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Book: Vitamin D

Gombart, Adrian F.

oxidative stress, immunity, and aging

(Oxidative stress and disease series ; 31)

2012

Author's details	ed. by Adrian F. Gombart
Series title	Oxidative stress and disease series ; 31 Oxidative stress and disease
Collection	Oxidative stress and disease
Keywords	Vitamin D in human nutrition ; Vitamin D deficiency ; Vitamin-D-Mangel ; Ernährung ; Vitaminbedarf
Subject	Vitamin ; Nutrition ; Ernährungsstatus ; Ernährungszustand ; Vitamin D
Subject code	615.328
Language	English
Size	XVII, 440 S., [2] Bl. : Ill., graph. Darst., 26 cm
Publisher	CRC Press
Publishing place	Boca Raton u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT017480447
ISBN	978-1-4398-5020-6 ; 1-4398-5020-8 ; 978-1-1381-9944-6 ; 1-1381-9944-3
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2012 A 6039	order for loan	Magazin

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Article ; Online: Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic.

Carr, Anitra C / Gombart, Adrian F

Nutrients

2022 Volume 14, Issue 3

Abstract: Vitamins C and D have well-known immune supportive roles, with deficiencies in both vitamins predisposing to increased risk and severity of respiratory infections. Numerous studies have indicated that administration of these vitamins, particularly to ... ...

Abstract	Vitamins C and D have well-known immune supportive roles, with deficiencies in both vitamins predisposing to increased risk and severity of respiratory infections. Numerous studies have indicated that administration of these vitamins, particularly to people who are deficient, can decrease the risk and severity of respiratory infections. This has stimulated an interest in the potential efficacy of these vitamins in people with novel coronavirus (SARS-CoV-2) infection and its more severe disease (COVID-19). In this overview, we highlight the current research evidence around the multiple levels of immune support provided by vitamins C and D in the context of general respiratory infections and with a focus on the current SARS-CoV-2 pandemic. These include: prevention of infection; attenuating infection symptoms and severity; adjunctive therapy for severe disease; attenuating ongoing sequelae (long COVID); and immunisation support. Although some of these topics have not yet been investigated in great depth concerning SARS-CoV-2 and COVID-19, extensive research into the role of these vitamins in general respiratory infections has highlighted directions for future research in the current pandemic.
MeSH term(s)	Ascorbic Acid/therapeutic use ; COVID-19/complications ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2022-02-06
Publishing country	Switzerland
Document type	Editorial ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14030689
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease.

Gombart, Adrian F / Michels, Alexander J / Eggersdorfer, Manfred

Aging cell

2022 Volume 22, Issue 1, Page(s) e13758

MeSH term(s)	Humans ; Alzheimer Disease ; Vitamin D ; Dietary Supplements ; Disease Progression
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.13758
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6581: Show issues

Location:
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The end of the line for neutrophils.

Gombart, Adrian F

Blood

2015 Volume 125, Issue 11, Page(s) 1688–1690

MeSH term(s)	Animals ; CCAAT-Enhancer-Binding Proteins/metabolism ; Humans ; Neutrophils/cytology ; Neutrophils/metabolism
Chemical Substances	CCAAT-Enhancer-Binding Proteins ; CEBPE protein, human (142805-41-2)
Language	English
Publishing date	2015-03-11
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2015-01-622209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Article: Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic

Carr, Anitra C. / Gombart, Adrian F.

Nutrients. 2022 Feb. 06, v. 14, no. 3

2022

Abstract	Vitamins C and D have well-known immune supportive roles, with deficiencies in both vitamins predisposing to increased risk and severity of respiratory infections. Numerous studies have indicated that administration of these vitamins, particularly to people who are deficient, can decrease the risk and severity of respiratory infections. This has stimulated an interest in the potential efficacy of these vitamins in people with novel coronavirus (SARS-CoV-2) infection and its more severe disease (COVID-19). In this overview, we highlight the current research evidence around the multiple levels of immune support provided by vitamins C and D in the context of general respiratory infections and with a focus on the current SARS-CoV-2 pandemic. These include: prevention of infection; attenuating infection symptoms and severity; adjunctive therapy for severe disease; attenuating ongoing sequelae (long COVID); and immunisation support. Although some of these topics have not yet been investigated in great depth concerning SARS-CoV-2 and COVID-19, extensive research into the role of these vitamins in general respiratory infections has highlighted directions for future research in the current pandemic.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; complications (disease) ; disease severity ; immunization ; pandemic ; people ; risk
Language	English
Dates of publication	2022-0206
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14030689
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.

Gombart, Adrian F / Pierre, Adeline / Maggini, Silvia

Nutrients

2020 Volume 12, Issue 1

Abstract: Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including ... ...

Abstract	Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response. Adequate amounts are essential to ensure the proper function of physical barriers and immune cells; however, daily micronutrient intakes necessary to support immune function may be higher than current recommended dietary allowances. Certain populations have inadequate dietary micronutrient intakes, and situations with increased requirements (e.g., infection, stress, and pollution) further decrease stores within the body. Several micronutrients may be deficient, and even marginal deficiency may impair immunity. Although contradictory data exist, available evidence indicates that supplementation with multiple micronutrients with immune-supporting roles may modulate immune function and reduce the risk of infection. Micronutrients with the strongest evidence for immune support are vitamins C and D and zinc. Better design of human clinical studies addressing dosage and combinations of micronutrients in different populations are required to substantiate the benefits of micronutrient supplementation against infection.
MeSH term(s)	Animals ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Communicable Diseases/therapy ; Humans ; Immune System/immunology ; Immune System/metabolism ; Infection Control/methods ; Micronutrients/administration & dosage ; Micronutrients/metabolism ; Nutritional Status ; Protective Factors ; Recommended Dietary Allowances ; Risk Factors
Chemical Substances	Micronutrients
Language	English
Publishing date	2020-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12010236
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

Gombart, Adrian F / Pierre, Adeline / Maggini, Silvia

Nutrients. 2020 Jan. 16, v. 12, no. 1

2020

Abstract	Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response. Adequate amounts are essential to ensure the proper function of physical barriers and immune cells; however, daily micronutrient intakes necessary to support immune function may be higher than current recommended dietary allowances. Certain populations have inadequate dietary micronutrient intakes, and situations with increased requirements (e.g., infection, stress, and pollution) further decrease stores within the body. Several micronutrients may be deficient, and even marginal deficiency may impair immunity. Although contradictory data exist, available evidence indicates that supplementation with multiple micronutrients with immune-supporting roles may modulate immune function and reduce the risk of infection. Micronutrients with the strongest evidence for immune support are vitamins C and D and zinc. Better design of human clinical studies addressing dosage and combinations of micronutrients in different populations are required to substantiate the benefits of micronutrient supplementation against infection.
Keywords	Recommended Dietary Allowances ; ascorbic acid ; ascorbic acid deficiency ; cells ; clinical trials ; copper ; design ; dosage ; folic acid ; humans ; immune response ; immune system ; infection ; iron ; nutrients ; pollution ; population ; risk reduction ; scurvy ; selenium ; vitamin A ; zinc
Language	English
Dates of publication	2020-0116
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12010236
Database	NAL-Catalogue (AGRICOLA)

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Article: Micronutrients to Support Vaccine Immunogenicity and Efficacy.

Calder, Philip C / Berger, Mette M / Gombart, Adrian F / McComsey, Grace A / Martineau, Adrian R / Eggersdorfer, Manfred

Vaccines

2022 Volume 10, Issue 4

Abstract: The world has entered the third year of the coronavirus disease 2019 (COVID-19) pandemic. Vaccination is the primary public health strategy to protect against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in addition to ... ...

Abstract	The world has entered the third year of the coronavirus disease 2019 (COVID-19) pandemic. Vaccination is the primary public health strategy to protect against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in addition to other measures, such as mask wearing and social distancing. Vaccination has reduced COVID-19 severity and mortality dramatically. Nevertheless, incidence globally remains high, and certain populations are still at risk for severe outcomes. Additional strategies to support immunity, including potentially enhancing the response to vaccination, are needed. Many vitamins and trace minerals have recognized immunomodulatory actions, and their status and/or supplementation have been reported to correspond to the incidence and severity of infection. Furthermore, a variety of observational and some interventional studies report that adequate micronutrient status or micronutrient supplementation is associated with enhanced vaccine responses, including to COVID-19 vaccination. Such data suggest that micronutrient supplementation may hold the potential to improve vaccine immunogenicity and effectiveness, although additional interventional studies to further strengthen the existing evidence are needed. Positive findings from such research could have important implications for global public health, since deficiencies in several micronutrients that support immune function are prevalent in numerous settings, and supplementation can be implemented safely and inexpensively.
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10040568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply to "Comment on: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.

Calder, Philip C / Carr, Anitra C / Gombart, Adrian F / Eggersdorfer, Manfred

Nutrients

2020 Volume 12, Issue 8

Abstract: We thank Tsoupras and Zabetakis for their interest in our recent publication [ ... ]. ...

Abstract	We thank Tsoupras and Zabetakis for their interest in our recent publication [...].
MeSH term(s)	Animals ; Fatty Acids ; Heart Diseases ; Humans ; Immune System ; Immunity ; Nutrients/pharmacology ; Nutritional Status ; Protective Agents/pharmacology ; Virus Diseases/prevention & control
Chemical Substances	Fatty Acids ; Protective Agents
Language	English
Publishing date	2020-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12082326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply to "Overstated Claims of Efficacy and Safety. Comment On: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.

Calder, Philip C / Carr, Anitra C / Gombart, Adrian F / Eggersdorfer, Manfred

Nutrients

2020 Volume 12, Issue 9

Abstract: We thank Vorland et al [ ... ]. ...

Abstract	We thank Vorland et al [...].
MeSH term(s)	Humans ; Immune System ; Nutrients ; Nutritional Status ; Protective Agents ; Virus Diseases/prevention & control
Chemical Substances	Protective Agents
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12092696
Database	MEDical Literature Analysis and Retrieval System OnLINE

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