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  1. Book ; Online ; E-Book: Nanotechnology for food, agriculture, and environment

    Thangadurai, Devarajan / Sangeetha, Jeyabalan / Prasad, Ram

    (Nanotechnology in the life sciences)

    2020  

    Author's details Devarajan Thangadurai, Jeyabalan Sangeetha, Ram Prasad, editors
    Series title Nanotechnology in the life sciences
    Language English
    Size 1 Online-Ressource (xvi, 405 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020372657
    ISBN 978-3-030-31938-0 ; 9783030319373 ; 3-030-31938-5 ; 3030319377
    DOI 10.1007/978-3-030-31938-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Functional Bionanomaterials

    Thangadurai, Devarajan / Sangeetha, Jeyabalan / Prasad, Ram

    From Biomolecules to Nanoparticles

    (Nanotechnology in the Life Sciences,)

    2020  

    Abstract: This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with ... ...

    Author's details edited by Devarajan Thangadurai, Jeyabalan Sangeetha, Ram Prasad
    Series title Nanotechnology in the Life Sciences,
    Abstract This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.
    Keywords Microbiology ; Nanotechnology ; Biomedical engineering ; Medical microbiology ; Plant breeding ; Biomedical Engineering/Biotechnology ; Medical Microbiology ; Plant Breeding/Biotechnology ; Nanotecnologia ; Enginyeria biomèdica ; Medicaments
    Subject code 610.28
    Language English
    Size 1 online resource (XVIII, 489 p. 66 illus., 59 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-41464-7 ; 3-030-41463-9 ; 978-3-030-41464-1 ; 978-3-030-41463-4
    DOI 10.1007/978-3-030-41464-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Pathogenesis of intrinsic acute kidney injury.

    Devarajan, Prasad

    Current opinion in pediatrics

    2022  Volume 35, Issue 2, Page(s) 234–238

    Abstract: Purpose of review: This review focuses on the pathogenesis of intrinsic acute kidney injury (AKI), emphasizing recent advances that hold therapeutic promise.: Recent findings: Enhanced endothelin and reduced endothelium-derived nitric oxide release ... ...

    Abstract Purpose of review: This review focuses on the pathogenesis of intrinsic acute kidney injury (AKI), emphasizing recent advances that hold therapeutic promise.
    Recent findings: Enhanced endothelin and reduced endothelium-derived nitric oxide release in AKI can be blocked using endothelin receptor antagonists or nitric oxide supplementation. Vasodilatory agents such as theophylline and caffeine may prevent AKI. Free labile iron is a potent factor in the generation of reactive oxygen species and tubule damage in AKI. Apoptosis via induction of p53 is an important mechanism of cell death in AKI, which can be blocked using small interfering RNA. The AKI-driven reduction in nicotinamide adenine dinucleotide can be countered using oral supplements. Surviving tubule cells regenerate after AKI, by upregulating genes encoding growth factors, such as hepatocyte growth factor. Pro-angiogenic agents (statins and erythropoietin) that can mobilize endothelial progenitor cells after AKI are currently being tested. The inflammatory response in AKI, including activation of C5a, can be therapeutically targeted. Contemporary single cell profiling technologies have identified novel genes with altered expression, new signalling pathways and drug targets in AKI.
    Summary: Recent advances in the pathogenesis of intrinsic AKI have provided a better understanding of the clinical continuum and the rational deployment of promising therapeutics.
    MeSH term(s) Humans ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Acute Kidney Injury/metabolism ; Apoptosis/physiology ; Reactive Oxygen Species ; Kidney/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Current State of the Art in Acute Kidney Injury.

    Devarajan, Prasad

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 70

    Abstract: Decades of pre-clinical research have revealed biologic pathways that have suggested potential therapies for acute kidney injury (AKI) in experimental models. However, translating these to human AKI has largely yielded disappointing results. Fortunately, ...

    Abstract Decades of pre-clinical research have revealed biologic pathways that have suggested potential therapies for acute kidney injury (AKI) in experimental models. However, translating these to human AKI has largely yielded disappointing results. Fortunately, recent discoveries in AKI molecular mechanisms are providing new opportunities for early detection and novel interventions. This review identifies technologies that are revealing the exceptionally complex nature of the normal kidney, the remarkable heterogeneity of the AKI syndrome, and the myriad responses of the kidney to AKI. Based on the current state of the art, novel approaches to improve the bench-to-bedside translation of novel discoveries are proposed. These strategies include the use of unbiased approaches to improve our understanding of human AKI, establishment of irrefutable biologic plausibility for proposed biomarkers and therapies, identification of patients at risk for AKI pre-injury using clinical scores and non-invasive biomarkers, initiation of safe, and effective preventive interventions of pre-injury in susceptible patients, identification of patients who may develop AKI post-injury using electronic triggers, clinical scores, and novel biomarkers, employment of sequential biomarkers to initiate appropriate therapies based on knowledge of the underlying pathophysiology, use of new biomarkers as criteria for enrollment in randomized clinical trials, assessing efficacy, and empowering the drug development process, and early initiation of anti-fibrotic therapies. These strategies are immediately actionable and hold tremendous promise for effective bench-to-bedside translation of novel discoveries that will change the current dismal prognosis of human AKI.
    Language English
    Publishing date 2020-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics.

    Pode-Shakked, Naomi / Devarajan, Prasad

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Acute kidney injury (AKI) is an increasingly common problem afflicting all ages, occurring in over 20% of non-critically ill hospitalized patients and >30% of children and >50% of adults in critical care units. AKI is associated with serious short-term ... ...

    Abstract Acute kidney injury (AKI) is an increasingly common problem afflicting all ages, occurring in over 20% of non-critically ill hospitalized patients and >30% of children and >50% of adults in critical care units. AKI is associated with serious short-term and long-term consequences, and current therapeutic options are unsatisfactory. Large gaps remain in our understanding of human AKI pathobiology, which have hindered the discovery of novel diagnostics and therapeutics. Although animal models of AKI have been extensively studied, these differ significantly from human AKI in terms of molecular and cellular responses. In addition, animal models suffer from interspecies differences, high costs and ethical considerations. Static two-dimensional cell culture models of AKI also have limited utility since they have focused almost exclusively on hypoxic or cytotoxic injury to proximal tubules alone. An optimal AKI model would encompass several of the diverse specific cell types in the kidney that could be targets of injury. Second, it would resemble the human physiological milieu as closely as possible. Third, it would yield sensitive and measurable readouts that are directly applicable to the human condition. In this regard, the past two decades have seen a dramatic shift towards newer personalized human-based models to study human AKI. In this review, we provide recent developments using human stem cells, organoids, and in silico approaches to advance personalized AKI diagnostics and therapeutics.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Animals ; Critical Illness/therapy ; Humans ; Intensive Care Units ; Kidney Tubules, Proximal ; Organoids ; Stem Cells
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acute kidney injury: Acute kidney injury: still misunderstood and misdiagnosed.

    Devarajan, Prasad

    Nature reviews. Nephrology

    2017  Volume 13, Issue 3, Page(s) 137–138

    MeSH term(s) Acute Kidney Injury ; Humans
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2017.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics

    Naomi Pode-Shakked / Prasad Devarajan

    International Journal of Molecular Sciences, Vol 23, Iss 7211, p

    2022  Volume 7211

    Abstract: Acute kidney injury (AKI) is an increasingly common problem afflicting all ages, occurring in over 20% of non-critically ill hospitalized patients and >30% of children and >50% of adults in critical care units. AKI is associated with serious short-term ... ...

    Abstract Acute kidney injury (AKI) is an increasingly common problem afflicting all ages, occurring in over 20% of non-critically ill hospitalized patients and >30% of children and >50% of adults in critical care units. AKI is associated with serious short-term and long-term consequences, and current therapeutic options are unsatisfactory. Large gaps remain in our understanding of human AKI pathobiology, which have hindered the discovery of novel diagnostics and therapeutics. Although animal models of AKI have been extensively studied, these differ significantly from human AKI in terms of molecular and cellular responses. In addition, animal models suffer from interspecies differences, high costs and ethical considerations. Static two-dimensional cell culture models of AKI also have limited utility since they have focused almost exclusively on hypoxic or cytotoxic injury to proximal tubules alone. An optimal AKI model would encompass several of the diverse specific cell types in the kidney that could be targets of injury. Second, it would resemble the human physiological milieu as closely as possible. Third, it would yield sensitive and measurable readouts that are directly applicable to the human condition. In this regard, the past two decades have seen a dramatic shift towards newer personalized human-based models to study human AKI. In this review, we provide recent developments using human stem cells, organoids, and in silico approaches to advance personalized AKI diagnostics and therapeutics.
    Keywords acute kidney injury ; kidney organoids ; kidney development ; tubuloids ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome.

    Chakradhar, Anjali / Baron, Rebecca M / Vera, Mayra Pinilla / Devarajan, Prasad / Chawla, Lakhmir / Hou, Peter C

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6667

    Abstract: Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition in critical care medicine for which there is a substantial need for early prognostic biomarkers of outcome. The present study seeks to link plasma renin levels ... ...

    Abstract Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition in critical care medicine for which there is a substantial need for early prognostic biomarkers of outcome. The present study seeks to link plasma renin levels and 30-day mortality in sepsis-associated ARDS patients treated at our institution. The Registry of Critical Illness (RoCI) prospectively enrolled patients from the intensive care units (ICU) within a single academic medical center, and a convenience sample of patients with sepsis-associated ARDS was analyzed from this cohort. This study was approved by the Mass General Brigham Institutional Review Boards (IRB) as part of the RoCI, and all procedures performed were in accordance with the ethical standards of the institutional board. From April 2012 to February 2019, a cohort of 32 adult sepsis-associated ARDS patients with 500 µL of plasma samples available on Day 0 and Day 3 of their ICU stay were enrolled. Renin levels were measured twice, on Day 0 and Day 3 via the direct renin enzyme-linked immunosorbent assay (ELISA EIA-525) by DRG diagnostics. Day 0 and Day 3 renin were statistically evaluated via logistic regression to predict 30-day mortality. Direct renin levels of 64 samples were assayed from 32 sepsis-associated ARDS patients (50% male; mean ± SD, 55 ± 13.8 years old). The 30-day hospital mortality rate was 59.4%. Patients who died within 30 days of admission were more likely to have an elevated Day 3 Renin (Odds ratio [OR] = 6, 95% CI 1.25-28.84) and have received vasopressors (OR = 13.33, 95% CI 1.43-123.95). Adjusting for vasopressor use as a proxy for septic shock status, patients with an Elevated Day 3 Renin had a 6.85 (95% CI 1.07-43.75) greater odds of death than those with Low-Normal Day 3 Renin. Patients with sustained Elevated Renin levels from Day 0 to Day 3 had the highest risk of death in a 30-day window. In this study, we found that renin may be a novel biomarker that has prognostic value for patients with sepsis-associated ARDS. Future studies evaluating renin levels in patients with sepsis-associated ARDS are needed to validate these findings.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Aged ; Female ; Renin ; Prognosis ; Sepsis/complications ; Sepsis/therapy ; Intensive Care Units ; Biomarkers ; Respiratory Distress Syndrome
    Chemical Substances Renin (EC 3.4.23.15) ; Biomarkers
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56994-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genomic and Proteomic Characterization of Acute Kidney Injury.

    Devarajan, Prasad

    Nephron

    2015  Volume 131, Issue 2, Page(s) 85–91

    Abstract: The incidence and severity of acute kidney injury (AKI) is rising globally, and the associated morbidity and mortality remain high despite promising advances in experimental therapeutics. The reasons include (a) an incomplete understanding of the complex ...

    Abstract The incidence and severity of acute kidney injury (AKI) is rising globally, and the associated morbidity and mortality remain high despite promising advances in experimental therapeutics. The reasons include (a) an incomplete understanding of the complex pathophysiology, (b) an inability to reliably identify risk factors for AKI and (c) a lack of biomarkers for the early prediction of AKI and its outcomes. Functional genomics, bioinformatics and proteomics have begun to uncover candidates that are emerging as biomarkers and therapeutic targets. This review will update the reader on current technologies in genomics (including targeted sequencing, genome wide association studies and transcriptome profiling) and proteomics (including gel electrophoresis and mass spectrometry methods) and their application on human AKI.
    MeSH term(s) Acute Kidney Injury/genetics ; Acute Kidney Injury/physiopathology ; Biomarkers ; Genomics ; Humans ; Proteomics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000437237
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    Zs.A 169: Show issues Location:
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  10. Article ; Online: NGAL for the detection of acute kidney injury in the emergency room.

    Devarajan, Prasad

    Biomarkers in medicine

    2014  Volume 8, Issue 2, Page(s) 217–219

    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Acute-Phase Proteins/analysis ; Biomarkers/analysis ; Emergency Service, Hospital ; Humans ; Lipocalin-2 ; Lipocalins/analysis ; Proto-Oncogene Proteins/analysis
    Chemical Substances Acute-Phase Proteins ; Biomarkers ; LCN2 protein, human ; Lipocalin-2 ; Lipocalins ; Proto-Oncogene Proteins
    Language English
    Publishing date 2014-02-12
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.13.149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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