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  1. Article: Influence of Preaging Temperature on the Indentation Strength of 3Y-TZP Aged in Ambient Atmosphere.

    Jeong, Ki-Won / Han, Jung-Suk / Yang, Gi-Uk / Kim, Dae-Joon

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 11

    Abstract: Yttria-stabilized zirconia (3Y-TZP) containing 0.25% ... ...

    Abstract Yttria-stabilized zirconia (3Y-TZP) containing 0.25% Al
    Language English
    Publishing date 2021-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14112767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aurora kinase A promotes hepatitis B virus replication and expression.

    Jeong, Gi Uk / Ahn, Byung-Yoon

    Antiviral research

    2019  Volume 170, Page(s) 104572

    Abstract: Cellular protein kinases play critical roles in various steps of the hepatitis B virus life cycle. We found that viral replication in infected or transfected hepatoma cell was markedly inhibited by treatment with A-443654, a specific inhibitor of Akt. ... ...

    Abstract Cellular protein kinases play critical roles in various steps of the hepatitis B virus life cycle. We found that viral replication in infected or transfected hepatoma cell was markedly inhibited by treatment with A-443654, a specific inhibitor of Akt. The antiviral mechanism of the drug mainly depended on the downregulation of Aurora A, a protein kinase that plays an essential role in mitosis but has not been implicated in the viral life cycle. Our data indicated that Aurora kinase A enhances viral replication and expression independently of its kinase activity required for mitotic function. Our findings suggest that mitotic kinases, considered to be an attractive target of antitumor agents, also provide a novel target for the development of antiviral therapy.
    MeSH term(s) Antiviral Agents/pharmacology ; Aurora Kinase A/antagonists & inhibitors ; Aurora Kinase A/genetics ; Down-Regulation ; Enzyme Inhibitors/pharmacology ; HeLa Cells ; Hep G2 Cells ; Hepatitis B virus/drug effects ; Hepatitis B virus/physiology ; Humans ; Indazoles/pharmacology ; Indoles/pharmacology ; Virus Replication/drug effects
    Chemical Substances A 443654 ; Antiviral Agents ; Enzyme Inhibitors ; Indazoles ; Indoles ; AURKA protein, human (EC 2.7.11.1) ; Aurora Kinase A (EC 2.7.11.1)
    Language English
    Publishing date 2019-07-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2019.104572
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Highly visible-light-active sulfur and carbon co-doped TiO

    An, Ha-Rim / Lim, Chaehun / Min, Chung Gi / Son, Byoungchul / Kim, Chang-Yeon / Park, Ji-In / Kim, Jong Pil / Jeong, Yesul / Seo, Jiwon / Lee, Moonsang / Park, Jihyang / Lee, Young-Seak / Lee, Hyun Uk

    Chemosphere

    2024  Volume 355, Page(s) 141859

    Abstract: To promptly and simply create highly crystalline S/C co-doped ... ...

    Abstract To promptly and simply create highly crystalline S/C co-doped TiO
    MeSH term(s) Carbon/chemistry ; Light ; Anti-Bacterial Agents ; Tetracycline ; Sulfur ; Titanium/chemistry ; Catalysis
    Chemical Substances Carbon (7440-44-0) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Sulfur (70FD1KFU70) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141859
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effect of Interstitial Lung Abnormality on Concurrent Chemoradiotherapy-treated Stage III Non-small Cell Lung Cancer Patients.

    Jeong, Won Gi / Kim, Yun-Hyeon / Ahn, Sung-Ja / Jeong, Jae-Uk / Lee, Byung Chan / Cho, Ick Joon / Kim, Yong-Hyub

    Anticancer research

    2023  Volume 43, Issue 4, Page(s) 1797–1807

    Abstract: Background/aim: Pre-treatment interstitial lung abnormality (ILA) is associated with post-cancer treatment adverse events and high mortality rate in lung cancer patients. This study aimed to assess whether ILA affects the survival and development of ... ...

    Abstract Background/aim: Pre-treatment interstitial lung abnormality (ILA) is associated with post-cancer treatment adverse events and high mortality rate in lung cancer patients. This study aimed to assess whether ILA affects the survival and development of symptomatic radiation pneumonitis (RP) in unresectable stage III non-small cell lung cancer (NSCLC) patients who had undergone definitive concurrent chemoradiotherapy (CCRT).
    Patients and methods: Data of stage III NSCLC patients who underwent definitive CCRT between January 2010 and November 2017 were retrospectively collected. Univariate and multivariate regression analyses were performed to evaluate the risk factors for symptomatic RP. The association between pre-treatment ILA and survival was assessed using Kaplan-Meier analysis with log-rank test and Cox proportional hazards regression.
    Results: This study included 201 patients (188 men) of a mean age of 64.7±7.3 years. Pre-treatment ILA and fibrotic ILA were observed in 21.9% and 12.9% of the patients, respectively. Symptomatic RP (grade ≥2) occurred in 13.5% of the patients. Fibrotic ILA was a significant risk factor for grade ≥2 RP and grade ≥3 RP (p=0.004 and 0.033, respectively). The survival rate was significantly poorer in patients with fibrotic ILA than in those without ILA. Cox proportional hazards regression revealed that fibrotic ILA was an independent risk factor for mortality (p<0.001).
    Conclusion: Pre-treatment fibrotic ILA is significantly associated with symptomatic RP and poor survival in unresectable stage III NSCLC patients who have undergone definitive CCRT. CCRT should be cautiously performed in patients presenting pre-treatment fibrotic ILA to prevent adverse outcomes.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Radiation Pneumonitis/etiology ; Chemoradiotherapy/adverse effects ; Lung Diseases, Interstitial/complications ; Lung
    Language English
    Publishing date 2023-02-22
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16333
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Bilateral sequential sudden sensorineural hearing loss in protein S deficiency.

    Park, Euyhyun / Lee, Sun-Uk / Choi, Jeong-Yoon / Im, Gi Jung / Yu, Sungwook / Kim, Ji-Soo

    Journal of neurology

    2021  Volume 268, Issue 3, Page(s) 1110–1113

    MeSH term(s) Hearing Loss, Sensorineural/etiology ; Hearing Loss, Sudden/etiology ; Humans ; Protein S Deficiency
    Language English
    Publishing date 2021-01-08
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-10384-7
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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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  6. Article ; Online: Iridium(III)-Catalyzed B(4)-Acylmethylation and B(3,5)-Diacylmethylation from

    Ko, Gi Hoon / Um, Kyusik / Noh, Hee Chan / Kim, Jin Young / Jeong, Haneal / Maeng, Chanyoung / Han, Sang Hoon / Han, Gi Uk / Lee, Phil Ho

    Organic letters

    2022  Volume 24, Issue 8, Page(s) 1604–1609

    Abstract: An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)-H bond ... ...

    Abstract An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)-H bond in
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00103
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  7. Article ; Online: Rhodium(III)-Catalyzed Sequential C-H Activation and Cyclization from N-Methoxyarylamides and 3-Diazooxindoles for the Synthesis of Isochromenoindolones.

    Ko, Gi Hoon / Maeng, Chanyoung / Jeong, Haneal / Han, Sang Hoon / Han, Gi Uk / Lee, Kyungsup / Noh, Hee Chan / Lee, Phil Ho

    Chemistry, an Asian journal

    2021  Volume 16, Issue 20, Page(s) 3179–3187

    Abstract: An efficient synthetic method for structurally various isochromenoindolones has been demonstrated through Rh(III)-catalyzed C-H activation followed by a cyclization reaction of N-methoxyarylamides with 3-diazooxindoles. The sequential reaction involves ... ...

    Abstract An efficient synthetic method for structurally various isochromenoindolones has been demonstrated through Rh(III)-catalyzed C-H activation followed by a cyclization reaction of N-methoxyarylamides with 3-diazooxindoles. The sequential reaction involves the streamlined formation of C-C and C-O bonds in one pot. The present method provides a broad range of isochromenoindolones as a new privileged scaffold in moderate to good yields with the release of methoxyamine and molecular nitrogen and has the benefits of a broad substrate scope and good functional group tolerance.
    Language English
    Publishing date 2021-08-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202100797
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  8. Article: Iridium(III)-Catalyzed B(4)-Acylmethylation and B(3,5)-Diacylmethylation from o-Carboranes and Sulfoxonium Ylides

    Ko, Gi Hoon / Um, Kyusik / Noh, Hee Chan / Kim, Jin Young / Jeong, Haneal / Maeng, Chanyoung / Han, Sang Hoon / Han, Gi Uk / Lee, Phil Ho

    Organic letters. 2022 Feb. 17, v. 24, no. 8

    2022  

    Abstract: An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)–H bond in o-carborane acids with sulfoxonium ylides is demonstrated through B(4)–H activation in ethanol under very mild conditions, affording a number of B(4)-acylmethylated o- ... ...

    Abstract An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)–H bond in o-carborane acids with sulfoxonium ylides is demonstrated through B(4)–H activation in ethanol under very mild conditions, affording a number of B(4)-acylmethylated o-carboranes. Additionally, the selective sequential B(4)- and B(6)-acylmethylation reactions finally gave B(3,5)-diacylmethylated o-carboranes in one pot.
    Keywords ethanol ; iridium ; regioselectivity
    Language English
    Dates of publication 2022-0217
    Size p. 1604-1609.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c00103
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Pathological Evaluation of Porcine Circovirus 2d (PCV2d) Strain and Comparative Evaluation of PCV2d and PCV2b Inactivated Vaccines against PCV2d Infection in a Specific Pathogen-Free (SPF) Yucatan Miniature Pig Model.

    Noh, Yun-Hee / Kim, Seung-Chai / Jeong, Chang-Gi / Lee, Seung-Chul / Lee, Dong-Uk / Yoon, In-Joong / Kim, Won-Il

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: Porcine circovirus type 2 (PCV2) is an economically important swine pathogen that causes porcine circovirus-associated diseases (PCVADs). The objective of this study was to evaluate the use of specific pathogen-free Yucatan miniature pigs (YMPs) as an ... ...

    Abstract Porcine circovirus type 2 (PCV2) is an economically important swine pathogen that causes porcine circovirus-associated diseases (PCVADs). The objective of this study was to evaluate the use of specific pathogen-free Yucatan miniature pigs (YMPs) as an experimental model for PCV2d challenge and vaccine assessment because PCV2-negative pigs are extremely rare in conventional swine herds in Korea. In the first experiment, every three pigs were subjected to PCV2d field isolate or mock challenge. During three weeks of experiments, the PCV2d infection group exhibited clinical outcomes of PCVAD with high viral loads, lymphoid depletion, and detection of PCV2d antigens in lymphoid organs by immunohistochemistry. In the second experiment, three groups of pigs were challenged with PCV2d after immunization for three weeks: a nonvaccinated group (three pigs), a PCV2b-Vac group vaccinated with a commercial PCV2b-based inactivated vaccine SuiShot
    Language English
    Publishing date 2022-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091469
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  10. Article ; Online: Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

    Dong Uk Lee / Mukhammad Kayumov / Junghun Park / Se Kye Park / Yeongkwon Kang / Yejin Ahn / Woojin Kim / Seung Hwa Yoo / Jun-Kyu Park / Bong-Gi Kim / Yong Suk Oh / In-Seok Jeong / Dong Yun Choi

    Bioactive Materials, Vol 34, Iss , Pp 112-

    2024  Volume 124

    Abstract: Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections, thrombosis, and intimal lesions caused by surface friction. However, achieving effective prevention of both bloodstream-associated infections and ... ...

    Abstract Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections, thrombosis, and intimal lesions caused by surface friction. However, achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities, specifically regarding electrostatic interactions. This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan (ZW@CMC) with antibacterial and antithrombotic activities for use in catheters. The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties, which facilitate the formation of a stable hydration layer with low friction. The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group. This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer. This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation. Subsequently, the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity, hemolysis, and catheter friction. Furthermore, in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment. This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.
    Keywords Zwitterionic ; Hydrogel ; Blood-clotting ; Antimicrobial ; Sepsis ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Subject code 600
    Language English
    Publishing date 2024-04-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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