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  1. Article ; Online: The role of primary cilia in obesity and diabetes.

    Volta, Francesco / Gerdes, Jantje M

    Annals of the New York Academy of Sciences

    2017  Volume 1391, Issue 1, Page(s) 71–84

    Abstract: One in 12 people worldwide suffers from diabetes and more than 90% of affected adult individuals are diagnosed with type 2 diabetes mellitus (T2DM). Obesity adds to the personal risk to develop T2DM, and both metabolic diseases are rampantly increasing ... ...

    Abstract One in 12 people worldwide suffers from diabetes and more than 90% of affected adult individuals are diagnosed with type 2 diabetes mellitus (T2DM). Obesity adds to the personal risk to develop T2DM, and both metabolic diseases are rampantly increasing worldwide. Over recent years, primary cilia have moved into the focus of basic and clinical research, after several human diseases have been identified as ciliopathies (i.e., they are linked to ciliary dysfunction). A subset of ciliopathies presents with obesity and diabetes, either as core symptoms or major complications. Several studies have shown a role for ciliary signaling in the satiety signaling centers of the hypothalamus and in other metabolically active tissues, such as pancreatic islets. Here, we discuss recent advances and perspectives in ciliary metabolic research.
    MeSH term(s) Animals ; Cilia/metabolism ; Cilia/pathology ; Ciliopathies/metabolism ; Ciliopathies/physiopathology ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Disease Models, Animal ; Humans ; Hypothalamus/metabolism ; Hypothalamus/physiology ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Obesity/metabolism ; Obesity/physiopathology
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.13216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Metabolic regulation through the endosomal system.

    Gilleron, Jerome / Gerdes, Jantje M / Zeigerer, Anja

    Traffic (Copenhagen, Denmark)

    2019  Volume 20, Issue 8, Page(s) 552–570

    Abstract: The endosomal system plays an essential role in cell homeostasis by controlling cellular signaling, nutrient sensing, cell polarity and cell migration. However, its place in the regulation of tissue, organ and whole body physiology is less well ... ...

    Abstract The endosomal system plays an essential role in cell homeostasis by controlling cellular signaling, nutrient sensing, cell polarity and cell migration. However, its place in the regulation of tissue, organ and whole body physiology is less well understood. Recent studies have revealed an important role for the endosomal system in regulating glucose and lipid homeostasis, with implications for metabolic disorders such as type 2 diabetes, hypercholesterolemia and non-alcoholic fatty liver disease. By taking insights from in vitro studies of endocytosis and exploring their effects on metabolism, we can begin to connect the fields of endosomal transport and metabolic homeostasis. In this review, we explore current understanding of how the endosomal system influences the systemic regulation of glucose and lipid metabolism in mice and humans. We highlight exciting new insights that help translate findings from single cells to a wider physiological level and open up new directions for endosomal research.
    MeSH term(s) Animals ; Endosomes/metabolism ; Glucose/metabolism ; Homeostasis ; Humans ; Lipid Metabolism ; Signal Transduction
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1483852-7
    ISSN 1600-0854 ; 1398-9219
    ISSN (online) 1600-0854
    ISSN 1398-9219
    DOI 10.1111/tra.12670
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Author Correction: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.

    Volta, Francesco / Scerbo, M Julia / Seelig, Anett / Wagner, Robert / O'Brien, Nils / Gerst, Felicia / Fritsche, Andreas / Häring, Hans-Ulrich / Zeigerer, Anja / Ullrich, Susanne / Gerdes, Jantje M

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4796

    Language English
    Publishing date 2021-08-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24865-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction

    Francesco Volta / M. Julia Scerbo / Anett Seelig / Robert Wagner / Nils O’Brien / Felicia Gerst / Andreas Fritsche / Hans-Ulrich Häring / Anja Zeigerer / Susanne Ullrich / Jantje M. Gerdes

    Nature Communications, Vol 12, Iss 1, Pp 1-

    Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

    2021  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Interplay between the Endocrine System and Immune Cells.

    Carvalho, Livia A / Gerdes, Jantje M / Strell, Carina / Wallace, Graham R / Martins, Joilson O

    BioMed research international

    2015  Volume 2015, Page(s) 986742

    MeSH term(s) Animals ; Endocrine System/immunology ; Endocrine System/metabolism ; Humans ; Immune System/immunology ; Immune System/metabolism
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2015/986742
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  6. Article ; Online: Interplay between the Endocrine System and Immune Cells

    Livia A. Carvalho / Jantje M. Gerdes / Carina Strell / Graham R. Wallace / Joilson O. Martins

    BioMed Research International, Vol

    2015  Volume 2015

    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

    Konxhe Kulaj / Alexandra Harger / Michaela Bauer / Özüm S. Caliskan / Tilak Kumar Gupta / Dapi Menglin Chiang / Edward Milbank / Josefine Reber / Angelos Karlas / Petra Kotzbeck / David N. Sailer / Francesco Volta / Dominik Lutter / Sneha Prakash / Juliane Merl-Pham / Vasilis Ntziachristos / Hans Hauner / Michael W. Pfaffl / Matthias H. Tschöp /
    Timo D. Müller / Stefanie M. Hauck / Benjamin D. Engel / Jantje M. Gerdes / Paul T. Pfluger / Natalie Krahmer / Kerstin Stemmer

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 13

    Abstract: Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of ...

    Abstract Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of insulinotropic proteins from adipose tissue to β-cells.
    Keywords Science ; Q
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo.

    Kulaj, Konxhe / Harger, Alexandra / Bauer, Michaela / Caliskan, Özüm S / Gupta, Tilak Kumar / Chiang, Dapi Menglin / Milbank, Edward / Reber, Josefine / Karlas, Angelos / Kotzbeck, Petra / Sailer, David N / Volta, Francesco / Lutter, Dominik / Prakash, Sneha / Merl-Pham, Juliane / Ntziachristos, Vasilis / Hauner, Hans / Pfaffl, Michael W / Tschöp, Matthias H /
    Müller, Timo D / Hauck, Stefanie M / Engel, Benjamin D / Gerdes, Jantje M / Pfluger, Paul T / Krahmer, Natalie / Stemmer, Kerstin

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 709

    Abstract: Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and ... ...

    Abstract Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling with (phospho)proteomics, and revealed that AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented insulinotropic GPCR/cAMP/PKA signaling by increasing total protein abundances and phosphosite dynamics, and ultimately enhanced 1st-phase glucose-stimulated insulin secretion (GSIS) in murine islets. Notably, insulinotropic effects were restricted to AdEVs isolated from obese and insulin resistant, but not lean mice, which was consistent with differential protein loads and AdEV luminal morphologies. Likewise, in vivo pre-treatment with AdEVs from obese but not lean mice amplified insulin secretion and glucose tolerance in mice. This data suggests that secreted AdEVs can inform pancreatic β-cells about insulin resistance in adipose tissue in order to amplify GSIS in times of increased insulin demand.
    MeSH term(s) Mice ; Animals ; Insulin Secretion ; Insulin/metabolism ; Glucose/metabolism ; Insulin-Secreting Cells/metabolism ; Obesity/metabolism ; Adipocytes/metabolism ; Extracellular Vesicles/metabolism ; Islets of Langerhans/metabolism
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36148-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.

    Xiong, Yan / Scerbo, M Julia / Seelig, Anett / Volta, Francesco / O'Brien, Nils / Dicker, Andrea / Padula, Daniela / Lickert, Heiko / Gerdes, Jantje Mareike / Berggren, Per-Olof

    eLife

    2020  Volume 9

    Abstract: Islet vascularization is essential for intact islet function and glucose homeostasis. We have previously shown that primary cilia directly regulate insulin secretion. However, it remains unclear whether they are also implicated in islet vascularization. ... ...

    Abstract Islet vascularization is essential for intact islet function and glucose homeostasis. We have previously shown that primary cilia directly regulate insulin secretion. However, it remains unclear whether they are also implicated in islet vascularization. At eight weeks, murine
    MeSH term(s) Animals ; Cell Line ; Endothelial Cells/physiology ; Female ; Glucose/metabolism ; HEK293 Cells ; Humans ; Islets of Langerhans/blood supply ; Islets of Langerhans/growth & development ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2/genetics ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Chemical Substances BBS4 protein, mouse ; Microtubule-Associated Proteins ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.56914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ciliary function and Wnt signal modulation.

    Gerdes, Jantje M / Katsanis, Nicholas

    Current topics in developmental biology

    2008  Volume 85, Page(s) 175–195

    Abstract: With the increase in complexity of morphogenetic signaling cascades over the course of evolution and the emergence of broadly ciliated organisms, the cilium seems to have acquired a role as regulator of paracrine signal transduction. Recently, several ... ...

    Abstract With the increase in complexity of morphogenetic signaling cascades over the course of evolution and the emergence of broadly ciliated organisms, the cilium seems to have acquired a role as regulator of paracrine signal transduction. Recently, several lines of evidence have provided a link between basal body and ciliary proteins and Wnt signaling. In this chapter, we will evaluate the evidence linking the basal body and cilium with the regulation of beta-catenin-dependent (canonical) and beta-catenin-independent (noncanonical) signaling processes as well as which role(s) Wnt signaling might play in ciliogenesis. In addition, we will discuss aberrant Wnt signaling could contribute to phenotypes common to most ciliopathies and why these phenotypes might be driven by loss of noncanonical rather than gain of noncanonical Wnt signaling.
    MeSH term(s) Animals ; Cilia/physiology ; Signal Transduction ; Wnt Proteins/metabolism
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/S0070-2153(08)00807-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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