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  1. Article ; Online: The Role of Exercise Before Cancer Treatment.

    Denehy, Linda / Edbrooke, Lara

    Seminars in oncology nursing

    2022  Volume 38, Issue 5, Page(s) 151330

    Abstract: Objectives: We aim to describe on the role of exercise in preparation for cancer treatments (prehabilitation) that include surgery and neoadjuvant or nonsurgical approaches. We discuss the evidence for the role of exercise and provide guidelines to ... ...

    Abstract Objectives: We aim to describe on the role of exercise in preparation for cancer treatments (prehabilitation) that include surgery and neoadjuvant or nonsurgical approaches. We discuss the evidence for the role of exercise and provide guidelines to exercise prescription and examples of the structure of prehabilitation exercise programs.
    Data source: We use peer-reviewed articles obtained through PubMed searches with search terms: exercise, oncology, cancer surgery, exercise physiology, respiratory exercises, prehabilitation, and behavior change.
    Conclusion: The emergence of prehabilitation in preparing patients for cancer care has followed a rapidly upward trajectory over the past 20 years. Exercise prehabilitation remains the cornerstone of management, particularly in patients attending for major surgery. Multimodal approaches to supporting patients before cancer treatment are now well accepted and include screening and individualized treatments of functional, nutritional, and psychological impairments. Respiratory training before surgery and the addition of behavior change strategies to improve adherence to interventions and promote improved longer-term outcomes are now included in many prehabilitation programs. For exercise to be an effective treatment in improving fitness and strength, supervised aerobic and resistance exercises at moderate intensity are recommended. There remains debate regarding the use of higher-intensity exercise, the appropriate outcome to measure efficacy, and the mechanisms driving the efficacy of exercise.
    Implications for nursing practice: We provide background evidence and knowledge pertaining to the role and provision of exercise prehabilitation. Understanding screening, risk factors, and potential efficacy assists in knowing who to refer for prehabilitation and what the programs include. This enables more effective com munication with patients attending for cancer treatments.
    MeSH term(s) Humans ; Preoperative Care ; Exercise ; Exercise Therapy ; Treatment Outcome ; Neoplasms/rehabilitation
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632682-1
    ISSN 1878-3449 ; 0749-2081
    ISSN (online) 1878-3449
    ISSN 0749-2081
    DOI 10.1016/j.soncn.2022.151330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prehabilitation exercise programs for patients undergoing cancer surgery, does one size fit all?

    Steffens, Daniel / Denehy, Linda

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 49, Issue 2, Page(s) 303–305

    MeSH term(s) Humans ; Preoperative Exercise ; Exercise ; Preoperative Care ; Exercise Therapy ; Neoplasms ; Postoperative Complications
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Editorial
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.11.591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: "The Ability to Go Out into the World Is the Most Important Thing"-A Qualitative Study of Important Exercise Outcomes for People with Lung Cancer.

    Bowman, Amy / Denehy, Linda / McDonald, Cassie E / Edbrooke, Lara

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 2, Page(s) 733–746

    Abstract: Whilst existing quantitative research identifies outcomes believed to be important by researchers and clinicians, it may neglect outcomes that are meaningful to patients. This study aimed to explore the outcomes of exercise that are important to people ... ...

    Abstract Whilst existing quantitative research identifies outcomes believed to be important by researchers and clinicians, it may neglect outcomes that are meaningful to patients. This study aimed to explore the outcomes of exercise that are important to people with lung cancer and their carers. Data collection involved a qualitative methodology including semi-structured interviews and focus groups. Question guide development was informed by the International Classification of Functioning (ICF) framework. Data were analyzed by two researchers with NVivo (v12) software using a conventional content analysis process, followed by directed content analysis to map outcomes to the ICF. Conduct and reporting adhered to COREQ guidelines. Fifteen participants provided data. Most participants had received their diagnoses 24 months prior to study involvement (
    MeSH term(s) Humans ; International Classification of Functioning, Disability and Health ; Lung Neoplasms/therapy ; Frailty ; Qualitative Research ; Focus Groups
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31020054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: CONCISE DENTAL ANATOMY AND MORPHOLOGY. BY JAMES L. FULLER, GERALD E. DENEHY ; ILLUSTRATED BY WILLIAM GIRSCH

    Fuller, James L. / Denehy, Gerald E.

    1977  

    Title variant CONCISE DENTAL ANATOMY AND MORPHOLOGY
    Keywords TOOTH / ANATOMY & HISTOLOGY
    Size VII,337 S.
    Publisher YEAR BOOK MEDICAL PUBLISHERS
    Publishing place CHICAGO; LONDON
    Document type Book
    HBZ-ID HT000130776
    ISBN 0-8151-3299-9 ; 978-0-8151-3299-8
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Identifying strategies for implementing a clinical guideline for cancer-related fatigue: a qualitative study.

    Pearson, Elizabeth J / Denehy, Linda / Edbrooke, Lara

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 395

    Abstract: Background: Clinical practice guidelines assist health professionals' (HPs) decisions. Costly to develop, many guidelines are not implemented in clinical settings. This paper describes an evaluation of contextual factors to inform clinical guideline ... ...

    Abstract Background: Clinical practice guidelines assist health professionals' (HPs) decisions. Costly to develop, many guidelines are not implemented in clinical settings. This paper describes an evaluation of contextual factors to inform clinical guideline implementation strategies for the common and distressing problem of cancer-related fatigue (CRF) at an Australian cancer hospital.
    Methods: A qualitative inquiry involving interviews and focus groups with consumers and multidisciplinary HPs explored key Canadian CRF guideline recommendations. Four HP focus groups examined the feasibility of a specific recommendation, while a consumer focus group examined experiences and preferences for managing CRF. Audio recordings were analysed using a rapid method of content analysis designed to accelerate implementation research. Strategies for implementation were guided by the Consolidated Framework for Implementation Research.
    Results: Five consumers and 31 multidisciplinary HPs participated in eight interviews and five focus groups. Key HP barriers to fatigue management were insufficient knowledge and time; and lack of accessible screening and management tools or referral pathways. Consumer barriers included priority for cancer control during short health consultations, limited stamina for extended or extra visits addressing fatigue, and HP attitudes towards fatigue. Enablers of optimal fatigue management were alignment with existing healthcare practices, increased HP knowledge of CRF guidelines and tools, and improved referral pathways. Consumers valued their HPs addressing fatigue as part of treatment, with a personal fatigue prevention or management plan including self-monitoring. Consumers preferred fatigue management outside clinic appointments and use of telehealth consultations.
    Conclusions: Strategies that reduce barriers and leverage enablers to guideline use should be trialled. Approaches should include (1) accessible knowledge and practice resources for busy HPs, (2) time efficient processes for patients and their HPs and (3) alignment of processes with existing practice. Funding for cancer care must enable best practice supportive care.
    MeSH term(s) Humans ; Australia ; Canada ; Qualitative Research ; Focus Groups ; Neoplasms ; Fatigue
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09377-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intensive preoperative rehabilitation improves functional capacity and postoperative hospital length of stay in elderly patients with lung cancer [commentary].

    Denehy, Linda

    Journal of physiotherapy

    2017  Volume 63, Issue 3, Page(s) 184

    MeSH term(s) Aged ; Hospitals ; Humans ; Length of Stay ; Lung Neoplasms ; Preoperative Care
    Language English
    Publishing date 2017-06-19
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2543915-7
    ISSN 1836-9561 ; 1836-9553 ; 0004-9514
    ISSN (online) 1836-9561
    ISSN 1836-9553 ; 0004-9514
    DOI 10.1016/j.jphys.2017.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Improving generalisability.

    Martis, W R / Denehy, L / Ismail, H / Riedel, B

    Anaesthesia

    2023  Volume 79, Issue 3, Page(s) 329

    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.16145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surviving COVID-19: a familiar road to recovery?

    Denehy, Linda / Puthucheary, Zudin

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 11, Page(s) 1211–1213

    MeSH term(s) Accidents, Traffic ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-10-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00447-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Physical activity and pain in people with cancer: a systematic review and meta-analysis.

    Peters, Mitchell / Butson, Grace / Mizrahi, David / Denehy, Linda / Lynch, Brigid M / Swain, Christopher T V

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 3, Page(s) 145

    Abstract: Purpose: Physical activity can provide analgesic benefit but its effect on cancer-related pain is unclear. This review synthesised and appraised the evidence for the effect of physical activity on pain in people living with or beyond cancer.: Methods!# ...

    Abstract Purpose: Physical activity can provide analgesic benefit but its effect on cancer-related pain is unclear. This review synthesised and appraised the evidence for the effect of physical activity on pain in people living with or beyond cancer.
    Methods: A systematic search of Ovid Medline and Embase was performed to identify randomised controlled trials (RCTs), randomised cross-over studies (RXTs), and prospective observational studies that examined physical activity and pain outcomes in adults living with or beyond cancer. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the GRADE system was used to assess evidence quality.
    Results: One hundred twenty-one studies (n = 13,806), including 102 RCTs, 6 RXTs, and 13 observational studies, met the criteria for inclusion. Meta-analyses of RCTs identified a decrease in pain intensity (n = 3734; standardised mean difference (SMD) - 0.30; 95% confidence interval (CI) - 0.45, - 0.15) and bodily pain (n = 1170; SMD 0.28; 95% CI 0.01, 0.56) but not pain interference (n = 207; SMD - 0.13, 95% CI - 0.42, 0.15) following physical activity interventions. Individual studies also identified a reduction in pain sensitivity but not analgesic use, although meta-analysis was not possible for these outcomes. High heterogeneity between studies, low certainty in some effect estimates, and possible publication bias meant that evidence quality was graded as very low to low.
    Conclusion: Physical activity may decrease pain in people living with and beyond cancer; however, high heterogeneity limits the ability to generalise this finding to all people with cancer or to specific types of cancer-related pain.
    MeSH term(s) Humans ; Cancer Pain ; Exercise ; Neoplasms ; Observational Studies as Topic ; Pain Measurement ; Pain Threshold ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-02-06
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08343-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Preoperative physiotherapy prevents postoperative pulmonary complications after major abdominal surgery: a meta-analysis of individual patient data.

    Boden, Ianthe / Reeve, Julie / Jernås, Anna / Denehy, Linda / Fagevik Olsén, Monika

    Journal of physiotherapy

    2024  

    Abstract: Questions: Among patients having elective abdominal surgery, how much does preoperative physiotherapy education with breathing exercise training reduce the incidence of postoperative pulmonary complications (PPCs), hospital length of stay and 12-month ... ...

    Abstract Questions: Among patients having elective abdominal surgery, how much does preoperative physiotherapy education with breathing exercise training reduce the incidence of postoperative pulmonary complications (PPCs), hospital length of stay and 12-month mortality? How stable are the treatment effects across different PPC definitions, including pneumonia? How much do the treatment effects on PPC, hospital length of stay and mortality vary within clinically relevant subgroups?
    Design: Individual participant-level meta-analysis (n = 800) from two randomised controlled trials analysed with multivariable regression.
    Participants: Adults undergoing major elective abdominal surgery.
    Interventions: Experimental participants received a single preoperative session with a physiotherapist within 4 weeks of surgery and educated on PPC prevention with breathing exercises and early mobilisation. They were taught breathing exercises and instructed to start them immediately on waking from surgery. The control group received no preoperative or postoperative physiotherapy, or early ambulation alone.
    Outcome measures: PPC, hospital length of stay and 12-month mortality.
    Results: Participants who received preoperative physiotherapy had 47% lower odds of developing a PPC (adjusted OR 0.53, 95% CI 0.34 to 0.85). This effect was stable regardless of PPC definition. Effects were greatest in participants who smoked, were aged ≤ 45 years, had abnormal body weight, had multiple comorbidities, or were undergoing bariatric or upper gastrointestinal surgery. Participants having operations ≤ 3 hours in duration were least responsive to preoperative physiotherapy. Participants with multiple comorbidities were more likely to have a shorter hospital stay if provided with preoperative physiotherapy (adjusted MD -3.2 days, 95% CI -6.2 to -0.3). Effects on mortality were uncertain.
    Conclusion: There is strong evidence to support preoperative physiotherapy in preventing PPCs after elective abdominal surgery.
    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2543915-7
    ISSN 1836-9561 ; 1836-9553 ; 0004-9514
    ISSN (online) 1836-9561
    ISSN 1836-9553 ; 0004-9514
    DOI 10.1016/j.jphys.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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