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Article ; Online: Acute hypoxemia due to right-to-left shunt via a patent foramen ovale during left internal thoracic artery to left anterior descending artery anastomosis in off-pump coronary artery bypass grafting: a case report.

Okutomi, Yuki / Sajima, Takeyuki / Yasuda, Atsushi / Sawamura, Shigehito

JA clinical reports

2023 Volume 9, Issue 1, Page(s) 15

Abstract: Background: A right-to-left shunt via a patent foramen ovale (PFO) during off-pump coronary artery bypass (OPCAB) may result in difficulties in oxygenation and circulatory management. We herein present a case of a marked shunt via a PFO during OPCAB.: ...

Abstract	Background: A right-to-left shunt via a patent foramen ovale (PFO) during off-pump coronary artery bypass (OPCAB) may result in difficulties in oxygenation and circulatory management. We herein present a case of a marked shunt via a PFO during OPCAB. Case presentation: A 74-year-old man who had aortic root enlargement, compressing the right atrium, and an atrial septal aneurysm, underwent OPCAB. When the heart was fixed for the anastomosis of the left anterior descending artery, sudden hypoxemia and hypotension were observed. Intraoperative transesophageal echocardiography (TEE) showed a right-to-left shunt via a PFO that was unnoticed preoperatively. After the anastomosis was completed, TEE revealed no shunt through the PFO. Conclusions: We should check for a PFO in case of an atrial septal aneurysm. Compression of the right atrium is considered an important anatomical risk of the right-to-left shunt in OPCAB.
Language	English
Publishing date	2023-03-16
Publishing country	Germany
Document type	Journal Article
ISSN	2363-9024
ISSN (online)	2363-9024
DOI	10.1186/s40981-023-00607-x
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Article ; Online: Nursery school absenteeism surveillance system and infection control measures in nursery schools.

Mukasa, Kyoko / Sugawara, Tamie / Okutomi, Yoichi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 29, Issue 11, Page(s) 1017–1022

Abstract: Introduction: The Nursery School Absenteeism Surveillance System (NSASSy), which includes 40% of all nursery schools in Japan, has a degree of effectiveness that is difficult to prove: nursery schools and areas without NSASSy cannot be evaluated for ... ...

Abstract	Introduction: The Nursery School Absenteeism Surveillance System (NSASSy), which includes 40% of all nursery schools in Japan, has a degree of effectiveness that is difficult to prove: nursery schools and areas without NSASSy cannot be evaluated for their incidence of infectious diseases as precisely as those with NSASSy. Instead, we examine nursery school countermeasures against infectious diseases by considering the endogeneity bias of NSASSy. Method: After sending questionnaires to 500 Tokyo metropolitan and nearby nursery schools in November 2022, we received their responses through the end of 2022. Questionnaires asked about infection control measures of nursery schools: (1) cooperation with public health centers; (2) cooperation with staff; (3) cooperation with children's parents; (4) precautions among children; (5) countermeasure systems; (6) precaution systems; (7) recording of health conditions of children; (8) usefulness of studying while students; and (9) usefulness of training at nursery schools. Ordered probit with inverse probability weighted adjustment was used as the estimation procedure. The explanatory variable was a dummy variable for using NSASSy. Probability in weight was estimated using the first-step probit for NSASSy. Explanatory variables were a dummy variable for publicly funded nursery schools and a dummy variable for local governments that had adopted NSASSy. Results: We analyzed 193 nursery schools. NSASSy was negative and associated significantly with (3) cooperation with children's parents and (7) recording of health conditions of children. These countermeasures were more likely to have been taken by NSASSy nursery schools.
MeSH term(s)	Child ; Humans ; Schools, Nursery ; Absenteeism ; Schools ; Communicable Diseases ; Infection Control
Language	English
Publishing date	2023-07-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.07.002
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Zs.A 5236: Show issues

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Article ; Online: Susceptibility of nursery teachers to measles, rubella, varicella and mumps in Japan.

Mukasa, Kyoko / Sugawara, Tamie / Okutomi, Yoichi

Vaccine

2023 Volume 41, Issue 43, Page(s) 6530–6534

Abstract: Background: A guideline published in 2018 by the Ministry of Health, Labour and Welfare stipulated confirmation of the vaccine history of nursery staff members.: Object: This study was conducted to elucidate nursery teachers' vaccine and infection ... ...

Abstract	Background: A guideline published in 2018 by the Ministry of Health, Labour and Welfare stipulated confirmation of the vaccine history of nursery staff members. Object: This study was conducted to elucidate nursery teachers' vaccine and infection histories for measles, mumps, rubella, and varicella through survey responses. Method: After sending questionnaires through the mail to 5000 nursery teachers in November 2022, we received responses through December 2022. We measured the proportion of susceptibility in three ways. Additionally, we compared the proportions of susceptibility by disease by age class. Results: After receiving 1620 responses in all, the data of 1229 respondents under 50 years old were analyzed. Under the broad definition by which "no answer" was also regarded as unvaccinated or uinfected as well as "unknown," the proportions of susceptibility for measles, rubella, and varicella were higher: 22-23%. For mumps, the proportion was 42%. For varicella, they were 31% for respondents in their 30 s, and 14% for respondents in their 40 s. For mumps, the respective values were 58% and 26%. Discussion: Respondents assessed for this study were less susceptible and unknown in comparison with earlier studies investigating health care workers, school teachers, university students, and pregnant women. Conclusion: The survey revealed that measles and rubella susceptibility was higher among respondents in their 30 s. However, it was higher for varicella and mumps among respondents in their 20 s.
MeSH term(s)	Pregnancy ; Humans ; Female ; Middle Aged ; Chickenpox/epidemiology ; Chickenpox/prevention & control ; Mumps/epidemiology ; Mumps/prevention & control ; Japan/epidemiology ; Rubella/epidemiology ; Rubella/prevention & control ; Measles/epidemiology ; Measles/prevention & control ; Herpesvirus 3, Human ; Chickenpox Vaccine ; Measles-Mumps-Rubella Vaccine ; Antibodies, Viral
Chemical Substances	Chickenpox Vaccine ; Measles-Mumps-Rubella Vaccine ; Antibodies, Viral
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.09.028
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Stability of lidocaine solutions following sodium bicarbonate alkalinization.

Hyuga, Shunsuke / Tomoda, Yoshinori / Okutomi, Toshiyuki

Regional anesthesia and pain medicine

2022

Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2022-103724
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Zs.B 2399: Show issues

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Article ; Online: Maternal heart rate variability patterns associated with maternal hypotension and non-reassuring fetal heart rate patterns following initiation of combined spinal-epidural labor analgesia: a prospective observational trial.

Hyuga, S / Parry, R / Dan, W / Onishi, Y / Gallos, G / Okutomi, T

International journal of obstetric anesthesia

2023 Volume 54, Page(s) 103645

Abstract: Background: We evaluated whether baseline maternal heart rate variability (HRV), including the Analgesia Nociception Index (ANI), is associated with maternal hypotension and fetal heart rate (FHR) abnormalities following combined spinal-epidural (CSE) ... ...

Abstract	Background: We evaluated whether baseline maternal heart rate variability (HRV), including the Analgesia Nociception Index (ANI), is associated with maternal hypotension and fetal heart rate (FHR) abnormalities following combined spinal-epidural (CSE) labor analgesia. Methods: Laboring women were enrolled in this prospective observational study. The primary endpoint was maternal hypotension. The secondary endpoint was FHR abnormalities within 30 min following CSE analgesia initiated with intrathecal plain bupivacaine 1.0 mg and fentanyl 20 µg. The maternal ANI, electrocardiogram, blood pressure, heart rate, oxygen saturation, and FHR tracings were recorded 15 min before and 30 min after CSE. Parturients were grouped based on presence of hypotension and FHR abnormalities. Patient demographics and HRV metrics were compared. Receiver operating characteristics (ROC) curves were constructed for the prediction of hypotension and FHR abnormalities. Results: No significant intergroup differences were detected in patient characteristics. Several baseline HRV metrics and ANI differed significantly between the normotensive (n = 50) and hypotensive (n = 31) groups and between parturients showing FHR abnormalities (n = 19) and those showing reassuring FHR traces (n = 62). The area under the ROC curve (AUC) for predicting hypotension of the baseline low-frequency (LF)/high-frequency (HF) ratio was 0.677 (95% CI 0.55 to 0.80), and that of the ANI was 0.858 (95% CI 0.78 to 0.94). For predicting non-reassuring FHR patterns, the AUC of the LF/HF ratio was 0.77 (95% CI 0.65 to 0.89), and that of the ANI was 0.833 (95% CI 0.72 to 0.94). Conclusions: The ANI can predict the propensity for maternal hypotension and non-reassuring FHR patterns following CSE.
MeSH term(s)	Pregnancy ; Female ; Humans ; Heart Rate, Fetal ; Labor, Obstetric/physiology ; Analgesia, Epidural ; Bupivacaine ; Hypotension ; Analgesia, Obstetrical
Chemical Substances	Bupivacaine (Y8335394RO)
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1086024-1
ISSN	1532-3374 ; 0959-289X
ISSN (online)	1532-3374
ISSN	0959-289X
DOI	10.1016/j.ijoa.2023.103645
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Zs.A 3311: Show issues

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Article: [The first labor analgesia with drug was already performed in late Meiji-Period (1868-1912): trace of opioid-scopolamine which was used in Akiko Yosano, back to its origins].

Okutomi, Toshiyuki

Masui. The Japanese journal of anesthesiology

2013 Volume 62, Issue 2, Page(s) 239–243

Abstract: There have been some records of labor analgesia with intravenous or rectal anesthetics in early Showa-period (1926-1989). However, the author found that labor analgesia had been already attempted for some women in late Meiji-period (1868-1912). One of ... ...

Abstract	There have been some records of labor analgesia with intravenous or rectal anesthetics in early Showa-period (1926-1989). However, the author found that labor analgesia had been already attempted for some women in late Meiji-period (1868-1912). One of agents used was pantopon, a water-soluble opioid without serious respiratory depression as morphine. The drug was developed and produced in Germany. Some doctors applied this agent with scopolamine to labor analgesia in Europe. They also reported that this combination also conferred excellent analgesic effects without any serious complications in the mother and fetus. This combination was originally used for general surgery with inhaled anesthesia at that period. It remains uncertain how Japanese doctors got pantopon scopolamine from Germany.
MeSH term(s)	Adjuvants, Anesthesia/administration & dosage ; Analgesia, Obstetrical/history ; Analgesics, Opioid/administration & dosage ; Famous Persons ; Female ; History, 19th Century ; History, 20th Century ; Humans ; Japan ; Literature/history ; Opium/administration & dosage ; Pregnancy ; Scopolamine Hydrobromide/administration & dosage
Chemical Substances	Adjuvants, Anesthesia ; Analgesics, Opioid ; Scopolamine Hydrobromide (451IFR0GXB) ; Opium (8008-60-4)
Language	Japanese
Publishing date	2013-02
Publishing country	Japan
Document type	Biography ; English Abstract ; Historical Article ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Article: [The first labor analgesia with drug was performed in late Meiji Period (1868-1912). Hypnosis also attracted attention as a method of labor analgesia in mid-Meiji Period].

Okutomi, Toshiyuki

Masui. The Japanese journal of anesthesiology

2013 Volume 62, Issue 11, Page(s) 1380–1384

Abstract: Ether or chloroform, was in use for ambulatory surgery after 1861 in Japan. An inhalational anesthetic, especially chloroform, was administered for cesarean section in early Meiji Period (from 1868) up to 1897. According to an article in 1903, chloroform ...

Abstract	Ether or chloroform, was in use for ambulatory surgery after 1861 in Japan. An inhalational anesthetic, especially chloroform, was administered for cesarean section in early Meiji Period (from 1868) up to 1897. According to an article in 1903, chloroform was recommended as a strategy for internal cephalic version. However, it is uncertain whether inhalational anesthetic had been utilized for vaginal deliveries before 1903. There is evidence that hypnosis had attracted attention as a method of labor analgesia around that time.
MeSH term(s)	Analgesia, Obstetrical/history ; Analgesia, Obstetrical/methods ; Anesthetics, Inhalation/history ; Cesarean Section/history ; Cesarean Section/methods ; Chloroform/history ; Ethers/history ; Female ; History, 19th Century ; History, 20th Century ; Humans ; Hypnosis, Anesthetic/history ; Hypnosis, Anesthetic/methods ; Japan ; Pregnancy
Chemical Substances	Anesthetics, Inhalation ; Ethers ; Chloroform (7V31YC746X)
Language	Japanese
Publishing date	2013-11
Publishing country	Japan
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Zs.B 360: Show issues

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Article: [Akiko Yosano, the famous Japanese poet and writer, is the first lady who experienced labor analgesia in Japan?].

Okutomi, Toshiyuki

Masui. The Japanese journal of anesthesiology

2011 Volume 60, Issue 10, Page(s) 1214–1220

Abstract: There have been some records of labor analgesia with intravenous or rectal anesthetics since 1925. It is widely believed that labor epidural analgesia in Japan started to become popular after the World War II (1939-1945). However, the author found that ... ...

Abstract	There have been some records of labor analgesia with intravenous or rectal anesthetics since 1925. It is widely believed that labor epidural analgesia in Japan started to become popular after the World War II (1939-1945). However, the author found that Akiko Yosano, a well-known Japanese female poet and writer, had labor analgesia for her 5th son as early as 1916. She was given a mixture of an opioid alkaloid and scopolamine and had painless labor and delivery. She took this experience as a pleasant surprise and described "Never once, had I screamed or feel sweaty during my labor". She loved this comfortable and easy labor so much that she had it again for her 6th son in 1917. Her obstetrician was Dr. Yuzo Ohmi, who had studied in Munich University from 1910 to 1913. He brought this miracle painkiller from Germany to Japan and gave it to her for the first time in Japan. Akiko's husband, Tekkan Yosano, met Dr. Ohmi on a ship to Marseilles in 1911. Then, they and Akiko promoted friendship in Munich and Japan. Her labor experience and friendship with Dr. Ohmi are described in her collected essays "Warera-naniwo-motomuruka? (What do we long for?)" and "Ai-Risei-oyobi-yuhki (Love, Reason, and Bravery)". Dr. Ohmi's wife became a pupil of Akiko.
MeSH term(s)	Analgesia, Epidural/history ; Analgesia, Obstetrical/history ; Anesthesiology/history ; Female ; History, 20th Century ; Humans ; Japan ; Poetry as Topic/history ; Pregnancy ; Scopolamine Hydrobromide/history
Chemical Substances	Scopolamine Hydrobromide (451IFR0GXB)
Language	Japanese
Publishing date	2011-10
Publishing country	Japan
Document type	Biography ; English Abstract ; Historical Article ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Zs.B 360: Show issues

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Article: [From balanced analgesia to epidural analgesia or combined spinal-epidural analgesia for relief of labor pain].

Okutomi, Toshiyuki

Masui. The Japanese journal of anesthesiology

2010 Volume 59, Issue 3, Page(s) 319–327

Abstract: The trial of labor analgesia in Japan dates back to the year 1929. After the foundation of the original Japan Society of Obstetric Anesthesia and Perinatology in 1961, various labor analgesia techniques were widely attempted. Some anesthetists relieved ... ...

Abstract	The trial of labor analgesia in Japan dates back to the year 1929. After the foundation of the original Japan Society of Obstetric Anesthesia and Perinatology in 1961, various labor analgesia techniques were widely attempted. Some anesthetists relieved the labor pain with balanced anesthesia using intravenous (diazepam and pethidine during the 1st stage of labor, followed by pentobarbital or ketamine during the 2nd stage of labor) combined with inhalational anesthetic (methoxyflurane or enflurane), while the others tried regional anesthesia. In 1990's, epidural analgesia with bupivacaine became more popular as a standard method of labor analgesia. Recently, the choice of local anesthetic has changed to ropivacaine or levobupivacaine, and in most cases combined with an opioid. Combined spinal-epidural analgesia or patient-controlled epidural analgesia has also been accepted in some hospitals, because these techniques may lessen the total consumption of local anesthetics and also induce mothers' satisfaction. However, the ideal labor analgesia technique has been still controversial. We, obstetric anesthesiologists, should grope for safer and more comfortable anesthetics to the mother and fetus. In next 50 years, the standard method for labor analgesia may change to no needle system with non-placental transfer anesthetics.
MeSH term(s)	Amides ; Analgesia, Epidural ; Analgesia, Obstetrical/methods ; Analgesia, Obstetrical/trends ; Analgesia, Patient-Controlled ; Analgesics, Opioid ; Anesthetics, Local ; Bupivacaine/analogs & derivatives ; Female ; Humans ; Labor Pain ; Pregnancy
Chemical Substances	Amides ; Analgesics, Opioid ; Anesthetics, Local ; ropivacaine (7IO5LYA57N) ; levobupivacaine (A5H73K9U3W) ; Bupivacaine (Y8335394RO)
Language	Japanese
Publishing date	2010-03
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Article ; Online: HIV Reactivation in Latently Infected Cells With Virological Synapse-Like Cell Contact.

Okutomi, Toshiki / Minakawa, Satoko / Hirota, Riku / Katagiri, Koko / Morikawa, Yuko

Viruses

2020 Volume 12, Issue 4

Abstract: HIV reactivation from latency is induced by cytokines but also by cell contact with other cells. To better understand this, J1.1 cells, a latent HIV-1-infected Jurkat derivative, were cocultured with its parental Jurkat. J1.1 cells became p17MA-positive ... ...

Abstract	HIV reactivation from latency is induced by cytokines but also by cell contact with other cells. To better understand this, J1.1 cells, a latent HIV-1-infected Jurkat derivative, were cocultured with its parental Jurkat. J1.1 cells became p17MA-positive and produced a high level of HIV p24CA antigen, only when they were cocultured with stimulated Jurkat with cell-to-cell contact. In contrast, very little p24CA was produced when they were cocultured without cell contact. Similar results were obtained when latent ACH-2 and its parental A3.01 cells were cocultured. Confocal microscopy revealed that not only HIV-1 p17MA and gp120Env but also LFA-1, CD81, CD59, and TCR CD3 accumulated at the cell contact site, suggesting formation of the virological synapse-like structure. LFA-1-ICAM-1 interaction was involved in the cell-to-cell contact. When J1.1 was cocultured with TCR-deficient Jurkat, the p17MA-positive rate was significantly lower, although the cell-to-cell contact was not impaired. Quantitative proteomics identified 54 membrane molecules, one of which was MHC class I, that accumulated at the cell contact site. Reactivation from latency was also influenced by the presence of stromal cells. Our study indicated that latent HIV-1 in J1.1/ACH-2 cells was efficiently reactivated by cell-to-cell contact with stimulated parental cells, accompanying the virological synapse-like structure.
MeSH term(s)	Cell Communication ; Coculture Techniques ; Fluorescent Antibody Technique ; HIV Infections/virology ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Jurkat Cells ; Lymphocyte Activation/immunology ; Lymphocyte Function-Associated Antigen-1/metabolism ; Protein Binding ; Stromal Cells ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Virus Activation ; Virus Latency
Chemical Substances	ICAM1 protein, human ; Lymphocyte Function-Associated Antigen-1 ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2020-04-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12040417
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