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  1. Article: Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes: a docking study

    Aatika, Sadia Muhammad Azam Basra M. A. R.

    Asian Pacific Journal of Tropical Biomedicine

    Abstract: Objective: To explore potential inhibitors of viral enzymes of SARS CoV- ... ...

    Abstract Objective: To explore potential inhibitors of viral enzymes of SARS CoV-2
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #914613
    Database COVID19

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  2. Article ; Online: Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome.

    Sadia, Aatika / Basra, Muhammad Asim Raza

    Drug development research

    2020  Volume 81, Issue 8, Page(s) 942–949

    Abstract: Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome ... ...

    Abstract Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). As much as the researchers are inundated for the quest of effective treatments from available drugs, the discovery and trials of new experimental drugs are also at a threshold for clinical trials. There has been much concern regarding the new and targeted drugs considering the comprehensive ambiguity regarding the mechanism and pathway of the drug action with respect to the new and unpredictable structural and nonstructural proteins (NSPs) of SARS CoV-2. This study was aimed to discuss functional pathways related to NSPs in CoVs with updated knowledge regarding SARS CoV-2, mechanisms of action of certain approved and investigational drugs for correct orientation regarding the treatment strategies, including nucleotide analog mechanism, receptor analog mechanism, and peptide-peptide interactions, along with the impact of COVID-19 on a global scale. Although there is a dire need for targeted drugs against SARS CoV-2, the practical achievement of its cure is possible by only using effective drugs with appropriate mechanisms to eliminate the disease.
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.

    Samra, Malka M / Sadia, Aatika / Azam, Muhammad / Imran, Muhammad / Ahmad, Irfan / Basra, Muhammad Asim Raza

    Arabian journal for science and engineering

    2022  Volume 47, Issue 6, Page(s) 7105–7122

    Abstract: Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental ... ...

    Abstract Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis,
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Journal Article
    ISSN 2193-567X
    ISSN 2193-567X
    DOI 10.1007/s13369-021-06521-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes

    Aatika Sadia / Muhammad Azam / Muhammad Asim Raza Basra

    Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 12, Pp 563-

    A docking study

    2020  Volume 568

    Abstract: Objective: To explore potential inhibitors of viral enzymes of SARS CoV-2. Methods: The in-silico docked potential of anti-viral, antibiotic, and analgesic drugs were studied for inhibition of the nonstructural protein (NSP) 9, NSP3, and NSP15 of SARS ... ...

    Abstract Objective: To explore potential inhibitors of viral enzymes of SARS CoV-2. Methods: The in-silico docked potential of anti-viral, antibiotic, and analgesic drugs were studied for inhibition of the nonstructural protein (NSP) 9, NSP3, and NSP15 of SARS CoV-2 using recent structural peculiarities of these enzymes, 3D optimized structures of drugs and algorithm-based ligand inhibitory potential. Results: Teicoplanin, azithromycin, and remdesivir potentially inhibited NSP9 (Dock-score 9 620, 5 472 and 6 252, respectively), NSP3 (Dock-score 9 846, 5 604 and 5 548, respectively) and NSP15 (Dock-score 10 960, 6414 and 6 002, respectively). Conclusions: Teicoplanin acts as a significant receptor antagonist and potentially inhibits the SARS CoV-2 enzymes.
    Keywords molecular docking ; oxicam ; antibiotics ; antiviral ; sars cov-2 ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome

    Sadia, Aatika / Basra, Muhammad Asim Raza

    Drug dev. res

    Abstract: Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome ... ...

    Abstract Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). As much as the researchers are inundated for the quest of effective treatments from available drugs, the discovery and trials of new experimental drugs are also at a threshold for clinical trials. There has been much concern regarding the new and targeted drugs considering the comprehensive ambiguity regarding the mechanism and pathway of the drug action with respect to the new and unpredictable structural and nonstructural proteins (NSPs) of SARS CoV-2. This study was aimed to discuss functional pathways related to NSPs in CoVs with updated knowledge regarding SARS CoV-2, mechanisms of action of certain approved and investigational drugs for correct orientation regarding the treatment strategies, including nucleotide analog mechanism, receptor analog mechanism, and peptide-peptide interactions, along with the impact of COVID-19 on a global scale. Although there is a dire need for targeted drugs against SARS CoV-2, the practical achievement of its cure is possible by only using effective drugs with appropriate mechanisms to eliminate the disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #654645
    Database COVID19

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    Inter-library loan at ZB MED

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  6. Article ; Online: Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes

    Basra, MuhammadAsim Raza / Sadia, Aatika / Azam, Muhammad

    Asian Pacific Journal of Tropical Biomedicine

    A docking study

    2020  Volume 10, Issue 12, Page(s) 563

    Keywords Biochemistry, Genetics and Molecular Biology (miscellaneous) ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ISSN 2221-1691
    DOI 10.4103/2221-1691.294093
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Working memory span and receptive vocabulary assessment in Urdu speaking children with speech sound disorder.

    Yasmin, Tahira / Hafeez, Huma / Sadia, Aatika / Lubna, Mubarak / Tarar, Sharmeen Aslam / Raza, Muhammad Hashim / Basra, Muhammad Asim Raza

    Acta psychologica

    2022  Volume 231, Page(s) 103777

    Abstract: Emerging evidence suggests that impaired speech may be related to reduced working memory (WM). The current study aimed to validate and compare the influence of articulation, short-term memory (STM), WM, and receptive vocabulary abilities of Pakistani ... ...

    Abstract Emerging evidence suggests that impaired speech may be related to reduced working memory (WM). The current study aimed to validate and compare the influence of articulation, short-term memory (STM), WM, and receptive vocabulary abilities of Pakistani children with speech sound disorder (SSD; N = 50) versus typically developing (TD; N = 30) children aged 7-13 years. Assessments included the Test for Assessment of Articulation and Phonology in Urdu (TAAPU), Peabody Picture Vocabulary Test-4, translated to Urdu (U-PPVT-4), and Digit Memory Test (DMT) used to determine speech articulation, receptive vocabulary, and memory abilities respectively. The percentage correct consonants (PCC) score was used to divide the SSD group further into SSD severity groups. The TD and SSD groups significantly differed in performance on all tasks (p < 0.05). Moreover, the SSD severity groups showed significant differences (p < 0.0001) in performance on different components of TAAPU (total errors and substitution errors) and DMT tasks. However, the SSD severity groups did not show significant differences in performance on the U-PPVT-4. Correlational analyses indicate statistically significant correlations of PCC with STM, WM, and receptive vocabulary. Regression analyses suggested that both WM and STM contribute to speech intelligibility in children with SSD. Our findings in Urdu-speaking children support previous results in English-speaking children suggesting the articulation skills, receptive vocabulary, STM, and WM were less developed in children with SSD than in TD children.
    Language English
    Publishing date 2022-11-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1480049-4
    ISSN 1873-6297 ; 0001-6918
    ISSN (online) 1873-6297
    ISSN 0001-6918
    DOI 10.1016/j.actpsy.2022.103777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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