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  1. Book ; Conference proceedings: Dynamic coordination in the brain

    Malsburg, Christoph von der / Phillips, William A. / Singer, Wolf

    from neurons to mind

    (Strüngmann Forum reports)

    2010  

    Event/congress Ernst-Strüngmann-Forum (20095, FrankfurtMain)
    Author's details ed. by Christoph von der Malsburg ; William A. Philips and Wolf Singer. [Fifth Ernst Strüngmann Forum held Aug. 16 - 21, 2009, Frankfurt am Main]
    Series title Strüngmann Forum reports
    Keywords Brain / physiology ; Brain / physiopathology ; Neurons / physiology ; Neural Pathways / physiology ; Psychophysiology ; Cognition / physiology
    Language English
    Size XIV, 352 S. : Ill., graph. Darst., 23 cm
    Publisher MIT Press
    Publishing place Cambridge, Mass. u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    Note Includes bibliographical references and index
    HBZ-ID HT016478338
    ISBN 978-0-262-01471-7 ; 0-262-01471-8
    Database Catalogue ZB MED Medicine, Health

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    2010 A 5024 order for loan Magazin

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  2. Article ; Online: Toward understanding the neural code of the brain.

    von der Malsburg, Christoph

    Biological cybernetics

    2021  Volume 115, Issue 5, Page(s) 439–449

    Abstract: ... invitation to comment on two of my papers, (von der Malsburg 1973) and (von der Malsburg and Schneider 1986 ...

    Abstract More and more, the neurosciences and the sciences concerned with mind and cognition are burying fundamental questions under layers of professional methodology. I therefore welcome Biological Cybernetics' invitation to comment on two of my papers, (von der Malsburg 1973) and (von der Malsburg and Schneider 1986) (henceforth referred to as (I) and (II)) as an opportunity to address two fundamental questions about brain and mind: How is the brain's structure generated? and How is mental content expressed by the brain's physical states? Those two questions are deeply entangled with each other and play a kind of gateway role on the way to making progress with the issues of perception, intelligence, creativity and consciousness.
    MeSH term(s) Brain ; Cognition ; Consciousness ; Creativity ; Neurosciences
    Language English
    Publishing date 2021-10-18
    Publishing country Germany
    Document type Editorial
    ZDB-ID 220699-7
    ISSN 1432-0770 ; 0340-1200
    ISSN (online) 1432-0770
    ISSN 0340-1200
    DOI 10.1007/s00422-021-00903-8
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  3. Article ; Online: Cognitive performance is linked to fitness in a wild primate.

    Fichtel, Claudia / Henke-von der Malsburg, Johanna / Kappeler, Peter M

    Science advances

    2023  Volume 9, Issue 28, Page(s) eadf9365

    Abstract: Cognitive performance varies widely across animal species, but the processes underlying cognitive evolution remain poorly known. For cognitive abilities to evolve, performance must be linked to individual fitness benefits, but these links have been ... ...

    Abstract Cognitive performance varies widely across animal species, but the processes underlying cognitive evolution remain poorly known. For cognitive abilities to evolve, performance must be linked to individual fitness benefits, but these links have been rarely studied in primates even though they exceed most other mammals in these traits. We subjected 198 wild gray mouse lemurs to four cognitive and two personality tests and subsequently monitored their survival in a mark-recapture study. Our study revealed that survival was predicted by individual variation in cognitive performance as well as body mass and exploration. Because cognitive performance covaried negatively with exploration, individuals gathering more accurate information enjoyed better cognitive performance and lived longer, but so did heavier and more explorative individuals. These effects may reflect a speed-accuracy trade-off, with alternative strategies yielding similar overall fitness. The observed intraspecific variation in selective benefits of cognitive performance, if heritable, can provide the basis for the evolution of cognitive abilities in members of our lineage.
    MeSH term(s) Animals ; Primates ; Cognition ; Happiness ; Phenotype ; Mammals
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf9365
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  4. Article ; Online: Linking cognition to ecology in wild sympatric mouse lemur species.

    Henke-von der Malsburg, Johanna / Kappeler, Peter M / Fichtel, Claudia

    Proceedings. Biological sciences

    2021  Volume 288, Issue 1963, Page(s) 20211728

    Abstract: Cognitive abilities covary with both social and ecological factors across animal taxa. Ecological generalists have been attributed with enhanced cognitive abilities, but which specific ecological factors may have shaped the evolution of which specific ... ...

    Abstract Cognitive abilities covary with both social and ecological factors across animal taxa. Ecological generalists have been attributed with enhanced cognitive abilities, but which specific ecological factors may have shaped the evolution of which specific cognitive abilities remains poorly known. To explore these links, we applied a cognitive test battery (two personality, ten cognitive tests;
    MeSH term(s) Animals ; Cheirogaleidae ; Cognition ; Diet ; Ecosystem ; Lemur ; Spatial Learning
    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2021.1728
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  5. Book ; Online: A Theory of Natural Intelligence

    von der Malsburg, Christoph / Stadelmann, Thilo / Grewe, Benjamin F.

    2022  

    Abstract: Introduction: In contrast to current AI technology, natural intelligence -- the kind of autonomous intelligence that is realized in the brains of animals and humans to attain in their natural environment goals defined by a repertoire of innate behavioral ...

    Abstract Introduction: In contrast to current AI technology, natural intelligence -- the kind of autonomous intelligence that is realized in the brains of animals and humans to attain in their natural environment goals defined by a repertoire of innate behavioral schemata -- is far superior in terms of learning speed, generalization capabilities, autonomy and creativity. How are these strengths, by what means are ideas and imagination produced in natural neural networks? Methods: Reviewing the literature, we put forward the argument that both our natural environment and the brain are of low complexity, that is, require for their generation very little information and are consequently both highly structured. We further argue that the structures of brain and natural environment are closely related. Results: We propose that the structural regularity of the brain takes the form of net fragments (self-organized network patterns) and that these serve as the powerful inductive bias that enables the brain to learn quickly, generalize from few examples and bridge the gap between abstractly defined general goals and concrete situations. Conclusions: Our results have important bearings on open problems in artificial neural network research.
    Keywords Computer Science - Artificial Intelligence ; Quantitative Biology - Neurons and Cognition ; I.2
    Publishing date 2022-04-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The what and why of binding: the modeler's perspective.

    von der Malsburg, C

    Neuron

    1999  Volume 24, Issue 1, Page(s) 95–104, 111–25

    MeSH term(s) Animals ; Brain/physiology ; Humans ; Mental Processes/physiology ; Models, Biological ; Neural Networks (Computer) ; Neurons/physiology ; Time Factors
    Language English
    Publishing date 1999-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/s0896-6273(00)80825-9
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  7. Article: Are generalists more innovative than specialists? A comparison of innovative abilities in two wild sympatric mouse lemur species.

    Henke-von der Malsburg, Johanna / Fichtel, Claudia

    Royal Society open science

    2018  Volume 5, Issue 8, Page(s) 180480

    Abstract: The propensity to flexibly innovate behavioural variants might advantage animals when dealing with novel or modified ecological or social challenges. Interspecific innovative abilities can be predicted by the degree of ecological generalism and ... ...

    Abstract The propensity to flexibly innovate behavioural variants might advantage animals when dealing with novel or modified ecological or social challenges. Interspecific innovative abilities can be predicted by the degree of ecological generalism and intraspecific variation is predicted by personality traits. To examine the effects of these factors on innovation, we compared problem-solving abilities in the generalist grey mouse lemurs (
    Language English
    Publishing date 2018-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.180480
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  8. Article ; Online: Structural insights into crista junction formation by the Mic60-Mic19 complex.

    Bock-Bierbaum, Tobias / Funck, Kathrin / Wollweber, Florian / Lisicki, Elisa / von der Malsburg, Karina / von der Malsburg, Alexander / Laborenz, Janina / Noel, Jeffrey K / Hessenberger, Manuel / Jungbluth, Sibylle / Bernert, Carola / Kunz, Séverine / Riedel, Dietmar / Lilie, Hauke / Jakobs, Stefan / van der Laan, Martin / Daumke, Oliver

    Science advances

    2022  Volume 8, Issue 35, Page(s) eabo4946

    Abstract: Mitochondrial cristae membranes are the oxidative phosphorylation sites in cells. Crista junctions (CJs) form the highly curved neck regions of cristae and are thought to function as selective entry gates into the cristae space. Little is known about how ...

    Abstract Mitochondrial cristae membranes are the oxidative phosphorylation sites in cells. Crista junctions (CJs) form the highly curved neck regions of cristae and are thought to function as selective entry gates into the cristae space. Little is known about how CJs are generated and maintained. We show that the central coiled-coil (CC) domain of the mitochondrial contact site and cristae organizing system subunit Mic60 forms an elongated, bow tie-shaped tetrameric assembly. Mic19 promotes Mic60 tetramerization via a conserved interface between the Mic60 mitofilin and Mic19 CHCH (CC-helix-CC-helix) domains. Dimerization of mitofilin domains exposes a crescent-shaped membrane-binding site with convex curvature tailored to interact with the curved CJ neck. Our study suggests that the Mic60-Mic19 subcomplex traverses CJs as a molecular strut, thereby controlling CJ architecture and function.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abo4946
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  9. Article ; Online: Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.

    Kohl, Christian / Tessarz, Peter / von der Malsburg, Karina / Zahn, Regina / Bukau, Bernd / Mogk, Axel

    Biological chemistry

    2011  Volume 392, Issue 7, Page(s) 601–608

    Abstract: ... by interacting with Get5. The GET pathway mediates the sorting of tail-anchored (TA) proteins, harboring a C ... protein sorting. Sgt2 activity in vivo relies on its N- and C-terminal domains, whereas the central TPR domain and ...

    Abstract Abstract TPR proteins modulate the activity of molecular chaperones. Here, we describe the S. cerevisiae TPR protein Sgt2 as interaction partner of Ssa1 and Hsp104 and as a component of the GET pathway by interacting with Get5. The GET pathway mediates the sorting of tail-anchored (TA) proteins, harboring a C-terminal trans-membrane segment, to the ER membrane. S. cerevisiae sgt2Δ cells show partial defects in TA protein sorting. Sgt2 activity in vivo relies on its N- and C-terminal domains, whereas the central TPR domain and thus chaperone interactions are dispensable. We show that TA protein sorting defects are more severe in sgt2Δ get5Δ mutants compared to single knockouts. Furthermore, overproduction of Sgt2 becomes toxic to get3Δ but not to get5Δ cells. Together, these findings indicate an additional, Get5-independent role of Sgt2 in TA protein sorting, pointing to parallel pathways of substrate delivery to Get3.
    MeSH term(s) Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Molecular Chaperones/metabolism ; Mutation ; Protein Binding ; Protein Transport ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Ubiquitin/genetics ; Ubiquitin/metabolism
    Chemical Substances Carrier Proteins ; Mdy2 protein, S cerevisiae ; Molecular Chaperones ; Saccharomyces cerevisiae Proteins ; Sgt2 protein, S cerevisiae ; Ubiquitin
    Language English
    Publishing date 2011-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/BC.2011.066
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  10. Article ; Online: Predicting the psychophysical similarity of faces and non-face complex shapes by image-based measures.

    Yue, Xiaomin / Biederman, Irving / Mangini, Michael C / Malsburg, Christoph von der / Amir, Ori

    Vision research

    2012  Volume 55, Page(s) 41–46

    Abstract: Shape representation is accomplished by a series of cortical stages in which cells in the first stage (V1) have local receptive fields tuned to contrast at a particular scale and orientation, each well modeled as a Gabor filter. In succeeding stages, the ...

    Abstract Shape representation is accomplished by a series of cortical stages in which cells in the first stage (V1) have local receptive fields tuned to contrast at a particular scale and orientation, each well modeled as a Gabor filter. In succeeding stages, the representation becomes largely invariant to Gabor coding (Kobatake & Tanaka, 1994). Because of the non-Gabor tuning in these later stages, which must be engaged for a behavioral response (Tong, 2003; Tong et al., 1998), a V1-based measure of shape similarity based on Gabor filtering would not be expected to be highly correlated with human performance when discriminating complex shapes (faces and teeth-like blobs) that differ metrically on a two-choice, match-to-sample task. Here we show that human performance is highly correlated with Gabor-based image measures (Gabor simple and complex cells), with values often in the mid 0.90s, even without discounting the variability in the speed and accuracy of performance not associated with the similarity of the distractors. This high correlation is generally maintained through the stages of HMAX, a model that builds upon the Gabor metric and develops units for complex features and larger receptive fields. This is the first report of the psychophysical similarity of complex shapes being predictable from a biologically motivated, physical measure of similarity. As accurate as these measures were for accounting for metric variation, a simple demonstration showed that all were insensitive to viewpoint invariant (nonaccidental) differences in shape.
    MeSH term(s) Discrimination (Psychology) ; Face ; Form Perception/physiology ; Humans ; Models, Neurological ; Pattern Recognition, Visual/physiology ; Photic Stimulation/methods ; Psychophysics ; Visual Pathways/physiology
    Language English
    Publishing date 2012-02-15
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2011.12.012
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