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  1. Article: EFFECT OF RESECTION OF GASTRIN RELEASING REGIONS ON ACID RESPONSE TO SHAM FEEDING AND INSULIN HYPOGLYCEMIA IN PAVLOV POUCH DOGS.

    OLBE, L

    Acta physiologica Scandinavica

    2011  Volume 62, Page(s) 169–175

    MeSH term(s) Animals ; Dogs ; Conditioning, Classical ; Gastric Juice ; Gastrins ; Hypoglycemia ; Insulin ; Pharmacology ; Physiology ; Reflex
    Chemical Substances Gastrins ; Insulin
    Language English
    Publishing date 2011-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 101-6
    ISSN 0001-6772
    ISSN 0001-6772
    DOI 10.1111/j.1748-1716.1964.tb03965.x
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  2. Article: Concept of Crohn's disease being conditioned by four main components, and irritable bowel syndrome being an incomplete Crohn's disease.

    Olbe, Lars

    Scandinavian journal of gastroenterology

    2008  Volume 43, Issue 2, Page(s) 234–241

    Abstract: Several mechanisms have been proposed for the development of Crohn's disease. Evidence in favour of a unifying 4-component concept to explain the development of Crohn's disease is presented. The four components are a genetic predisposition to an ... ...

    Abstract Several mechanisms have been proposed for the development of Crohn's disease. Evidence in favour of a unifying 4-component concept to explain the development of Crohn's disease is presented. The four components are a genetic predisposition to an increased intestinal permeability, the key and initial triggering factor being an oral-pharyngeal bacterium that increases the mucosal permeability of the small intestine with only a minimal inflammatory reaction, an adherent-invasive strain of Escherichia coli that penetrates the mucosa and causes an acute inflammatory reaction in the intestinal wall, and finally a secondary invasion of bacteria causing the chronic inflammatory characteristics. Irritable bowel syndrome (IBS) is a functional bowel disorder with intermittent symptoms of varying intensity. Clinically, there is evidence to suggest a link between IBS patients with diarrhoea and patients with Crohn's disease. The common denominator and initial trigger for IBS with diarrhoea and Crohn's disease seems to be an increased small intestinal permeability, probably caused by an oral-pharyngeal bacterial strain. The important missing factor in IBS patients seems to be the adherent-invasive strain of E. coli in the proximal colon, causing the acute inflammatory process in patients with Crohn's disease. IBS with diarrhoea can then be looked upon as an incomplete Crohn's disease.
    MeSH term(s) Crohn Disease/microbiology ; Crohn Disease/pathology ; Crohn Disease/physiopathology ; Diarrhea/microbiology ; Diarrhea/pathology ; Diarrhea/physiopathology ; Humans ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Intestinal Mucosa/physiopathology ; Irritable Bowel Syndrome/microbiology ; Irritable Bowel Syndrome/pathology ; Irritable Bowel Syndrome/physiopathology
    Language English
    Publishing date 2008
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365520701676971
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  3. Article: Strong activation of PAR-2 receptors: a common trigger for the development of gastrointestinal adenocarcinomas?

    Olbe, Lars

    Scandinavian journal of gastroenterology

    2007  Volume 42, Issue 9, Page(s) 1133–1137

    Abstract: Helicobacter pylori infection is considered to be an important factor in the development of gastric cancer, while duodenogastroesophageal reflux is claimed to be the main cause of development of esophageal adenocarcinoma. A pronounced activation of PAR-2 ...

    Abstract Helicobacter pylori infection is considered to be an important factor in the development of gastric cancer, while duodenogastroesophageal reflux is claimed to be the main cause of development of esophageal adenocarcinoma. A pronounced activation of PAR-2 receptors may be a common denominator in triggering the development of these cancers, and possibly pancreatic and colonic cancers as well. Evidence supporting such a concept is presented.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/microbiology ; Animals ; Barrett Esophagus/etiology ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/metabolism ; Gastric Acid/chemistry ; Gastric Acid/secretion ; Gastroesophageal Reflux/complications ; Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Rats ; Receptor, PAR-2/biosynthesis ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Trypsin/biosynthesis ; Trypsin/metabolism
    Chemical Substances Receptor, PAR-2 ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365520601175983
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  4. Article: Therapeutic applications of vagotomy.

    Olbe, L

    The Yale journal of biology and medicine

    1994  Volume 67, Issue 3-4, Page(s) 153–157

    Abstract: The treatment of the peptic ulcer disease involves several options. The present discussion deals with the long-term management with emphasis on the application of vagotomy. Eradication of Helicobacter pylori is the treatment of choice in ordinary peptic ... ...

    Abstract The treatment of the peptic ulcer disease involves several options. The present discussion deals with the long-term management with emphasis on the application of vagotomy. Eradication of Helicobacter pylori is the treatment of choice in ordinary peptic ulcer patients. Exceptions are non-steroidal, anti-inflammatory drug-induced ulcers and the Zollinger-Ellison syndrome. Failures to eradicate H. pylori in old or unfit duodenal ulcer patients and most gastric ulcer patients will lead to intermittent antisecretory treatment or continuous maintenance treatment. Maintenance treatment will usually mean lifelong treatment, and optimal results are probably obtained with a full-dose antisecretory regime. Failures to eradicate H. pylori in young and fit duodenal ulcer patients is the group of patients to whom proximal gastric vagotomy can still be recommended as an elective surgical procedure. The proximal gastric vagotomy should preferably be performed with the laparoscopic technique. Evidence is presented that completeness of vagotomy is of clinical importance. The completeness of vagotomy can be tested and defined.
    MeSH term(s) Duodenal Ulcer/therapy ; Gastric Acid/secretion ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Peptic Ulcer/therapy ; Vagotomy
    Language English
    Publishing date 1994-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
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  5. Article: INHIBITION OF GASTRIC ACID RESPONSE TO SHAM FEEDING IN PAVLOV POUCH DOGS BY ACIDIFICATION OF ANTRUM.

    ANDERSSON, S / OLBE, L

    Acta physiologica Scandinavica

    2005  Volume 61, Page(s) 55–64

    MeSH term(s) Animals ; Dogs ; Food ; Gastric Acid ; Gastric Acidity Determination ; Gastric Juice ; Gastrins ; Hydrogen-Ion Concentration ; Pharmacology ; Stomach ; Vagus Nerve
    Chemical Substances Gastrins
    Language English
    Publishing date 2005-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 101-6
    ISSN 0001-6772
    ISSN 0001-6772
    DOI 10.1111/j.1748-1716.1964.tb02942.x
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  6. Article ; Online: Expression of protease-activated-receptor 2 (PAR-2) in human esophageal mucosa.

    Inci, Kamuran / Edebo, Anders / Olbe, Lars / Casselbrant, Anna

    Scandinavian journal of gastroenterology

    2009  Volume 44, Issue 6, Page(s) 664–671

    Abstract: Objective: The role of duodenal reflux in gastroesophageal reflux disease (GERD) containing bile salts and pancreatic enzymes (with special attention to trypsin) is still under discussion. Proteinase-activated receptors (PARs) are a novel family and PAR- ...

    Abstract Objective: The role of duodenal reflux in gastroesophageal reflux disease (GERD) containing bile salts and pancreatic enzymes (with special attention to trypsin) is still under discussion. Proteinase-activated receptors (PARs) are a novel family and PAR-2 is a unique member of this family because it is activated by trypsin. The aim of the present study was to examine the presence and the position of the PAR-2 receptor in human esophageal mucosa in different subgroups of GERD.
    Material and methods: Distal biopsies taken from healthy controls, patients with erosive reflux disease (ERD), patients with specialized intestinal metaplasia (SIM) and adenocarcinoma were analyzed for the PAR-2 receptor with reverse-transcription polymerase chain reaction (RT-PCR), Western blotting and immunohistochemistry.
    Results: Gene transcripts for the PAR-2 receptor were found in all groups, with increased levels in SIM patients compared to controls. However, this visual pattern was not seen for the protein expression of the PAR-2 receptor showing no apparent quantitative differences between the groups. Immunohistochemistry revealed distinct staining for the PAR-2 receptor in the luminal part of the esophageal epithelium.
    Conclusions: The localization of the PAR-2 receptor indicates that the receptor can be cleaved and activated by trypsin in duodenogastric esophageal refluxate. The data thus suggest that the trypsin-PAR-2 pathway may be involved in the pathogenesis of GERD.
    MeSH term(s) Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophagus/metabolism ; Esophagus/pathology ; Female ; Gastroesophageal Reflux/genetics ; Gastroesophageal Reflux/pathology ; Gene Expression ; Humans ; Male ; Metaplasia/genetics ; Metaplasia/pathology ; Middle Aged ; Mucous Membrane/metabolism ; Mucous Membrane/pathology ; Receptor, PAR-2/biosynthesis
    Chemical Substances Receptor, PAR-2
    Language English
    Publishing date 2009
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365520902783683
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  7. Article: The pathophysiology of gastric ulcer.

    Olbe, L

    Scandinavian journal of gastroenterology. Supplement

    1979  Volume 55, Page(s) 49–55

    MeSH term(s) Animals ; Gastric Juice/analysis ; Gastric Juice/secretion ; Humans ; Stomach Ulcer/physiopathology
    Language English
    Publishing date 1979
    Publishing country England
    Document type Journal Article
    ISSN 0085-5928
    ISSN 0085-5928
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  8. Article: The influence of Helicobacter pylori infection on postprandial duodenal acid load and duodenal bulb pH in humans.

    Hamlet, A / Olbe, L

    Gastroenterology

    1996  Volume 111, Issue 2, Page(s) 391–400

    Abstract: Background & aims: Recently, we postulated a new concept of duodenal ulcer pathogenesis suggesting that antral Helicobacter pylori infection blocks inhibitory pathways to the gastrin and parietal cells, resulting in an increased and prolonged ... ...

    Abstract Background & aims: Recently, we postulated a new concept of duodenal ulcer pathogenesis suggesting that antral Helicobacter pylori infection blocks inhibitory pathways to the gastrin and parietal cells, resulting in an increased and prolonged postprandial acid secretion. the aim of this study was to examine duodenal acid load and duodenal bulb pH after a meal before and after eradication of H. pylori.
    Methods: Using a marker-dilution method and a pH electrode in the duodenal bulb, gastric emptying, acid secretion, gastrin release, duodenal acid load, and duodenal bulb pH were studied during 2 hours after peptone meals of pH 7.0 and 2.0 in 8 H. pylori-negative controls and 8 H. pylori-infected subjects before and 6 months after eradication.
    Results: The H. pylori-infected subjects had an increased gastric emptying, gastrin release, and acid secretion, higher duodenal acid load, and lower duodenal bulb pH after the meals. These responses were normalized after eradication.
    Conclusions: H. pylori-infected subjects have an increased and prolonged postprandial acid secretion, partly caused by an impaired low pH inhibition of acid secretion, gastrin release, and gastric emptying, resulting in an increased duodenal acid load and a prolongation of low pH in the duodenal bulb, as a general prerequisite for the development of duodenal ulcer disease.
    MeSH term(s) Adult ; Duodenum/metabolism ; Eating ; Female ; Gastric Acid/metabolism ; Gastric Emptying ; Gastrins/metabolism ; Helicobacter Infections/drug therapy ; Helicobacter Infections/metabolism ; Helicobacter Infections/physiopathology ; Helicobacter pylori ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged
    Chemical Substances Gastrins
    Language English
    Publishing date 1996-08
    Publishing country United States
    Document type Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/gast.1996.v111.pm8690204
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  9. Article: Intragastric CO2 and nitric oxide participate in the regulation of peptone-induced gastrin release in humans.

    Holm, M / Olbe, L / Fändriks, L

    Scandinavian journal of gastroenterology

    2000  Volume 35, Issue 12, Page(s) 1260–1265

    Abstract: ... gastrin ranged between 11 and 23 pmol/l. Peptone in Sörensen's phosphated buffer (pH 6.9, PCO2 0 mmHg ...

    Abstract Background: Moderate acidification of the gastric lumen inhibits peptone-induced gastrin release. The aim of the present study was to investigate if the gastric acid neutralization products CO2 (from secreted HCO3) and NO (from reduced salivary nitrite) could act as intermediate messengers between luminal acidity and the inhibition of peptone-induced gastrin release.
    Methods: Fourteen healthy volunteers (mean age, 27 years; range, 20-39 years; 3 women) participated in the study. Intragastric perfusion with saline or peptone was performed on the healthy volunteers. Venous blood samples were analyzed for serum gastrin concentrations. Intragastric NO was measured by chemiluminescence.
    Results: Basal serum gastrin ranged between 11 and 23 pmol/l. Peptone in Sörensen's phosphated buffer (pH 6.9, PCO2 0 mmHg) increased serum gastrin by 83% +/- 23%, whereas acidified peptone (pH 2.0) did not stimulate gastrin release. Acidified peptone buffered with NaHCO3 to neutrality (pH 6.9, PCO2 approximately 600 mmHg) increased serum gastrin by 166% +/- 29%. Low intragastric NO levels were obtained by deviation of saliva. During such salivary depletion, acidified peptone (pH 2.0) stimulated gastrin release to a level of about 40% of the control response (pH 6.9). This peptone-induced gastrin response during salivary deviation was inhibited by addition of nitrite to the perfusate.
    Conclusions: Acid-induced inhibition of peptone-stimulated gastrin release is partly dependent on intraluminal NO formed in the reaction between salivary nitrite and gastric acid. In addition, the gastric acid neutralization product CO2 seems to potentiate the effect of peptone on gastrin release.
    MeSH term(s) Adult ; Carbon Dioxide/metabolism ; Carbon Dioxide/pharmacology ; Female ; Gastric Mucosa/metabolism ; Gastrins/blood ; Gastrins/metabolism ; Humans ; Hydrogen-Ion Concentration ; Male ; Nitric Oxide/metabolism ; Nitric Oxide/pharmacology ; Peptones/pharmacology ; Saliva/metabolism
    Chemical Substances Gastrins ; Peptones ; Carbon Dioxide (142M471B3J) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2000-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/003655200453593
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  10. Article: A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.

    Olbe, Lars / Carlsson, Enar / Lindberg, Per

    Nature reviews. Drug discovery

    2003  Volume 2, Issue 2, Page(s) 132–139

    MeSH term(s) Animals ; Clinical Trials as Topic ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Esomeprazole ; Humans ; Omeprazole/chemistry ; Omeprazole/pharmacokinetics ; Omeprazole/therapeutic use ; Proton Pump Inhibitors ; Stereoisomerism
    Chemical Substances Enzyme Inhibitors ; Proton Pump Inhibitors ; Omeprazole (KG60484QX9) ; Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2003-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd1010
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