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  1. Article ; Online: Letter to the Editor concerning "ProDisc-C versus anterior cervical discectomy and fusion for the surgical treatment of symptomatic cervical disc disease: two-year outcomes of Asian prospective randomized controlled multicentre study" by N. Kumar, et al. (Eur Spine J [2022]: doi: 10.1007/s00586-021-07055-0).

    Gadjradj, Pravesh S / Sommer, Fabian

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2022  Volume 31, Issue 9, Page(s) 2448–2449

    MeSH term(s) Diskectomy ; Humans ; Intervertebral Disc Degeneration/surgery ; Intervertebral Disc Displacement/surgery ; Prospective Studies ; Spinal Fusion
    Language English
    Publishing date 2022-05-30
    Publishing country Germany
    Document type Letter ; Multicenter Study ; Comment
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-022-07265-0
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  2. Article ; Online: Schalock, R. L., Verdugo, M. Á., Lee, C. S., Lee, T., van Loon, J., Swart, K. y Claes, C. (2015). Manual de la Escala de Eficacia y Eficiencia Organizacional (OEES). Un enfoque sistemático para mejorar los resultados organizacionales.

    Fabián SAINZ MODINOS

    Siglo Cero, Vol 46, Iss 2, Pp 101-

    2015  Volume 102

    Keywords Psychology ; BF1-990 ; Vocational rehabilitation. Employment of people with disabilities ; HD7255-7256 ; Social sciences (General) ; H1-99
    Language Spanish
    Publishing date 2015-12-01T00:00:00Z
    Publisher Universidad de Salamanca
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: A Musicology of Performance : Theory and Method Based on Bach's Solos for Violin

    Fabian, Dorottya

    2015  

    Keywords Theory of music & musicology ; Classical music (c 1750 to c 1830) ; Individual composers & musicians, specific bands & groups ; j. s. bach ; perception ; baroque performance practice ; violin ; musical performance ; Dynamics (music) ; Johann Sebastian Bach ; Tempo ; Vibrato
    Size 1 electronic resource (354 pages)
    Publisher Open Book Publishers
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232045
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Electronic structure of rhombus-shaped nanographenes: system size evolution from closed- to open-shell ground states.

    Sandoval-Salinas, M E / Bernabeu-Cabañero, R / Pérez-Jiménez, A J / San-Fabián, E / Sancho-García, J C

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 16, Page(s) 11697–11706

    Abstract: We theoretically study and characterize a set of rhombus-shaped nanographenes of increasing size, ... ...

    Abstract We theoretically study and characterize a set of rhombus-shaped nanographenes of increasing size, or
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp01103h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; E-Book: Ärztliches Leben und Denken im arabischen Mittelalter

    Bürgel, Johann Christoph / Käs, Fabian

    (Islamic history and civilization ; volume 135)

    2016  

    Author's details von Johann Christoph Burgel ; bearbeitet von Fabian Käs
    Series title Islamic history and civilization ; volume 135
    Collection
    Language German
    Size 1 Online-Ressource (XXXVI, 534 Seiten), Illustrationen
    Publisher Brill
    Publishing place Leiden ; Boston
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019441924
    ISBN 978-90-04-32616-3 ; 9789004326101 ; 90-04-32616-2 ; 9004326103
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: A therapeutic antibody targeting annexin-A1 inhibits cancer cell growth in vitro and in vivo.

    Al-Ali, Hussein N / Crichton, Scott J / Fabian, Charlene / Pepper, Chris / Butcher, David R / Dempsey, Fiona C / Parris, Christopher N

    Oncogene

    2024  Volume 43, Issue 8, Page(s) 608–614

    Abstract: In this study we conducted the first investigation to assess the efficacy of a novel therapeutic antibody developed to target annexin-A1 (ANXA1). ANXA1 is an immunomodulatory protein which has been shown to be overexpressed in, and promote the ... ...

    Abstract In this study we conducted the first investigation to assess the efficacy of a novel therapeutic antibody developed to target annexin-A1 (ANXA1). ANXA1 is an immunomodulatory protein which has been shown to be overexpressed in, and promote the development and progression of, several cancer types. In particular, high ANXA1 expression levels correlate with poorer overall survival in pancreatic and triple-negative breast cancers, two cancers with considerable unmet clinical need. MDX-124 is a humanised IgG1 monoclonal antibody which specifically binds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2). Here we show that MDX-124 significantly reduced proliferation (p < 0.013) in a dose-dependent manner across a panel of human cancer cell lines expressing ANXA1. The anti-proliferative effect of MDX-124 is instigated by arresting cell cycle progression with cancer cells accumulating in the G
    MeSH term(s) Animals ; Humans ; Mice ; Annexin A1/antagonists & inhibitors ; Annexin A1/metabolism ; Cell Line ; Neoplasms
    Chemical Substances Annexin A1
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-023-02919-9
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  7. Article ; Online: Crisis neonatales y evolución a epilepsia en un hospital de tercer nivel.

    Hernández-Prieto, A / Garrido-Martín, M / Gómez-Martín, H / Pablos-López, A / Alonso-Díez, C / Hernández-Fabián, A / Justel-Rodríguez, M / Garrido-Pedraz, J M / Prieto-Matos, P

    Revista de neurologia

    2024  Volume 77, Issue 10, Page(s) 249–252

    Abstract: Introduction: Given the immaturity of the newborn, neonatal seizures are a diagnostic challenge. Most of them are secondary to an acute event. A small percentage constitute the onset of epilepsy.: Aims: The aim was to analyse neonates with a ... ...

    Title translation Neonatal seizures and progression to epilepsy in a tertiary hospital.
    Abstract Introduction: Given the immaturity of the newborn, neonatal seizures are a diagnostic challenge. Most of them are secondary to an acute event. A small percentage constitute the onset of epilepsy.
    Aims: The aim was to analyse neonates with a diagnosis of seizures admitted to a tertiary hospital between November 2009 and May 2021, and their subsequent progression to epilepsy.
    Material and methods: A retrospective observational study was carried out using the hospital database. Information was collected on neonates with a discharge diagnosis of 'seizures' or 'moderate or severe hypoxic-ischaemic encephalopathy'. Different variables were analysed: aetiology of the seizures, type, persistence over time, treatment and electroclinical correlates.
    Results: Of 165 patients, 55 presented neonatal seizures. As regards aetiology, 43 patients (78%) had seizures secondary to an acute event, of which 19 (34%) were hypoxic-ischaemic encephalopathies, and 22 (40%) had other acute disorders. Genetic alteration was found in six of them (11%). Thirteen patients (24%) progressed to subsequent epilepsy, of whom seven had symptomatic epilepsy, with a period of latency after the acute event in two patients. Six patients had neonatal epilepsy with unprovoked seizures. Twenty-two (62%) showed electroclinical correlates. All of the confirmed crises (100%) were focal. All the seizures were treated. The drug of choice was phenobarbital.
    Conclusions: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.
    MeSH term(s) Infant, Newborn ; Humans ; Tertiary Care Centers ; Epilepsy/etiology ; Seizures/etiology ; Affect ; Hospitalization ; Hypoxia-Ischemia, Brain/complications
    Language Spanish
    Publishing date 2024-01-01
    Publishing country Spain
    Document type Observational Study ; English Abstract ; Journal Article
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7710.2023218
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  8. Article ; Online: Patient perceptions of surgical training in the private sector in South Africa - a single centre survey.

    Lutrin, D / Etheredge, H / Fabian, J / Bouter, C / Tager, S

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2022  Volume 60, Issue 1, Page(s) 34–39

    Abstract: Background: As the worldwide demand for specialist surgeons increases, and to complement surgical training provided through governmental institutions, private hospitals are increasingly hosting trainees. Wits Donald Gordon Medical Centre (WDGMC) is a ... ...

    Abstract Background: As the worldwide demand for specialist surgeons increases, and to complement surgical training provided through governmental institutions, private hospitals are increasingly hosting trainees. Wits Donald Gordon Medical Centre (WDGMC) is a private academic hospital in Johannesburg with a Colorectal Unit (CRU) that hosts several trainees. While published studies demonstrate that the involvement of trainees in surgery does not adversely impact outcomes, private patients' perceptions of the role of trainees in their care have not been as widely researched.
    Methods: This was a prospective, cross-sectional study using a self-administered questionnaire hosted on a REDCap database. Statistical analysis was performed using SPSS version 26.
    Results: One hundred and seventy-four patients participated in the study, and 74.1% of respondents felt that training of doctors should occur in private hospitals in South Africa. Of the sample, 83.3% would allow a supervised trainee to perform a part of their operation, provided they had been made aware of trainee participation in advance (78%). Sixty per cent of patients felt that interaction with a trainee enhanced their care, and 52.3% of patients suggested that seeing more than one doctor a day improved their experience.
    Conclusion: Our results suggest that privately funded patients support the surgical training of medical doctors in private academic training hospitals, and they are willing to be participants in the training process. Moreover, training programmes in this setting appear to enhance the patient experience. We are optimistic that these findings could be used to advocate for expanded training opportunities across the private sector in South Africa.
    MeSH term(s) Cross-Sectional Studies ; Humans ; Private Sector ; Prospective Studies ; South Africa ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-21
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
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    Zs.B 593: Show issues Location:
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  9. Article ; Online: Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy.

    Fabian, Lacramioara / Karimi, Esmat / Farman, Gerrie P / Gohlke, Jochen / Ottenheijm, Coen A C / Granzier, Hendrikus L / Dowling, James J

    Human molecular genetics

    2024  

    Abstract: Nemaline myopathy (NM) is a rare congenital neuromuscular disorder characterized by muscle weakness and hypotonia, slow gross motor development, and decreased respiratory function. Mutations in at least twelve genes, all of each encode proteins that are ... ...

    Abstract Nemaline myopathy (NM) is a rare congenital neuromuscular disorder characterized by muscle weakness and hypotonia, slow gross motor development, and decreased respiratory function. Mutations in at least twelve genes, all of each encode proteins that are either components of the muscle thin filament or regulate its length and stability, have been associated with NM. Mutations in Nebulin (NEB), a giant filamentous protein localized in the sarcomere, account for more than 50% of NM cases. At present, there remains a lack of understanding of whether NEB genotype influences nebulin function and NM-patient phenotypes. In addition, there is a lack of therapeutically tractable models that can enable drug discovery and address the current unmet treatment needs of patients. To begin to address these gaps, here we have characterized five new zebrafish models of NEB-related NM. These mutants recapitulate most aspects of NEB-based NM, showing drastically reduced survival, defective muscle structure, reduced contraction force, shorter thin filaments, presence of electron-dense structures in myofibers, and thickening of the Z-disks. This study represents the first extensive investigation of an allelic series of nebulin mutants, and thus provides an initial examination in pre-clinical models of potential genotype-phenotype correlations in human NEB patients. It also represents the first utilization of a set of comprehensive outcome measures in zebrafish, including correlation between molecular analyses, structural and biophysical investigations, and phenotypic outcomes. Therefore, it provides a rich source of data for future studies exploring the NM pathomechanisms, and an ideal springboard for therapy identification and development for NEB-related NM.
    Language English
    Publishing date 2024-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddae033
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  10. Article ; Online: Approaching psychology's current crises by exploring the vagueness of psychological concepts: Recommendations for advancing the discipline.

    Hutmacher, Fabian / Franz, David J

    The American psychologist

    2024  

    Abstract: ... PsycInfo Database Record (c) 2024 APA, all rights reserved). ...

    Abstract Psychology is currently facing a multilayered crisis stemming from the fact that the results of many psychological studies cannot be replicated (replication crisis), that psychological research has neglected cross-cultural and cross-temporal variation (universality crisis), and that many psychological theories are ill-developed and underspecified (theory crisis). In the present article, we use ideas derived from debates in theoretical and philosophical psychology as a basis for responding to all three crises. In short, we claim that psychological concepts are inherently vague in the sense that their meanings and the rules for their application are indeterminate. This does not imply that psychological concepts are ineffable or lack meaning. It implies, however, that hoping to arrive at a finite set of necessary and sufficient criteria that define psychological concepts once and for all is an illusion. From this, we deduce four recommendations for responding to psychology's crises. First, we argue that the replication crisis could be approached by paying more attention to the context conditions under which psychological realities and knowledge about these realities are being created. Second, we claim that the universality crisis can be alleviated by putting more effort into exploring variability across times and cultures. Third, we contend that acknowledging the language dependence of psychological research could be a fruitful way of addressing the theory crisis. Last, we show that embracing theoretical and methodological pluralism would be an antidote against psychology's crises in general. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209464-2
    ISSN 1935-990X ; 0003-066X
    ISSN (online) 1935-990X
    ISSN 0003-066X
    DOI 10.1037/amp0001300
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