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  1. Article ; Online: Racial and Geographic Variation of Prenatal Care Coordination Receipt in the State of Wisconsin, 2010-2019.

    Mallinson, David C / Gillespie, Kate H

    Journal of community health

    2024  

    Abstract: Medicaid-funded obstetric care coordination programs supplement prenatal care with tailored services to improve birth outcomes. It is uncertain whether these programs reach populations with elevated risks of adverse birth outcomes-namely non-white, ... ...

    Abstract Medicaid-funded obstetric care coordination programs supplement prenatal care with tailored services to improve birth outcomes. It is uncertain whether these programs reach populations with elevated risks of adverse birth outcomes-namely non-white, highly rural, and highly urban populations. This study evaluates racial and geographic variation in the receipt of Wisconsin Medicaid's Prenatal Care Coordination (PNCC) program during 2010-2019. We sample 250,596 Medicaid-paid deliveries from a cohort of linked Wisconsin birth records and Medicaid claims. We measure PNCC receipt during pregnancy dichotomously (none; any) and categorically (none; assessment/care plan only; service receipt), and we stratify the sample on three maternal characteristics: race/ethnicity, urbanicity of residence county; and region of residence county. We examine annual trends in PNCC uptake and conduct logistic regressions to identify factors associated with assessment or service receipt. Statewide PNCC outreach decreased from 25% in 2010 to 14% in 2019, largely due to the decline in beneficiaries who only receive assessments/care plans. PNCC service receipt was greatest and persistent in Black and Hispanic populations and in urban areas. In contrast, PNCC service receipt was relatively low and shrinking in American Indian/Alaska Native, Asian/Pacific Islander, and white populations and in more rural areas. Additionally, being foreign-born was associated with an increased likelihood of getting a PNCC assessment in Asian/Pacific Islander and Hispanic populations, but we observed the opposite association in Black and white populations. Estimates signal a gap in PNCC receipt among some at-risk populations in Wisconsin, and findings may inform policy to enhance PNCC outreach.
    Language English
    Publishing date 2024-02-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-024-01338-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When more is less: heritable gain-of-function chk1 mutations impair human fertility.

    Gillespie, David A

    The FEBS journal

    2022  Volume 290, Issue 7, Page(s) 1719–1724

    Abstract: Heritable loss-of-function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein ...

    Abstract Heritable loss-of-function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein kinase, despite its central role in DNA damage signalling and checkpoint activation. Remarkably, two recent reports now demonstrate that heritable, gain-of-function mutations within the Chk1 C-terminal regulatory domain can cause female infertility in humans. In vitro, oocytes from individuals heterozygous for such mutant Chk1 alleles fail to undergo the first mitotic division after fertilization owing to arrest in G2 phase of the cell cycle. This arrest results from inhibition of the master regulator of mitosis, the cyclin-dependent kinase CDK1, through the same molecular mechanisms that are engaged by activated Chk1 to impose G2 checkpoint arrest in somatic cells bearing DNA damage. Remarkably, the failure of this first zygotic division in heterozygotes in vitro can be rescued through treatment with selective Chk1 inhibitor drugs, allowing development of apparently normal blastocysts and offering hope that a pharmacological solution to this cause of infertility may be possible.
    MeSH term(s) Female ; Humans ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; DNA Damage ; Fertility/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Gain of Function Mutation ; Mutation ; Phosphorylation ; Protein Kinases/genetics ; Protein Kinases/metabolism
    Chemical Substances Checkpoint Kinase 1 (EC 2.7.11.1) ; Protein Kinases (EC 2.7.-) ; CHEK1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: When more is less: heritable gain‐of‐function chk1 mutations impair human fertility

    Gillespie, David A.

    The FEBS Journal. 2023 Apr., v. 290, no. 7 p.1719-1724

    2023  

    Abstract: Heritable loss‐of‐function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein ...

    Abstract Heritable loss‐of‐function mutations in genes encoding key regulators of DNA repair and genome stability can result in degenerative progeroid and/or cancer predisposition syndromes; however, such mutations have never been found to affect the Chk1 protein kinase, despite its central role in DNA damage signalling and checkpoint activation. Remarkably, two recent reports now demonstrate that heritable, gain‐of‐function mutations within the Chk1 C‐terminal regulatory domain can cause female infertility in humans. In vitro, oocytes from individuals heterozygous for such mutant Chk1 alleles fail to undergo the first mitotic division after fertilization owing to arrest in G2 phase of the cell cycle. This arrest results from inhibition of the master regulator of mitosis, the cyclin‐dependent kinase CDK1, through the same molecular mechanisms that are engaged by activated Chk1 to impose G2 checkpoint arrest in somatic cells bearing DNA damage. Remarkably, the failure of this first zygotic division in heterozygotes in vitro can be rescued through treatment with selective Chk1 inhibitor drugs, allowing development of apparently normal blastocysts and offering hope that a pharmacological solution to this cause of infertility may be possible.
    Keywords DNA damage ; DNA repair ; blastocyst ; cyclin-dependent kinase ; female fertility ; gain-of-function mutation ; genome ; heterozygosity ; human fertility ; interphase ; loss-of-function mutation ; mitosis ; mutants ; oocytes
    Language English
    Dates of publication 2023-04
    Size p. 1719-1724.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16415
    Database NAL-Catalogue (AGRICOLA)

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  4. Book ; Online ; Conference proceedings: Proceedings of the 5th International Symposium on Biological Control of Arthropods

    Mason, Peter G. / Gillespie, David R. / Vincent, Charles

    Langkawi, Malaysia : September 11-15, 2017

    2017  

    Event/congress International Symposium on Biological Control of Arthropods (5., 2017, Langkawi)
    Author's details edited by Peter G. Mason, David R. Gillespie and Charles Vincent
    Language English
    Size 1 Online-Ressource (332 Seiten)
    Publisher CABI
    Publishing place Wallingford ; Boston, MA
    Publishing country Great Britain
    Document type Book ; Online ; Conference proceedings
    Note Open Access
    HBZ-ID HT020561781
    ISBN 9781786394118 ; 1786394111
    DOI 10.1079/9781786394118.0000
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Absolute indications and permanent inferior vena cava filters are best.

    Gillespie, David L

    Journal of vascular surgery. Venous and lymphatic disorders

    2020  Volume 8, Issue 4, Page(s) 593

    MeSH term(s) Anticoagulants ; Costs and Cost Analysis ; Humans ; Patients ; Pulmonary Embolism/diagnostic imaging ; Vena Cava Filters
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2020.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Conference proceedings: Proceedings of the 5th International Symposium on Biological Control of Arthropods

    Vincent, Charles / Gillespie, David R / Mason, Peter

    2017  

    Keywords Pest control ; Insects (entomology) ; biological control agents ; nonindigenous species ; integrated control ; arthropods ; IPM ; rules ; exotic species ; Third World ; nontarget effects ; weeds ; animals ; pest control ; genotypic variation ; insect pests ; eukaryotes ; nonindigenous organisms ; integrated pest management ; genetic variation ; plant pests ; biocontrol agents ; biological control ; insects ; non-native species ; genetic analysis ; native species ; insect control ; parasitoids ; Developing Countries ; compatibility ; pest insects ; non-indigenous species ; non-native organisms ; genetic diversity ; pests ; species diversity ; weed control ; socioeconomic aspects ; augmentation ; forest pests ; social impact ; Underdeveloped Countries ; pesticides ; plants ; importation ; biocontrol ; pest arthropods ; introduction ; policy ; simulation models ; predators ; introduced organisms ; socioeconomics ; integrated plant protection ; economic impact ; genetic variability ; genotypic variability ; natural enemies ; biological control organisms ; Asia ; exotic organisms ; regulations ; arthropod pests ; parasites ; Hexapoda ; chemical control ; invertebrates ; introduced species ; non-indigenous organisms
    Language English
    Size 1 electronic resource (332 pages)
    Publisher CABI
    Document type Book ; Online ; Conference proceedings
    Note English
    HBZ-ID HT030379764
    ISBN 9781786394118 ; 1786394111
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online ; E-Book: Gland-preserving salivary surgery

    Gillespie, M. Boyd / Walvekar, Rohan R. / Schaitkin, Barry M. / Eisele, David W.

    a problem-based approach

    2018  

    Author's details M. Boyd Gillespie, Rohan R. Walvekar, Barry M. Schaitkin, David W. Eisele editors
    Keywords Medicine ; Otolaryngologic surgery ; Surgery
    Subject code 617.5
    Language English
    Size 1 Online-Ressource (xv, 267 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019627995
    ISBN 978-3-319-58335-8 ; 9783319583334 ; 3-319-58335-2 ; 3319583336
    DOI 10.1007/978-3-319-58335-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Failure of retrieval of inferior vena cava filters.

    Gillespie, David L

    Journal of vascular surgery. Venous and lymphatic disorders

    2019  Volume 8, Issue 1, Page(s) 53

    MeSH term(s) Device Removal ; Humans ; Pulmonary Embolism ; Vena Cava Filters
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2019.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: All-cause and Infection-attributable Mortality Amongst Adults With Bloodstream Infection-a Population-based Study.

    Underwood, Jonathan / Griffiths, Rowena / Gillespie, David / Akbari, Ashley / Ahmed, Haroon

    Open forum infectious diseases

    2024  Volume 11, Issue 5, Page(s) ofae126

    Abstract: Background: Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall ... ...

    Abstract Background: Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall mortality, infection-attributable mortality, and causes of death for four leading BSI pathogens.
    Methods: This retrospective cohort study was conducted within the Secure Anonymized Information Linkage Databank, containing anonymized population-scale electronic health record data for Wales, UK. We included adults with
    Results: We identified 35 691 adults with BSI (59.6%
    Conclusions: This population-level study challenges the assumption that most deaths following BSIs are directly attributable to uncontrolled infection, particularly subacutely more than 30 days from BSI. Our findings underscore the need for reevaluating clinical trial design and developing better preventive strategies for BSIs.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The authors reply.

    Selewski, David T / Gillespie, Scott E / Gist, Katja M / Basu, Rajit K

    Critical care medicine

    2023  Volume 51, Issue 8, Page(s) e170–e172

    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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