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Article ; Online: Alberto Cevolini, L’ordine del sapere. Un approccio evolutivo, Milano-Udine, Mimesis, 2022

Giulia Crippa

Bibliothecae.it, Vol 12, Iss 2, Pp 650-

2023 Volume 655

Keywords	Bibliography. Library science. Information resources ; Z
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	University of Bologna
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Spontaneous formation of L-isoaspartate and gain of function in fibronectin.

Curnis, Flavio / Longhi, Renato / Crippa, Luca / Cattaneo, Angela / Dondossola, Eleonora / Bachi, Angela / Corti, Angelo

The Journal of biological chemistry

2006 Volume 281, Issue 47, Page(s) 36466–36476

Abstract: ... which in turn can be enzymatically "repaired" to RGD by protein-l-isoAsp-O-methyltransferase. We show here ... beta3-integrin binding site containing the L-isoDGR sequence, which is enzymatically "deactivated ... to DGR by protein-L-isoAsp-O-methyltransferase. Furthermore, rapid NGR-to-isoDGR sequence transition ...

Abstract	Isoaspartate formation in extracellular matrix proteins, by aspartate isomerization or asparagine deamidation, is generally viewed as a degradation reaction occurring in vivo during tissue aging. For instance, non-enzymatic isoaspartate formation at RGD-integrin binding sites causes loss of cell adhesion sites, which in turn can be enzymatically "repaired" to RGD by protein-l-isoAsp-O-methyltransferase. We show here that isoaspartate formation is also a mechanism for extracellular matrix activation. In particular, we show that deamidation of Asn263 at the Asn-Gly-Arg (NGR) site in fibronectin N-terminal region generates an alpha(v)beta3-integrin binding site containing the L-isoDGR sequence, which is enzymatically "deactivated" to DGR by protein-L-isoAsp-O-methyltransferase. Furthermore, rapid NGR-to-isoDGR sequence transition in fibronectin fragments generates alpha(v)beta3 antagonists (named "isonectins") that competitively bind RGD binding sites and inhibit endothelial cell adhesion, proliferation, and tumor growth. Time-dependent generation of isoDGR may represent a sort of molecular clock for activating latent integrin binding sites in proteins.
MeSH term(s)	Amino Acid Sequence ; Animals ; Binding, Competitive ; Cell Adhesion ; Extracellular Matrix/metabolism ; Fibronectins/chemistry ; Humans ; Integrins/chemistry ; Isoaspartic Acid/chemistry ; Isoaspartic Acid/physiology ; Melanoma, Experimental ; Mice ; Models, Molecular ; Molecular Sequence Data ; Oligopeptides/chemistry ; Recombinant Proteins/chemistry
Chemical Substances	Fibronectins ; Integrins ; Isoaspartic Acid ; Oligopeptides ; Recombinant Proteins ; arginyl-glycyl-aspartic acid (78VO7F77PN)
Language	English
Publishing date	2006-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M604812200
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Article: Cynara cardunculus l. as a potential industry crop

Cravero, V / Martin, E / Crippa, I / Lopez Anido, F / Garcia, S.M / Cointry, E

Acta horticulturae. 2013 Apr., , no. 983

2013

Abstract: Fourteen Cynara cardunculus L. accessions were compared in order to evaluate fresh total ...

Abstract	Fourteen Cynara cardunculus L. accessions were compared in order to evaluate fresh total aboveground biomass production as well as its partition into leaves, stalks and capitula at the anthesis stage. For each botanical variety, percentages of dry matter were also calculated. An ANOVA was performed and mean values were compared by Duncan's test. Euclidean distances were calculated and a cluster analysis was performed. Total fresh biomass and all its components showed significant differences among accessions (p<0.001). The total fresh biomass ranged between 1188 and 3235 g/plant and its partitioning was strongly affected by the botanical variety. Cluster analysis showed three main groups, one including two cultivated cardoons, a second one, three globe artichoke cultivars, whereas a third one, grouping all wild cardoons together with three cultivated cardoons and two globe artichoke accessions. In both cardoon cultivars, the percentage of dry matter ranged between 30 to 35% for all components of aboveground biomass, whereas in globe artichoke values ranged between 20% for capitula to 40% for leaves. The low inputs management required, adaptability to the local conditions, and the results obtained in the present study suggest the suitability of C. cardunculus as a source to be exploited as an industry or energy crop.
Keywords	Cynara cardunculus ; aboveground biomass ; analysis of variance ; artichokes ; biomass production ; cardoons ; cluster analysis ; cultivars ; energy crops ; energy industry ; flowering ; leaves
Language	English
Size	p. 117-121.
Publishing place	International Society for Horticultural Science
Document type	Article
Note	Paper presented at the VIII International Symposium on Artichoke, Cardoon and their Wild Relatives, held April 10-13, 2012, Viterbo, Italy.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correlation and path-coefficent analysis in half sib families of globe artichoke (Cynara cardunculus var. Scolymus (l.) Fiori)

Crippa, I, Martín, E.A, Espósito, M.A, Cravero, V.P, López Anido, F.S and Cointry, E.L

Electronic Journal of Plant Breeding, Vol 2, Iss 1, Pp 151-

2011 Volume 156

Abstract: The yield is a complex trait and indirect selection through correlated, less complex and easy measurement traits would be anadvisable strategy to increase yield. To assess artichoke genetic variation for different agronomic traits, the phenotypic ... ...

Abstract	The yield is a complex trait and indirect selection through correlated, less complex and easy measurement traits would be anadvisable strategy to increase yield. To assess artichoke genetic variation for different agronomic traits, the phenotypic andgenotypic correlation coefficients among these traits and the direct and indirect effects of these traits on the total yield, 10 halfsibfamilies were used. Total yield recorded positive genotypic correlation with number of heads and the length, diameter andweight of heads. Number of head and their weight had direct positive contribution towards total yield per plant. Indirect effect ofplant diameter and length and weight of head, on number of heads plant height, are shown. These results allow us to selectmaterials with high yields by choosing those with a large diameter of plant and upper length of main head.
Keywords	Genetic correlation ; Agronomic traits ; Path analysis ; Half-sibs ; Cynara ; Agriculture (General) ; S1-972 ; Agriculture ; S ; DOAJ:Agriculture (General) ; DOAJ:Agriculture and Food Sciences ; Plant culture ; SB1-1110 ; DOAJ:Plant Sciences
Subject code	580
Language	English
Publishing date	2011-03-01T00:00:00Z
Publisher	Indian Society of Plant Breeders
Document type	Article ; Online
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Article ; Online: Spontaneous Formation of Exceptional Points at the Onset of Magnetism.

Crippa, L / Sangiovanni, G / Budich, J C

Physical review letters

2023 Volume 130, Issue 18, Page(s) 186403

Abstract: We reveal how symmetry-protected nodal points in topological semimetals may be promoted to pairs of generically stable exceptional points (EPs) by symmetry-breaking fluctuations at the onset of long-range order. This intriguing interplay between non- ... ...

Abstract	We reveal how symmetry-protected nodal points in topological semimetals may be promoted to pairs of generically stable exceptional points (EPs) by symmetry-breaking fluctuations at the onset of long-range order. This intriguing interplay between non-Hermitian (NH) topology and spontaneous symmetry breaking is exemplified by a magnetic NH Weyl phase spontaneously emerging at the surface of a strongly correlated three-dimensional topological insulator, when entering the ferromagnetic regime from a high-temperature paramagnetic phase. Here, electronic excitations with opposite spin acquire significantly different lifetimes, thus giving rise to an anti-Hermitian structure in spin that is incompatible with the chiral spin texture of the nodal surface states, and hence facilitate the spontaneous formation of EPs. We present numerical evidence of this phenomenon by solving a microscopic multiband Hubbard model nonperturbatively in the framework of dynamical mean-field theory.
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.186403
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Book ; Article ; Online: Double-edged sword

Crippa, Lorenzo / Saavedra-Lux, Laura

Understanding the localized effect of foreign direct investment inflow in conflict settings

2023

Abstract: We analyse how inward foreign direct investment (FDI) received amid ongoing violence shapes armed conflict. We argue that FDI affects patterns of violence by influencing the state's counterinsurgency strategy. To prevent disinvestment, governments strive ...

Abstract	We analyse how inward foreign direct investment (FDI) received amid ongoing violence shapes armed conflict. We argue that FDI affects patterns of violence by influencing the state's counterinsurgency strategy. To prevent disinvestment, governments strive to capture territory linked to investment. Yet, heightened military presence in areas close to FDI projects reinforces rebel group reliance on irregular warfare, thus amplifying civilian victimization as a tool to elicit cooperation or enforce control. Using subnational, georeferenced data on FDI and armed conflict in African countries from 2003 to 2019, we find that conflict events within 5-10 km of a foreign investment see 25 per cent more civilian casualties. The effect is largely driven by increased rebelled, deliberate civilian targeting, and amplified for extractive FDI. We address endogeneity concerns by comparing conflict dynamics between areas that experience an investment with areas that will experience one in the future within the same country-year. Our findings underscore the influence of globalization on political stability.
Keywords	ddc:330 ; O16 ; Q34 ; FDI ; armed conflict ; civilian victimization
Subject code	338
Language	English
Publisher	Helsinki: The United Nations University World Institute for Development Economics Research (UNU-WIDER)
Publishing country	de
Document type	Book ; Article ; Online
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Article: Fresh biomass production and partitioning of aboveground growth in the three botanical varieties of Cynara cardunculus L

Cravero, Vanina / Martin, Eugenia / Crippa, Ignacio / Anido, Fernando López / García, Stella Maris / Cointry, Enrique

Industrial crops and products. 2012 May, v. 37, no. 1

2012

Abstract: Fourteen accessions of Cynara cardunculus were compared with the aim to evaluate the fresh biomass production and its partition, aiming at its potential use for industrial purposes. At anthesis stage, when plants have the maximum vegetative development, ... ...

Abstract	Fourteen accessions of Cynara cardunculus were compared with the aim to evaluate the fresh biomass production and its partition, aiming at its potential use for industrial purposes. At anthesis stage, when plants have the maximum vegetative development, stalks, leaves and capitula were weighed separately. The percentage of dry matter per gram of fresh biomass was also calculated. The first capitulum components of each plant: bracts, flowers and remnant receptacle were also weighed separately. The total fresh biomass ranged between 1188 and 3235g/plant, with variable values within each botanical variety, whereas the partition of the aboveground biomass was strongly affected by botanical variety. In both cardoons varieties, the percentage of dry matter ranged between 30 and 35% for all components of aboveground biomass, whereas in globe artichoke values ranged between 20% for capitula and 40% for leaves. Regarding capitula components, receptacle weight was of greatest importance in globe artichoke and cultivated cardoon. In wild cardoon flowers weight was more important than the other components. Results suggest that Cynara cardunculus var. scolymus and C. cardundulus var. cardunculus, might be considered as double purpose crops if after the capitula (in globe artichoke) or leaves (in cardoon) harvest, the fresh matter remaining is artificially dried and cut. On the other hand, Cynara cardunculus var. sylvestris, might be incorporated into the culture system as an industry or energy crop due the low inputs management that it requires, its adaptability to the local conditions and its aboveground biomass production.
Keywords	Cynara cardunculus ; aboveground biomass ; artichokes ; biomass production ; bracts ; cardoons ; cutting ; drying ; energy crops ; flowering ; flowers ; leaves ; primary productivity ; wild flowers
Language	English
Dates of publication	2012-05
Size	p. 253-258.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	0926-6690
ISSN	0926-6690
DOI	10.1016/j.indcrop.2011.12.028
Database	NAL-Catalogue (AGRICOLA)

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Article: Right Hemicolectomy with Complete Mesocolic Excision Using the Versius Surgical System: A Step-by-Step Guide.

Baldari, Ludovica / Boni, Luigi / Cassinotti, Elisa / Crippa, Jacopo / Mari, Giulio

Chirurgia (Bucharest, Romania : 1990)

2023 Volume 118, Issue 1, Page(s) 54–62

Abstract: The application of new robotic platforms in colorectal surgery has increased greatly in the last 10 years. New systems have been released and entered the surgical panorama, broadening the technological offer. Robotic surgery applied to colorectal ... ...

Abstract	The application of new robotic platforms in colorectal surgery has increased greatly in the last 10 years. New systems have been released and entered the surgical panorama, broadening the technological offer. Robotic surgery applied to colorectal oncological surgery has been widely described. Hybrid robotic surgery in right sided colonic cancer has been previously reported. According to the site and local extension of a right-sided colon cancer, a different lymphadenectomy could be required. For more distant and locally advanced tumors a complete mesocolic excision (CME) is indicated. CME for right colon cancer is a complex operation compared to standard right hemicolectomy. Therefore a hybrid robotic system may be effectively applied to CME during a minimally-invasive right hemicolectomy to improve the dissection accuracy. Here we report a step-by-step hybrid laparoscopic/robotic right hemicolectomy with CME performed with the Versius Surgical System, a tele-operated surgical robotic system intended for the use of robotic assisted surgery.
MeSH term(s)	Humans ; Robotic Surgical Procedures ; Treatment Outcome ; Laparoscopy ; Lymph Node Excision ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Colectomy
Language	English
Publishing date	2023-03-13
Publishing country	Romania
Document type	Journal Article
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
DOI	10.21614/chirurgia.2828
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Article: Attachment networks in young adults.

Carli, Lucia L / Alì, Paolo Alessandro / Anzelmo, Elena / Caprin, Claudia / Crippa, Franca / Gallucci, Marcello / Moioli, Loredana / Traficante, Daniela / Feeney, Judith A

Frontiers in psychology

2024 Volume 14, Page(s) 1321185

Abstract: Introduction: This study investigated attachment networks in a sample of Italian young adults. Attachment networks were defined in terms of attachment functions, attachment strength, the presence of a primary figure, and full-blown attachments.: ... ...

Abstract	Introduction: This study investigated attachment networks in a sample of Italian young adults. Attachment networks were defined in terms of attachment functions, attachment strength, the presence of a primary figure, and full-blown attachments. Method: Participants were 405 young adults, and we studied the effects of the demographic variables of gender, romantic status (whether single, involved in a romantic relationship for less or more than 24 months) and employment (whether university students or workers) on the structure of attachment networks. Participants were asked to answer the WHO-TO questionnaire, and derived indexes were analyzed using mixed ANOVAs, linear and logistic regression techniques. Results: Results indicated that while friends still had great importance in the network, partners were acquiring increasing relevance; at the same time, parents, and particularly mothers, remained central figures, particularly for the secure base function. Regarding the demographic variables, we observed that women reported stronger bonds with their mothers than men did, while the importance of friends was higher for men than for women. Additionally, our study supports previous findings underlining the importance of romantic partners in this phase of life, with participants involved in romantic relationships for longer than 24 months showing a fully developed attachment bond with their partners. Finally, for workers, the transfer of functions from the family-of-origin to external figures seemed to be fostered. Discussion: In conclusion, young Italian young adults go through a phase of intensive restructuring of attachment bond networks, particularly in relation to the consolidation of romantic relationships and work commitments.
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1321185
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Article ; Online: Infantile spasms in Down syndrome responsive to phenobarbital.

Moraes Neto, Roddie / Franklin, Gustavo L / Crippa, Ana Chrystina De Souza

Pediatrics international : official journal of the Japan Pediatric Society

2022 Volume 64, Issue 1, Page(s) e15070

MeSH term(s)	Anticonvulsants/therapeutic use ; Down Syndrome/complications ; Down Syndrome/drug therapy ; Electroencephalography ; Humans ; Infant ; Phenobarbital/therapeutic use ; Spasms, Infantile/diagnosis ; Spasms, Infantile/drug therapy
Chemical Substances	Anticonvulsants ; Phenobarbital (YQE403BP4D)
Language	English
Publishing date	2022-03-21
Publishing country	Australia
Document type	Letter
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15070
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