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  1. Article ; Online: Recognising symptoms of congenital myasthenic syndromes in children: A guide for paediatricians.

    Orriëns, Lynn B / Eker, Dilan / Braakman, Hilde M H / Merkus, Peter J F M / Erasmus, Corrie E

    Acta paediatrica (Oslo, Norway : 1992)

    2023  Volume 112, Issue 11, Page(s) 2434–2439

    Abstract: Aim: Congenital myasthenic syndromes (CMS) are a rare and diverse group of treatable neuromuscular transmission disorders. Diagnosis is often substantially delayed. This study aimed to identify common symptoms of CMS in children and their manifestation ... ...

    Abstract Aim: Congenital myasthenic syndromes (CMS) are a rare and diverse group of treatable neuromuscular transmission disorders. Diagnosis is often substantially delayed. This study aimed to identify common symptoms of CMS in children and their manifestation to aid diagnosis and early intervention.
    Methods: We performed a retrospective cohort study, including 18 children (median age 13 years, range 9 years 5 months-18 years 0 month) with CMS. Data on CMS symptoms and their manifestation were extracted from patients' charts and supplemented with parental telephone interviews. Descriptive analyses were used to identify common symptoms.
    Results: A median diagnostic delay of 4 years and 7 months (interquartile range: 51 months) was observed. Proximal muscle weakness (100%), ptosis (89%), clumsy gait (82%), difficulty eating solid foods (78%) and recurrent respiratory tract infections (72%) were most common in these patients. Symptoms mostly co-occurred and frequently had a fluctuating character, aggravated by infections or fatigue.
    Conclusion: Early referral to diagnose CMS is crucial to enable timely initiation of treatment. Heightened attention to a combination of symptoms related to muscle weakness, rather than individual symptoms, should support paediatricians in flagging these neuromuscular disorders. Medical history taking should be tailored to parents' perceptions, asking questions about recognisable symptoms of muscle weakness.
    Language English
    Publishing date 2023-08-14
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Catch-up alveolar development into adulthood: also in those born prematurely?

    Merkus, Peter J F M

    The European respiratory journal

    2016  Volume 47, Issue 3, Page(s) 710–713

    MeSH term(s) Humans ; Infant, Premature
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00005-2016
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  3. Article ; Online: The value of chest CT as a COVID-19 screening tool in children.

    Merkus, Peter J F M / Klein, Willemijn M

    The European respiratory journal

    2020  Volume 55, Issue 6

    MeSH term(s) Age Factors ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/virology ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Sensitivity and Specificity ; Tomography, X-Ray Computed
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01241-2020
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  4. Article ; Online: Maternal depressive symptoms during pregnancy and infant wheezing up to 2 years of age.

    van Gelder, Marleen M H J / van Wijk, Emma J C / Roukema, Jolt / Roeleveld, Nel / Verhaak, Chris M / Merkus, Peter J F M

    Annals of epidemiology

    2023  Volume 88, Page(s) 43–50

    Abstract: Purpose: To determine whether maternal depressive symptoms at multiple time points during pregnancy are associated with infant wheezing in the first 2 years of life to assess etiologically relevant time windows.: Methods: We included Dutch women ... ...

    Abstract Purpose: To determine whether maternal depressive symptoms at multiple time points during pregnancy are associated with infant wheezing in the first 2 years of life to assess etiologically relevant time windows.
    Methods: We included Dutch women participating in the PRIDE Study with delivery in 2013-2019. Maternal depressive symptoms were assessed with the Hospital Anxiety and Depression Scale and Edinburgh Depression Scale at enrollment and in gestational weeks 17 and 34. The International Study of Asthma and Allergies in Childhood questionnaire was used to assess infant wheezing biannually postpartum. Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) were estimated with modified Poisson regression.
    Results: Among 5294 pregnancies included, maternal depressive symptoms in gestational weeks 15-22 was associated with any wheezing in the first 2 years of life (RR 1.36, 95% CI 1.04-1.78) and with current wheezing at 12 (RR 1.29, 95% CI 1.03-1.61) and 18 months (RR 1.33, 1.04-1.69). Depressive symptoms in gestational weeks 32-35 seemed to be associated with any wheezing reported at two years (RR 1.27, 95% CI 0.96-1.69) and current wheezing at 12 months (RR 1.28, 95% CI 1.02-1.60). Four trajectories of depressive symptoms were identified. Only the trajectory with increasing symptoms throughout pregnancy seemed to be associated with infant wheezing (RR 1.36, 95% CI 0.97-1.89).
    Conclusions: Maternal depressive symptoms in mid- and late pregnancy may be associated with development of infant wheezing, particularly those with onset in the second half of pregnancy. Research is needed to identify biological pathways and associations with more objective, long-term respiratory morbidity.
    MeSH term(s) Pregnancy ; Infant ; Humans ; Female ; Depression/epidemiology ; Depression/diagnosis ; Respiratory Sounds/etiology ; Mothers ; Postpartum Period
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074355-8
    ISSN 1873-2585 ; 1047-2797
    ISSN (online) 1873-2585
    ISSN 1047-2797
    DOI 10.1016/j.annepidem.2023.11.004
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  5. Article ; Online: Standing on shoulders.

    Merkus, Peter J F M

    The European respiratory journal

    2014  Volume 43, Issue 2, Page(s) 329–330

    MeSH term(s) Capillaries/physiology ; Female ; Humans ; Lung/physiology ; Male ; Pulmonary Diffusing Capacity
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00122813
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  6. Article ; Online: Setting the stage for CFTR modulator studies in infants.

    Merkus, Peter J F M

    Thorax

    2014  Volume 69, Issue 10, Page(s) 888–890

    MeSH term(s) Cystic Fibrosis/physiopathology ; Female ; Humans ; Male ; Maximal Midexpiratory Flow Rate/physiology ; Neonatal Screening/methods
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2013-204248
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  8. Article ; Online: Nasopharyngeal microbiota in children is associated with severe asthma exacerbations.

    van Beveren, Gina J / de Steenhuijsen Piters, Wouter A A / Boeschoten, Shelley A / Louman, Sam / Chu, Mei Ling / Arp, Kayleigh / Fraaij, Pieter L / de Hoog, Matthijs / Buysse, Corinne / van Houten, Marlies A / Sanders, Elisabeth A M / Merkus, Peter J F M / Boehmer, Annemie L / Bogaert, Debby

    The Journal of allergy and clinical immunology

    2024  

    Abstract: Background: The respiratory microbiome has been associated with the etiology and disease course of asthma.: Objective: We sought to assess the nasopharyngeal microbiota in children with a severe asthma exacerbation and their associations with ... ...

    Abstract Background: The respiratory microbiome has been associated with the etiology and disease course of asthma.
    Objective: We sought to assess the nasopharyngeal microbiota in children with a severe asthma exacerbation and their associations with medication, air quality, and viral infection.
    Methods: A cross-sectional study was performed among children aged 2 to 18 years admitted to the medium care unit (MCU; n = 84) or intensive care unit (ICU; n = 78) with an asthma exacerbation. For case-control analyses, we matched all cases aged 2 to 6 years (n = 87) to controls in a 1:2 ratio. Controls were participants of either a prospective case-control study or a longitudinal birth cohort (n = 182). The nasopharyngeal microbiota was characterized by 16S-rRNA-gene sequencing.
    Results: Cases showed higher Shannon diversity index (ICU and MCU combined; P = .002) and a distinct microbial community composition when compared with controls (permutational multivariate ANOVA R
    Conclusions: Our results demonstrate that children admitted with asthma exacerbations harbor a microbiome characterized by overgrowth of Staphylococcus and "oral" microbes and an underrepresentation of beneficial niche-appropriate commensals. Several of these associations may be explained by (environmental or medical) exposures, although cause-consequence relationships remain unclear and require further investigations.
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.02.020
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  9. Article ; Online: The Indirect Basophil Activation Test Is a Safe, Reliable, and Accessible Tool to Diagnose a Peanut Allergy in Children.

    Ruinemans-Koerts, Janneke / Brouwer, Marianne L / Schmidt-Hieltjes, Yvonne / Stevens, Petra / Merkus, Peter J F M / Doggen, Carine M J / Savelkoul, Huub F J / van Setten, Petra A

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 5, Page(s) 1305–1311.e3

    Abstract: Background: The gold standard for the diagnosis of a peanut allergy is an oral food challenge (OFC), but it is a time-consuming, patient-unfriendly, and expensive test. The in vitro direct basophil activation test (BAT) for peanuts was shown to be a ... ...

    Abstract Background: The gold standard for the diagnosis of a peanut allergy is an oral food challenge (OFC), but it is a time-consuming, patient-unfriendly, and expensive test. The in vitro direct basophil activation test (BAT) for peanuts was shown to be a promising diagnostic tool for replacing the OFC.
    Objective: To determine the diagnostic accuracy of the indirect (passive) BAT. Compared with the direct BAT, the timing of the indirect BAT is more flexible, and the problem of nonresponding basophils (unresponsive to IgE receptor-mediated signaling) is circumvented.
    Methods: In 74 children, suspected of peanut allergy and eligible for an OFC, indirect BAT results for peanut extract, Ara h2, and Ara h6 were compared with the results of a double-blind placebo-controlled food challenge. The reactivity and sensitivity of the basophils in the BAT were correlated to both the allergy status and the threshold dose in the OFC.
    Results: The combined basophil reactivity for Ara h2 and Ara h6 showed the highest accuracy (94%) for the diagnosis of a peanut allergy, with positive and negative predictive values of 96% and 89%, respectively. The sensitivity of the basophils for Ara h2 significantly discriminates between patients who tolerated up to 0.4 g of peanut protein in the OFC and those who did not.
    Conclusions: Because the indirect BAT showed a high diagnostic accuracy for peanut allergy, it is a promising alternative to the classical direct BAT and could lead to a reduction in OFC use.
    MeSH term(s) Allergens ; Antigens, Plant ; Arachis ; Basophil Degranulation Test ; Basophils ; Child ; Humans ; Peanut Hypersensitivity/diagnosis
    Chemical Substances Allergens ; Antigens, Plant
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.12.040
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  10. Article ; Online: Monitoring asthma: no matter how?

    van den Wijngaart, Lara S / Roukema, Jolt / Merkus, Peter J F M

    The European respiratory journal

    2016  Volume 48, Issue 3, Page(s) 614–616

    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01217-2016
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