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  1. Article: [Source Appointment and Assessment of Heavy Metal Pollution in Surface Dust in the Main District Bus Stops of Tianshui City].

    Li, Chun-Yan / Wang, Xin-Min / Wang, Hai / Lü, Xiao-Bin

    Huan jing ke xue= Huanjing kexue

    2024  Volume 45, Issue 1, Page(s) 417–428

    Abstract: In this study, a PMF model was used to identify the sources and pollution level of heavy metals in the surface dust of a bus station. On the basis of the traditional heavy metal pollution evaluation methods, the Hakanson toxicity response coefficient was ...

    Abstract In this study, a PMF model was used to identify the sources and pollution level of heavy metals in the surface dust of a bus station. On the basis of the traditional heavy metal pollution evaluation methods, the Hakanson toxicity response coefficient was used to modify the traditional weight. The matter-element extension theory was introduced to reflect the toxicological properties and hazard degree of the heavy metals, and the matter-element extension model was established to evaluate the pollution level of heavy metals in the surface dust of the study area. The results were compared with
    Language Chinese
    Publishing date 2024-01-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202302023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities.

    Yan, Chun-Yan / Zhao, Meng-Lu / Wei, Ya-Nan / Zhao, Xi-He

    Molecular therapy oncolytics

    2023  Volume 28, Page(s) 212–229

    Abstract: Breast cancer is the leading cause of cancer-related deaths in females worldwide, and the liver is one of the most common sites of distant metastases in breast cancer patients. Patients with breast cancer liver metastases face limited treatment options, ... ...

    Abstract Breast cancer is the leading cause of cancer-related deaths in females worldwide, and the liver is one of the most common sites of distant metastases in breast cancer patients. Patients with breast cancer liver metastases face limited treatment options, and drug resistance is highly prevalent, leading to a poor prognosis and a short survival. Liver metastases respond extremely poorly to immunotherapy and have shown resistance to treatments such as chemotherapy and targeted therapies. Therefore, to develop and to optimize treatment strategies as well as to explore potential therapeutic approaches, it is crucial to understand the mechanisms of drug resistance in breast cancer liver metastases patients. In this review, we summarize recent advances in the research of drug resistance mechanisms in breast cancer liver metastases and discuss their therapeutic potential for improving patient prognoses and outcomes.
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges.

    Wei, Ya-Nan / Yan, Chun-Yan / Zhao, Meng-Lu / Zhao, Xi-He

    Molecular therapy oncolytics

    2023  Volume 31, Page(s) 100752

    Abstract: Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks ... ...

    Abstract Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.100752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats' choroid plexus.

    Meng, Chun-Yan / Ma, Xin-Yi / Xu, Ming-Yan / Pei, Sheng-Fei / Liu, Yang / Hao, Zhuo-Lu / Li, Qing-Zhao / Feng, Fu-Min

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9326

    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59889-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor.

    Zhang, Jun-An / Haddleton, David / Wilson, Paul / Zhu, Lin-Hua / Dai, Chun-Yan / Zhao, Lin-Lu

    Bioconjugate chemistry

    2024  Volume 35, Issue 3, Page(s) 400–411

    Abstract: Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen ( ...

    Abstract Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (
    MeSH term(s) Humans ; Fluorocarbon Polymers ; Photochemotherapy ; Oxygen ; Cell Line, Tumor ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Hypoxia/drug therapy ; Porphyrins ; Hydrogen-Ion Concentration ; Nanoparticles
    Chemical Substances Fluorocarbon Polymers ; Oxygen (S88TT14065) ; Photosensitizing Agents ; Porphyrins
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Management of biofilm by an innovative layer-structured membrane for membrane biofilm reactor (MBfR) to efficient methane oxidation coupled to denitrification (AME-D).

    Yuan, Chun-Yan / Yan, Wei-Jia / Sun, Fei-Yun / Tu, Hong-Hua / Lu, Jian-Jiang / Feng, Liang / Dong, Wen-Yi

    Water research

    2024  Volume 251, Page(s) 121107

    Abstract: Aerobic methane oxidation coupled with denitrification (AME-D) has garnered significant attention as a promising technology for nitrogen removal from water. Effective biofilm management on the membrane surface is essential to enhance the efficiency of ... ...

    Abstract Aerobic methane oxidation coupled with denitrification (AME-D) has garnered significant attention as a promising technology for nitrogen removal from water. Effective biofilm management on the membrane surface is essential to enhance the efficiency of nitrate removal in AME-D systems. In this study, we introduce a novel and scalable layer-structured membrane (LSM) developed using a meticulously designed polyurethane sponge. The application of the LSM in advanced biofilm management for AME-D resulted in a substantial enhancement of denitrification performance. Our experimental results demonstrated remarkable improvements in nitrate-removal flux (92.8 mmol-N m
    MeSH term(s) Methane/metabolism ; Nitrates/metabolism ; Denitrification ; Bioreactors/microbiology ; Bacteria/metabolism ; Oxidation-Reduction ; Biofilms ; Nitrogen/metabolism
    Chemical Substances Methane (OP0UW79H66) ; Nitrates ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of

    Wang, Shuo / Lu, Ming-Yuan / Wan, Si-Kang / Lyu, Chun-Yan / Tian, Zi-You / Liu, Kai / Lu, Hua

    Journal of the American Chemical Society

    2024  Volume 146, Issue 8, Page(s) 5678–5692

    Abstract: The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) ... ...

    Abstract The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) of
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Analysis of VOCs Emission Characteristics and Emission Reduction Potential of Typical Industries in Jinan, China].

    Wu, Wen-Lu / Shan, Chun-Yan / Zhao, Jing-Lin / Cui, Yu-Nong

    Huan jing ke xue= Huanjing kexue

    2023  Volume 44, Issue 11, Page(s) 5924–5932

    Abstract: Based on the air pollutant emission inventory of Jinan in 2020, the VOCs emission status and existing problems of typical industries including the chemical industry, industrial coating, printing, and furniture manufacturing were investigated and analyzed, ...

    Abstract Based on the air pollutant emission inventory of Jinan in 2020, the VOCs emission status and existing problems of typical industries including the chemical industry, industrial coating, printing, and furniture manufacturing were investigated and analyzed, and two emission reduction scenarios were designed to estimate the emission reduction potential according to the enterprise scales and the end-of-pipe treatment techniques. The results showed that the VOCs emissions of the typical industries from large to small were the chemical industry(7947.92 t), industrial coating(2383.29 t), printing(792.87 t), and furniture manufacturing(143.79 t). The chemical industry and industrial painting were dominated by large enterprises, accounting for 46.45% and 50.89% of VOCs emissions, whereas printing and furniture manufacturing were dominated by medium-sized enterprises, accounting for 51.76% and 42.37% of VOCs emissions, respectively. The end-of-pipe treatment was dominated by a single inefficient treatment technique, and the utilization rate of efficient treatment techniques such as combustion techniques and combination techniques was only 7.46%. The on-site investigation reported some problems in some enterprises, including incomplete source substitution, inadequate management of fugitive emissions, and unsuitable end-of-pipe treatment facilities. Therefore, VOCs emissions of typical industries had a certain reduction potential. Under the two designed emission reduction scenarios, the chemical industry had the greatest emission reduction potential, with emission reduction rates of 69.58%-84.99%, and the emission reduction rates of industrial coating, printing, and furniture manufacturing industries were 26.98%-34.74%, 36.96%-59.74%, and 8.55%-40.45%, respectively. Among the four industries, large and medium-sized enterprises had greater emission reduction potential, with average emission reduction rates of 70.00% and 44.23%, respectively. Under the scenario of a higher emission reduction target, the average emission reduction rates of small and micro enterprises were greatly increased, reaching 87.49% and 79.65%, respectively. The results of this study could provide scientific basis for developing VOCs governance in typical industries and enterprises.
    Language Chinese
    Publishing date 2023-11-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202212035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Gut Microbiome Composition of the Fire Ant Solenopsis invicta: an Integrated Analysis of Host Genotype and Geographical Distribution.

    Xiao, Qian / Wang, Lei / Chen, Si-Qi / Zheng, Chun-Yan / Lu, Yong-Yue / Xu, Yi-Juan

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0358522

    Abstract: Gut symbiotic bacteria are known to be closely related to insect development, nutrient metabolism, and disease resistance traits, but the most important factors leading to changes in these communities have not been well clarified. To address this, we ... ...

    Abstract Gut symbiotic bacteria are known to be closely related to insect development, nutrient metabolism, and disease resistance traits, but the most important factors leading to changes in these communities have not been well clarified. To address this, we examined the associations between the gut symbiotic bacteria and the host genotype and geographical distribution of Solenopsis invicta in China, where it is invasive and has spread primarily by human-mediated dispersal. Thirty-two phyla were detected in the gut symbiotic bacteria of
    MeSH term(s) Animals ; Humans ; Ants/genetics ; Ants/microbiology ; Gastrointestinal Microbiome/genetics ; Bacteria/genetics ; Proteobacteria/genetics ; Genotype
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03585-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Analysis of Factors Influencing Air Quality in Different Periods during COVID-19

    Wen-Lu Wu / Chun-Yan Shan / Jing Liu / Jing-Lin Zhao / Jin-Yun Long

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4199, p

    A Case Study of Tangshan, China

    2023  Volume 4199

    Abstract: This study aimed to analyze the main factors influencing air quality in Tangshan during COVID-19, covering three different periods: the COVID-19 period, the Level I response period, and the Spring Festival period. Comparative analysis and the difference- ... ...

    Abstract This study aimed to analyze the main factors influencing air quality in Tangshan during COVID-19, covering three different periods: the COVID-19 period, the Level I response period, and the Spring Festival period. Comparative analysis and the difference-in-differences (DID) method were used to explore differences in air quality between different stages of the epidemic and different years. During the COVID-19 period, the air quality index (AQI) and the concentrations of six conventional air pollutants (PM 2.5 , PM 10 , SO 2 , NO 2 , CO, and O 3 -8h) decreased significantly compared to 2017–2019. For the Level I response period, the reduction in AQI caused by COVID-19 control measures were 29.07%, 31.43%, and 20.04% in February, March, and April of 2020, respectively. During the Spring Festival, the concentrations of the six pollutants were significantly higher than those in 2019 and 2021, which may be related to heavy pollution events caused by unfavorable meteorological conditions and regional transport. As for the further improvement in air quality, it is necessary to take strict measures to prevent and control air pollution while paying attention to meteorological factors.
    Keywords air quality ; COVID-19 ; anthropogenic factors ; meteorological factors ; difference-in-differences analysis ; backward trajectory cluster ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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