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  1. Article: Plasma Kallikrein Inhibitors as Potential Treatment for Diabetic Macular Edema, Retinal Vein Occlusion, Hereditary Angioedema and Other Related Diseases.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 2, Page(s) 129–130

    Abstract: The invention in this patent application relates to ( ...

    Abstract The invention in this patent application relates to (
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Targeting the Inhibition of B-Cell Lymphoma 2 Protein for the Treatment of Cancer.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 10, Page(s) 1320–1322

    Abstract: The invention in this patent application relates to 1,3,4,7-tetrahydro- ... ...

    Abstract The invention in this patent application relates to 1,3,4,7-tetrahydro-2
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Inhibitors of Interleukin 4 Induced Protein 1 (IL4I1) as Potential Treatment for Cancer.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 2, Page(s) 127–128

    Abstract: The invention in this patent application relates to piperazine-2,3-dione derivatives represented generally by formula 1. These compounds show activities as selective interleukin 4 induced protein 1 (IL4I1) inhibitors and may potentially be useful in ... ...

    Abstract The invention in this patent application relates to piperazine-2,3-dione derivatives represented generally by formula 1. These compounds show activities as selective interleukin 4 induced protein 1 (IL4I1) inhibitors and may potentially be useful in preventing and treating IL4Il-related diseases, such as endometrial, ovarian, and triple negative breast cancers.
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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  4. Article: Inhibitors of Son of Sevenless Isoform 1 (SOS1) as a Potential Treatment for RAS Mutant Cancers.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 15, Issue 1, Page(s) 9–11

    Abstract: The invention in this patent application relates to 1-aminophthalazine derivatives represented generally by formula 1. These compounds are inhibitors of the interaction of the catalytic site of SOS1 with RAS-family proteins which are involved in ... ...

    Abstract The invention in this patent application relates to 1-aminophthalazine derivatives represented generally by formula 1. These compounds are inhibitors of the interaction of the catalytic site of SOS1 with RAS-family proteins which are involved in controlling cell proliferation. They may potentially be used as a treatment for RAS mutant cancers such as pancreatic, lung, and colorectal cancers, cholangiocarcinoma, multiple myeloma, melanoma, and thyroid cancer.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 15, Issue 1, Page(s) 6–8

    Abstract: The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating ... ...

    Abstract The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer's disease, Parkinson's disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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  6. Article: The Potential of NOD-like Receptor Protein 3 Inflammasome Inhibitors in the Treatments of Diseases.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 10, Page(s) 1323–1325

    Abstract: The invention in this patent application relates to 4-aminopyridazin-6-one derivatives represented generally by formula 1. These compounds are inhibitors of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and may potentially provide a useful ...

    Abstract The invention in this patent application relates to 4-aminopyridazin-6-one derivatives represented generally by formula 1. These compounds are inhibitors of the NOD-like receptor protein 3 (NLRP3) inflammasome pathway and may potentially provide a useful treatment for one or more of the diseases and disorders mediated by NLRP3, including but not limited to immune diseases, inflammatory diseases, autoimmune diseases, autoinflammatory fever syndromes, cryopyrin-associated periodic syndrome, chronic liver disease, kidney-related disease, hyperoxaluria, lupus nephritis, Type I and Type II diabetes, nephropathy, neurodegenerative diseases, Alzheimer's disease, cardiovascular diseases, metabolic diseases and many more.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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    Inter-library loan at ZB MED

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  7. Article: Orexin Receptor Agonists as Possible Treatment for Narcolepsy and Idiopathic Hypersomnia.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 9, Page(s) 1411–1412

    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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    Inter-library loan at ZB MED

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  8. Article: Combination of Cyclin-Dependent Kinase 4 Inhibitors and Androgen Receptor Inhibitors as Cancer Therapy.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 9, Page(s) 1408–1410

    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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  9. Article: Inhibitors of Transforming Growth Factor Beta Receptor 1 (TGFβr1) May Enhance the Efficacy of Several Monoclonal Antibodies as Cancer Therapy.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 9, Page(s) 1405–1407

    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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  10. Article: Adenosine Receptor Antagonists as Potential Cancer Therapy.

    Abdel-Magid, Ahmed F

    ACS medicinal chemistry letters

    2021  Volume 12, Issue 12, Page(s) 1892–1893

    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.1c00620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

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