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  1. Article ; Online: PETER-assay

    Florian Urban / Kathrin Hajek / Tobias Naber / Boris Anczykowski / Marcus Schäfer / Joachim Wegener

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    Combined Impedimetric Detection of Permeability (PE) and Resistance (TER) of Barrier-Forming Cell Layers

    2020  Volume 11

    Abstract: ... monolayer in one single experiment (PETER-assay). The novel approach is entirely based on AC impedance ... cytochalasin D. PETER provides an excellent time-resolution and completely automated data collection. ...

    Abstract Abstract Epithelial and endothelial barrier function is typically studied in vitro by growing the cells of interest on permeable supports that are sandwiched between two fluid compartments. This setup mimics the physiological situation with the cell layer as the diffusion barrier at the interface between two chemically distinct fluids. Routinely, the barrier function is quantitatively described by two key parameters: (i) the transepithelial or transendothelial electrical resistance (TER) as a measure of the permeability for small inorganic ions and (ii) the permeability coefficient (PE) as a descriptor of the permeability for molecular tracers. So far the two parameters have been determined in separate experiments. This study introduces a device that allows for simultaneous detection of PE and TER of the very same cell monolayer in one single experiment (PETER-assay). The novel approach is entirely based on AC impedance measurements in two different modes, so that TER and PE become available in real time. The new approach is demonstrated for three epithelial cell lines derived from the kidney (MDCK-I, MDCK-II, NRK) with very different barrier properties under stationary conditions and when challenged by barrier-breaking fungal toxin cytochalasin D. PETER provides an excellent time-resolution and completely automated data collection.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Antwort zum Leserbrief zur Publikation Tobias Kastenberger, Peter Kaiser, Simone Bode und Mitarb. Die Behandlung der avaskulären Kahnbeinpseudarthrose: gefäßgestielter Knochenspan vom Beckenkamm oder vom medialen Femurkondyl? Handchir Mikrochir Plast Chir 2020; 52: 419–424

    Kastenberger, Tobias / Kaiser, Peter / Bode, Simone / Horling, Lukas / Schmidle, Gernot / Arora, Rohit

    Handchirurgie · Mikrochirurgie · Plastische Chirurgie

    2021  Volume 53, Issue 01, Page(s) 91–92

    Language German
    Publishing date 2021-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 392414-2
    ISSN 1439-3980 ; 0722-1819
    ISSN (online) 1439-3980
    ISSN 0722-1819
    DOI 10.1055/a-1345-1165
    Database Thieme publisher's database

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  3. Book ; Online: The History of Peter the Great

    Voltaire / Smollett, Tobias

    Emperor of Russia

    2014  

    Abstract: French Enlightenment thinker Voltaire saw much to admire in Russian emperor Peter the Great. Most ... significantly, Voltaire admired Peter''s tireless efforts to drag Russia from its medieval mindset and thrust ... it into an age of rationality. This exhaustive biography focuses more on Peter''s philosophy and values ...

    Abstract French Enlightenment thinker Voltaire saw much to admire in Russian emperor Peter the Great. Most significantly, Voltaire admired Peter''s tireless efforts to drag Russia from its medieval mindset and thrust it into an age of rationality. This exhaustive biography focuses more on Peter''s philosophy and values than his wartime exploits
    Language English
    Size Online-Ressource (405 p)
    Publisher The Floating Press
    Publishing place Auckland
    Document type Book ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Drei Fragen an . Prof. Dr. Peter Weingarten

    Löser, Tobias

    2017  

    Keywords Text ; ddc:300 ; ddc:630 ; ländliche Räume -- Deutschland -- Interview -- ländliche Entwicklung
    Language German
    Publishing country de
    Document type Article ; Online
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  5. Book ; Thesis: Formen und Funktionen von Intertextualität und Intermedialität in der Ästhetik des Widerstands von Peter Weiss

    Mandel, Tobias / Weiss, Peter

    (Kunst und Gesellschaft ; Bd. 9)

    2013  

    Author's details Tobias Mandel
    Series title Kunst und Gesellschaft ; Bd. 9
    Keywords Intertextualität ; Intermedialität
    Language German
    Size 662 S., 21 cm, 940 g
    Publisher Röhrig
    Publishing place St. Ingbert
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Tübingen, 2012
    ISBN 3861105381 ; 9783861105381
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article: Comment on "the historical origins of the safe haven status of the Swiss franc" by Ernst Baltensperger and Peter Kugler

    Straumann, Tobias / Baltensperger, Ernst / Kugler, Peter

    Aussenwirtschaft : schweizerische Zeitschrift für internationale Wirtschaftsbeziehungen ; the Swiss Review of international economic relations Vol. 67, No. 2 , p. 29-30

    2016  Volume 67, Issue 2, Page(s) 29–30

    Author's details Tobias Straumann
    Language English
    Publisher Rüegger
    Publishing place Zürich
    Document type Article
    ZDB-ID 668-3
    ISSN 0004-8216
    Database ECONomics Information System

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  7. Article ; Online: Reply to Erik Rud, Peter Lauritzen, and Eduard Baco's Letter to the Editor re: Henrik Grönberg, Martin Eklund, Wolfgang Picker, et al. Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging. Eur Urol 2018;74:722-8.

    Eklund, Martin / Ström, Peter / Grönberg, Henrik / Nordström, Tobias

    European urology

    2018  Volume 75, Issue 4, Page(s) e104–e105

    MeSH term(s) Hematologic Tests ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms
    Language English
    Publishing date 2018-12-01
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.11.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Patient's and physician's behavior on the management of benign prostatic hyperplasia among the patients at the risk of clinical progression. A multicenter noninterventional trial in Slovakia by "Prostate and Expectations of Treatment: Epidemiology Research" (PETER) study group.

    Weibl, Peter / Laurinc, Peter / Tomaškin, Roman / Klatte, Tobias / Shariat F, Shahrokh / Helbich, Miroslav / Fačkovcova, Danica / Bujdák, Peter

    Wiener klinische Wochenschrift

    2015  Volume 127, Issue 11-12, Page(s) 434–439

    Abstract: Objectives: The aim of the survey was to assess physician's behavior and the global knowledge about patient's preferences and their psychological burden linked to lower urinary tract symptoms (LUTS) in an outpatient setting in Slovakia.: Methods: The ...

    Abstract Objectives: The aim of the survey was to assess physician's behavior and the global knowledge about patient's preferences and their psychological burden linked to lower urinary tract symptoms (LUTS) in an outpatient setting in Slovakia.
    Methods: The study included 36 outpatient urological clinics. Overall, 1132 newly diagnosed LUTS patients were screened within 1 month. A total of 454 questionnaires were obtained from 459 LUTS patients with risk of progression (RP). Inclusion criteria were: age > 50 years, IPSS > 8, prostate volume ≥ 30 cm3, and PSA ≥ 1.5 to ≤ 10 ng/ml.
    Results: The digital rectal examination, PSA testing, and urinalysis were used in all the centers as first visit examinations. The least frequently performed diagnostic procedure was uroflowmetry (74 %). The physician's preferred therapy for patients with RP was standard combined treatment in (52.6 %); followed by α-blocker alone (45 %) and monotherapy with 5-α-reductase inhibitors (5-ARI) only in 3 % of all asked urologists. Patient's mean age was 63.3 years (SD ±  7.4); baseline PSA value 2.2 ng/ml (SD + 3.2); prostate volume was 38.0 ml (SD ±  16.7 ml); Qmax was 11.5 ml/s (SD ±  4.6); and IPSS score 12.5 (SD ±  6.3). The most bothersome symptoms were nocturia (prevalence of ≥ 75 %), weak urinary stream (61 %), and retarded voiding (43 %). Patient's expectations of treatment were rapid improvement of symptoms (36.0 %), stabilization of symptoms (35.5 %), and reduction of potential risk of surgical intervention (25.8 %).
    Conclusions: Our research reflects the physician's behavior, patient's self-perception of the disease and therapeutic priorities in the current outpatient practice in Slovakia.
    MeSH term(s) Aged ; Causality ; Comorbidity ; Disease Progression ; Humans ; Male ; Middle Aged ; Patient Care Management/statistics & numerical data ; Patient Satisfaction/statistics & numerical data ; Patients/psychology ; Physician-Patient Relations ; Physicians/psychology ; Practice Patterns, Physicians'/statistics & numerical data ; Prevalence ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/psychology ; Quality of Life/psychology ; Slovenia/epidemiology ; Urination Disorders/diagnosis ; Urination Disorders/epidemiology ; Urination Disorders/psychology
    Language English
    Publishing date 2015-06
    Publishing country Austria
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-015-0751-5
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  9. Article ; Online: Patient's behavior and attitudes toward the management of benign prostatic hyperplasia among patients with the risk of disease progression: prospective study by "Prostate and Expectations of Treatment Epidemiology Research (PETER) study group".

    Weibl, Peter / Klatte, Tobias / Laurinc, Peter / Tomaškin, Roman / Shariat, Shahrokh F / Helbich, Miroslav / Fackovcova, Danica / Bujdák, Peter

    Wiener klinische Wochenschrift

    2015  Volume 127, Issue 9-10, Page(s) 363–368

    Abstract: Background: The aim of the study was to evaluate patients attitudes with benign prostatic hyperplasia at the risk of progression during a 12-month period of observation.: Materials and methods: A total of 426 patients from 45 outpatients centers were ...

    Abstract Background: The aim of the study was to evaluate patients attitudes with benign prostatic hyperplasia at the risk of progression during a 12-month period of observation.
    Materials and methods: A total of 426 patients from 45 outpatients centers were included and prospectively followed. Inclusion criteria were: age > 50 years, International Prostate Symptom Score (IPSS) > 8, prostate volume > 30 cm(3) (transabdominal ultrasound) and PSA > 1.5 to < 10 ng/ml.
    Results: In all, 28.6% patients were naive, 62.9% used monotherapy (alpha-blocker), and 8.5% combined treatment (alpha-blocker/5alpha-reductase inhibitor/dutasteride). The most bothersome symptoms were the weak urine stream (60.8%) and nocturia (59.2%). Patients expectations from the treatment were stabilization of the disease and reducing the risk of surgery rather than rapid resolution of symptoms. Despite the presence of symptoms, 2.3% patients claimed that benign prostatic hyperplasia/lower urinary tract symptoms had no impact on their quality of life (QoL), in 48.1 % only little impact on QoL, and 47.9% patients percepted their symptoms as severe. Out of 71.4% patients treated previously, 26.5% patients were indecisive about the satisfaction of present treatment. Visual analog score was percepted more optimistically rather than the IPSS. Pearson's correlation r = 0.68 at the beginning and r = 0.83 at the end of the study.
    Conclusions: Prostate and Expectations of Treatment Epidemiology Research study highlights and reflects on patients behavior and self-perception, patients self-perception of the disease and therapeutic priorities during the 1 year of observation.
    MeSH term(s) 5-alpha Reductase Inhibitors/therapeutic use ; Adrenergic alpha-Antagonists/therapeutic use ; Aged ; Aged, 80 and over ; Comorbidity ; Disease Progression ; Drug Therapy, Combination ; Dutasteride/therapeutic use ; Humans ; Lower Urinary Tract Symptoms/epidemiology ; Lower Urinary Tract Symptoms/pathology ; Lower Urinary Tract Symptoms/psychology ; Lower Urinary Tract Symptoms/therapy ; Male ; Middle Aged ; Patient Satisfaction ; Prospective Studies ; Prostate/pathology ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/pathology ; Prostatic Hyperplasia/psychology ; Prostatic Hyperplasia/therapy ; Research ; Risk ; Ultrasonography
    Chemical Substances 5-alpha Reductase Inhibitors ; Adrenergic alpha-Antagonists ; Prostate-Specific Antigen (EC 3.4.21.77) ; Dutasteride (O0J6XJN02I)
    Language English
    Publishing date 2015-05
    Publishing country Austria
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-014-0668-4
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  10. Article ; Online: Reply to Ola Bratt and Anna Öfverholm's Letter to the Editor re: Peter Ström, Tobias Nordström, Henrik Grönberg, Martin Eklund. The Stockholm-3 Model for Prostate Cancer Detection: Algorithm Update, Biomarker Contribution, and Reflex Test Potential. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2017.12.028.

    Eklund, Martin / Ström, Peter / Nordström, Tobias / Grönberg, Henrik

    European urology

    2018  Volume 74, Issue 1, Page(s) e10–e11

    MeSH term(s) Algorithms ; Biomarkers ; Humans ; Male ; Prostatic Neoplasms ; Reflex
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-03-26
    Publishing country Switzerland
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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