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  1. Article ; Online: Physiological trajectories after traumatic brain injury: markers or makers of disease?

    Jha, Ruchira M / Kochanek, Patrick M

    The Lancet. Neurology

    2023  Volume 23, Issue 1, Page(s) 7–9

    MeSH term(s) Humans ; Brain Injuries, Traumatic
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00428-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials.

    Diaz-Arrastia, Ramon / Kochanek, Patrick M

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Volume 20, Issue 6, Page(s) 1428–1432

    MeSH term(s) Humans ; Brain Injuries, Traumatic/drug therapy
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01438-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6156: Show issues Location:
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  3. Article ; Online: Targeting interleukin-6 after cardiac arrest-Let us not forget the brain.

    Kochanek, Patrick M / Simon, Dennis W / Wagner, Amy K

    Resuscitation

    2023  Volume 184, Page(s) 109715

    MeSH term(s) Humans ; Brain/diagnostic imaging ; Heart Arrest/therapy ; Interleukin-6
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2023-02-02
    Publishing country Ireland
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1048: Show issues Location:
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  4. Article: A Perfect Tribute to the Tremendous Academic Growth of Pediatric Critical Care Medicine in Turkey.

    Kochanek, Patrick M

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2019  Volume 21, Issue 1, Page(s) 1

    MeSH term(s) Child ; Critical Care/methods ; Humans ; Pediatrics ; Turkey
    Language English
    Publishing date 2019-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5600: Show issues Location:
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    Zs.MO 472: Show issues

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  5. Article ; Online: The Evolution of Ketamine in Severe Pediatric Traumatic Brain Injury, From Contraband to Promising Neuroprotectant?

    Kochanek, Patrick M / Herrmann, Jeremy R / Bleck, Thomas P

    Critical care medicine

    2023  Volume 51, Issue 5, Page(s) 677–680

    MeSH term(s) Humans ; Child ; Ketamine/therapeutic use ; Neuroprotective Agents/therapeutic use ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries/drug therapy
    Chemical Substances Ketamine (690G0D6V8H) ; Neuroprotective Agents
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Fluid therapy after brain injury: the pendulum swings again.

    Kochanek, Patrick M / Jha, Ruchira M

    The Lancet. Neurology

    2021  Volume 20, Issue 8, Page(s) 587–589

    MeSH term(s) Brain Injuries/therapy ; Fluid Therapy ; Humans
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00204-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Black swans or red herrings - Inflammatory derangement after cardiac arrest.

    Kernan, Kate F / Kochanek, Patrick M

    Resuscitation

    2021  Volume 171, Page(s) 100–102

    MeSH term(s) Heart Arrest/therapy ; Humans
    Language English
    Publishing date 2021-12-14
    Publishing country Ireland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: A Special 50-Year Perspective on Our Field.

    Kochanek, Patrick M

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2018  Volume 19, Issue 5, Page(s) 389

    MeSH term(s) Critical Care/history ; History, 20th Century ; History, 21st Century ; Hospitals, Pediatric/history ; Humans ; Interviews as Topic ; Pediatrics/history ; United States
    Language English
    Publishing date 2018-02-24
    Publishing country United States
    Document type Editorial ; Historical Article ; Introductory Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000001494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 472: Show issues

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  9. Article ; Online: Letter: Evolution and Impact of the Brain Trauma Foundation Guidelines.

    Carney, Nancy / Kochanek, Patrick M / Adelson, P David

    Neurosurgery

    2022  Volume 91, Issue 4, Page(s) e117–e118

    MeSH term(s) Brain Injuries, Traumatic/therapy ; Humans ; Intracranial Pressure
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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    Zs.MO 539: Show issues

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  10. Article: Neuronal RBM5 modulates cell signaling responses to traumatic and hypoxic-ischemic injury in a sex-dependent manner.

    Snyder, Kara / Gorse, Kiersten / Kochanek, Patrick M / Jackson, Travis C

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 379

    Abstract: It is not clear if inhibiting the pro-death gene RNA binding motif 5 (RBM5) is neuroprotective in isolated primary neurons or if it regulates cell survival in a sex-dependent manner. Here we established sex-dichotomized primary cortical neuron cultures ... ...

    Abstract It is not clear if inhibiting the pro-death gene RNA binding motif 5 (RBM5) is neuroprotective in isolated primary neurons or if it regulates cell survival in a sex-dependent manner. Here we established sex-dichotomized primary cortical neuron cultures from transgenic mice harboring a floxed RBM5 gene-trap. Lentivirus-mediated expression of CRE was used to silence RBM5 expression. Male and female neurons were maintained in next-generation Neurobasal-Plus media and subjected to a mechanical stretch-injury (to model traumatic brain injury) or oxygen-glucose deprivation/OGD (to model ischemia). RBM5 KO did not affect 24 h post-injury survival as determined by lactate dehydrogenase (LDH) release, in either paradigm. In contrast, female KO neurons had increased spectrin breakdown products post-insult (in both models). Furthermore, in OGD, RBM5 KO in male neurons exacerbated injury-induced downregulation of pro-survival AKT activation (pAKT473) but conversely led to pAKT473 sparing in female neurons. Moreover, global proteomics identified 19 differentially expressed (DE) proteins in OGD-injured male neurons, and 102 DE proteins in injured female neurons. Two novel RBM5-regulated proteins (PIGQ and EST1C) were identified in injured male KO neurons, and 8 novel proteins identified in injured female KO neurons (S35A5, DHTK1, STX3, IF3M, RN167, K1C14, DYHS, and MED13). In summary, RBM5 inhibition does not modify neuronal survival in primary mouse neurons in 2 clinically relevant models of excitotoxic insult, but RBM5 does regulate intracellular responses to injury in a sex-dependent manner.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01677-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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