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  1. Article ; Online: Visible-Light-Induced C-F Bond Activation for the Difluoroalkylation of Indoles.

    Shreiber, Scott T / Granados, Albert / Matsuo, Bianca / Majhi, Jadab / Campbell, Mark W / Patel, Shivani / Molander, Gary A

    Organic letters

    2022  Volume 24, Issue 46, Page(s) 8542–8546

    Abstract: An aryl disulfide mediated C-F bond activation of the trifluoromethyl group to generate valuable ...

    Abstract An aryl disulfide mediated C-F bond activation of the trifluoromethyl group to generate valuable
    MeSH term(s) Catalysis ; Indoles/chemistry ; Oxidation-Reduction ; Hydrocarbons, Fluorinated
    Chemical Substances Indoles ; Hydrocarbons, Fluorinated
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c03549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Photochemical C-F Activation Enables Defluorinative Alkylation of Trifluoroacetates and -Acetamides.

    Campbell, Mark W / Polites, Viktor C / Patel, Shivani / Lipson, Juliette E / Majhi, Jadab / Molander, Gary A

    Journal of the American Chemical Society

    2021  Volume 143, Issue 47, Page(s) 19648–19654

    Abstract: The installation ... ...

    Abstract The installation of
    MeSH term(s) Acetamides/chemistry ; Alkenes/chemistry ; Alkylation ; Catalysis/radiation effects ; Esters/chemical synthesis ; Fluoroacetates/chemistry ; Ketones/chemistry ; Ketones/radiation effects ; Molecular Structure
    Chemical Substances Acetamides ; Alkenes ; Esters ; Fluoroacetates ; Ketones
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c11059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Photochemical C–F Activation Enables Defluorinative Alkylation of Trifluoroacetates and -Acetamides

    Campbell, Mark W. / Polites, Viktor C. / Patel, Shivani / Lipson, Juliette E. / Majhi, Jadab / Molander, Gary A.

    Journal of the American Chemical Society. 2021 Nov. 18, v. 143, no. 47

    2021  

    Abstract: ... efficient retrosynthetic approach would be the functionalization of a single C–F bond from a trifluoromethyl ... group. Recent advances in this line of attack have enabled the C–F activation of trifluoromethylarenes ... but limit the accessible motifs to only benzylic gem-difluorinated scaffolds. In contrast, the C–F ...

    Abstract The installation of gem-difluoromethylene groups into organic structures remains a daunting synthetic challenge despite their attractive structural, physical, and biochemical properties. A very efficient retrosynthetic approach would be the functionalization of a single C–F bond from a trifluoromethyl group. Recent advances in this line of attack have enabled the C–F activation of trifluoromethylarenes, but limit the accessible motifs to only benzylic gem-difluorinated scaffolds. In contrast, the C–F activation of trifluoroacetates would enable their use as a bifunctional gem-difluoromethylene synthon. Herein, we report a photochemically mediated method for the defluorinative alkylation of a commodity feedstock: ethyl trifluoroacetate. A novel mechanistic approach was identified using our previously developed diaryl ketone HAT catalyst to enable the hydroalkylation of a diverse suite of alkenes. Furthermore, electrochemical studies revealed that more challenging radical precursors, namely trifluoroacetamides, could also be functionalized via synergistic Lewis acid/photochemical activation. Finally, this method enabled a concise synthetic approach to novel gem-difluoro analogs of FDA-approved pharmaceutical compounds.
    Keywords Lewis acids ; alkenes ; alkylation ; catalysts ; electrochemistry ; feedstocks ; photochemistry
    Language English
    Dates of publication 2021-1118
    Size p. 19648-19654.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c11059
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Low Incidence and Brief Duration of Gastrointestinal Adverse Events with Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Over 96 Weeks: Post hoc Analyses of AMBER and EMERALD.

    Dunn, Keith / Baugh, Bryan / Bejou, Nika / Luo, Donghan / Campbell, Jennifer / Seyedkazemi, Sareh / Anderson, David

    Journal of the International Association of Providers of AIDS Care

    2022  Volume 21, Page(s) 23259582221088202

    Abstract: ... tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg. 362 and 763 patients initiated D/C/F/TAF in AMBER and ... EMERALD, respectively. All D/C/F/TAF-related gastrointestinal AEOIs were grade 1/2 in severity; none were ... serious. Across studies, incidence of D/C/F/TAF-related diarrhea and nausea were each ≤5% in Wk1 (≤1% post ...

    Abstract Gastrointestinal intolerance has been associated with ritonavir-boosted protease inhibitors. This post hoc analysis evaluated gastrointestinal adverse events of interest (AEOIs; diarrhea, nausea, abdominal discomfort, flatulence [MedDRAv21]) through Wk96 among patients enrolled in the phase 3 AMBER (treatment-naïve) and EMERALD (virologically suppressed) studies of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg. 362 and 763 patients initiated D/C/F/TAF in AMBER and EMERALD, respectively. All D/C/F/TAF-related gastrointestinal AEOIs were grade 1/2 in severity; none were serious. Across studies, incidence of D/C/F/TAF-related diarrhea and nausea were each ≤5% in Wk1 (≤1% post-Wk2); prevalence of each decreased to <5% post-Wk2. In each study, there was 1 case of D/C/F/TAF-related abdominal discomfort during Wk1 and none thereafter. Incidence of D/C/F/TAF-related flatulence was <1% throughout. Median duration of D/C/F/TAF-related gastrointestinal AEOIs was 16.5 (AMBER) and 8.5 (EMERALD) days. In conclusion, in treatment-naïve and virologically suppressed patients, incidences and prevalences of D/C/F/TAF-related gastrointestinal AEOIs were low and tended to present early.
    MeSH term(s) Alanine ; Anti-HIV Agents/adverse effects ; Cobicistat/adverse effects ; Darunavir/adverse effects ; Diarrhea/chemically induced ; Diarrhea/epidemiology ; Emtricitabine/adverse effects ; Flatulence/chemically induced ; Flatulence/drug therapy ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Incidence ; Nausea/chemically induced ; Nausea/drug therapy ; Tenofovir/analogs & derivatives
    Chemical Substances Anti-HIV Agents ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Emtricitabine (G70B4ETF4S) ; Cobicistat (LW2E03M5PG) ; Alanine (OF5P57N2ZX) ; Darunavir (YO603Y8113)
    Language English
    Publishing date 2022-04-24
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2709037-1
    ISSN 2325-9582 ; 2325-9574
    ISSN (online) 2325-9582
    ISSN 2325-9574
    DOI 10.1177/23259582221088202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to P.F. Pinsky, C.P. Crum, and M.W. McIntosh et al.

    Menon, Usha / Kalsi, Jatinderpal K / Gentry-Maharaj, Aleksandra / Ryan, Andy / Burnell, Matthew / Parmar, Max / Fallowfield, Lesley / Campbell, Stuart / McGuire, Alistair / Skates, Steven / Jacobs, Ian

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2015  Volume 34, Issue 2, Page(s) 201–202

    MeSH term(s) Biomarkers, Tumor/blood ; Early Detection of Cancer/methods ; Female ; Humans ; Ovarian Neoplasms/blood
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015-11-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2015.64.1365
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  6. Book ; Online: An Atom-Probe Tomographic Study of the Compositional Trajectories During gamma(f.c.c.)/gamma-prime(L12) Phase-Separation in a Ni-Al-Cr-Re Superalloy

    Baik, Sung-Il / Mao, Zugang / Ren, Qingqiang / Campbell, Carelyn E. / Zhang, Chuan / Zhou, Bicheng / Noebe, Ronald D. / Seidman, David N

    2019  

    Abstract: The compositional diffusional-trajectories for a phase separation of gamma(f.c.c.)/gamma-prime(L12 ... Re and depletion of Al on the gamma(f.c.c.) matrix-side develop as a result of diffusional fluxes ... crossing the gamma(f.c.c.)/gamma-prime(L12) interface.The experimental (APT) compositional trajectories ...

    Abstract The compositional diffusional-trajectories for a phase separation of gamma(f.c.c.)/gamma-prime(L12) phases are studied in a quaternary Ni-10Al-8.5Cr-2Re alloy, aged at 700 deg.C for 0 to 1024 h, utilizing atom-probe tomography (APT). As the gamma-prime(L12)-precipitates grow, the enrichments of Ni, Cr, and Re and depletion of Al on the gamma(f.c.c.) matrix-side develop as a result of diffusional fluxes crossing the gamma(f.c.c.)/gamma-prime(L12) interface.The experimental (APT) compositional trajectories of the two-phases, gamma(f.c.c.)/gamma-prime(L12), are displayed in a quaternary phase-diagram, employing a tetrahedron, and compared with the Philippe-Voorhees (P-V) coarsening model which includes the off-diagonal terms in the diffusion tensor for the multi-component system.

    Comment: 12 pages, 3 Figures
    Keywords Condensed Matter - Materials Science
    Publishing date 2019-04-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.

    Shen, Kai / Tolbert, Caitlin E / Guilluy, Christophe / Swaminathan, Vinay S / Berginski, Matthew E / Burridge, Keith / Superfine, Richard / Campbell, Sharon L

    The Journal of biological chemistry

    2011  Volume 286, Issue 52, Page(s) 45103–45115

    Abstract: Vinculin is an essential and highly conserved cell adhesion protein, found at both focal adhesions and adherens junctions, where it couples integrins or cadherins to the actin cytoskeleton. Vinculin is involved in controlling cell shape, motility, and ... ...

    Abstract Vinculin is an essential and highly conserved cell adhesion protein, found at both focal adhesions and adherens junctions, where it couples integrins or cadherins to the actin cytoskeleton. Vinculin is involved in controlling cell shape, motility, and cell survival, and has more recently been shown to play a role in force transduction. The tail domain of vinculin (Vt) contains determinants necessary for binding and bundling of actin filaments. Actin binding to Vt has been proposed to induce formation of a Vt dimer that is necessary for cross-linking actin filaments. Results from this study provide additional support for actin-induced Vt self-association. Moreover, the actin-induced Vt dimer appears distinct from the dimer formed in the absence of actin. To better characterize the role of the Vt strap and carboxyl terminus (CT) in actin binding, Vt self-association, and actin bundling, we employed smaller amino-terminal (NT) and CT deletions that do not perturb the structural integrity of Vt. Although both NT and CT deletions retain actin binding, removal of the CT hairpin (1061-1066) selectively impairs actin bundling in vitro. Moreover, expression of vinculin lacking the CT hairpin in vinculin knock-out murine embryonic fibroblasts affects the number of focal adhesions formed, cell spreading as well as cellular stiffening in response to mechanical force.
    MeSH term(s) Actins/genetics ; Actins/metabolism ; Animals ; Avian Proteins/genetics ; Avian Proteins/metabolism ; Cells, Cultured ; Chickens ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Focal Adhesions/genetics ; Focal Adhesions/metabolism ; Mice ; Mice, Knockout ; Protein Binding ; Protein Multimerization/physiology ; Protein Structure, Tertiary ; Vinculin/genetics ; Vinculin/metabolism
    Chemical Substances Actins ; Avian Proteins ; VCL protein, Gallus gallus ; Vinculin (125361-02-6)
    Language English
    Publishing date 2011-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M111.244293
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  8. Article: Treatment of the Sicca syndrome and Sjogren's syndrome with E.F.A., pyridoxine and vitamin C.

    Horrobin, D F / Campbell, A / McEwen, C G

    Progress in lipid research

    1981  Volume 20, Page(s) 253–254

    MeSH term(s) Ascorbic Acid/therapeutic use ; Fatty Acids, Essential/therapeutic use ; Humans ; Lacrimal Apparatus Diseases/drug therapy ; Pyridoxine/therapeutic use ; Salivary Gland Diseases/drug therapy ; Sjogren's Syndrome/drug therapy ; Syndrome
    Chemical Substances Fatty Acids, Essential ; Pyridoxine (KV2JZ1BI6Z) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 1981
    Publishing country England
    Document type Journal Article
    ZDB-ID 282560-0
    ISSN 1873-2194 ; 0163-7827 ; 0079-6832
    ISSN (online) 1873-2194
    ISSN 0163-7827 ; 0079-6832
    DOI 10.1016/0163-7827(81)90048-5
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  9. Article: Roderick Angus Gordon, C.D., B.SC., M.D., D.A., F.R.C.P.(C), F.F.A.R.C.S., F.A.C.A.

    Campbell, S M

    Canadian Anaesthetists' Society journal

    1969  Volume 16, Issue 4, Page(s) 347–351

    MeSH term(s) Anesthesiology ; Canada ; History of Medicine ; Societies, Medical
    Language English
    Publishing date 1969-07
    Publishing country Canada
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 82022-2
    ISSN 0008-2856
    ISSN 0008-2856
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  10. Article ; Online: Post-Dobbs Challenges in Research and Patient Protections.

    Campbell, Aimee N C / Greenfield, Shelly F

    JAMA psychiatry

    2024  

    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2024.0598
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