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  1. Article ; Online: [2021: towards a new phase for Nephrology].

    Romagnani, Paola

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2021  Volume 38, Issue 4

    MeSH term(s) Nephrology
    Language Italian
    Publishing date 2021-08-30
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
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    Zs.A 4313: Show issues Location:
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  2. Article ; Online: Mechanisms and trade-offs of kidney repair: consequences for the nephrology clinician.

    Romagnani, Paola

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 37, Issue 6, Page(s) 1046–1048

    MeSH term(s) Humans ; Kidney ; Nephrology
    Language English
    Publishing date 2020-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  3. Article ; Online: Progenitor hierarchy among parietal epithelial cells depicted at the single-cell level.

    Romagnani, Paola / Barisoni, Laura

    Kidney international

    2023  Volume 104, Issue 1, Page(s) 33–35

    Abstract: The role of parietal epithelial cells (PECs) in kidney function and disease was recently revisited. Building on previous studies of human kidney tissue, in the current issue, Liu et al. further characterize PECs using single-cell RNA sequencing data and ... ...

    Abstract The role of parietal epithelial cells (PECs) in kidney function and disease was recently revisited. Building on previous studies of human kidney tissue, in the current issue, Liu et al. further characterize PECs using single-cell RNA sequencing data and confirm the crucial pathophysiological role of PECs in murine kidney biology as a reservoir for different types of progenitors.
    MeSH term(s) Humans ; Mice ; Animals ; Kidney Glomerulus ; Podocytes/physiology ; Epithelial Cells/physiology ; Kidney
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.04.019
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    Zs.A 797: Show issues Location:
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  4. Article ; Online: Polyploid tubular cells: a shortcut to stress adaptation.

    De Chiara, Letizia / Lazzeri, Elena / Romagnani, Paola

    Kidney international

    2024  Volume 105, Issue 4, Page(s) 709–716

    Abstract: Tubular epithelial cells (TCs) compose the majority of kidney parenchyma and play fundamental roles in maintaining homeostasis. Like other tissues, mostly immature TC with progenitor capabilities are able to replace TC lost during injury via clonal ... ...

    Abstract Tubular epithelial cells (TCs) compose the majority of kidney parenchyma and play fundamental roles in maintaining homeostasis. Like other tissues, mostly immature TC with progenitor capabilities are able to replace TC lost during injury via clonal expansion and differentiation. In contrast, differentiated TC lack this capacity. However, as the kidney is frequently exposed to toxic injuries, evolution positively selected a response program that endows differentiated TC to maintain residual kidney function during kidney injury. Recently, we and others have described polyploidization of differentiated TC, a mechanism to augment the function of remnant TC after injury by rapid hypertrophy. Polyploidy is a condition characterized by >2 complete sets of chromosomes. Polyploid cells often display an increased functional capacity and are generally more resilient to stress as evidenced by being conserved across many plants and eukaryote species from flies to mammals. Here, we discuss the occurrence of TC polyploidy in different contexts and conditions and how this integrates into existing concepts of kidney cell responses to injury. Collectively, we aim at stimulating the acquisition of novel knowledge in the kidney field as well as accelerating the translation of this basic response mechanism to the clinical sphere.
    MeSH term(s) Animals ; Hepatocytes ; Cell Differentiation ; Epithelial Cells ; Polyploidy ; Kidney ; Mammals
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.10.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  5. Article ; Online: Polyploid tubular cells and chronic kidney disease.

    De Chiara, Letizia / Romagnani, Paola

    Kidney international

    2022  Volume 102, Issue 5, Page(s) 959–961

    Abstract: Defective DNA repair drives chronic kidney disease (CKD), but mechanisms are unclear. Airik and colleagues use a genetic model of defective DNA repair mimicking karyomegalic nephritis, a form of CKD characterized by tubular epithelial cells (TEC) with ... ...

    Abstract Defective DNA repair drives chronic kidney disease (CKD), but mechanisms are unclear. Airik and colleagues use a genetic model of defective DNA repair mimicking karyomegalic nephritis, a form of CKD characterized by tubular epithelial cells (TEC) with large nuclei and tubulointerstitial nephritis. They show that DNA damage in TEC triggers endoreplication leading to polyploid TEC and CKD. Blocking endoreplication preserved kidney function, suggesting that DNA damage triggers CKD via TEC polyploidization, questioning the concept of G2/M-arrest.
    MeSH term(s) Humans ; Nephritis, Interstitial/genetics ; Epithelial Cells ; Renal Insufficiency, Chronic/genetics ; Nephritis ; Polyploidy ; Kidney Tubules
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Organoids: Modelling polycystic kidney disease.

    Romagnani, Paola

    Nature materials

    2017  Volume 16, Issue 11, Page(s) 1058–1059

    MeSH term(s) Humans ; Organoids ; Pluripotent Stem Cells ; Polycystic Kidney Diseases
    Language English
    Publishing date 2017-10-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/nmat5013
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  7. Article ; Online: Erratum to: FC041 tubular epithelial cell polyploidy is essential to survive AKI but contributes to CKD progression.

    De Chiara, Letizia / Lazzeri, Elena / Romagnani, Paola

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 37, Issue 8, Page(s) 1588

    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfab341
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    Zs.A 2198: Show issues Location:
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  8. Article ; Online: Renal Progenitors Derived from Urine for Personalized Diagnosis of Kidney Diseases.

    Mazzinghi, Benedetta / Melica, Maria Elena / Lasagni, Laura / Romagnani, Paola / Lazzeri, Elena

    Kidney & blood pressure research

    2024  Volume 49, Issue 1, Page(s) 258–265

    Abstract: Background: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the ... ...

    Abstract Background: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the complexity of kidney diseases, revealing their frequent genetic etiology, particularly in children and young subjects. Genetic heterogeneity and drug screening require patient-derived disease models to establish a correct diagnosis and evaluate new potential treatments and outcomes.
    Summary: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome.
    Key messages: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare.
    MeSH term(s) Humans ; Precision Medicine ; Stem Cells ; Kidney Diseases/diagnosis ; Kidney Diseases/urine ; Kidney/pathology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/urine ; Urine/cytology
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000538507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1458: Show issues Location:
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  9. Article ; Online: Glomerulonephritis: immunopathogenesis and immunotherapy.

    Anders, Hans-Joachim / Kitching, A Richard / Leung, Nelson / Romagnani, Paola

    Nature reviews. Immunology

    2023  Volume 23, Issue 7, Page(s) 453–471

    Abstract: Glomerulonephritis' (GN) is a term used to describe a group of heterogeneous immune-mediated disorders characterized by inflammation of the filtration units of the kidney (the glomeruli). These disorders are currently classified largely on the basis of ... ...

    Abstract 'Glomerulonephritis' (GN) is a term used to describe a group of heterogeneous immune-mediated disorders characterized by inflammation of the filtration units of the kidney (the glomeruli). These disorders are currently classified largely on the basis of histopathological lesion patterns, but these patterns do not align well with their diverse pathological mechanisms and hence do not inform optimal therapy. Instead, we propose grouping GN disorders into five categories according to their immunopathogenesis: infection-related GN, autoimmune GN, alloimmune GN, autoinflammatory GN and monoclonal gammopathy-related GN. This categorization can inform the appropriate treatment; for example, infection control for infection-related GN, suppression of adaptive immunity for autoimmune GN and alloimmune GN, inhibition of single cytokines or complement factors for autoinflammatory GN arising from inborn errors in innate immunity, and plasma cell clone-directed or B cell clone-directed therapy for monoclonal gammopathies. Here we present the immunopathogenesis of GN and immunotherapies in use and in development and discuss how an immunopathogenesis-based GN classification can focus research, and improve patient management and teaching.
    MeSH term(s) Humans ; Glomerulonephritis/therapy ; Glomerulonephritis/etiology ; Adaptive Immunity ; Immunity, Innate ; Cytokines ; Immunotherapy
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00816-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5565: Show issues Location:
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  10. Article ; Online: The five types of glomerulonephritis classified by pathogenesis, activity and chronicity (GN-AC).

    Romagnani, Paola / Kitching, A Richard / Leung, Nelson / Anders, Hans-Joachim

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue Supplement_2, Page(s) ii3–ii10

    Abstract: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders. Currently, GN is classified largely by histological patterns that are difficult to understand and teach, and most importantly, do not indicate treatment choices. Indeed, altered ... ...

    Abstract Glomerulonephritis (GN) is a diverse group of immune-mediated disorders. Currently, GN is classified largely by histological patterns that are difficult to understand and teach, and most importantly, do not indicate treatment choices. Indeed, altered systemic immunity is the primary pathogenic process and the key therapeutic target in GN. Here, we apply a conceptual framework of immune-mediated disorders to GN guided by immunopathogenesis and hence immunophenotyping: (i) infection-related GN require pathogen identification and control; (ii) autoimmunity-related GN, defined by presence of autoantibodies and (iii) alloimmunity-related GN in transplant recipients both require the suppression of adaptive immunity in lymphoid organs and bone marrow; (iv) autoinflammation-related GN, e.g. inborn errors of immunity diagnosed by genetic testing, requires suppression of single cytokine or complement pathways; and (v) Monoclonal gammopathy-related GN requires B or plasma cell clone-directed therapy. A new GN classification should include disease category, immunological activity to tailor the use of the increasing number of immunomodulatory drugs, and chronicity to trigger standard chronic kidney disease care including the evolving spectrum of cardio-renoprotective drugs. Certain biomarkers allow diagnosis and the assessment of immunological activity and disease chronicity without kidney biopsy. The use of these five GN categories and a therapy-focused GN classification is likely to overcome some of the existing hurdles in GN research, management and teaching by reflecting disease pathogenesis and guiding the therapeutic approach.
    MeSH term(s) Humans ; Glomerulonephritis/diagnosis ; Glomerulonephritis/etiology ; Glomerulonephritis/therapy ; Biomarkers ; Autoantibodies ; Renal Insufficiency, Chronic ; Nephrectomy
    Chemical Substances Biomarkers ; Autoantibodies
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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