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  1. Book ; Online: Source Imaging in Drug Resistant Epilepsy - Current Evidence and Practice

    Beniczky, Sándor / Trinka, Eugen

    2020  

    Keywords Medicine ; Neurology & clinical neurophysiology ; Epilepsy ; focus ; presurgical evaluation ; source imaging ; source localization
    Size 1 electronic resource (117 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230534
    ISBN 9782889636730 ; 2889636739
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Phenobarbital in Status epilepticus - Rediscovery of an effective drug.

    Trinka, Eugen

    Epilepsy & behavior : E&B

    2023  Volume 141, Page(s) 109104

    Abstract: Phenobarbital (PB) is one of the oldest Antiseizure Medicines (ASMs), which is in clinical use since 1912. Its value in the treatment of Status epilepticus is currently discussed controversially. Phenobarbital has fallen out of favor in many countries ... ...

    Abstract Phenobarbital (PB) is one of the oldest Antiseizure Medicines (ASMs), which is in clinical use since 1912. Its value in the treatment of Status epilepticus is currently discussed controversially. Phenobarbital has fallen out of favor in many countries across Europe because of reports of hypotension, arrhythmias, and hypopnea. Phenobarbital has a strong antiseizure effect with remarkably little sedation. It exerts its clinical effects, through the increase of GABE-ergic inhibition and decrease of glutamatergic excitation by inhibition of AMPA receptors. Despite good preclinical evidence, there are remarkably few randomized controlled studies on humans in SE, which suggest, that it is at least as good as lorazepam in first-line treatment in early SE, and significantly better than valproic acid in benzodiazepine-resistant SE. Data from randomized trials and large non-randomized prospective and retrospective studies suggest, that Phenobarbital is well tolerated even if used in very high dose protocols. Thus, despite its decline in its popularity at least in Europe and North America, it should be considered a highly cost-effective treatment for early and established SE, not only in resource-limited settings. This paper was presented at the 8th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in September 2022.
    MeSH term(s) Humans ; Anticonvulsants/therapeutic use ; Retrospective Studies ; Prospective Studies ; Status Epilepticus/drug therapy ; Status Epilepticus/etiology ; Phenobarbital/therapeutic use
    Chemical Substances Anticonvulsants ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epilepsy surgery in multiple sclerosis.

    Moser, Tobias / Trinka, Eugen

    Epileptic disorders : international epilepsy journal with videotape

    2024  Volume 26, Issue 2, Page(s) 267–268

    MeSH term(s) Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/surgery ; Multiple Sclerosis/pathology ; Epilepsy/surgery ; Epilepsy/pathology ; Hippocampus/pathology ; Sclerosis/pathology
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Letter
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1002/epd2.20195
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    Zs.MN 11: Show issues

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  4. Book ; Conference proceedings: Proceedings of the Innsbruck Colloquium on Status Epilepticus

    Trinka, Eugen

    Innsbruck, Austria, April 2 - 5, 2009

    (Epilepsia ; 50, Suppl. 12)

    2009  

    Event/congress Colloquium on Status Epilepticus (2009, Innsbruck)
    Author's details guest ed.: Eugen Trinka
    Series title Epilepsia ; 50, Suppl. 12
    Collection
    Language English
    Size 99 S. : graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016192547
    Database Catalogue ZB MED Medicine, Health

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    Zs A 517 -50,Suppl.12- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Comment about the safety of excipients used to dissolve topiramate for parenteral administration.

    Löscher, Wolfgang / Trinka, Eugen

    Epilepsy & behavior : E&B

    2023  Volume 145, Page(s) 109304

    MeSH term(s) Humans ; Excipients/adverse effects ; Topiramate/adverse effects ; Fructose/adverse effects
    Chemical Substances Excipients ; Topiramate (0H73WJJ391) ; Fructose (30237-26-4)
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109304
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  6. Book: The causes of epilepsy

    Shorvon, S. D. / Guerrini, Renzo / Schachter, Steven C. / Trinka, Eugen

    common and uncommon causes in adults and children

    2019  

    Author's details edited by Simon Shorvon, Renzo Guerrini, Steven Schachter, Eugen Trinka
    Keywords Epilepsy/Etiology
    Subject code 616.853
    Language English
    Size xxii, 989 Seiten, Illustrationen, 29 cm
    Edition Second edition
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Previous edition: 2011
    HBZ-ID HT020135161
    ISBN 978-1-108-42075-4 ; 1-108-42075-3
    Database Catalogue ZB MED Medicine, Health

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    2019 A 1235 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Prevention of epileptogenesis - are we there yet?

    Koepp, Matthias / Trinka, Eugen / Löscher, Wolfgang / Klein, Pavel

    Current opinion in neurology

    2024  

    Abstract: Purpose of review: To review recent progress in preventing epileptogenesis in patients with epilepsy.: Recent findings: The recent success of epilepsy prevention and disease modification in tuberous sclerosis using simple EEG biomarkers to guide ... ...

    Abstract Purpose of review: To review recent progress in preventing epileptogenesis in patients with epilepsy.
    Recent findings: The recent success of epilepsy prevention and disease modification in tuberous sclerosis using simple EEG biomarkers to guide treatment initiation, and the identification of biomarkers to enrich the targeted patient population has made clinical trials of epilepsy prevention after acquired central nervous system (CNS) insults such as traumatic brain injury, stroke or infection both feasible and timely. Two such trials are currently on-going to prevent poststroke epilepsy.
    Summary: No disease-modifying or preventive treatments exist for epilepsy, and their development remains a major unmet need.. We have entered though the era of change in the treatment of epilepsy from symptomatic only to disease prevention. In this review, we summarize developments and review opportunities, challenges, and potential solutions to develop preventive treatment for acquired epilepsies in humans. The 'Holy Grail' of epilepsy is within our reach.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001256
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  8. Article ; Online: Evidence based noninvasive presurgical evaluation for patients with drug resistant epilepsies.

    Trinka, Eugen / Koepp, Matthias / Kalss, Gudrun / Kobulashvili, Teia

    Current opinion in neurology

    2024  Volume 37, Issue 2, Page(s) 141–151

    Abstract: Purpose of review: To review the current practices and evidence for the diagnostic accuracy and the benefits of presurgical evaluation.: Recent findings: Preoperative evaluation of patients with drug-resistant focal epilepsies and subsequent epilepsy ...

    Abstract Purpose of review: To review the current practices and evidence for the diagnostic accuracy and the benefits of presurgical evaluation.
    Recent findings: Preoperative evaluation of patients with drug-resistant focal epilepsies and subsequent epilepsy surgery leads to a significant proportion of seizure-free patients. Even those who are not completely seizure free postoperatively often experience improved quality of life with better social integration. Systematic reviews and meta-analysis on the diagnostic accuracy are available for Video-electroencephalographic (EEG) monitoring, magnetic resonance imaging (MRI), electric and magnetic source imaging, and functional MRI for lateralization of language and memory. There are currently no evidence-based international guidelines for presurgical evaluation and epilepsy surgery.
    Summary: Presurgical evaluation is a complex multidisciplinary and multiprofessional clinical pathway. We rely on limited consensus-based recommendations regarding the required staffing or methodological expertise in epilepsy centers.
    MeSH term(s) Humans ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/surgery ; Quality of Life ; Electroencephalography/methods ; Epilepsy/diagnostic imaging ; Epilepsy/surgery ; Magnetic Resonance Imaging/methods ; Treatment Outcome
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Review ; Meta-Analysis ; Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001253
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  9. Article: Editorial: Effects of epilepsy on memory-Therapeutic implications, biomarkers, and comorbidities.

    Höller, Yvonne / Michaelis, Rosa / Trinka, Eugen / Jacobs, Julia

    Frontiers in neurology

    2023  Volume 14, Page(s) 1140941

    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1140941
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  10. Article ; Online: What is the risk of unprovoked seizures after acute symptomatic status epilepticus?

    Lattanzi, Simona / Trinka, Eugen / Meletti, Stefano

    Epilepsia

    2023  Volume 64, Issue 12, Page(s) 3408–3409

    MeSH term(s) Humans ; Status Epilepticus/etiology ; Seizures/etiology ; Risk Factors
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Letter
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17792
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