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Article ; Online: Development of High-Performance Polyindole/Silicon Carbide Nanocomposites for Optoelectrical and Sensing Applications.

Gopika, R / Arun, K / Ramesan, M T

Langmuir : the ACS journal of surfaces and colloids

2024 Volume 40, Issue 15, Page(s) 8046–8058

Abstract: In this study, silicon carbide (SiC)-reinforced polyindole (PIn) nanocomposites were prepared by a simple in situ polymerization method. The successful reinforcement of the nanofiller within the host matrix was characterized using different analytical ... ...

Abstract	In this study, silicon carbide (SiC)-reinforced polyindole (PIn) nanocomposites were prepared by a simple in situ polymerization method. The successful reinforcement of the nanofiller within the host matrix was characterized using different analytical techniques. The chemical bonding of SiC in the polymer was identified by the characteristic peak around 800 cm
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c04001
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Article ; Online: Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection.

Gopika, K M / Sivajith, S / Sugunan, Aadharsa / Sudheesh, M S

Current pharmaceutical biotechnology

2022 Volume 24, Issue 8, Page(s) 970–987

Abstract: The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of ... ...

Abstract	The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of COVID-19 infection that is the starting point in the generation of microthrombi and sepsis eventually leading to acute respiratory distress syndrome (ARDs) and multi-organ failure. The dramatic fall in lung function during ARDs is attributed to the microthrombi-induced coagulopathy primed by a hyperactive immune system. Due to the lack of effective antiviral agents, the line of treatment is limited to the management of two key risk factors i.e., immune activation and coagulopathy. In the present review, we describe the mechanistic role, therapeutic targets, and opportunities to control immune activation and coagulopathy during the pathogenesis of COVID-19-induced ARDs.
MeSH term(s)	Humans ; COVID-19/complications ; SARS-CoV-2 ; Pandemics ; Respiratory Distress Syndrome/etiology ; Multiple Organ Failure
Language	English
Publishing date	2022-07-15
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/1389201023666220713113713
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Article ; Online: Social Determinants Predicting the Community Pharmacists' Workforce Preparedness for, and Response to, the Public Health Emergencies.

Venkataraman, Rajesh / Rajiah, Kingston / Anand, Meghana / Surendran, Gopika

Disaster medicine and public health preparedness

2023 Volume 17, Page(s) e515

Abstract: Objectives: To identify the predicting factors that contribute to preparedness for public health emergencies among community pharmacists in India.: Methods: Multistage cluster sampling was done. The geographic breakdown was done based on villages and ...

Abstract	Objectives: To identify the predicting factors that contribute to preparedness for public health emergencies among community pharmacists in India. Methods: Multistage cluster sampling was done. The geographic breakdown was done based on villages and areas and used as clusters. A simple random method was done in the first stage to select the villages as clusters. From each selected village, a simple random method was done in the second stage to select the areas. From each selected area, all the community pharmacies were selected. The survey questionnaire had 3 sections with 43 items: (A) demographic information, (B) preparedness, (C) response toward infectious diseases. The participants chose "Yes/No", in sections B and C. A score of 1 was given for "Yes", and a score of zero was given for "No". Results: Multiple correlation analyses were conducted between participants' preparedness and response (PR) scores and independent variables. The independent variables such as "More than one Pharmacist working in a pharmacy", "Pharmacists who are trained more than once on disaster management", and encountered more than 1 patient with the infectious disease were positively and significantly correlated with the dependent variable (PR scores). Conclusions: Community pharmacists were aware of the issues they may face in their community concerning public health emergencies. They believed that the medications available in their pharmacy are sufficient to face any emergency. They could identify the clinical manifestations of public health emergency conditions and provide counselling to the customers toward them. Community pharmacists who were trained more than once in disaster management were the strongest predicting factor.
MeSH term(s)	Humans ; Pharmacists ; Public Health ; Emergencies ; Community Pharmacy Services ; Social Determinants of Health ; Workforce
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2023.155
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Article ; Online: Implications of solid waste dumps on the microplastic abundance in groundwater in Kollam, India.

Priya, K L / Iqbal, Shabana / Archana, A R / Gopika, B / Mina, Michi / Haddout, S / M Madhu, Athul

Journal of environmental management

2023 Volume 348, Page(s) 119224

Abstract: Water pollution caused by microplastics has garnered increasing attention in recent years due to its potential ecological and human health risks. However, there are very limited studies and a general lack of consensus regarding the presence and negative ... ...

Abstract	Water pollution caused by microplastics has garnered increasing attention in recent years due to its potential ecological and human health risks. However, there are very limited studies and a general lack of consensus regarding the presence and negative impacts of microplastics in groundwater. Due to their small size, microplastics can easily be transported at surface as well as subsurface levels, potentially reaching the groundwater table and contaminating the groundwater system This contamination is expected to occur more rapidly in landfill areas and other locations where plastic waste is dumped. In this study, we examined well water samples collected from areas near various dumping sites to assess the abundance and characteristics of microplastics. An average of 12 items/L of microplastics were found in groundwater wells near eight dumping sites in Kollam Corporation. The predominant shape of microplastics in the groundwater samples was fibres, followed by flakes, with black being the predominant colour. The areal extent of solid waste dumping was observed to have an influence on the abundance of microplastics. Additionally, the pH of groundwater near heavy dumping sites was found to be in the acidic range, indicating the intrusion of leachate from dumps into groundwater. The study revealed that the leachate from solid waste dumps is the primary source of microplastics in groundwater. Furthermore, a risk assessment of the microplastic pollution was carried out using an index namely Microplastic Pollution Index and the areas of high risks were identified. The locations having heavy solid waste dumping and those near coastal areas were observed to be at high risk, thereby indicating that both the leachate from dumps and sea water intrusion can cause higher microplastic pollution risk in the groundwater system. The findings of this study are expected to support managers in formulating and implementing effective solid waste management plans to mitigate microplastic pollution in the groundwater system.
MeSH term(s)	Humans ; Solid Waste/analysis ; Microplastics ; Refuse Disposal ; Plastics ; Environmental Monitoring ; Water Pollutants, Chemical/analysis ; Groundwater ; Waste Disposal Facilities ; India ; Water Pollution
Chemical Substances	Solid Waste ; Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119224
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Article ; Online: Addressing the decline in graduate students' mental well-being.

SenthilKumar, Gopika / Mathieu, Natalia M / Freed, Julie K / Sigmund, Curt D / Gutterman, David D

American journal of physiology. Heart and circulatory physiology

2023 Volume 325, Issue 4, Page(s) H882–H887

Abstract: At the American Physiology Summit 2023 session entitled, "Mental Health for Graduate Students," numerous students expressed struggling with poor mental well-being primarily because of negative experiences during their graduate training. In fact, studies ... ...

Abstract	At the American Physiology Summit 2023 session entitled, "Mental Health for Graduate Students," numerous students expressed struggling with poor mental well-being primarily because of negative experiences during their graduate training. In fact, studies show that up to 50% of graduate students report symptoms of depression, anxiety, or burnout during their training, and poor mental well-being is a major contributor to students' decision to leave academia. Most of the current solutions focus on treatment or wellness strategies; while these are important and necessary, the training environment or culture that often contributes to worsening well-being continues to persist. In this collaborative article between trainees and mentors across various career stages, we discuss how the pace of scientific advancements and the associated competition, lack of sufficient support for students from diverse backgrounds, and mentor-mentee relationships crucially influence graduate students' mental well-being. We then offer specific solutions at the individual, institutional, and national levels that can serve as a starting point for improving graduate students' mental health and overall training experience.
MeSH term(s)	Humans ; Mental Health ; Psychological Well-Being ; Students
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Editorial
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00466.2023
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Article ; Online: Aptamers: Features, Synthesis and Applications.

P U, Aiswarya / Raj, Gopika / John, Jinju / Mohan K, Malavika / John, Franklin / George, Jinu

Chemistry & biodiversity

2023 Volume 20, Issue 10, Page(s) e202301008

Abstract: Aptamers have become a topic of interest among the researchers and scientists since they not only possess all of the benefits of antibodies but also possess special qualities including heat stability, low cost, and limitless uses⋅ Here we give a review ... ...

Abstract	Aptamers have become a topic of interest among the researchers and scientists since they not only possess all of the benefits of antibodies but also possess special qualities including heat stability, low cost, and limitless uses⋅ Here we give a review about the features, applications, and challenges of aptamers and also how they are beneficial over the antibodies for biomedical applications. Their unique features make aptamers a prominent tool in therapeutics, diagnostics, biosensors and targeted drug delivery. In conclusion, aptamers represent exciting materials for a variety of applications and can be modified to improve their properties and to extend their applications in biomedical field.
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301008
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Article ; Online: Civet latrines in three habitats of a coffee dominated landscape of the Western Ghats biodiversity hotspot.

Sinu, Palatty Allesh / Fahira, P P / Rajesh, T P / Viswan, Gopika / Manoj, K / Hariraveendra, M / Jose, Thomas

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22698

Abstract: Civets are frugivorous animals in the Order Carnivora. They are relatively less shy towards people and anthropogenic habitats. It has been reported that the civets' preference of defecating in open sites enable them to be important seed dispersers of ... ...

Abstract	Civets are frugivorous animals in the Order Carnivora. They are relatively less shy towards people and anthropogenic habitats. It has been reported that the civets' preference of defecating in open sites enable them to be important seed dispersers of degraded forests and urban ecosystems of Asia and Africa. We surveyed for scats of palm civet (Paradoxurus hermaphroditus) in forest fragments of sacred groves (closed), coffee plantations (partly closed) and home gardens (relatively open) during the fruit ripening period of Coffee and Caryota urens - the two preferred fruits of civet - to report the microhabitat characteristics and seed composition of civet latrines. The microhabitat of each scat position - whether on or off the ground and the shade type - was recorded. The scat analysis showed the presence of 4234 seeds belonging to coffee (90.2%), C. urens (9.7%), and an anonymous Rubiacea species (0.10%) in a total of 105 scats collected from coffee plantations (55), home gardens (5), and sacred groves (45). The number of scats sampled from the three habitats was different, but not the number of seeds per scat. Overall, the number of scats increased with the canopy cover, but the trend was different for different habitats. In home garden and coffee plantations, it decreased, but in sacred groves, it increased with the canopy cover. The number of scats sampled above the ground - on tree branches, logs and built-up structures- was more than that was on the ground. The findings contradict the general belief that the civet latrines occur more in open areas than the shaded areas. Because the civet latrines are seen more above ground than on the ground, their efficiency as seed dispersal agent may be examined critically in different contexts.
MeSH term(s)	Humans ; Animals ; Ecosystem ; Viverridae ; Toilet Facilities ; Biodiversity ; Forests ; Trees
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50193-2
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Article: Double Labial Talon Cusp on Permanent Incisior-An Unusual Occurrence.

Arulraj, Peterlouis / Manoharan, Gv Murali Gopika / Vijayalakshmi, Dhanaraj / Ramamoorthy, Kolappan / Kedarnath, Priyadharshini Subramaniam / Senthilkumaran, Mathivanan

Journal of pharmacy & bioallied sciences

2023 Volume 15, Issue Suppl 1, Page(s) S789–S791

Abstract: A labial or lingual talon cusp is a well distinct extra cusp that is positioned on the plane or surface of the tooth of either upper or lower tooth usually covers an area of at least fifty percent of the teeth extends from the CEJ to the edge of the ... ...

Abstract	A labial or lingual talon cusp is a well distinct extra cusp that is positioned on the plane or surface of the tooth of either upper or lower tooth usually covers an area of at least fifty percent of the teeth extends from the CEJ to the edge of the incisors. A talon cusp is considered be an extra or an accessory cusp enlarges from cingulum and to continually enlarge to be a fully formed cusp. Around three fourth of all documented talon cusps are present in the permanent dentition. The usual radiographic finding is a double teeth appearance. Here, we shared one case report of rare entity of double talon or eagle cusp on permanent central incisor.
Language	English
Publishing date	2023-07-05
Publishing country	India
Document type	Case Reports
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_594_22
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Article ; Online: Rare and complicated functional posterior mediastinal paraganglioma.

SenthilKumar, Gopika / Rokkas, Chris K / Sheinin, Yuri M / Linsky, Paul L

BMJ case reports

2022 Volume 15, Issue 6

Abstract: Functional mediastinal paragangliomas (PGs) are rare, catecholamine-secreting tumours. Surgical resection is the preferred treatment, but it can be complicated by catecholamine-related symptoms, involvement of cardiac structures and/or tumour supply from ...

Abstract	Functional mediastinal paragangliomas (PGs) are rare, catecholamine-secreting tumours. Surgical resection is the preferred treatment, but it can be complicated by catecholamine-related symptoms, involvement of cardiac structures and/or tumour supply from major blood vessels. We report a case of a man in his 30s with a subcarinal functional PG complicated by all three factors. The PG had arterial supplies from the right coronary and bronchial arteries, with mass effect on the left atrium. Given the high risk of intraoperative bleeding, catecholamine surges and injury to right coronary artery, we attempted a minimally invasive strategy that incorporates best practices from the few published cases on functional PGs. We show that a multidisciplinary approach involving alpha/beta blockade, preoperative embolisation of tumour blood supply, robotic-assisted tumour mobilisation and, if needed, open resection with cardiopulmonary bypass can be a safe strategy in the treatment of functional mediastinal paragangliomas adherent to cardiac structures.
MeSH term(s)	Catecholamines ; Humans ; Male ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/surgery ; Mediastinum ; Paraganglioma/complications ; Paraganglioma/diagnostic imaging ; Paraganglioma/surgery ; Paraganglioma, Extra-Adrenal
Chemical Substances	Catecholamines
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-250500
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Article ; Online: Functionally Graded Bioactive Composites Based on Poly(vinyl alcohol) Made through Thiol-Ene Click Reaction.

Adarsh, Rajeswari K / Das, Eva C / Gopan, Gopika V / Selvam, Shivaram / Komath, Manoj

ACS omega

2022 Volume 7, Issue 33, Page(s) 29246–29255

Abstract: Functionally graded materials (FGMs) composed of a polymer matrix embedded with calcium phosphate particles are preferred for bone tissue engineering, as they can mimic the hierarchical and gradient structure of bones. In this study, we report the design ...

Abstract	Functionally graded materials (FGMs) composed of a polymer matrix embedded with calcium phosphate particles are preferred for bone tissue engineering, as they can mimic the hierarchical and gradient structure of bones. In this study, we report the design and development of a FGM based on thiolated poly(vinyl alcohol) (TPVA) and nano-hydroxyapatite (nano-HA) with graded bioactivity, cell compatibility, and degradability properties that are conducive for bone regeneration. The polymer matrix comprises crosslinked poly(vinyl alcohol) with ester and thioether linkages formed via the thiol-ene click reaction, avoiding undesired additives and byproducts. Freshly precipitated and spray-dried HA was mixed with the TPVA hydrogel, and layers of varying concentrations were cast. Upon lyophilization, the hydrogel structure yielded porous sheets of the graded composite of TPVA and nano-HA. The new FGM showed higher values of tensile strength and degradation in phosphate buffer saline (PBS)
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03382
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