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Article: Da-Cheng-Qi decoction improves severe acute pancreatitis capillary leakage syndrome by regulating tight junction-associated proteins.

Tu, Jiamin / Jiang, Yinping / Tu, Lei / Chen, Yafeng / Pan, Liyun / Fan, Xinjuan / Tian, Jiyun / Li, Jianguo / Wang, Xinji / Fu, Honghao / Xu, Bing / Feng, Dianxu

Frontiers in pharmacology

2024 Volume 15, Page(s) 1138251

Abstract: Background and aims: To investigate mechanisms underlying the effects of Da-Cheng-Qi decoction ...

Abstract	Background and aims: To investigate mechanisms underlying the effects of Da-Cheng-Qi decoction (DCQD) on severe acute pancreatitis (SAP) capillary leakage syndrome. Methods: In this study, a SAP rat model was established using retrograde perfusion of 5% sodium taurocholate into the biliopancreatic duct. The study included three randomized groups: control, SAP (modeling), and DCQD (via gavage at 2 h pre-modeling and 2 and 4 h post-modeling). HPLC was used to analyzed major components of DCQD. Pathological changes and capillary permeability in the rat pancreatic tissues were examined. mRNA levels of claudin 5, occludin, zonula occludin-1 (ZO-1), and junctional adhesion molecules (JAM-C) were assessed using qRT-PCR. Tight junction-associated protein expression was evaluated using immunofluorescence and Western blot analyses. Human umbilical vein endothelial cells (HUVECs) were used to investigate the mechanism m of DCQD. Results: Serum levels of amylase, TNF-α, IL-1β, IL-2, and IL-6 were higher in the SAP group compared to the DCQD group ( Conclusion: DCQD can improve capillary permeability in both
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1138251
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Article ; Online: Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage.

Zeng, Peng / Wang, Xiao-Ming / Su, Hong-Fei / Zhang, Teng / Ning, Lin-Na / Shi, Yan / Yang, Shu-Sheng / Lin, Li / Tian, Qing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 90, Page(s) 153630

Abstract: ... modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used ...

Abstract	Background: Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb. Purpose: To study the protective effects of DCQ on ICH and its possible mechanisms of action. Methods: The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed. Results: The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14 Conclusion: The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
MeSH term(s)	Animals ; Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Emodin/pharmacology ; Hippocampus/drug effects ; Proteomics ; Rats ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Chemical Substances	Da-Cheng-Qi ; Drugs, Chinese Herbal ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Emodin (KA46RNI6HN)
Language	English
Publishing date	2021-06-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153630
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Article ; Online: Spatial Association Effect of Haze Pollution in Cheng-Yu Urban Agglomeration.

Zhang, Degang / Lu, Yuanquan / Tian, Yuan

Scientific reports

2020 Volume 10, Issue 1, Page(s) 9753

Abstract: ... in Cheng-Yu urban agglomeration which is the fourth largest urban agglomeration and a comprehensive ... characteristics of this network. The results show that: haze pollution in Cheng-Yu urban agglomeration is ...

Abstract	This study takes a network perspective to examine the spatial spillover effects of haze pollution in Cheng-Yu urban agglomeration which is the fourth largest urban agglomeration and a comprehensive demonstration zone of new urbanization in China. Firstly, we use Granger causality test to construct haze pollution spatial association network, and then we apply social network analysis to reveal the structural characteristics of this network. The results show that: haze pollution in Cheng-Yu urban agglomeration is a complex multithreaded network. Chongqing, Chengdu, Guang'an, Luzhou, Deyang and Nanchong are the centers of the network, sending and transmitting the most relationships. The haze pollution spatial association network can be divided into net beneficiary block, net overflow block, bilateral overflow block and broker block. These four blocks present obvious geographical distribution characteristics and are partly related to the difference of urbanization. The above results contribute by illustrating the current spatial spillover situation of haze pollution and provide a theoretical foundation for the government that it should simultaneously consider cities' statues and their spatial spillover effects in the network rather than simple geographic proximity when formulating future haze pollution control policies in urban agglomeration.
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-66665-8
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Article: Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage

Zeng, Peng / Wang, Xiao-Ming / Su, Hong-Fei / Zhang, Teng / Ning, Lin-Na / Shi, Yan / Yang, Shu-Sheng / Lin, Li / Tian, Qing

Phytomedicine. 2021 Sept., v. 90

2021

Abstract: ... treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese ...

Abstract	Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb.To study the protective effects of DCQ on ICH and its possible mechanisms of action.The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed.The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14ᵗʰ day after ICH. The proteomics data revealed that DCQ significantly corrected the pathological signals in the CPu and hippocampus after ICH. The numbers of amoebic microglia in the CPu and M2 microglia in both CPu and hippocampus were significantly increased after DCQ and emodin treatment. The increase in GluN2B-containing NMDA receptor (NR2B) and postsynaptic density protein-95, activation of mitogen-activated protein kinase (MAPK) signals in the CPu, and secondary neurodegeneration (SND) in the hippocampus were significantly recovered in DCQ-treated rats. Inhibition of MAPK p38 (p38) in the hippocampus was observed after DCQ and emodin treatment.The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
Keywords	active ingredients ; emodin ; hemorrhage ; hippocampus ; mitogen-activated protein kinase ; models ; neurodegenerative diseases ; neuroglia ; proteomics ; rhubarb ; stroke ; therapeutics
Language	English
Dates of publication	2021-09
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153630
Database	NAL-Catalogue (AGRICOLA)

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Article: Subjective well-being of the elderly in Xi Cheng District, Beijing.

Li, Shuo / Xie, Zhaohui / Shao, Jun / Xiao, Cunli / Tian, Liang / Zhao, Rongfeng / Gong, Jiakai / Han, Jinxiang / Wang, Yue / Han, Chao / Dang, Liping / Zhang, Yushi / Chen, Bo / Luo, Xiaojing / Guo, Wei

Shanghai archives of psychiatry

2014 Volume 24, Issue 6, Page(s) 335–346

Abstract: ... of elderly residents of Xi Cheng District in Beijing.: Methods: This cross-sectional study administered ... a self-completion survey to a stratified random sample of 2342 residents of Xi Cheng District who were 60 ...

Abstract	Background: In 2010 the Beijing Municipal Government promulgated a policy aimed at improving the quality of life and subjective well-being of elderly residents that included a component focused on mental health. Aim: Identify factors associated with subjective well-being in a representative sample of elderly residents of Xi Cheng District in Beijing. Methods: This cross-sectional study administered a self-completion survey to a stratified random sample of 2342 residents of Xi Cheng District who were 60 to 80 years of age. The level of well-being was assessed using a validated Chinese version of the Memorial University of Newfoundland Scale of Happiness (MUNSH). Detailed socioeconomic variables were obtained using a questionnaire developed by the authors. Social support, anxiety, and depression were assessed using validated Chinese versions of the Social Support Rating Scale (SSRS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Results: Among the 2342 respondents, 1616 (69.0%) had a total MUNSH score of 32 or above, indicating a high level of happiness; 423 (18.1%) has a total SSRS score 32 or below, indicating poor social support; 201 (8.6%) had a total SDS score of 53 or above, indicating significant depression; and 126 (5.3%) had a total SAS score of 50 or above, indicating significant anxiety. In the multivariate regression analysis the self-reported level of depression was the most important factor related to well-being. Anxiety, social support, income level, the quality of family relationships, the ability to self-regulate emotions, and regular exercise were also significantly related to well-being; but gender, marital status, age and educational level were not associated with well-being. Conclusion: Among elderly urban residents in Beijing, self-reports of poor subjective well-being are closely associated with self-reports of depressive and anxiety symptoms and also associated with social factors such as social support, income level and family relationships. Prospective studies are needed to identify the causal relationships of these variables and, based on the findings, to develop targeted interventions aimed at improving the quality of life and well-being of elderly community members.
Language	English
Publishing date	2014-07-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2941986-4
ISSN	1002-0829
ISSN	1002-0829
DOI	10.3969/j.issn.1002-0829.2012.06.005
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Article: Topical Delivery of Modified Da-Cheng-Qi Decoction () Using Low-Frequency Ultrasound Sonophoresis for Refractory Metastatic Malignant Bowel Obstruction: An Open-Label Single-Arm Clinical Trial.

Tian, Ai-Ping / Yin, Yu-Kun / Yu, Lei / Yang, Bo-Yan / Li, Ning / Li, Jian-Ying / Bian, Zhi-Min / Hu, Shang-Ying / Weng, Chun-Xiao / Feng, Li

Chinese journal of integrative medicine

2019 Volume 26, Issue 5, Page(s) 382–387

Abstract: Objective: To evaluate the efficacy and safety of topical delivery of modified Da-Cheng- Qi ...

Abstract	Objective: To evaluate the efficacy and safety of topical delivery of modified Da-Cheng- Qi Decoction (, MDCQD) by low-frequency ultrasound sonophoresis (LFUS) in patients with refractory metastatic malignant bowel obstruction (MBO) using an objective performance criteria (OPC) design. Methods: Fifty patients with refractory metastatic MBO were enrolled in this open-label single-arm clinical trial. Alongside fasting, gastrointestinal decompression, glycerol enema, intravenous nutrition and antisecretory therapy, a 50 g dose of MDCQD (prepared as a hydrogel) was applied through topical delivery at the site of abodminal pain or Tianshu (S 25) using LFUS for 30 min, twice daily for 5 consecutive days. The overall outcome was the remission of intestinal obstruction, and improvement on abdominal pain, abdominal distention, nausea and vomiting scores. Indicators of safety evaluation included liver and renal function as well as blood coagulation indicators. Results: Among 50 patients, 5 patients (10%) showed complete remission of intestinal obstruction and 21 patients (42%) showed improvement of intestinal obstruction. The overall remission rate of bowel obstruction was 52%. The results of the symptom score, based on the severity and frequency of the episode, are as follows: 26 patients (52%) showed improvment on symptom scores, 20 patients (40%) did not respond to treatment, and 4 patients (8%) discontinued treatment due to intolerance. No serious adverse effects or abnormal changes on liver and renal function or blood coagulation were observed. Conclusion: Topical delivery of MDCQD at 100 g/day using LFUS can improve the treatment response in patients with refractory metastatic MBO.
MeSH term(s)	Administration, Cutaneous ; Adult ; Aged ; Drugs, Chinese Herbal/administration & dosage ; Female ; Humans ; Intestinal Neoplasms/complications ; Intestinal Neoplasms/secondary ; Intestinal Obstruction/drug therapy ; Intestinal Obstruction/etiology ; Male ; Middle Aged ; Ultrasonic Therapy/methods
Chemical Substances	Da-Cheng-Qi ; Drugs, Chinese Herbal
Language	English
Publishing date	2019-05-24
Publishing country	China
Document type	Clinical Trial ; Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-019-3041-7
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Article ; Online: Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro.

Qin, Hui / Wen, Hao-Tian / Gu, Kai-Juan / Hu, Xu-Dong / Yang, Tao / Yan, Xiao-Feng / Ye, Ting-Jie / Huo, Jin-Lin / Hu, Jing

Drug design, development and therapy

2019 Volume 13, Page(s) 2873–2886

Abstract: ... respiratory impairment. Xin Jia Xuan Bai Cheng Qi Decoction (XJXBCQ) is a traditional prescription commonly ...

Abstract	Purpose: Pulmonary fibrosis (PF) is a common clinical disease, which results in serious respiratory impairment. Xin Jia Xuan Bai Cheng Qi Decoction (XJXBCQ) is a traditional prescription commonly used in treating lung diseases. We investigate the effect of XJXBCQ against PF and its mechanism via the regulation of TGF-β1/Smad in vitro and in vivo. Materials and methods: XJXBCQ was first extracted and probed for chemical characterization. An PF model in vitro and in vivo was established in rats and in MRC-5 cells. In bleomycin (BLM)-induced rats model, lung function such as peak expiratory flow (PEF), minute ventilation (MV) and hydroxyproline (HYP) were measured; histopathological changes of lung tissue and TGF-β1 in peripheral blood of rats were detected. TGF-β receptor, Smad2 and its phosphorylation expression were tested by Western blot assay in rats model. Then the effects of XJXBCQ on TGF-β1/Smad signal pathway were assessed by Western blot analysis in vitro, and IL-17A and IL-25 levels were evaluated by ELISA in vivo. Results: Our results showed that XJXBCQ significantly enhanced the lung functions, such as PEF, MV and HYP, by reducing the expression level of lung inflammatory cytokine and the content and fibrosis of lung collagen. Moreover, XJXBCQ effectively inhibited TGF-β1, Smad2 and its phosphorylation expression, and the activation of Smad7 in vitro and in vivo. Furthermore, XJXBCQ had an inhibitory effect on the α-smooth muscle actin (α-SMA) and fibronectin (Fn) in vitro and downregulated IL-17A and IL-25 by inhibiting the activation of TGF-β1/Smad signaling pathway in vitro and in vivo. Further, XJXBCQ effectively inhibitied ventilation volume and peak expiratory content remodeling and hydroxyproline content through inhibition of TGF-βRⅡ, Smad2 and its phosphorylation expression, and activation of Smad7 in vivo. Conclusion: XJXBCQ extract had an anti-PF effect in vitro and in vivo, which could be attributed to the inhibition of the expression of p-Smad2 and increase in the expression of Smad7 by regulating the TGF-β1/Smad activity.
MeSH term(s)	Animals ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Male ; Plant Extracts/pharmacology ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/physiopathology ; Rats ; Rats, Wistar ; Receptors, Transforming Growth Factor beta/metabolism ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Smad7 Protein/metabolism ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; Plant Extracts ; Receptors, Transforming Growth Factor beta ; Smad2 Protein ; Smad7 Protein ; Transforming Growth Factor beta1
Language	English
Publishing date	2019-08-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S185418
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Article: Protective effect of Lai Fu Cheng Qi decoction on severe acute pancreatitis-induced myocardial injury in a rat model.

Li, Nan / Tian, Ying / Wang, Chunli / Zhang, Peng / You, Shengyi

Experimental and therapeutic medicine

2015 Volume 9, Issue 4, Page(s) 1133–1140

Abstract: The aim of the present study was to evaluate the effects of Lai Fu Cheng Qi decoction on myocardial ... intragastric administration of Lai Fu Cheng Qi decoction. The serum levels of creatine kinase isoenzyme (CK-MB ...

Abstract	The aim of the present study was to evaluate the effects of Lai Fu Cheng Qi decoction on myocardial injury in rats with severe acute pancreatitis (SAP). In total, 30 rats were randomly divided into sham, SAP and decoction treatment groups. SAP was induced by a retrograde pancreatic duct injection of 5% sodium taurocholate in the SAP and decoction treatment groups. Rats in decoction treatment group also received intragastric administration of Lai Fu Cheng Qi decoction. The serum levels of creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) were detected using an automatic biochemical analyzer. In addition, myocardial Na
Language	English
Publishing date	2015-02-03
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2015.2250
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Article ; Online: Analysis of synephrine in da-cheng-qi decoction by HPLC employing precolumn derivatization with 9-fluorenylmethyl chloroformate.

Liu, Ying / Xu, Fengguo / Zhang, Zunjian / Yang, Cheng / Song, Rui / Tian, Yuan

Journal of chromatographic science

2009 Volume 47, Issue 10, Page(s) 925–930

Abstract: ... Chinese medicinal prescription, da-cheng-qi decoction. After purified by solid-phase extraction (SPE ...

Abstract	A sensitive and reliable method has been developed to determine synephrine in a famous purgative Chinese medicinal prescription, da-cheng-qi decoction. After purified by solid-phase extraction (SPE), the decoction was derivatized with 9-fluorenylmethyl chloroformate in borate buffer and analyzed by reversed-phase high-performance liquid chromatography equipped with a diode-array detector. The chromatographic separation was carried out on a Shimadzu shim-pack VP-ODS column using acetonitrile-water as mobile phase. This method was validated in terms of linearity, recovery, precision, accuracy, and repeatability. Calibration curves were linear (r(2) > 0.99) over the concentration range of 0.78-100 microg/mL, and the mean recovery was 93.28%. The intra- and inter-batch precisions were less than 2% in terms of relative standard deviations. The accuracy and repeatability were well within the acceptable range. The limit of detection was 0.25 microg/mL. This validated method also can be used for assays of herbal products, fruits, dietary supplements, and biological samples containing synephrine.
MeSH term(s)	Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Fluorenes/chemistry ; Synephrine/analysis
Chemical Substances	Drugs, Chinese Herbal ; Fluorenes ; 1-(9-fluorenyl)methyl chloroformate (9PLB0BTT90) ; Synephrine (PEG5DP7434)
Language	English
Publishing date	2009-09-02
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/47.10.925
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Book ; Audio / Video: Xiao cheng zhi chun

Tian, Zhuangzhuang

Springtime in a small town

2002

Author's details	[Regie: Tian Zhuangzhuang]
Language	Chinese
Size	1 DVD (Region 1-8), 111 Min
Publishing place	China/Hongkong
Document type	Book ; Audio / Video
Note	Audiosprache: Chinesisch ; Untertitel: Chinesisch (Langzeichen), Englisch
Database	Former special subject collection: coastal and deep sea fishing

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