LIVIVO - Search results -

Search results

Result 1 - 10 of total 22

Search options

Article ; Online: Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression.

Mulligan-Kehoe, Mary Jo

2013 Volume 23, Issue 4, Page(s) 114–120

Abstract: The vasa vasorum are unique networks of vessels that become angiogenic in response to changes in the vessel wall. Structural studies, using various imaging modalities, show that the vasa vasorum form a plexus of microvessels during the atherosclerotic ... ...

Abstract	The vasa vasorum are unique networks of vessels that become angiogenic in response to changes in the vessel wall. Structural studies, using various imaging modalities, show that the vasa vasorum form a plexus of microvessels during the atherosclerotic disease process. The events that stimulate vasa vasorum neovascularization remain unclear. Anti-angiogenic molecules have been shown to inhibit/regress the neovascularization; they provide significant insight into vasa vasorum function, structure, and specific requirements for growth and stability. This review discusses evidence for and against potential stimulators of vasa vasorum neovascularization. Anti-angiogenic rPAI-123, a truncated isoform of plasminogen activator inhibitor-1 (PAI-1) stimulates a novel pathway for regulating plasmin activity. This mechanism contributes significantly to vasa vasorum regression/collapse and is discussed as a model of regression.
MeSH term(s)	Angiogenesis Inhibitors/metabolism ; Animals ; Humans ; Models, Biological ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/physiopathology ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/physiopathology ; Plasminogen Activator Inhibitor 1/metabolism ; Vasa Vasorum/metabolism ; Vasa Vasorum/physiopathology
Chemical Substances	Angiogenesis Inhibitors ; Plasminogen Activator Inhibitor 1
Language	English
Publishing date	2013-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/j.tcm.2012.09.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3419: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The vasa vasorum in diseased and nondiseased arteries.

Mulligan-Kehoe, Mary Jo

American journal of physiology. Heart and circulatory physiology

2009 Volume 298, Issue 2, Page(s) H295–305

Abstract: The vasa vasorum form a network of microvasculature that originate primarily in the adventitial layer of large arteries. These vessels supply oxygen and nutrients to the outer layers of the arterial wall. The expansion of the vasa vasorum to the second ... ...

Abstract	The vasa vasorum form a network of microvasculature that originate primarily in the adventitial layer of large arteries. These vessels supply oxygen and nutrients to the outer layers of the arterial wall. The expansion of the vasa vasorum to the second order is associated with neovascularization related to progression of atherosclerosis. Immunohistological analysis of human plaques from autopsied aortas have defined plaque progression and show a significant correlation with vasa vasorum neovascularization. Recent technological advances in microcomputed tomography have enabled investigation of vasa vasorum structure and function in nondiseased large arteries from pigs and dogs. Smaller mammals, particularly mice with genetic modifications that enable disease development, have been used extensively to study the vasa vasorum in diseased vessels. Despite the fact that most mouse models that are used to study atherosclerosis are unable to develop plaque to the extent found in humans, studies in both humans and mice underscore the importance of angiogenic vasa vasorum in progression of atherosclerosis. Those who have examined the vasa vasorum in occluded vessels of nondiseased pigs and dogs find that inhibition of the vasa vasorum makes the animals atheroprone. Atherosclerosis is a multifactorial disease. There is increasing evidence that factors, produced in response to changes in the arterial wall, collaborate with the vasa vasorum to enhance the disease process.
MeSH term(s)	Animals ; Arteritis/diagnostic imaging ; Arteritis/pathology ; Arteritis/physiopathology ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/pathology ; Atherosclerosis/physiopathology ; Disease Models, Animal ; Disease Progression ; Dogs ; Humans ; Mice ; Neovascularization, Pathologic/diagnostic imaging ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/physiopathology ; Swine ; Tomography, X-Ray Computed ; Vasa Vasorum/diagnostic imaging ; Vasa Vasorum/pathology ; Vasa Vasorum/physiopathology
Language	English
Publishing date	2009-11-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00884.2009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Vasa vasorum in normal and diseased arteries.

Mulligan-Kehoe, Mary Jo / Simons, Michael

Circulation

2014 Volume 129, Issue 24, Page(s) 2557–2566

MeSH term(s)	Adventitia/blood supply ; Adventitia/physiology ; Adventitia/physiopathology ; Animals ; Arteries/physiology ; Arteries/physiopathology ; Atherosclerosis/physiopathology ; Homeostasis/physiology ; Humans ; Vasa Vasorum/physiology ; Vasa Vasorum/physiopathology ; Veins/physiology ; Veins/physiopathology
Language	English
Publishing date	2014-06-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.113.007189
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.60: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Vascular disease in scleroderma: angiogenesis and vascular repair.

Mulligan-Kehoe, Mary Jo / Simons, Michael

Rheumatic diseases clinics of North America

2008 Volume 34, Issue 1, Page(s) 73–9; vi

Abstract: Vascular abnormalities are one of the primary pathologic components of scleroderma. An early vascular indicator is aberrant nail fold capillaries that appear to undergo a switch from a pro- to anti-angiogenic process. Later in the disease process, ... ...

Abstract	Vascular abnormalities are one of the primary pathologic components of scleroderma. An early vascular indicator is aberrant nail fold capillaries that appear to undergo a switch from a pro- to anti-angiogenic process. Later in the disease process, ineffective and aberrant wound healing becomes apparent with frequent and widespread fibrosis. Pulmonary hypertension, largely due to the loss of pulmonary arterial vasculature, is frequently observed in late stages of the disease. The common theme of all these processes is abnormal regeneration of the vasculature and ongoing vascular losses due to defective maintenance of the vasculature. Although most aspects of vascular injury in scleroderma are poorly understood, certain biologic themes are beginning to emerge that are important in understanding scleroderma-related vascular disease.
MeSH term(s)	Angiogenesis Inhibitors/physiology ; Capillaries/pathology ; Humans ; Neovascularization, Physiologic/physiology ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/physiopathology ; Vascular Diseases/etiology ; Vascular Diseases/physiopathology ; Wound Healing/physiology
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2008-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2007.12.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 363: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Advances in imaging angiogenesis and inflammation in atherosclerosis

Zagorchev, Lyubomir / Mulligan-Kehoe, Mary Jo

Thrombosis and Haemostasis

2011 Volume 105, Issue 05, Page(s) 820–827

Abstract: Advances in imaging technology have provided powerful tools for dissecting the angiogenic and inflammatory aspects of atherosclerosis. Improved technology along with multi-modal approaches has expanded the utilisation of imaging. Recent advances provide ... ...

Abstract	Advances in imaging technology have provided powerful tools for dissecting the angiogenic and inflammatory aspects of atherosclerosis. Improved technology along with multi-modal approaches has expanded the utilisation of imaging. Recent advances provide the ability to better define structure and development of angiogenic vessels, identify relationships between inflammatory mediators and the vessel wall, validate biological effects of anti-inflammatory and anti-angiogenic drugs, delivery and/or targeting specific molecules to inflammatory regions of atherosclerotic plaques.
Keywords	Atherosclerosis ; inflammation ; angiogenesis ; imaging
Language	English
Publishing date	2011-01-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH10-08-0562
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Current concepts in normal and defective angiogenesis: implications for systemic sclerosis.

Mulligan-Kehoe, Mary Jo / Simons, Michael

Current rheumatology reports

2005 Volume 9, Issue 2, Page(s) 173–179

Abstract: Vascular abnormalities are a major component of systemic sclerosis, but little is known about the events or mechanisms that initiate vascular injury and prevent its repair. Early stages of systemic sclerosis are characterized by an exaggerated angiogenic ...

Abstract	Vascular abnormalities are a major component of systemic sclerosis, but little is known about the events or mechanisms that initiate vascular injury and prevent its repair. Early stages of systemic sclerosis are characterized by an exaggerated angiogenic response later replaced by defective wound healing and fibrosis. In this review, we summarize the current knowledge of the angiogenic imbalance in systemic sclerosis.
MeSH term(s)	Connective Tissue/blood supply ; Connective Tissue/pathology ; Humans ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Physiologic ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/physiopathology ; Wound Healing
Language	English
Publishing date	2005-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057357-1
ISSN	1523-3774
ISSN	1523-3774
DOI	10.1007/s11926-007-0013-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5531: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The functions of plasminogen activator inhibitor-1: do we have all the pieces of PAI?

Mulligan-Kehoe, Mary Jo / Schwartz, Gary N / Zacharski, Leo R

Thrombosis research

2006 Volume 117, Issue 5, Page(s) 483–486

MeSH term(s)	Binding Sites ; Gene Expression Regulation ; Humans ; Plasminogen Activator Inhibitor 1/genetics ; Plasminogen Activator Inhibitor 1/metabolism ; Plasminogen Activator Inhibitor 1/physiology ; Plasminogen Activators/metabolism ; Vitronectin/metabolism
Chemical Substances	Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human ; Vitronectin ; Plasminogen Activators (EC 3.4.21.-)
Language	English
Publishing date	2006
Publishing country	United States
Document type	Editorial
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2005.05.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 863: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.

Huang, Li-Hao / Melton, Elaina M / Li, Haibo / Sohn, Paul / Rogers, Maximillian A / Mulligan-Kehoe, Mary Jo / Fiering, Steven N / Hickey, William F / Chang, Catherine C Y / Chang, Ta-Yuan

The Journal of biological chemistry

2016 Volume 291, Issue 12, Page(s) 6232–6244

Abstract: Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. However, in mouse models for atherosclerosis, global Acat1 knockout (Acat1(-/-)) did not ... ...

Abstract	Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for treating atherosclerosis. However, in mouse models for atherosclerosis, global Acat1 knockout (Acat1(-/-)) did not prevent lesion development. Acat1(-/-) increased apoptosis within lesions and led to several additional undesirable phenotypes, including hair loss, dry eye, leukocytosis, xanthomatosis, and a reduced life span. To determine the roles of Acat1 in monocytes/macrophages in atherosclerosis, we produced a myeloid-specific Acat1 knockout (Acat1(-M/-M)) mouse and showed that, in the Apoe knockout (Apoe(-/-)) mouse model for atherosclerosis, Acat1(-M/-M) decreased the plaque area and reduced lesion size without causing leukocytosis, dry eye, hair loss, or a reduced life span. Acat1(-M/-M) enhanced xanthomatosis in apoe(-/-) mice, a skin disease that is not associated with diet-induced atherosclerosis in humans. Analyses of atherosclerotic lesions showed that Acat1(-M/-M) reduced macrophage numbers and diminished the cholesterol and cholesteryl ester load without causing detectable apoptotic cell death. Leukocyte migration analysis in vivo showed that Acat1(-M/-M) caused much fewer leukocytes to appear at the activated endothelium. Studies in inflammatory (Ly6C(hi)-positive) monocytes and in cultured macrophages showed that inhibiting ACAT1 by gene knockout or by pharmacological inhibition caused a significant decrease in integrin β 1 (CD29) expression in activated monocytes/macrophages. The sparse presence of lesion macrophages without Acat1 can therefore, in part, be attributed to decreased interaction between inflammatory monocytes/macrophages lacking Acat1 and the activated endothelium. We conclude that targeting ACAT1 in a myeloid cell lineage suppresses atherosclerosis progression while avoiding many of the undesirable side effects caused by global Acat1 inhibition.
MeSH term(s)	Acetyl-CoA C-Acetyltransferase/genetics ; Acetyl-CoA C-Acetyltransferase/metabolism ; Animals ; Apoptosis ; Atherosclerosis/genetics ; Atherosclerosis/immunology ; Atherosclerosis/pathology ; B-Lymphocytes/metabolism ; Bone Marrow/pathology ; Cell Movement ; Cell Proliferation ; Diet, High-Fat/adverse effects ; Disease Progression ; Endothelium, Vascular/immunology ; Endothelium, Vascular/pathology ; Female ; Hematopoietic Stem Cells/physiology ; Leukocytosis/genetics ; Leukocytosis/immunology ; Macrophages/immunology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/enzymology
Chemical Substances	Acat1 protein, mouse (EC 2.3.1.9) ; Acetyl-CoA C-Acetyltransferase (EC 2.3.1.9)
Language	English
Publishing date	2016-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M116.713818
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model.

Chung, Eun Joo / McKay-Corkum, Grace / Chung, Su / White, Ayla / Scroggins, Bradley T / Mitchell, James B / Mulligan-Kehoe, Mary Jo / Citrin, Deborah

International journal of radiation oncology, biology, physics

2015 Volume 94, Issue 5, Page(s) 1163–1172

Abstract: Purpose: To determine whether the delivery of recombinant truncated plasminogen activator inhibitor-1 (PAI-1) protein (rPAI-1(23)) would protect from the development of radiation-induced lung injury.: Methods and materials: C57Bl/6 mice received ... ...

Abstract	Purpose: To determine whether the delivery of recombinant truncated plasminogen activator inhibitor-1 (PAI-1) protein (rPAI-1(23)) would protect from the development of radiation-induced lung injury. Methods and materials: C57Bl/6 mice received intraperitoneal injections of rPAI-1(23) (5.4 μg/kg/d) or vehicle for 18 weeks, beginning 2 days before irradiation (IR) (5 daily fractions of 6 Gy). Cohorts of mice were followed for survival (n=8 per treatment) and tissue collection (n=3 per treatment and time point). Fibrosis in lung was assessed with Masson-Trichrome staining and measurement of hydroxyproline content. Senescence was assessed with staining for β-galactosidase activity in lung and primary pneumocytes. Results: Hydroxyproline content in irradiated lung was significantly reduced in mice that received rPAI-1(23) compared with mice that received vehicle (IR+vehicle: 84.97 μg/lung; IR+rPAI-1(23): 56.2 μg/lung, P=.001). C57Bl/6 mice exposed to IR+vehicle had dense foci of subpleural fibrosis at 19 weeks, whereas the lungs of mice exposed to IR+rPAI-1(23) were largely devoid of fibrotic foci. Cellular senescence was significantly decreased by rPAI-1(23) treatment in primary pneumocyte cultures and in lung at multiple time points after IR. Conclusions: These studies identify that rPAI-1(23) is capable of preventing radiation-induced fibrosis in murine lungs. These antifibrotic effects are associated with increased fibrin metabolism, enhanced matrix metalloproteinase-3 expression, and reduced senescence in type 2 pneumocytes. Thus, rPAI-1(23) is a novel therapeutic option for radiation-induced fibrosis.
MeSH term(s)	Alveolar Epithelial Cells/drug effects ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/radiation effects ; Animals ; Cell Proliferation ; Cellular Senescence/drug effects ; Cellular Senescence/radiation effects ; Collagen/metabolism ; Cytokines/metabolism ; Female ; Fibrin/metabolism ; Hydroxyproline/analysis ; Hydroxyproline/metabolism ; Lung/metabolism ; Lung/radiation effects ; Matrix Metalloproteinase 3/metabolism ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Plasminogen Activator Inhibitor 1/metabolism ; Plasminogen Activator Inhibitor 1/therapeutic use ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/prevention & control ; Radiation Pneumonitis/complications ; Radiation Pneumonitis/metabolism ; Real-Time Polymerase Chain Reaction ; Recombinant Proteins/therapeutic use
Chemical Substances	Cytokines ; Plasminogen Activator Inhibitor 1 ; Recombinant Proteins ; SERPINE1 protein, human ; Fibrin (9001-31-4) ; Collagen (9007-34-5) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2015-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2015.11.044
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism.

Mollmark, Jessica / Ravi, Saranya / Sun, Baiming / Shipman, Samantha / Buitendijk, Maarten / Simons, Michael / Mulligan-Kehoe, Mary Jo

Circulation research

2011 Volume 108, Issue 12, Page(s) 1419–1428

Abstract: Rationale: The antiangiogenic activity of rPAI-1(23), a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density ... ...

Abstract	Rationale: The antiangiogenic activity of rPAI-1(23), a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B48-deficient mice. Objective: The objective of this study was to examine rPAI-1(23)-stimulated mechanisms that cause vasa vasorum collapse. Methods and results: The rPAI-1(23) protein opposed PAI-1 antiproteolytic function by stimulating a 1.6-fold increase in plasmin activity compared with the saline-treated counterpart. The increased proteolytic activity corresponded to increased activity of matrix metalloproteinase-3 and degradation of fibrin(ogen), nidogen, and perlecan in the adventitia of descending aortas. PAI-1 activity was reduced by 48% in response to rPAI-1(23); however, PAI-1 protein expression levels were similar in the rPAI-1(23)- and saline-treated hypercholesterolemic mice. Coimmunoprecipitation assays demonstrated a novel PAI-1-plasminogen complex in protein from the descending aorta of rPAI-1(23)- and saline-treated mice, but complexed PAI-1 was 1.6-fold greater in rPAI-1(23)-treated mice. Biochemical analyses demonstrated that rPAI-1(23) and PAI-1 binding interactions with plasminogen increased plasmin activity and reduced PAI-1 antiproteolytic activity. Conclusions: We conclude that rPAI-1(23) causes regression or collapse of adventitial vasa vasorum in hypercholesterolemic mice by stimulating an increase in plasmin activity. The rPAI-1(23)-enhanced plasmin activity was achieved through a novel mechanism by which rPAI-1(23) and PAI-1 bound plasminogen in a cooperative manner to increase plasmin activity and reduce PAI-1 activity.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Fibrinolysin/genetics ; Fibrinolysin/metabolism ; Hypercholesterolemia/genetics ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/pathology ; Mice ; Mice, Knockout ; Plasminogen/genetics ; Plasminogen/metabolism ; Serpin E2/pharmacology ; Vasa Vasorum/metabolism ; Vasa Vasorum/pathology
Chemical Substances	Angiogenesis Inhibitors ; Serpin E2 ; Serpine2 protein, mouse ; Plasminogen (9001-91-6) ; Fibrinolysin (EC 3.4.21.7)
Language	English
Publishing date	2011-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.111.246249
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito