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Article ; Online: Measurement of the Dependence of the Hadron Production Fraction Ratios f_{s}/f_{u} and f_{d}/f_{u} on B Meson Kinematic Variables in Proton-Proton Collisions at sqrt[s]=13 TeV.

Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Damanakis, K / Dragicevic, M / Escalante Del Valle, A / Hussain, P S / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Schieck, J / Schöfbeck, R / Schwarz, D / Sonawane, M /

Templ, S / Waltenberger, W / Wulz, C-E / Darwish, M R / Janssen, T / Kello, T / Rejeb Sfar, H / Van Mechelen, P / Bols, E S / D'Hondt, J / De Moor, A / Delcourt, M / El Faham, H / Lowette, S / Morton, A / Müller, D / Sahasransu, A R / Tavernier, S / Van Doninck, W / Van Putte, S / Vannerom, D / Clerbaux, B / De Lentdecker, G / Favart, L / Hohov, D / Jaramillo, J / Lee, K / Mahdavikhorrami, M / Makarenko, I / Malara, A / Paredes, S / Pétré, L / Postiau, N / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / Dobur, D / Knolle, J / Lambrecht, L / Mestdach, G / Rendón, C / Samalan, A / Skovpen, K / Tytgat, M / Van Den Bossche, N / Vermassen, B / Wezenbeek, L / Benecke, A / Bruno, G / Bury, F / Caputo, C / David, P / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Mondal, K / Taliercio, A / Tran, T T / Vischia, P / Wertz, S / Alves, G A / Coelho, E / Hensel, C / Moraes, A / Rebello Teles, P / Aldá Júnior, W L / Alves Gallo Pereira, M / Barroso Ferreira Filho, M / Brandao Malbouisson, H / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / Dos Santos Sousa, V / Fonseca De Souza, S / Martins, J / Mora Herrera, C / Mota Amarilo, K / Mundim, L / Nogima, H / Santoro, A / Silva Do Amaral, S M / Sznajder, A / Thiel, M / Vilela Pereira, A / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Rodozov, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Shumka, E / Thakur, S / Cheng, T / Javaid, T / Mittal, M / Yuan, L / Ahmad, M / Bauer, G / Hu, Z / Lezki, S / Yi, K / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Jiang, C H / Kapoor, A / Liao, H / Liu, Z-A / Milosevic, V / Monti, F / Sharma, R / Tao, J / Thomas-Wilsker, J / Wang, J / Zhang, H / Zhao, J / Agapitos, A / An, Y / Ban, Y / Levin, A / Li, C / Li, Q / Lyu, X / Mao, Y / Qian, S J / Sun, X / Wang, D / Xiao, J / Yang, H / Lu, M / You, Z / Lu, N / Gao, X / Leggat, D / Okawa, H / Zhang, Y / Lin, Z / Lu, C / Xiao, M / Avila, C / Barbosa Trujillo, D A / Cabrera, A / Florez, C / Fraga, J / Mejia Guisao, J / Ramirez, F / Rodriguez, M / Ruiz Alvarez, J D / Giljanovic, D / Godinovic, N / Lelas, D / Puljak, I / Antunovic, Z / Kovac, M / Sculac, T / Brigljevic, V / Chitroda, B K / Ferencek, D / Mishra, S / Roguljic, M / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Stepennov, A / Finger, M / Kveton, A / Ayala, E / Carrera Jarrin, E / Abdelalim, A A / Salama, E / Abdullah Al-Mashad, M / Mahmoud, M A / Bhowmik, S / Dewanjee, R K / Ehataht, K / Kadastik, M / Lange, T / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Eerola, P / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Rantanen, M M / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Amendola, C / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Gras, P / Hamel de Monchenault, G / Lohezic, V / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Simkina, P / Titov, M / Baldenegro Barrera, C / Beaudette, F / Buchot Perraguin, A / Busson, P / Cappati, A / Charlot, C / Damas, F / Davignon, O / Diab, B / Falmagne, G / Fontana Santos Alves, B A / Ghosh, S / Granier de Cassagnac, R / Hakimi, A / Harikrishnan, B / Liu, G / Motta, J / Nguyen, M / Ochando, C / Portales, L / Salerno, R / Sarkar, U / Sauvan, J B / Sirois, Y / Tarabini, A / Vernazza, E / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Bourgatte, G / Brom, J-M / Chabert, E C / Collard, C / Darej, D / Goerlach, U / Grimault, C / Le Bihan, A-C / Van Hove, P / Beauceron, S / Blancon, B / Boudoul, G / Carle, A / Chanon, N / Choi, J / Contardo, D / Depasse, P / Dozen, C / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Grenier, G / Ille, B / Laktineh, I B / Lethuillier, M / Mirabito, L / Perries, S / Torterotot, L / Vander Donckt, M / Verdier, P / Viret, S / Lomidze, I / Toriashvili, T / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Röwert, N / Teroerde, M / Diekmann, S / Dodonova, A / Eich, N / Eliseev, D / Erdmann, M / Fackeldey, P / Fasanella, D / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Lee, M Y / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mondal, S / Mukherjee, S / Noll, D / Novak, A / Nowotny, F / Pozdnyakov, A / Rath, Y / Redjeb, W / Rehm, F / Reithler, H / Schmidt, A / Schuler, S C / Sharma, A / Stein, A / Torres Da Silva De Araujo, F / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Haj Ahmad, W / Hlushchenko, O / Kress, T / Nowack, A / Pooth, O / Stahl, A / Ziemons, T / Zotz, A / Aarup Petersen, H / Aldaya Martin, M / Alimena, J / Asmuss, P / Baxter, S / Bayatmakou, M / Becerril Gonzalez, H / Behnke, O / Bhattacharya, S / Blekman, F / Borras, K / Brunner, D / Campbell, A / Cardini, A / Cheng, C / Colombina, F / Consuegra Rodríguez, S / Correia Silva, G / De Silva, M / Eckerlin, G / Eckstein, D / Estevez Banos, L I / Filatov, O / Gallo, E / Geiser, A / Giraldi, A / Greau, G / Grohsjean, A / Guglielmi, V / Guthoff, M / Jafari, A / Jomhari, N Z / Kaech, B / Kasemann, M / Kaveh, H / Kleinwort, C / Kogler, R / Komm, M / Krücker, D / Lange, W / Leyva Pernia, D / Lipka, K / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Mendizabal Morentin, M / Metwally, J / Meyer, A B / Milella, G / Mormile, M / Mussgiller, A / Nürnberg, A / Otarid, Y / Pérez Adán, D / Ranken, E / Raspereza, A / Ribeiro Lopes, B / Rübenach, J / Saggio, A / Savitskyi, M / Scham, M / Scheurer, V / Schnake, S / Schütze, P / Schwanenberger, C / Shchedrolosiev, M / Sosa Ricardo, R E / Stafford, D / Tonon, N / Van De Klundert, M / Vazzoler, F / Ventura Barroso, A / Walsh, R / Walter, D / Wang, Q / Wen, Y / Wichmann, K / Wiens, L / Wissing, C / Wuchterl, S / Yang, Y / Zimermmane Castro Santos, A / Albrecht, A / Albrecht, S / Antonello, M / Bein, S / Benato, L / Bonanomi, M / Connor, P / De Leo, K / Eich, M / El Morabit, K / Feindt, F / Fröhlich, A / Garbers, C / Garutti, E / Hajheidari, M / Haller, J / Hinzmann, A / Jabusch, H R / Kasieczka, G / Keicher, P / Klanner, R / Korcari, W / Kramer, T / Kutzner, V / Labe, F / Lange, J / Lobanov, A / Matthies, C / Mehta, A / Moureaux, L / Mrowietz, M / Nigamova, A / Nissan, Y / Paasch, A / Pena Rodriguez, K J / Quadfasel, T / Rieger, M / Rieger, O / Savoiu, D / Schindler, J / Schleper, P / Schröder, M / Schwandt, J / Sommerhalder, M / Stadie, H / Steinbrück, G / Tews, A / Wolf, M / Brommer, S / Burkart, M / Butz, E / Chwalek, T / Dierlamm, A / Droll, A / Faltermann, N / Giffels, M / Gosewisch, J O / Gottmann, A / Hartmann, F / Horzela, M / Husemann, U / Klute, M / Koppenhöfer, R / Link, M / Lintuluoto, A / Maier, S / Mitra, S / Müller, Th / Neukum, M / Oh, M / Quast, G / Rabbertz, K / Rauser, J / Shvetsov, I / Simonis, H J / Trevisani, N / Ulrich, R / van der Linden, J / Von Cube, R F / Wassmer, M / Wieland, S / Wolf, R / Wozniewski, S / Wunsch, S / Zuo, X / Anagnostou, G / Assiouras, P / Daskalakis, G / Kyriakis, A / Stakia, A / Diamantopoulou, M / Karasavvas, D / Kontaxakis, P / Manousakis-Katsikakis, A / Panagiotou, A / Papavergou, I / Saoulidou, N / Theofilatos, K / Tziaferi, E / Vellidis, K / Zisopoulos, I / Bakas, G / Chatzistavrou, T / Karapostoli, G / Kousouris, K / Papakrivopoulos, I / Tsipolitis, G / Zacharopoulou, A / Adamidis, K / Bestintzanos, I / Evangelou, I / Foudas, C / Gianneios, P / Kamtsikis, C / Katsoulis, P / Kokkas, P / Kosmoglou Kioseoglou, P G / Manthos, N / Papadopoulos, I / Strologas, J / Csanád, M / Farkas, K / Gadallah, M M A / Lökös, S / Major, P / Mandal, K / Pásztor, G / Rádl, A J / Surányi, O / Veres, G I / Bartók, M / Bencze, G / Hajdu, C / Horvath, D / Sikler, F / Veszpremi, V / Beni, N / Czellar, S / Karancsi, J / Molnar, J / Szillasi, Z / Teyssier, D / Raics, P / Ujvari, B / Zilizi, G / Csorgo, T / Nemes, F / Novak, T / Babbar, J / Bansal, S / Beri, S B / Bhatnagar, V / Chaudhary, G / Chauhan, S / Dhingra, N / Gupta, R / Kaur, A / Kaur, H / Kaur, M / Kumar, S / Kumari, P / Meena, M / Sandeep, K / Sheokand, T / Singh, J B / Singla, A / Ahmed, A / Bhardwaj, A / Chhetri, A / Choudhary, B C / Kumar, A / Naimuddin, M / Ranjan, K / Saumya, S / Baradia, S / Barman, S / Bhowmik, D / Dutta, S / Gomber, B / Maity, M / Palit, P / Saha, G / Sahu, B / Sarkar, S / Behera, P K / Behera, S C / Kalbhor, P / Komaragiri, J R / Kumar, D / Muhammad, A / Panwar, L / Pradhan, R / Pujahari, P R / Saha, N R / Sikdar, A K / Verma, S / Naskar, K / Aziz, T / Das, I / Dugad, S / Kumar, M / Mohanty, G B / Suryadevara, P / Banerjee, S / Guchait, M / Karmakar, S / Majumder, G / Mazumdar, K / Thachayath, A / Bahinipati, S / Das, A K / Kar, C / Mal, P / Mishra, T / Muraleedharan Nair Bindhu, V K / Nayak, A / Saha, P / Swain, S K / Vats, D / Alpana, A / Dube, S / Kansal, B / Laha, A / Pandey, S / Rastogi, A / Sharma, S / Bakhshiansohi, H / Khazaie, E / Zeinali, M / Chenarani, S / Etesami, S M / Khakzad, M / Mohammadi Najafabadi, M / Grunewald, M / Abbrescia, M / Aly, R / Aruta, C / Colaleo, A / Creanza, D / Cristella, L / De Filippis, N / De Palma, M / Di Florio, A / Elmetenawee, W / Errico, F / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / Margjeka, I / Mastrapasqua, V / My, S / Nuzzo, S / Pellecchia, A / Pompili, A / Pugliese, G / Radogna, R / Ramos, D / Ranieri, A / Selvaggi, G / Silvestris, L / Simone, F M / Sözbilir, Ü / Stamerra, A / Venditti, R / Verwilligen, P / Abbiendi, G / Battilana, C / Bonacorsi, D / Borgonovi, L / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Cuffiani, M / Dallavalle, G M / Diotalevi, T / Fabbri, F / Fanfani, A / Giacomelli, P / Giommi, L / Grandi, C / Guiducci, L / Lo Meo, S / Lunerti, L / Marcellini, S / Masetti, G / Navarria, F L / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Costa, S / Di Mattia, A / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Bardelli, G / Camaiani, B / Cassese, A / Ceccarelli, R / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Latino, G / Lenzi, P / Lizzo, M / Meschini, M / Paoletti, S / Sguazzoni, G / Viliani, L / Benussi, L / Bianco, S / Meola, S / Piccolo, D / Bozzo, M / Chatagnon, P / Ferro, F / Robutti, E / Tosi, S / Benaglia, A / Boldrini, G / Brivio, F / Cetorelli, F / De Guio, F / Dinardo, M E / Dini, P / Gennai, S / Ghezzi, A / Govoni, P / Guzzi, L / Lucchini, M T / Malberti, M / Malvezzi, S / Massironi, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Pinolini, B S / Ragazzi, S / Redaelli, N / Tabarelli de Fatis, T / Zuolo, D / Buontempo, S / Carnevali, F / Cavallo, N / De Iorio, A / Fabozzi, F / Iorio, A O M / Lista, L / Paolucci, P / Rossi, B / Sciacca, C / Azzi, P / Bacchetta, N / Bisello, D / Bortignon, P / Bragagnolo, A / Carlin, R / Checchia, P / Dorigo, T / Gasparini, F / Gasparini, U / Grosso, G / Gulmini, M / Layer, L / Lusiani, E / Margoni, M / Meneguzzo, A T / Pazzini, J / Ronchese, P / Rossin, R / Simonetto, F / Strong, G / Tosi, M / Yarar, H / Zanetti, M / Zotto, P / Zucchetta, A / Abu Zeid, S / Aimè, C / Braghieri, A / Calzaferri, S / Fiorina, D / Montagna, P / Re, V / Riccardi, C / Salvini, P / Vai, I / Vitulo, P / Asenov, P / Bilei, G M / Ciangottini, D / Fanò, L / Magherini, M / Mantovani, G / Mariani, V / Menichelli, M / Moscatelli, F / Piccinelli, A / Presilla, M / Rossi, A / Santocchia, A / Spiga, D / Tedeschi, T / Azzurri, P / Bagliesi, G / Bertacchi, V / Bhattacharya, R / Bianchini, L / Boccali, T / Bossini, E / Bruschini, D / Castaldi, R / Ciocci, M A / D'Amante, V / Dell'Orso, R / Donato, S / Giassi, A / Ligabue, F / Matos Figueiredo, D / Messineo, A / Musich, M / Palla, F / Parolia, S / Ramirez-Sanchez, G / Rizzi, A / Rolandi, G / Roy Chowdhury, S / Sarkar, T / Scribano, A / Spagnolo, P / Tenchini, R / Tonelli, G / Turini, N / Venturi, A / Verdini, P G / Barria, P / Campana, M / Cavallari, F / Del Re, D / Di Marco, E / Diemoz, M / Longo, E / Meridiani, P / Organtini, G / Pandolfi, F / Paramatti, R / Quaranta, C / Rahatlou, S / Rovelli, C / Santanastasio, F / Soffi, L / Tramontano, R / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Bartosik, N / Bellan, R / Bellora, A / Biino, C / Cartiglia, N / Costa, M / Covarelli, R / Demaria, N / Grippo, M / Kiani, B / Legger, F / Mariotti, C / Maselli, S / Mecca, A / Migliore, E / Monteno, M / Mulargia, R / Obertino, M M / Ortona, G / Pacher, L / Pastrone, N / Pelliccioni, M / Ruspa, M / Shchelina, K / Siviero, F / Sola, V / Solano, A / Soldi, D / Staiano, A / Tornago, M / Trocino, D / Umoret, G / Vagnerini, A / Vlasov, E / Belforte, S / Candelise, V / Casarsa, M / Cossutti, F / Della Ricca, G / Sorrentino, G / Dogra, S / Huh, C / Kim, B / Kim, D H / Kim, G N / Kim, J / Lee, J / Lee, S W / Moon, C S / Oh, Y D / Pak, S I / Ryu, M S / Sekmen, S / Yang, Y C / Kim, H / Moon, D H / Asilar, E / Kim, T J / Park, J / Choi, S / Han, S / Hong, B / Lee, K S / Lim, J / Park, S K / Yoo, J / Goh, J / Kim, H S / Kim, Y / Lee, S / Almond, J / Bhyun, J H / Jeon, S / Kim, J S / Ko, S / Kwon, H / Lee, H / Oh, B H / Oh, S B / Seo, H / Yang, U K / Yoon, I / Jang, W / Kang, D Y / Kang, Y / Kim, D / Kim, S / Ko, B / Lee, J S H / Lee, Y / Merlin, J A / Park, I C / Roh, Y / Song, D / Watson, I J / Yang, S / Ha, S / Yoo, H D / Choi, M / Kim, M R / Yu, I / Beyrouthy, T / Maghrbi, Y / Dreimanis, K / Pikurs, G / Potrebko, A / Seidel, M / Veckalns, V / Ambrozas, M / Carvalho Antunes De Oliveira, A / Juodagalvis, A / Rinkevicius, A / Tamulaitis, G / Bin Norjoharuddeen, N / Hoh, S Y / Yusuff, I / Zolkapli, Z / Benitez, J F / Castaneda Hernandez, A / Encinas Acosta, H A / Gallegos Maríñez, L G / León Coello, M / Murillo Quijada, J A / Sehrawat, A / Valencia Palomo, L / Ayala, G / Castilla-Valdez, H / Heredia-De La Cruz, I / Lopez-Fernandez, R / Mondragon Herrera, C A / Perez Navarro, D A / Sánchez Hernández, A / Oropeza Barrera, C / Vazquez Valencia, F / Pedraza, I / Salazar Ibarguen, H A / Uribe Estrada, C / Bubanja, I / Mijuskovic, J / Raicevic, N / Ahmad, A / Asghar, M I / Awais, A / Awan, M I M / Gul, M / Hoorani, H R / Khan, W A / Avati, V / Grzanka, L / Malawski, M / Bialkowska, H / Bluj, M / Boimska, B / Górski, M / Kazana, M / Szleper, M / Zalewski, P / Bunkowski, K / Doroba, K / Kalinowski, A / Konecki, M / Krolikowski, J / Araujo, M / Bargassa, P / Bastos, D / Boletti, A / Faccioli, P / Gallinaro, M / Hollar, J / Leonardo, N / Niknejad, T / Pisano, M / Seixas, J / Varela, J / Adzic, P / Dordevic, M / Milenovic, P / Milosevic, J / Aguilar-Benitez, M / Alcaraz Maestre, J / Barrio Luna, M / Bedoya, Cristina F / Cepeda, M / Cerrada, M / Colino, N / De La Cruz, B / Delgado Peris, A / Fernández Del Val, D / Fernández Ramos, J P / Flix, J / Fouz, M C / Gonzalez Lopez, O / Goy Lopez, S / Hernandez, J M / Josa, M I / León Holgado, J / Moran, D / Perez Dengra, C / Pérez-Calero Yzquierdo, A / Puerta Pelayo, J / Redondo, I / Redondo Ferrero, D D / Romero, L / Sánchez Navas, S / Sastre, J / Urda Gómez, L / Vazquez Escobar, J / Willmott, C / de Trocóniz, J F / Alvarez Gonzalez, B / Cuevas, J / Fernandez Menendez, J / Folgueras, S / Gonzalez Caballero, I / González Fernández, J R / Palencia Cortezon, E / Ramón Álvarez, C / Rodríguez Bouza, V / Soto Rodríguez, A / Trapote, A / Vico Villalba, C / Brochero Cifuentes, J A / Cabrillo, I J / Calderon, A / Duarte Campderros, J / Fernandez, M / Fernandez Madrazo, C / García Alonso, A / Gomez, G / Lasaosa García, C / Martinez Rivero, C / Martinez Ruiz Del Arbol, P / Matorras, F / Matorras Cuevas, P / Piedra Gomez, J / Prieels, C / Scodellaro, L / Vila, I / Vizan Garcia, J M / Jayananda, M K / Kailasapathy, B / Sonnadara, D U J / Wickramarathna, D D C / Dharmaratna, W G D / Liyanage, K / Perera, N / Wickramage, N / Abbaneo, D / Auffray, E / Auzinger, G / Baechler, J / Baillon, P / Barney, D / Bendavid, J / Bermúdez Martínez, A / Bianco, M / Bilin, B / Bin Anuar, A A / Bocci, A / Brondolin, E / Caillol, C / Camporesi, T / Cerminara, G / Chernyavskaya, N / Chhibra, S S / Choudhury, S / Cipriani, M / d'Enterria, D / Dabrowski, A / David, A / De Roeck, A / Defranchis, M M / Deile, M / Dobson, M / Dünser, M / Dupont, N / Fallavollita, F / Florent, A / Forthomme, L / Franzoni, G / Funk, W / Giani, S / Gigi, D / Gill, K / Glege, F / Gouskos, L / Govorkova, E / Haranko, M / Hegeman, J / Innocente, V / James, T / Janot, P / Kaspar, J / Kieseler, J / Kratochwil, N / Laurila, S / Lecoq, P / Leutgeb, E / Lourenço, C / Maier, B / Malgeri, L / Mannelli, M / Marini, A C / Meijers, F / Mersi, S / Meschi, E / Moortgat, F / Mulders, M / Orfanelli, S / Orsini, L / Pantaleo, F / Perez, E / Peruzzi, M / Petrilli, A / Petrucciani, G / Pfeiffer, A / Pierini, M / Piparo, D / Pitt, M / Qu, H / Quast, T / Rabady, D / Racz, A / Reales Gutiérrez, G / Rovere, M / Sakulin, H / Salfeld-Nebgen, J / Scarfi, S / Selvaggi, M / Silva, P / Sphicas, P / Stahl Leiton, A G / Summers, S / Tatar, K / Treille, D / Tropea, P / Tsirou, A / Wanczyk, J / Wozniak, K A / Zeuner, W D / Caminada, L / Ebrahimi, A / Erdmann, W / Horisberger, R / Ingram, Q / Kaestli, H C / Kotlinski, D / Lange, C / Missiroli, M / Noehte, L / Rohe, T / Aarrestad, T K / Androsov, K / Backhaus, M / Calandri, A / Datta, K / De Cosa, A / Dissertori, G / Dittmar, M / Donegà, M / Eble, F / Galli, M / Gedia, K / Glessgen, F / Gómez Espinosa, T A / Grab, C / Hits, D / Lustermann, W / Lyon, A-M / Manzoni, R A / Marchese, L / Martin Perez, C / Mascellani, A / Nessi-Tedaldi, F / Niedziela, J / Pauss, F / Perovic, V / Pigazzini, S / Ratti, M G / Reichmann, M / Reissel, C / 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Physical review letters

2023 Volume 131, Issue 12, Page(s) 121901

Abstract: The dependence of the ratio between the B_{s}^{0} and B^{+} hadron production fractions, f_{s}/f_{u ... of 61.6 fb^{-1}. The f_{s}/f_{u} ratio is observed to depend on the B p_{T} and to be consistent ... to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton ...

Abstract	The dependence of the ratio between the B_{s}^{0} and B^{+} hadron production fractions, f_{s}/f_{u}, on the transverse momentum (p_{T}) and rapidity of the B mesons is studied using the decay channels B_{s}^{0}→J/ψϕ and B^{+}→J/ψK^{+}. The analysis uses a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 61.6 fb^{-1}. The f_{s}/f_{u} ratio is observed to depend on the B p_{T} and to be consistent with becoming asymptotically constant at large p_{T}. No rapidity dependence is observed. The ratio of the B^{0} to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton collisions, using the B^{0}→J/ψK^{*0} decay channel. The result is found to be within 1 standard deviation of unity and independent of p_{T} and rapidity, as expected from isospin invariance.
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.121901
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Article ; Online: Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Journal of the American Chemical Society

2019 Volume 141, Issue 21, Page(s) 8450–8461

Abstract: Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines ... the pore-forming subunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin F ... a biotin analogue of ipomoeassin F to pull down Sec61α from live cells, yet it is also reversible ...

Abstract	Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medicinal chemistry, we used chemical proteomics to identify Sec61α (protein transport protein Sec61 subunit alpha isoform 1), the pore-forming subunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin F in living cells. The interaction is specific and strong enough to survive lysis conditions, enabling a biotin analogue of ipomoeassin F to pull down Sec61α from live cells, yet it is also reversible, as judged by several experiments including fluorescent streptavidin staining, delayed competition in affinity pulldown, and inhibition of TNF biogenesis after washout. Sec61α forms the central subunit of the ER protein translocation complex, and the binding of ipomoeassin F results in a substantial, yet selective, inhibition of protein translocation in vitro and a broad ranging inhibition of protein secretion in live cells. Lastly, the unique resistance profile demonstrated by specific amino acid single-point mutations in Sec61α provides compelling evidence that Sec61α is the primary molecular target of ipomoeassin F and strongly suggests that the binding of this natural product to Sec61α is distinctive. Therefore, ipomoeassin F represents the first plant-derived, carbohydrate-based member of a novel structural class that offers new opportunities to explore Sec61α function and to further investigate its potential as a therapeutic target for drug discovery.
MeSH term(s)	Binding Sites/drug effects ; Glycoconjugates/chemistry ; Glycoconjugates/pharmacology ; Humans ; Molecular Structure ; Protein Transport/drug effects ; SEC Translocation Channels/antagonists & inhibitors ; SEC Translocation Channels/metabolism
Chemical Substances	Glycoconjugates ; SEC Translocation Channels ; ipomoeassin F
Language	English
Publishing date	2019-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.8b13506
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Article: Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Journal of the American Chemical Society. 2019 May 06, v. 141, no. 21

2019

Abstract	Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medicinal chemistry, we used chemical proteomics to identify Sec61α (protein transport protein Sec61 subunit alpha isoform 1), the pore-forming subunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin F in living cells. The interaction is specific and strong enough to survive lysis conditions, enabling a biotin analogue of ipomoeassin F to pull down Sec61α from live cells, yet it is also reversible, as judged by several experiments including fluorescent streptavidin staining, delayed competition in affinity pulldown, and inhibition of TNF biogenesis after washout. Sec61α forms the central subunit of the ER protein translocation complex, and the binding of ipomoeassin F results in a substantial, yet selective, inhibition of protein translocation in vitro and a broad ranging inhibition of protein secretion in live cells. Lastly, the unique resistance profile demonstrated by specific amino acid single-point mutations in Sec61α provides compelling evidence that Sec61α is the primary molecular target of ipomoeassin F and strongly suggests that the binding of this natural product to Sec61α is distinctive. Therefore, ipomoeassin F represents the first plant-derived, carbohydrate-based member of a novel structural class that offers new opportunities to explore Sec61α function and to further investigate its potential as a therapeutic target for drug discovery.
Keywords	amino acids ; biogenesis ; biotin ; cell lines ; chemistry ; cytotoxins ; drugs ; fluorescence ; medicinal properties ; mutation ; neoplasm cells ; protein transport ; proteomics ; staining ; streptavidin ; therapeutics ; transport proteins ; tumor necrosis factors
Language	English
Dates of publication	2019-0506
Size	p. 8450-8461.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.8b13506
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Binding of the PET radiotracer [¹⁸F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice.

Levigoureux, Elise / Lancelot, Sophie / Bouillot, Caroline / Chauveau, Fabien / Verdurand, Mathieu / Verchere, Jeremy / Billard, Thierry / Baron, Thierry / Zimmer, Luc

Current Alzheimer research

2014 Volume 11, Issue 10, Page(s) 955–960

Abstract: ... specific PET radiotracer of aggregated α-syn is currently available. Recently, [(18)F]BF227 has been ... depositions in brainstem and thalamus. Our in vivo and in vitro studies showed that [(18)F]BF227 does not bind ... to α-syn aggregates. These results highlight the fact that [(18)F]BF227 PET has no suitable ...

Abstract	Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many neurodegenerative diseases, collectively termed synucleinopathies. There is currently no pre-mortem diagnosis tool for these diseases. Although some compounds have been described as potential ligands for α-syn aggregates, no specific PET radiotracer of aggregated α-syn is currently available. Recently, [(18)F]BF227 has been proposed as an α-syn PET radiotracer in the absence of other specific candidates. We proposed here, for the first time, to use this radiotracer in an accelerated mouse model of synucleinopathy presenting α-syn depositions in brainstem and thalamus. Our in vivo and in vitro studies showed that [(18)F]BF227 does not bind to α-syn aggregates. These results highlight the fact that [(18)F]BF227 PET has no suitable characteristics for monitoring this experimental synucleinopathy, justifying the need to develop alternative α-syn PET radiotracers.
MeSH term(s)	Animals ; Benzoxazoles/chemistry ; Brain Stem/diagnostic imaging ; Brain Stem/pathology ; Disease Models, Animal ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation/genetics ; Positron-Emission Tomography ; Radioligand Assay ; Tauopathies/diagnostic imaging ; Tauopathies/genetics ; Thalamus/diagnostic imaging ; Thalamus/pathology ; Thiazoles/chemistry ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
Chemical Substances	2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole ; Benzoxazoles ; Thiazoles ; alpha-Synuclein ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2014-05-01
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205170-3
ISSN	1875-5828 ; 1567-2050
ISSN (online)	1875-5828
ISSN	1567-2050
DOI	10.2174/1567205011666141107154201
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Article ; Online: Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8+ T cell epitopes.

Rotem, Shahar / Cohen, Ofer / Bar-Haim, Erez / Bar-On, Liat / Ehrlich, Sharon / Shafferman, Avigdor

PloS one

2014 Volume 9, Issue 1, Page(s) e85215

Abstract: ... of the bacterial infection and provided complete protection against lethal challenge (10LD50) with F. tularensis holarctica ...

Abstract	Recently we described an unbiased bacterial whole-genome immunoinformatic analysis aimed at selection of potential CTL epitopes located in "hotspots" of predicted MHC-I binders. Applying this approach to the proteome of the facultative intra-cellular pathogen Francisella tularensis resulted in identification of 170 novel CTL epitopes, several of which were shown to elicit highly robust T cell responses. Here we demonstrate that by DNA immunization using a short DNA fragment expressing six of the most prominent identified CTL epitopes a potent and specific CD8+ T cell responses is being induced, to all encoded epitopes, a response not observed in control mice immunized with the DNA vector alone Moreover, this CTL-specific mediated immune response prevented disease development, allowed for a rapid clearance of the bacterial infection and provided complete protection against lethal challenge (10LD50) with F. tularensis holarctica Live Vaccine Strain (LVS) (a total to 30 of 30 immunized mice survived the challenge while all control DNA vector immunized mice succumbed). Furthermore, and in accordance with these results, CD8 deficient mice could not be protected from lethal challenge after immunization with the CTL-polyepitope. Vaccination with the DNA poly-epitope construct could even protect mice (8/10) against the more demanding pulmonary lethal challenge of LVS. Our approach provides a proof-of-principle for selecting and generating a multi-epitpoe CD8 T cell-stimulating vaccine against a model intracellular bacterium.
MeSH term(s)	Animals ; Bacterial Vaccines/genetics ; Bacterial Vaccines/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Disease Models, Animal ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Female ; Francisella tularensis/genetics ; Francisella tularensis/immunology ; Immunologic Memory ; Lymphocyte Activation/immunology ; Mice ; Mice, Knockout ; Tularemia/immunology ; Tularemia/mortality ; Tularemia/prevention & control ; Vaccines, Attenuated/immunology
Chemical Substances	Bacterial Vaccines ; Epitopes, T-Lymphocyte ; Vaccines, Attenuated
Language	English
Publishing date	2014-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0085215
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Article ; Online: Variability and genetic structure of yellow passion fruit (Passiflora edulis f.flavicarpa Degener) in Colombia using microsatellite DNA markers = Variabilidad y estructura genética del maracuyá (Passiflora edulis f. flavicarpa Degener) en Colombia por medio de marcadores microsatélite

Ocampo Pérez, John A. / Acosta-Barón, Natali / Hernández Fernández, Javier

Agronomía Colombiana

2017

Abstract: Colombia is one of the leading producers of yellow passion fruit but the genetic studies based on molecular markers from commercial plantations have not been considered to select interesting market material. The goal of this study was to assess the ... ...

Abstract	Colombia is one of the leading producers of yellow passion fruit but the genetic studies based on molecular markers from commercial plantations have not been considered to select interesting market material. The goal of this study was to assess the genetic variability and the population structure of 51 Colombian commercial yellow passion fruit accessions (102 individuals), and to provide the necessary information for prospective selection and breeding programs. Thus, a total of six microsatellites were amplified with 58 alleles identified and an average of 9.66 alleles per locus, including nine private and 31 rare. Diversity indexes showed polymorphic information content values of 0.74 (PIC), an observed (Ho) and expected (He) heterozygosity average of 0.52 and 0.78, respectively. Spatial distribution showed the greatest allelic richness (11 to 14) in most of the Valle del Cauca accessions. The average genetic distance among accessions was 0.68, and the cluster analysis showed three main groups poorly supported (bootstrap <50%), with slight geographical structure and high differentiation between individuals of the same accession. Structure analysis indicated K=4 as the genetic structure´s uppermost hierarchical level, while Bayesian clustering showed a division of individuals into four genetically distinct groups. The low geographic structure and high variability of the accessions could be explained by allogamy and seed exchange frequency among farmers. Results issued suggest a complementary agromorphological assessment to establish total genetic variability and implement a breeding program through assisted selection of superior genotypes in search of more productive and resistant cultivars to phytosanitary problems.
Keywords	genetic variation ; variación genética ; passiflora ; tropical fruits ; frutas tropicales ; genetic markers ; marcadores genéticos
Language	English
Publishing date	2017-12-04T19:50:45Z
Publisher	Universidad Nacional de Colombia
Publishing country	fr
Document type	Article ; Online
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Article: A propos du remplissage vasculaire. Un entretien avec le Pr J.F. Baron.

Baron, J F

Presse medicale (Paris, France : 1983)

1999 Volume 28, Issue 17, Page(s) 928–930

Title translation	Apropos of vascular filling. Interview with Prof. J.F. Baron.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Blood Circulation ; Blood Pressure ; Blood Volume ; Female ; Humans ; Male ; Reference Values ; Shock/diagnosis ; Shock/etiology ; Shock/prevention & control
Language	French
Publishing date	1999-05
Publishing country	France
Document type	Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
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Article ; Online: Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)F]fluoro-D-glucose uptake during ventilator-induced and endotoxemic lung injury.

Saha, Dalia / Takahashi, Kazue / de Prost, Nicolas / Winkler, Tilo / Pinilla-Vera, Miguel / Baron, Rebecca M / Vidal Melo, Marcos F

Molecular imaging and biology

2012 Volume 15, Issue 1, Page(s) 19–27

Abstract: ... responsible for 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake in murine models of acute lung injury (ALI ...

Abstract	Purpose: The aim of the study was to use micro-autoradiography to investigate the lung cell types responsible for 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake in murine models of acute lung injury (ALI). Procedures: C57/BL6 mice were studied in three groups: controls, ventilator-induced lung injury (VILI), and endotoxin. VILI was produced by high tidal volumes and zero end-expiratory pressure and endotoxin ALI, by intranasal administration. Following FDG injection, the lungs were processed and exposed to autoradiographic emulsion. Grain density over cells was used to quantify FDG uptake. Results: Neutrophils, macrophages, and type 2 epithelial cells presented higher grain densities during VILI and endotoxin ALI than controls. Remarkably, cell grain density in specific cell types was dependent on the injury mechanism. Whereas macrophages showed high grain densities during endotoxin ALI, similar to those exhibited by neutrophils, type 2 epithelial cells demonstrated the second highest grain density (with neutrophils as the highest) during VILI. Conclusions: In murine models of VILI and endotoxin ALI, FDG uptake occurs not only in neutrophils but also in macrophages and type 2 epithelial cells. FDG uptake by individual cell types depends on the mechanism underlying ALI.
MeSH term(s)	Acute Lung Injury/metabolism ; Acute Lung Injury/pathology ; Analysis of Variance ; Animals ; Autoradiography/methods ; Endothelial Cells/chemistry ; Endothelial Cells/metabolism ; Endotoxemia/metabolism ; Endotoxemia/pathology ; Female ; Fluorodeoxyglucose F18/chemistry ; Fluorodeoxyglucose F18/pharmacokinetics ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy ; Molecular Imaging/methods ; Neutrophils/chemistry ; Neutrophils/metabolism ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Ventilator-Induced Lung Injury/metabolism ; Ventilator-Induced Lung Injury/pathology
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2012-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-012-0575-x
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Article ; Online: Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8+ T cell epitopes.

Shahar Rotem / Ofer Cohen / Erez Bar-Haim / Liat Bar-On / Sharon Ehrlich / Avigdor Shafferman

PLoS ONE, Vol 9, Iss 1, p e

2014 Volume 85215

Abstract: ... of the bacterial infection and provided complete protection against lethal challenge (10LD50) with F. tularensis holarctica ...

Abstract	Recently we described an unbiased bacterial whole-genome immunoinformatic analysis aimed at selection of potential CTL epitopes located in "hotspots" of predicted MHC-I binders. Applying this approach to the proteome of the facultative intra-cellular pathogen Francisella tularensis resulted in identification of 170 novel CTL epitopes, several of which were shown to elicit highly robust T cell responses. Here we demonstrate that by DNA immunization using a short DNA fragment expressing six of the most prominent identified CTL epitopes a potent and specific CD8+ T cell responses is being induced, to all encoded epitopes, a response not observed in control mice immunized with the DNA vector alone Moreover, this CTL-specific mediated immune response prevented disease development, allowed for a rapid clearance of the bacterial infection and provided complete protection against lethal challenge (10LD50) with F. tularensis holarctica Live Vaccine Strain (LVS) (a total to 30 of 30 immunized mice survived the challenge while all control DNA vector immunized mice succumbed). Furthermore, and in accordance with these results, CD8 deficient mice could not be protected from lethal challenge after immunization with the CTL-polyepitope. Vaccination with the DNA poly-epitope construct could even protect mice (8/10) against the more demanding pulmonary lethal challenge of LVS. Our approach provides a proof-of-principle for selecting and generating a multi-epitpoe CD8 T cell-stimulating vaccine against a model intracellular bacterium.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The comparability of English, French and Dutch scores on the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F)

Linda Kwakkenbos / Linda M Willems / Murray Baron / Marie Hudson / David Cella / Cornelia H M van den Ende / Brett D Thombs

PLoS ONE, Vol 9, Iss 3, p e

an assessment of differential item functioning in patients with systemic sclerosis.

2014 Volume 91979

Abstract: The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) is commonly used to assess ... of the English, French, and Dutch versions of the FACIT-F in systemic sclerosis (SSc) patients.The FACIT-F was ... of the FACIT-F can be reasonably treated as having equivalent scoring metrics. ...

Abstract	The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) is commonly used to assess fatigue in rheumatic diseases, and has shown to discriminate better across levels of the fatigue spectrum than other commonly used measures. The aim of this study was to assess the cross-language measurement equivalence of the English, French, and Dutch versions of the FACIT-F in systemic sclerosis (SSc) patients.The FACIT-F was completed by 871 English-speaking Canadian, 238 French-speaking Canadian and 230 Dutch SSc patients. Confirmatory factor analysis was used to assess the factor structure in the three samples. The Multiple-Indicator Multiple-Cause (MIMIC) model was utilized to assess differential item functioning (DIF), comparing English versus French and versus Dutch patient responses separately.A unidimensional factor model showed good fit in all samples. Comparing French versus English patients, statistically significant, but small-magnitude DIF was found for 3 of 13 items. French patients had 0.04 of a standard deviation (SD) lower latent fatigue scores than English patients and there was an increase of only 0.03 SD after accounting for DIF. For the Dutch versus English comparison, 4 items showed small, but statistically significant, DIF. Dutch patients had 0.20 SD lower latent fatigue scores than English patients. After correcting for DIF, there was a reduction of 0.16 SD in this difference.There was statistically significant DIF in several items, but the overall effect on fatigue scores was minimal. English, French and Dutch versions of the FACIT-F can be reasonably treated as having equivalent scoring metrics.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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