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Article: Impact of loop diuretic dosage in a population of patients with acute heart failure: a retrospective analysis.

Meani, P / Pagnoni, M / Mondellini, G M / Fiorenza, S / Brunner-La Rocca, H P

2023 Volume 10, Page(s) 1267042

Abstract: Background: Loop diuretics are essential for managing congestion in acute heart failure (AHF) patients, but concerns exist about their dosing and administration. This study aims to explore the relationship between aggressive diuretic treatment and ... ...

Abstract	Background: Loop diuretics are essential for managing congestion in acute heart failure (AHF) patients, but concerns exist about their dosing and administration. This study aims to explore the relationship between aggressive diuretic treatment and clinical outcomes in AHF patients. Methods: We randomly selected 370 AHF patients from admissions at Maastricht University Medical Center between January 2011 and March 2017. Patients were divided into four quartiles based on diuretic doses administrated during index hospitalization. The primary endpoint was a composite of cardiovascular (CV) rehospitalization or death at 1 year. Results: 42.4% of patients experimented the primary outcome The composite endpoint rates were 35.4%, 41.6%, 38.5%, and 54.9%, respectively, from lowest to highest dose quartiles ( Conclusions: High loop diuretic doses are associated with poor outcomes in AHF patients, reflecting disease severity rather than harm from aggressive diuretic use. Furthermore, high diuretic doses do not seem to negatively affect kidney function.
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1267042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The MIS-HF in clinical practice.

Gingele, A J / Boyne, J / Knackstedt, C / Brunner-La Rocca, H P

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2022 Volume 30, Issue 12, Page(s) 582–583

Language	English
Publishing date	2022-11-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-022-01731-6
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Article: Phenotypic patient profiling for improved implementation of guideline-directed medical therapy: An exploratory analysis in a large real-world chronic heart failure cohort.

Radhoe, Sumant P / Clephas, Pascal R D / Linssen, Gerard C M / Oortman, Remko M / Smeele, Frank J / Van Drimmelen, Annemarie A / Schaafsma, Henk-Jan / Westendorp, Paul H / Brunner-La Rocca, Hans-Peter / Brugts, Jasper J

Frontiers in pharmacology

2023 Volume 14, Page(s) 1081579

Abstract: Aims: ...

Abstract	Aims:
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1081579
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Article: Introduction of a new scoring tool to identify clinically stable heart failure patients.

Gingele, A J / Brandts, L / Brunner-La Rocca, H P / Cleuren, G / Knackstedt, C / Boyne, J J J

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2022 Volume 30, Issue 9, Page(s) 402–410

Abstract: Introduction: Heart failure (HF) poses a burden on specialist care, making referral of clinically stable HF patients to primary care a desirable goal. However, a structured approach to guide patient referral is lacking.: Methods: The Maastricht ... ...

Abstract	Introduction: Heart failure (HF) poses a burden on specialist care, making referral of clinically stable HF patients to primary care a desirable goal. However, a structured approach to guide patient referral is lacking. Methods: The Maastricht Instability Score-Heart Failure (MIS-HF) questionnaire was developed to objectively stratify the clinical status of HF patients: patients with a low MIS-HF (0-2 points, indicating a stable clinical condition) were considered for treatment in primary care, whereas high scores (> 2 points) indicated the need for specialised care. The MIS-HF was evaluated in 637 consecutive HF patients presenting between 2015 and 2018 at Maastricht University Medical Centre. Results: Of the 637 patients, 329 (52%) had a low score and 205 of these 329 (62%) patients were referred to primary care. The remaining 124 (38%) patients remained in secondary care. Of the 308 (48%) patients with a high score (> 2 points), 265 (86%) remained in secondary care and 41 (14%) were referred to primary care. The primary composite endpoint (mortality, cardiac hospital admissions) occurred more frequently in patients with a high compared to those with a low MIS-HF after 1 year of follow-up (29.2% vs 10.9%; odds ratio (OR) 3.36, 95% confidence interval (CI) 2.20-5.14). No significant difference in the composite endpoint (9.8% vs 12.9%; OR 0.73, 95% CI 0.36-1.47) was found between patients with a low MIS-HF treated in primary versus secondary care. Conclusion: The MIS-HF questionnaire may improve referral policies, as it helps to identify HF patients that can safely be referred to primary care.
Language	English
Publishing date	2022-01-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-021-01654-8
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Article: Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study.

Raafs, Anne G / Adriaans, Bouke P / Henkens, Michiel T H M / Verdonschot, Job A J / Abdul Hamid, Myrurgia A / Díez, Javier / Knackstedt, Christian / van Empel, Vanessa P M / Brunner-La Rocca, Hans-Peter / González, Arantxa / Wildberger, Joachim E / Heymans, Stephane R B / Hazebroek, Mark R

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Background: Collagen cross-linking is a fundamental process in dilated cardiomyopathy (DCM) and occurs when collagen deposition exceeds degradation, leading to impaired prognosis. This study investigated the associations of collagen-metabolism ... ...

Abstract	Background: Collagen cross-linking is a fundamental process in dilated cardiomyopathy (DCM) and occurs when collagen deposition exceeds degradation, leading to impaired prognosis. This study investigated the associations of collagen-metabolism biomarkers with left ventricular function and prognosis in DCM. Methods: DCM patients who underwent endomyocardial biopsy, blood sampling, and cardiac MRI were included. The primary endpoint included death, heart failure hospitalization, or life-threatening arrhythmias, with a follow-up of 6 years (5-8). Results: In total, 209 DCM patients were included (aged 54 ± 13 years, 65% male). No associations were observed between collagen volume fraction, circulating carboxy-terminal propeptide of procollagen type-I (PICP), or collagen type I carboxy-terminal telopeptide [CITP] and matrix metalloproteinase [MMP]-1 ratio and cardiac function parameters. However, CITP:MMP-1 was significantly correlated with global longitudinal strain (GLS) in the total study sample (R = -0.40, Conclusion: The degree of myocardial cross-linking (CITP:MMP-1) is associated with myocardial longitudinal contraction, and MMP-1 is an independent predictor of outcome in DCM patients.
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175695
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Article: Elderly primary care hypertension patients-who to refer for echocardiography?

Bekkers, S C A M / Brunner-La Rocca, H P

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2014 Volume 22, Issue 5, Page(s) 231–233

Language	English
Publishing date	2014-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-014-0550-z
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Article ; Online: Myocardial Fibrosis Assessment Using T1 and ECV Mapping With Histologic Validation in Chronic Dilated Cardiomyopathy.

Raafs, Anne G / Adriaans, Bouke P / Henkens, Michiel T H M / Verdonschot, Job A J / Ramaekers, Mitch J F G / Gommers, Suzanne / Abdul Hamid, Myrurgia A / Schalla, Simon / Knackstedt, Christian / van Empel, Vanessa P M / Brunner-la Rocca, Hans-Peter / Wildberger, J E / Bekkers, Sebastiaan C A M / Hazebroek, Mark R

JACC. Cardiovascular imaging

2022 Volume 15, Issue 10, Page(s) 1828–1830

MeSH term(s)	Cardiomyopathies/pathology ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/pathology ; Contrast Media ; Fibrosis ; Humans ; Magnetic Resonance Imaging, Cine ; Myocardium/pathology ; Predictive Value of Tests
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Letter
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2022.05.002
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Article: Telemedicine in heart failure-more than nice to have?

Eurlings, C G M J / Boyne, J J / de Boer, R A / Brunner-La Rocca, H P

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2018 Volume 27, Issue 1, Page(s) 5–15

Abstract: Telemedicine in chronic diseases like heart failure is rapidly evolving and has two important goals: improving and individualising care as well as reducing costs. In this paper, we provide a critical and an updated review of the current evidence by ... ...

Abstract	Telemedicine in chronic diseases like heart failure is rapidly evolving and has two important goals: improving and individualising care as well as reducing costs. In this paper, we provide a critical and an updated review of the current evidence by discussing the most important trials, meta-analyses and systematic reviews. So far, evidence for the CardioMEMS device is most convincing. Other trials regarding invasive and non-invasive telemonitoring and telephone support show divergent results, but several meta-analyses and systematic reviews uniformly reported a beneficial effect. Voice-over systems and ECG monitoring had neutral results. Lack of direct comparison between different modalities makes it impossible to determine the most effective method. Dutch studies showed predominantly non-significant results, mainly due to underpowered studies or because of a high standard of usual care. There are no conclusive results on cost-effectiveness of telemedicine because of the above shortcomings. The adherence of elderly patients was good in the trials, being essential for the compliance of telemedicine in the entire heart failure population. In the future perspective, telemedicine should be better standardised and evolve to be more than an addition to standard care to improve care and reduce costs.
Language	English
Publishing date	2018-12-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-018-1202-5
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Article: Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands : Design and rationale of the Chronic Heart failure ESC guideline-based Cardiology practice Quality project (CHECK-HF) registry.

Brugts, J J / Linssen, G C M / Hoes, A W / Brunner-La Rocca, H P

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2018 Volume 26, Issue 5, Page(s) 272–279

Abstract: Aims: Data from patient registries give insight into the management of patients with heart failure (HF), but actual data from unselected real-world HF patients are scarce. Therefore, we performed a cross sectional study of current HF care in the period ... ...

Abstract	Aims: Data from patient registries give insight into the management of patients with heart failure (HF), but actual data from unselected real-world HF patients are scarce. Therefore, we performed a cross sectional study of current HF care in the period 2013-2016 among more than 10,000 unselected HF patients at HF outpatient clinics in the Netherlands. Methods: In 34 participating centres, all 10,910 patients with chronic HF treated at cardiology centres were included in the CHECK-HF registry. Of these, most (96%) were managed at a specific HF outpatient clinic. Heart failure was typically diagnosed according to the ESC guidelines 2012, based on signs, symptoms and structural and/or functional cardiac abnormalities. Information on diagnostics, treatment and co-morbidities were recorded, with specific focus on drug therapy and devices. In our cohort, the mean age was 73 years (SD 12) and 60% were male. Frequent co-morbidities reported in the patient records were diabetes mellitus 30%, hypertension 43%, COPD 19%, and renal insufficiency 58%. In 47% of the patients, ischaemia was the origin of HF. In our registry, the prevalence of HF with preserved ejection fraction was 21%. Conclusion: The CHECK-HF registry will provide insight into the current, real world management of patient with chronic HF, including HF with reduced ejection fraction, preserved ejection fraction and mid-range ejection fraction, that will help define ways to improve quality of care. Drug and device therapy and guideline adherence as well as interactions with age, gender and co-morbidities will receive specific attention.
Language	English
Publishing date	2018-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-018-1103-7
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Article ; Online: Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study.

Weerts, Jerremy / Amin, Hesam / Barandiarán Aizpurua, Arantxa / Gevaert, Andreas B / Handoko, M Louis / Dauw, Jeroen / Tun, Han Naung / Rommel, Karl-Philipp / Verbrugge, Frederik H / Kresoja, Karl-Patrik / Sanders-van Wijk, Sandra / Brunner-La Rocca, Hans-Peter / Bayés-Genís, Antoni / Lumens, Joost / Knackstedt, Christian / van Empel, Vanessa P M

ESC heart failure

2023 Volume 10, Issue 6, Page(s) 3493–3503

Abstract: ... the complex HFA-PEFF and H: Methods and results: We developed an online tool, the HFpEF calculator ... were correct in 50% (HFA-PEFF: 50% [50-75]; H: Conclusions: Manual calculation of HFpEF diagnostic ...

Abstract	Aims: Diagnosis of heart failure with preserved ejection fraction (HFpEF) can be challenging. This study aimed to evaluate the potential of a webtool to enhance the scoring accuracy when applying the complex HFA-PEFF and H Methods and results: We developed an online tool, the HFpEF calculator, that enables the automatic calculation of current HFpEF algorithms. We assessed the accuracy of manual vs. automatic scoring, defined as the percentage of correct scores, in a cohort of cardiologists with varying clinical experience. Cardiologists scored eight online clinical cases using a triple cross-over design (i.e. two manual-two automatic-two manual-two automatic). Data were analysed in study completers (n = 55, 29% heart failure specialists, 42% general cardiologists, and 29% cardiology residents). Manually calculated scores were correct in 50% (HFA-PEFF: 50% [50-75]; H Conclusions: Manual calculation of HFpEF diagnostic algorithms is often inaccurate. Using an automated webtool to calculate HFpEF algorithms significantly improved correct scoring. This new approach may impact the eventual diagnostic decision in up to two-thirds of cases, supporting its routine use in clinical practice.
MeSH term(s)	Humans ; Heart Failure/diagnosis ; Cross-Over Studies ; Stroke Volume ; Prospective Studies ; Algorithms
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14525
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