comparing ANC Visits and Skilled Birth Attendant

Pawan Dubey / Akash Mishra / Neelima Alka Singh / Rabindranath Mishra / Sachit Ganapathy

Journal of Clinical and Diagnostic Research, Vol 17, Iss 1, Pp YC01-YC

2023 Volume 05

Abstract: Introduction: India is a major contributor to both maternal and neonatal death worldwide. Majority of these fatalities can be averted by adequate utilization of Antenatal care (ANC) services. Large scale surveys like National Family Health Survey follow ... ...

Abstract	Introduction: India is a major contributor to both maternal and neonatal death worldwide. Majority of these fatalities can be averted by adequate utilization of Antenatal care (ANC) services. Large scale surveys like National Family Health Survey follow hieratical characters in which subjects within the clusters are often correlated. The ordinary logistic model ignores this correlation and provide compromised estimate of effect size of predictors. Multilevel model that incorporates correlation is the appropriate method. Aim: To demonstrate the adequacy of multilevel logistic model over ordinary logistic model in hieratical data sets with ANC visits >4 and delivery assisted by Skilled Birth Attendant (SBA). Materials and Methods: This retrospective, cross-sectional study was conducted at the Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India, from October 2021 to March 2022. The data of 174607 women, who delivered the children within five years, obtained using cluster sampling, from country wide survey during 20th January 2015 to 4th December 2016 (India’s National Family Health Survey-IV) was used. Firstly, the model adequacy of ordinary and multilevel logistic models was evaluated for ANC >4 visits and delivery assisted by SBA, the same data set of fourth round National Family Health Survey by considering the outcomes;. Thereafter, predictors of late or no registration of pregnancy were identified using three level logistic model. Results: Because of high Variance Partition Coefficients (VPC) at state and district levels, the multilevel model applied on components ANC >4 visits and delivery assisted by SBA suggested better accuracy of the multilevel logistic model (-2Log L=189334 for ANC >4 visits and 141148 for delivery assisted by SBA) than the ordinary logistic model (-2Log L=220268 for ANC >4 visits and 151978 for delivery assisted by SBA). For the late (registration in third trimester of pregnancy) or no registration of pregnancy, each predictor was found ...
Keywords	antenatal care ; multilevel modelling ; national family health survey ; variance partition coefficient ; Medicine ; R
Subject code	310
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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